Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects: Proceedings of a conference held at Airlie House March 6–8 1981 PDF
Preview Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects: Proceedings of a conference held at Airlie House March 6–8 1981
Function and Regulation ofMonoamine Enzymes: Basic and Clinical Aspects Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects Proceedingsofa conference held at AirlieHouse March 6-8 1981 editedby EARL USDIN NationalInstituteofMentalHealth NORMAN WEINER UniversityofColorado MOUSSA B. H. YOUDIM TechnionFacultyofMedicine M This book was edited by DrUsdin in his private capacity. Noofficial support or endorsement by the NIMH isintendedor should beinferred. © The Contributors, 1981 Softcoverreprintofthe hardcover 1stedition 1981 All rights reserved. No part ofthis publication may be reproduced or transmitted, in any form or by any means, without permission. Firstpublished1981by Scientific and Medical Division MACMILLAN PUBLISHERS LTD London and Basingstoke Companies and representatives throughout the world ISBN978-1-349-06278-2 ISBN978-1-349-06276-8(ellook) 001 10.1007/978-1-349-06276-8 Contents Introduction xi Preface xiii Participants xv Abbreviations xxi Tyrosine Hydroxylase Insituphosphorylationofvasdeferens tyrosinehydroxylaseduringhypogastricnerve stimulation.NormanWeiner,Fu-LiLee,JohnMeligeniandA.WilliamTank 3 Aschematicmodelfortheallostericactivationoftyrosinehydroxylase.P.R. Vu/lietand N. Weiner 15 Isoelectricfocusing oftyrosinehydroxylase.JohnMeligeniandNorman Weiner 25 Rolefortyrosinehydroxylaseactivationintheregulation ofdopaminesynthesis.B. Zivkovic 35 The control oftyrosinehydroxylaseactivity:Enzymeactivationvs.feedback inhibition. RobertL.Perlman 45 Neurolepticdrugs modifyretinal dopamine-containingamacrinecelltyrosine hydroxylaseactivity.JosephCohenandNortonH.Neff 55 Short-term and long-termregulationoftyrosinehydroxylaseactivityinretinaland mesolimbicdopamine-containingneurons.P.MichaelIuvoneandAlbertL.Rauch 65 Therapid activationand deactivationofadrenaltyrosinehydroxylaseandproteinkinase followingelectroconvulsiveshock.JosephM.MasseranoandNorman Weiner 75 Centralnoradrenergicneurons:Studies onthemechanismoftheinvivoactivationof tyrosinehydroxylase.K.GyslingandR.H.Roth 83 Invivotreatmentsassociatedwiththeactivationoftyrosinehydroxylaseinrabbit vasculature.GlennS.TakimotoandNorman Weiner 95 Regulatorypropertiesoftyrosinehydroxylase:Multipleforms, subunitstructureand cyclicnucleotide independentphosphorylation.JoachimD.Raese,GeorgeMakkand JackD.Barchas 105 Themodificationofthekineticsoftyrosinehydroxylaseinvitroand invivo:apossible roleforcarboxymethylationintheregulationofLdopasynthesis.StephenP.Mann 115 Activatingsheepantibodiestotyrosinehydroxylase.JohnW.HaycockandJack C. Waymire 121 v vi Partialdestructionofnoradrenergicterminalsisfollowed byincreasedtyrosine hydroxylaseactivityinresidual terminals.M.J.Zigmond,A.L.AchesonandE.M. Stricker 131 Molecularbiology oftyrosinehydroxylaseinduction.A.Guidotti.D.M.Chuang.K. KumakuraandE.Costa 141 RegulationoftyrosinehydroxylasebycyclicAMPanddexamethasoneinmouse neuroblastomacells.A. W.TankandN. Weiner 149 DISCUSSION 157 2 Tryptophanand PhenylalanineHydroxylases Regulatorypropertiesofpterin-dependenthydroxylases:variationsonatheme.Seymour Kaufman 165 Invitroand invivoactivationoftryptophanhydroxylaseintherat brain.S.EI Mestikway, S.Bourgoin.F.ArtaudandM.Hamon 175 Theregulationoftryptophanhydroxylaseactivity.DonaldM.Kuhn 187 Regulationoftryptophanhydroxylaseactivity:Studieswithslicesofrat brain stem and someinvivotreatments.Margaret C.Boadle-Biber 195 Modulationoftryptophanhydroxylasestability:Apossiblemechanismformonoamine enzymeregulation.AnthonyVitto 205 Calcium,cofactorand propranolol-inducedchangesinthekinetic variationsofrat raphe tryptophanhydroxylaseactivity.SuzanneKnappandArnoldJ.Mandell 215 3 PterinCofactors The hydroxylasecofactorand catecholaminesynthesis. WalterLovenberg,Robert LevineandLeonardMiller 225 Adrenergic-cyclicAMPregulationofbiopterinbiosynthesisinthepinealgland. Gregory Kapatos, SeymourKaufman. JoanL. WellerandDavidC.Klein 231 Controloftissue tetrahydrobiopterinlevelsthroughGTP-cyclohydrolase:Afactorinthe regulationofmonoaminesynthesis.O.H. Viveros.M.M.Abou-Donia, C.-L.Lee.S.P. Wilsonand C.A.Nichol 241 New aspectsinbiopterin biosynthesis.H.-Ch.Curtius,M.Hdusermann,A.Niederweiser, W.EndresandM.Viscontini 251 Sepiapterin(6-lactyl-7,8-dihydropterin)isanintermediateinbiopterinbiosynthesisina cell-freepreparationfrom rat striatum.GregoryKapatos,SetsukoKatohandSeymour Kaufman 263 Striataltyrosinehydroxylase:The roleofcofactorconcentrationinthe scalingofenzyme periodicityandbehavioralstereotypy.ArnoldJ.MandellandPatrick V.Russo 271 DISCUSSION 281 vii 4 MonoamineSynthesisandMetabolisminIntactSystems Transynapticregulationofadrenaltyrosinehydroxylaseintracingcentralautonomic pathways.Jean-PierreGagner.SergeGauthierandTheodoreL. Sourkes 287 Hormonalinvolvement infootshock-inducedchangesincatecholaminesynthesis inbrain slices.AdrianJ.Dunn.NealR.KramarcyandRichardL.Delanoy 297 Stimulantdrugeffectsoncatecholaminesynthesisregulation.RobertL. Patrick 307 Transportsystems fortyrosineandtheirrelation tocatecholaminebiosynthesis.J. Bruinvels 315 ThesiteofdecarboxylationofexogenousL-dopaintheratstriatum.FranzHeftiand EldadMelamed 327 Regulationofdopa biosynthesisbypresynapticdopaminereceptorsandoq- adrenoreceptors.MenekGoldstein,JoseM.Rabey,KeithMarkey,PatriciaPasseltiner andJorgenEngel 339 Neurotransmitterinteractionsinthemedian raphe nucleus.C.M.ForchettiandJ.L. Meek 347 Combinedimmunocytochemicalandradioautographicstudyofdopaminergicterminals intheneostriatum.V.M.Pickel,A.Beaudet,T.H.Joh,D.J.ReisandM.Cuenod 353 Evidenceforaperipheral dopaminergicneural system.ZravkoLackovic,MajaReljaand NortonH.Neff 361 The metabolismofdopamineinsheepblood.D.F.Sharman 371 Regulatorydysfunctionoftyrosinehydroxylaseand dopamine-J3-hydroxylaseinfamilial dysautonomia.N.EricNaftchi,FeliciaB.AxelrodandMargaretDemeny 377 Effectsofchronicamphetamineadministrationonbehaviourand monoamine metabolismincats.MichaelE.TrulsonandBarryL.Jacobs 387 Amathematicalmodelofcentraldopaminergictransmissionandthedopamine hypothesisofschizophrenia.RoyKing.JoachimD.RaeseandJackD.Barchas 399 S Dopamine-B-Hydroxylase Dopamine-J3-hydroxylase:Comparisonofsolubleand membraneforms.Norman Kirshner.JosephP.Albanesi,EllenC.RobinsonandJacquelineReynolds 409 Semidehydroascorbateastheenzymic productofdopamineJ3-hydroxylation: Mechanismandfunctional significance.EmanuelJ.Diliberto.Jr. 421 Catecholaminesynthesizingenzymesinrat pheochromocytomaPC-12cells.Esther Sabban,JimFong,KeithMarkey,LouisShenkman.Menek GoldsteinandLloydA. Greene - 431 RegulationofcirculatingdopamineJ3-hydroxylasebydisposal pathways:Effectsof endocrinefunction.JonM.Stolk,JeffreyH.Hurst.RasB.Guchhait,RobertJ.Fadden andBruceC.Nisula 435 FunctionalimplicationsofdopamineJ3-hydroxylaselocalizationandnorepinephrine synthesiscapacityinlargeand smallvesiclesofsympathicneurons.RichardL. Klein andAsaK.Thureson-Klein 443 viii Isolation andpurificationofdopaminef3-hydroxylasefromthesplenicnerveandpurified noradrenergicvesicles.Wen-HsunYang 453 DISCUSSION 461 6 MonoamineOxidase EnergyofactivationofMAO.TheodoreL. SourkesandMadanM.Kwatra 465 HowdoMAO-A and MAO-Bselecttheirsubstrates?Thermodynamicalaspects.E.A. ZellerandK.L.Arora 469 CatalyticmechanismofMAO fromliver.MazharHusain,DaleE.Edmondsonand ThomasP.Singer 477 TopologyandlipidproteinassociationofMAO-A andMAO-B.RosaH.Huang 489 Theprocessing andassembly ofratliverMAO.DavidSmithandRoyMcCauley 503 RoleoftypeAandtypeBmonoamineoxidaseinthemetabolismofepinephrineinrat brain.Ray W.FullerandSusanK.Hemrick-Luecke 509 DifferencesinthepreferentialdeaminationofI-norepinephrine,dopamine andserotonin byMAOinrodentandprimate brain.NancyA.GarrickandDennisL.Murphy 517 Aliphatic aminesasMAO substratesintherat:Theeffectofselectiveinhibitorsonthe deaminationofn-pentylamine.MargheritaStroltn-Benedetti.NicoleSontag,Thierry BoucherandJean-PaulKan 527 Oxidativedeaminationoftrace aminesinthebrain.A.A.Boulton,B.A.Davis,D.A. Durden,A.V.Juorio,S.R.PhilipsandP.H.Yu 539 Cardiovascularchanges accompanyingMAOinhibitioninman.DennisL. Murphy, BenjaminRoy,DavidPickar,StevenLipper,RobertM.Cohen,DavidJimerson,Charles R.Lake,G.Muscettola,JuanSaavedraandIrwinJ.Kopin 549 PlateletMAO activityindepressedpatients.JeanC.Shih,KerrinWhite,JavadRazani, GeorgeSimpsonandR.BruceSloane 561 Anomalies inMAO assays using.!I.A and.!l.Omeasurementswithbenzylamineas z49 substrate.R.W.VonKorffandA.R.Wolfe 565 DISCUSSIONS 575 InteractionofacetyleniccompoundswithMAO activesite:structure-activityand pharmacologicalstudies.M.B.Y.Youdim,J.P.M.FinbergandM.Tenne 911 7 Aldehydereductasesanddehydrogenases Substratecompetitionforaldehydemetabolism.KeithF.Tipton,IanL. Smith,Catherine M.RyleandA.JenniferRivett ·581 Thestructureandfunction ofaldehydereductases.AnthonyJ.TurnerandSusanR. Whittle 591 Functionalgroupsinpigkidneyaldehydereductase.T.G.Flynn,D.FergusonandW.S. Davidson 601 Roleofmagnesium andcalciumionsintheregulationofmitochondrialaldehyde dehydrogenase.HenryWeinerandKojiroTakahashi 611 ix Acritical appraisalofaldehyde reductaseactivitiesinbrain.PaulaL.HoffmanandBoris Tabakoff 621 Thepurification andpropertiesofmousebrain aldehydedehydrogenase.D.R.Petersen andN.A.Atkinson 633 Actionsofamine-aldehydecondensationproducts.ChristineL. Melchior 643 8 Transferases 3-Substituted-4-methoxy-5-hydroxybenzaldehydesandbenzoicacidsasinhibitorsof catechol-O-methyltransferase.RonaldT.BorchardtandJoanA.Huber 657 COMT-AandCOMT-B:Catalyticdifferencesandroleofdisulfidebonds. Giovanni MarzulloandArnoldJ.Friedhoff 665 Immunohistochemicallocalizationofcatechol-O-methyltransferaseinbrain:potential roleasanenzymaticbarrier.BoydK.Hartman,GaryP.KaplanandCyrusR.Creveling 675 UseofacatecholO-methyltransferaseinhibitor toenhancecentalactionofL-dopa.A. Reches,D.JiangandS.Fahn 683 Stereochemicalaspectsofbindingofaromaticandnon-aromaticsubstratesand inhibitorstophenylethanolamineN-methyltransferase.GaryL. GrunewaldandMichael F.Rafferty 691 PurificationofsheeppinealN-acetyltransferase.M.A.A.NamboodiriandD.C.Klein 70I InactivationofpinealN-acetyltransferasedisulfideexchange:ApossibleroleofS-S peptides.DavidC.KleinandM.A.A.Namboodiri 711 Investigationsoftherelationshipbetweenchangesinneuralactivity and changes intissue biochemistry:Somecriteriaandtheexampleofserotonin N-acetyltransferase.R.E. ZigmondandC.W.Bowers 723 Regulationofphenolsulfotransferaseactivity intherat.RandallK.Pearson,TimothyP. Maus,RobertJ.Anderson,LeeC.Woodson,CristophReiterandRichardM. Weinshilboum 735 Phenolsulphotransferaseanditsclinicalimportance.M.Sandler,GlenRein,Vivette Glover,SusanM.BonhamCarterandJuliaLittlewood 743 DISCUSSION 755 9 ApplicationsofElectrochemicalDetectionTechniques Thedeterminationofcatecholamineandindoleamineenzymaticactivitiesusingliquid chromatographywithelectrochemicaldetection.C.LeRoyBlank,P.Wong,M.Bulawa andP.Lin 759 Electrochemicalrecordingofbrain catecholamineand serotoninreleaseduring behavioralchanges.P.J.Knott,P.H.Hutson,R.P.ScraggsandG.Curzon 771 Directamperometricmeasurementoftherate ofreleaseofdopaminefromsuperfused braintissue.R.Mark Wightman,John N.CavinessandAnnM.Hmelovsky 781 x 10 Monoamine-ReceptorInteractions Modulationofdopamine-sensitive adenylatecyclasebycalmodulinand guanyl nucleotides.M.E.GnegyandS.D.Bagley 793 Treatmentwith6-hydroxydopamineormorphineinducessupersensitivity ofthe dopaminereceptor-adenylatecyclasecomplex.N.H.Neff,M.Parenti,S.Gentlemanand M.C.Olianas 803 Mechanisms oftheinternalizationofbeta-adrenergicreceptor recognitionsites.D.-M. Chuang,L. Farber,M.L.BarbacciaandE.Costa 809 Correlationofdopamineandopiate bindingwithadenylate cyclaseinrat striatum.Susan Gentleman 817 Regulation ofintracellularand nuclearmetabolism bystimulation ofl3-adrenergic receptorsonC6gliomacells.JoanP.SchwartzandPierluigiOnali 825 II Genetic andDevelopmentalAspects Genetic variationsinnumberofdopamineneurons inmousebrain:Evidencethat all dopaminesystems areinvolved.HarrietBakerandDonaldJ.Reis 835 Developmentandregulationofhypertensioninthespontaneouslyhypertensiverat: Enzymaticandnutritional studies.TomLloydandBrendaBoyd 843 BiochemicalandgeneticanalysisofMAO AandB.JohnE.Pintar.RichardM. Cawthon,MorrisHawkinsJr.,CarmelaM.CastiglioneandXandraO.Breakefield 855 Substrateand speciesrelatedvariationsduringtheperinatal developmentofMAO activity. MargaretheHolzbauer 865 Transformationofcatecholaminergicprecursorsintoglucagon(A)cellsinthemouse embryonicpancrease.G.Teitelman,T.H.JohandD.J.Reis 873 Morphologicalchanges intheadrenergicground plexusoftheiriselicitedbylead. cadmiumand mercury.HdkenBjorklund.LarsOlson,,.IkeSeigerandBarryHoffer 885 Regulationofintracellularenzymeproteolysisbysmall-moleculecofactors.RolandD. Ciaranello 895 DISCUSSION 905 GENERALDISCUSSION 907 SubjectIndex 923
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