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Frontiers of Nuclear Medicine/Aktuelle Nuklearmedizin PDF

321 Pages·1971·11.8 MB·English
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Frontiers of Nuclear Medicine Aktuelle Nuklearmedizin Frontiers of Nuclear Medicine Aktuelle Nuklearmedizin Editor : Wolfgang Horst Springer-Verlag Berlin Heidelberg New York 1971 Professor Dr. med. WOLFGANG HORST Direktor der Universitatsklinik und Poliklinik fUr Nuklearmedizin und Radiotherapie, Kantonsspital, CH-8006 ZUrich With 180 Figures ISBN-13: 978-3-642-65094-9 e-ISBN-13: 978-3-642-65092-5 DOl: 10.1007/978-3-642-65092-5 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is con cerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photo copying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to the publisher, the amount of the fee to be deter mined by agreement with the publisher. © by Springer-Verlag, Berlin· Heidelberg 1971. Softcover reprint of the hardcover 18t edition 1971 Library of Congress Catalog Card Number 71-152727 The reproduction in this book of registered trade-marks does not warrant the assumption, even without any special marking, that such names are to be considered free undef the trade-mark law and may be used by anyone. Preface That nuclear medicine has advanced so far and so fast is due in no small measure to GEORGE VON HEVESY. His work on radioactive indicator technique laid the foundation on which this young branch of medicine was able to develop in the decade which followed World War II. In the intervening years the second generation has grown up in nuclear medicine. Some of them were still exposed to VON HEVESY'S influence, for instance, his address to the 1957 meeting of the Italian Society of Nuclear Medicine in Turin, or his Marie Curie Memorial Lecture at the Pittsburg meeting of the North American Society of Nuclear Medicine in 1961. Others again will remember that he helped to found the European Society of Nuclear Medicine in 1962-1963 and became its honorary president. It was VON HEVESY who, together with HEILMEYER, insisted that this be a completely open society, having neither national nor geographical attributes, its Europeanness being reflected in the variety of languages spoken at its congresses. Its members exhibited a similar variety, including in addition to those medically qualified -specialists in internal medicine, radiologists and laboratory research workers-physicists, chemists and engineers. A group of young second-generation scientists from eleven countries have dedicated these papers to the memory of the great pioneer of nuclear medicine. This book contains new results reported by doctors, physicists, chemists and computer specialists-results so far-ranging as to push the frontiers of nuclear medicine still further forward. Zurich, April 1971 W. HORST Vorwort Die Nuklearmedizin verdankt ihre heutige schnelle Entwicklung in besonderem MaBe GEORG VON HEVESY. Seine Arbeiten uberdieradioaktivelndikatortechnik waren ein wichtiges Fundament, auf dem sich dieser junge Zweig der Medizin im ersten Jahrzehnt nach dem 2. Weltkrieg entwickelte. Inzwischtm ist bereits die zweite Generation von Nuklearmedizinern heran gewachsen. Sie hat das Wirken VON HEVESYS z. T. noch mitedebt, so z. B. in Italien seinen Festvortrag anlaBlich der Tagung der Italienischen Gesellschaft fur Nuklearmedizin 1957 in Turin oder seine Gedachtnislesung fiir Marie Curie 1961 in Pittsburg anlaBlich der dortigen Tagung der Gesellschaft fUr Nuklearmedizin von Nordamerika. Andere werden sich an VON HEVESY erinnern, als er 1962 und 1963 die europaische Gesellschaft fur Nuklearmedizin mitbegrundete und ihr Ehrenprasident wurde. Er war es, der damals mit HEILMEYER zusammen diese Gesellschaft als offene Gesellschaft verstanden wissen wollte, die weder nationale noch geographische Attribute tragen sollte und die ihre europaische Vielfalt auch in der Zahl der KongreBsprachen widerspiegelt. Die gleiche Vielfalt findet sich unter ihren Mit gliedern: Arzte - Internisten, Radiologen, Laboratoriumsmediziner usw. -, Physiker, Ingenieure und Chemiker. Eine Gruppe von jungen Wissenschaftlern der zweiten Generation hat nun wissenschaftliche Arbeiten dem Andenken des groBen Pioniers der Nuklearmedizin gewidmet. Es sind Arzte, Physiker, Chemiker und Computerfachleute aus 11 Lan dern, die in diesem Buch ihre neuen Ergebnisse mitteilen - Ergebnisse, die in ihrer Vielgestaltigkeit die wissenschaftliche Front der heutigen Nuklearmedizin aufreiBen. Zurich, April 1971 W. HORST George von Hevesy . . memotlam 1n * 1. VIII. 1885 Budapest t 5. VII. 1966 Freiburg i. Br. GEORGE VON HEVESY GEORGE VON HEVESY was a pioneer of GEORG VON HEVESY war ein Pionier nuclear medicine. He received the Nobel der Nuklearmedizin. Er erhielt 1943 fiir seine Prize in 1943 for his studies in the field of Arbeiten iiber die radioaktive Indikatortech radioactive indicator technique and was one nik den Nobelpreis und war Mitbegriinder of the founders and honorary president of the und Ehrenprasident der europaischen Gesell European Society of Nuclear Medicine as schaft fur Nuclearmedizin sowie Ehrenmit well as honorary member of the North glied der Gesellschaft fur Nuclearmedizin von American Society of Nuclear Medicine. Nordamerika. The George von Hevesy Prize for Nuclear Der Georg von Heve8Y Prei8 fur Nuklear Medicine was awarded for the first time at medizin wurde erstmals anlaBlich der 7. Jah the 7th annual meeting of the European restagung der europaischen Gesellschaft fUr Society of Nuclear Medicine, held in Zurich Nuclearmedizin 1969 in Ziirich verliehen an in 1969. The recipient was H. SAUL WINCHELL, M.D., Donner Laboratory, University of California, Berkeley. On the occasion of the 8th annual meeting AnlaBlich der 8. Jahrestagung der euro of the European Society of Nuclear Medicine, paischen Gesellschaft fiir Nuclearmedizin held in Hanover in 1970, the first George von 1970 in Hannover wurde die erste Georg von Hevesy Memorial Lecture was read by H evesy Gedachtnisvorlesung gehalten von Professor E. ERIC POCHIN, M.A., M.D., F.R.C.R., President emeritus I.C.R.P., Medical Research Council, University of London. x George von Hevesy GEORGE VON HEVESY was born in Budapest on 1st August, 1885. He studied chemistry, mathematics and physics in Budapest, Berlin and Freiburg im Breis gau, where he also obtained his doctorate. He then worked for two years with LORENZ and WILLSTATTER at the ETH Zurich, in 1911 was with HABER in Karlsruhe and until 1913 with RUTHERFORD in Manchester. In 1913, with P ANETH in Vienna, he carried out the earliest work on radioactive indicators. After a short period at the University of Budapest, he joined NIELS BOHR in Copen hagen until 1926; in 1922 he discovered hafnium and in the following year did his first work on radioactive indicators in biology. From 1926 to 1934 he was Director of the Physical-Chemical Institute of the University of Freiburg i. Br., returning to Copenhagen until 1943. In 1935 he and CHIEWITZ carried out the first work with an artificial radionuclide, 32p, with the support of O. H. LAWRENCE and the collaboration of A. KROGH. He was awarded the Nobel Prize in 1943. From then until 1961 he worked in Stockholm, in the THEORELL and VON EULER Institutes and the Radiumhemmet. His interests now embraced clinical, physio logical and biological problems and radiobiology. GEORGE VON HEVESY died on 5th July, 1966, in Freiburg i. Br., surrounded by his family and tended by his friend and physician, L. HEILMEYER. He published more than 400 articles in the course of his career, in addition to a number of world-famous books which had been translated into many languages. GEORG VON HEVESY wurde am 1. August 1885 in Budapest geboren. - Studium von Chemie, Mathematik und Physik in Budapest, Berlin und zuletzt in Freiburg im Breisgau, wo er auch promovierte. AnschlieBend zwei Jahre bei LORENZ und WILLSTATTER an der ETH Zurich; 1911 bei HABER in Karlsruhe und bis 1913 bei RUTHERFORD in Manchester. In Wien 1913 erste chemische Radioindikatorarbeit mit P ANETH. - N ach kurzerer Tatigkeit an der Universitat Budapest bis 1926 bei NIELS BOHR in Kopenhagen. 1922 Entdeckung des Haf niums; 1923 erste biologische Radioindikatorarbeit. 1926-1934 Direktor des Physikalisch-chemischen Instituts der Universitat Freiburg im Breisgau. 1934 bis 1943 wieder bei NIELS BOHR in Kopenhagen. 1935 gemeinsam mit CHIEWITZ erste biologische Arbeit mit einem kunstlichen Radionuklid (32P); Unterstutzung durch O. H. LAWRENCE und Zusammenarbeit mit A. KROGH. 1943 Nobelpreis. 1943-1961 in Stockholm im Institut THEORELL und VON EULER sowie im Radiumhemmet. Seine Arbeitskraft galt jetzt klinischen, physiologischen und biologischen Problemen und der Radiobiologie. GEORG VON HEVESY starb am 5. Juli 1966 in Freiburg im Breisgau, umsorgt von seiner Familie und seinem Freund und Arzt L. HEILMEYER. Sein Lebenswerk umfaBt mehr als 400 Veroffentlichungen neben einer Zahl weltweit bekannter Bucher, die in viele Sprachen ubersetzt wurden. George von Hevesy XI Horwrary degrees : Membership of academies: Ehrendoktor der UniversiUiten von: Mitglied der Akademien: 1929 Cape Town, Sc.D. 1925 Danish Academy of Sciences 1945 Uppsala, Phil.D. 1926 Akademie der Wissenschaften in 1948 Freiburg im Breisgau, Phil.D. Heidelberg 1950 Ghent, D.Sc. 1928 Gothenburg Academy of Sciences 1950 Copenhagen, Phil.D. 1939 Royal Society, London 1954 Sao Paulo, Med.D. 1942 Swedish Academy of Sciences 1955 Rio de Janeiro, Med.D. 1945 Hungarian Academy of Sciences 1957 Turin, Med.D. 1948 Rome Academy of Sciences (Lincei) 1957 Burlington, Jur.D. 1948 Genoa Academy of Sciences 1959 Freiburg im Breisgau, Med.D. 1948 National Academy, Boston 1959 Liege, Sc.D. 1950 Brussels Academy of Sciences 1960 London, Sc.D. 1950 National Academy of India 1964 Cambridge, Sc.D. 1961 Pontificial Academy 1965 Budapest, Dr. Ing. 1965 Osterreichische Akademie der Wissenschaften M edal8 and prizes: Honorary member o/learned 80cietie8: Auszeichnungen und Prei8e: Ehrenmitglied der wi88en8cha/tlichen Ge8ell- 8cha/ten: 1929 Cannizzaro Prize, Rome 1939 Chemical Society, London 1942 Danish Cancer Research Prize 1945 Chemical Society, Helsingfors 1944 Nobel Prize of 1943 1948 Royal Institution 1949 Copley Medal, Royal Society 1951 Deutsche Bunsen-Gesellschaft 1950 Faraday Medal, Chemical Society 1952 Swedish Medical Society 1950 Brussels Academy Medal 1955 Biochemical Society, Helsingfors 1951 Bailey Medal, College of Physicians, 1955 Austrian Society of Physics and London Chemistry 1956 Silvanus Thompson Medal, British 1958 Japan Chemical Society Society of Radiology 1958 Society of Nuclear Medicine, U.S.A. 1957 Medal of the City of Paris 1958 British Society of Radiology 1957 Mitglied des Ordens Pour Ie Merite der 1960 Deutsche Phyaiologische Gesellschaft BRD 1960 Akademie Halle 1958 Cotius-Medaille der Akademie der 1963 Gesellschaft fUr Nuclearmedizin, Wissenschaften in Halle Mitbegriinder, Ehrenprasident 1959 Atoms for Peace Award 1965 Swedish Society of Radiobiology 1961 Rosenberger Medal of Chicago University 1961 Niels Bohr Medal of the Danish Engineering Society

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That nuclear medicine has advanced so far and so fast is due in no small measure to GEORGE VON HEVESY. His work on radioactive indicator technique laid the foundation on which this young branch of medicine was able to develop in the decade which followed World War II. In the intervening years the se
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