Frontiers of Medicine

236 Pages·1977·5.192 MB·English

by  Arthur Kornberg M.D. (auth.), Gordon M. Meade M. D. (eds.)

Frontiers of
Medicine
A SYMPOSIUM IN CELEBRATION OF THE 50TH ANNIVERSARY OF
THE UNIVERSITY OF ROCHESTER MEDICAL CENTER HELD IN
ROCHESTER, NEW YORK, APRIL 1-2, 1976
CONTRIBUTORS
William Ferguson Anderson, M.B., Ch.B., M.D., David Cargill Professor in Geriatric
Medicine, University of Glasgow, Scotland; Consultant in Organization of Patient
Care, World Health Organization.
Mary Ellen Avery, M.D., Rotch Professor and Chairman of Pediatrics, Harvard Medical
School, Boston, Massachusetts.
Zanvil Cohn, M.D., Professor and Senior Physician, Rockefeller University, New York,
New York.
Alexander Comfort, M.B., B.Ch., D.Sc., Fellow, Institute for Higher Studies, Santa
Barbara, California; Clinical Lecturer, Department of Psychiatry, Stanford University,
Palo Alto, California.
Allen P. Kaplan, M.D., Head, Allergic Diseases Section, Laboratory of Clinical Investiga
tion, National Institute of Allergy and Infectious Diseases, National Institutes of
Health, Bethesda, Maryland.
C. Henry Kempe, M.D., Professor of Pediatrics and Microbiology, University of Colorado
Medical Center, Denver, Colorado.
Arthur Kornberg, M.D., Professor of Biochemistry, Stanford University, Palo Alto, Cali
fornia; Nobel Laureate, 1959.
John Money, Ph.D., Professor of Medical Psychology and Associate Professor of Pediatrics,
Johns Hopkins University, Baltimore, Maryland.
Paul Quie, M.D., Professor of Pediatrics, Laboratory Medicine, Pathology and Microbiology,
University of Minnesota Medical School, Minneapolis, Minnesota.
Nathan Shock, Ph.D., Chief, Gerontology Research Center, National Institute on Aging,
Baltimore, Maryland.
Virginia Stone, R.N., Ph.D., Professor, School of Nursing, Duke University, Durham, North
Carolina.
Jean Wilson, M.D., Professor of Medicine, University of Texas Health Science Center,
Dallas, Texas.
Frontiers of
Medicine
Edited by
Gordon M. Meade, M.D.
University of Rochester School of Medicine and Dentistry
Rochester, New York
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging in Publication Data
Main entry under title:
Frontiers of medicine.
"Proceedings of a symposium of the 50th anniversary of the University of
Rochester Medical Center held in Rochester, New York, April1-2, 1976."
Includes index.
1. Medicine-Congresses. 2. Pediatrics-Congresses. 3. Sex-Congresses. 4.
Inflammation-Congresses. 5. Geriatrics-Congresses. 6. Rochester, N.Y. Univer
sity. Medical Center. I. Meade GordonM. II. Rochester, N.Y. University. Medical
Center. [DNLM: 1. Medicine-Congresses. WB100 F935f 1976]
R106.F76 616 77-3334
ISBN 978-1-4684-2387-7 ISBN 978-1-4684-2385-3 (eBook)
DOI 10.1007/978-1-4684-2385-3
Proceedings of a Symposium in celebration of the
50th Anniversary of the University of Rochester Medical Center
held in Rochester, New York, April 1-2, 1976
© 1977 Springer Science+Business Media New York
Originally published by Plenum Press, New York in 1977
Softcover reprint of the hardcover 1st edition 1977
A Division of Plenum Publishing Corporation
227 West 17th Street, New York, N.Y. 10011
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted,
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
UNIVERSITY OF ROCHESTER 50TH ANNIVERSARY PROGRAM
Chairman - Clarence L. A. Wynd
Coordinator- Gordon M. Meade, M.D.
"Frontiers of Medicine" Symposium Committee
Donald G. Anderson, M.D.
Chairman: 1973-1974
William A. Peck, M.D.
Cha~man: 1974-1976
Loretta C. Ford, R.N., Ed.D.
Raymond Hinshaw, M.D.
Paul Horowicz, Ph.D.
Paul La Celie, M.D.
Rene Menguy, M.D.
Ernest Saward, M.D.
FOREWORD
In September 1925 the first class of medical students was
admitted to the University of Rochester School of Medicine and
Dentistry. On January 4, 1926 the Strong Memorial Hospital was
officially opened. The first patient was admitted the next day.
On January 7th Dr. John J. Morton, Jr., newly appointed Chief of
Surgery, performed the first operation. Ten days later the first
baby was delivered. From these small beginnings the University of
Rochester Medical Center had a steady and strong growth into the
internationally renowned center of teaching, research and patient
care that it is today.
In recognition of its semicentennial the Medical Center con
ducted a series of events during the 1975 - 76 year in which medi
cal faculty and staff~ alumni, community physicians and distin
guished visitors participated.
This symposium on "Frontiers of Medicine" was a climactic
event of the year's program. The twelve outstanding physicians
and scientists undertook to look forward, in selected areas of
biological science and medicine, to what promise there may be for
developments to come which will significantly affect mankind's
health and the quality of life.
Four areas were chosen for discussion to cover the span of
human life and to include aspects of it which are of vital in
terest and in which significant developments now seem to be prob
able in the years ahead. So far as possible the presentations
sought to cover the basic science, the clinical and the sociologic
aspects of each subject area.
The "Frontiers of Medicine" Symposium was fully supported by
the Eastman Kodak Company.
vii
MODERATORS
TOMORROW'S CHILDREN - Gilbert B. Forbes, M.D. - Professor of
Pediatrics and of Radiation and Biophysics - University of
Rochester School of Medicine and Dentistry.
HUMAN SEXUALITY - William A. Peck, M.D. - Professor of Medicine
and of Biochenistry, Head of Endocrinology Unit - University
of Rochester School of Medicine and Dentistry.
MOLECULAR BIOLOGY OF DISEASE - THE INFLAMMATORY PROCESS -
J. Lowell Orbison, M.D. - George Hoyt Whipple Professor of
Pathology; Dean, Director, Medical Center - University of
Rochester School of Medicine and Dentistry.
SEVENTH AGE OF MAN - T. Franklin Williams, M.D. - Professor of
Medicine, of Radiation Biology and Biophysics, and of
Preventive Medicine and Community Health, University of
Rochester School of Medicine and Dentistry; Medical Director,
Monroe Community Hospital.
viii
CONTENTS
TOMORROW'S CHILDREN
Genes and Nutrition in Development • • . . . . • . . • . 1
Arthur Kornberg
Problems and Progress in Perinatology 21
Mary Ellen Avery
Vindication of the Rights of Children 33
C. Henry Kempe
HUMAN SEXUALITY
The Genetic and Endocrinological Basis for
Sex Determination • • 59
Jean Wilson
Clinical Frontiers and the Three Phases of
Sexuality - Proception, Acception,
and Conception . . • . • . . . • . 71
John Money
Sexuality in a Zero Growth Society . . . . . • . . . . . 79
Alexander Comfort
THE MOLECULAR BIOLOGY OF DISEASE - THE INFLAMMATORY RESPONSE
Physiology and Biochemistry of Phagocytic Cells 95
Zanvil Cohn
Chemical and Immune Mediators of the
Inflammatory Response 105
Allen Kaplan
ix
CONTENTS
X
Clinical Manifestations of Defects in the
Inflammatory Response • • • • • 145
Paul Quie
THE SEVENTH AGE OF MAN
The Biological Basis of Aging 167
Nathan Shock
Physical, Mental and Social Health in Old Age 201
William Ferguson Anderson
Humanization of the Seventh Age of Man . . . • . • • • . 209
Virginia Stone
INDEX • • • • • • • • • • • • • • • • • • • • • • • • • • • 223