Frontiers in Anti-infective Drug Discovery, Volume (1)

436 Pages·2010·7.28 MB·English

by  ur-Rahman

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Frontiers in Anti-Infective Drug Discovery
Bentham Science Publishers Ltd.
http://www.bentham.org/fiaidd
Volume 1
Contents

Preface i
Contributors ii
Strategies for Effective Naked-DNA Vaccination Against Infectious Diseases 1
Pieranna Chiarella, Emanuela Massi, Mariangela De Robertis, Vito M. Fazio
and Emanuela Signori
Light Activated Compounds as Patented Antimicrobial Agents 17
David A. Phoenix and Frederick Harris
Proteases and Kinases: Attractive Targets for Combating Infectious Diseases 49
Mona Arabshahi, Usha Bughani, Surya N. Vangapandu, Ritu Aneja,
Ramesh Chandra, Daniel Kalman and Harish Joshi
Antibacterial Therapy in the Elderly 70
Ayman M. Noreddin and Walid F. El-Khatib
SARS Coronavirus Anti-Infectives 83
Tommy R. Tong
Probiotics as Drugs Against Human Gastrointestinal Pathogens 107
Yolanda Sanz, Inmaculada Nadal and Ester Sánchez
Insights into the Treatment of Helicobacter pylori Infection 124
Campo Salvatore Maria Antonio, Hassan Cesare, Burza Maria Antonietta,
Ridola Lorenzo, Cristofari Francesca, Morini Sergio and Zullo Angelo
Inhibitors of Bacterial Efflux Pumps as Adjuvants in Antibacterial Therapy 138
and Diagnostic Tools for Detection of Resistance by Efflux
Françoise Van Bambeke, Jean-Marie Pagès and Ving J. Lee
Drugs Candidates in Advanced Clinical Trials Against Tuberculosis 176
Marcus Vinícius Nora de Souza, Marcelle de Lima Ferreira and
Raoni Schroeder B. Gonçalves
Drug Effects on Drug Targets: Inhibition of Enzymes by Neuroleptics, 202
Antimycotics, Antibiotics and Other Drugs on Human Pathogenic Amoebas
and their Anti-Proliferative Effects
Raúl N. Ondarza
Macrophage Inflammatory Protein 1 and CCR5 as Potential Therapeutic 227
Targets for HIV Infection and Acquired Immunodeficiency Syndrome
Tsuyoshi Kasama, Ryo Takahashi, Michihito Sato and Kuninobu Wakabayashi
Small-Molecule Inhibitors of Raf for Treatment of Malignant Diseases 238
Li Li, Shuhong Wu, Wei Guo and Bingliang Fang
Tigecycline: A New Treatment Choice Against Acinetobacter baumannii 251
Virginia Bosó-Ribelles, Eva Romá-Sánchez, Jorge Carmena, Cristina Cáceres
and Daniel Bautista
Cefepime and its Role in Pediatric Infections 261
Sukhbir K. Shahid
Antibacterial Properties of Organosulfur Anti-Infectives: A Review of 269
Patent Literature 1999-2009
Monika I. Konaklieva and Balbina J. Plotkin
A Review of the Carbapenems in Clinical Use and Clinical Trials 279
Tze Shien Lo, Justin M. Welch, Augusto M. Alonto and
Eileen Anne R. Vicaldo-Alonto
Anti-Infective Quinone Derivatives of Recent Patents 294
Junko Koyama
Targets and Patented Drugs for Chemotherapy of Chagas Disease 323
Vilma G. Duschak and Alicia S. Couto
Recent Patents on Development of Nucleic Acid-Based Antiviral Drugs 409
against Seasonal and Pandemic Influenza Virus Infections
Edward G. Saravolac and Jonathan P. Wong
Author Index 426
Preface Frontiers in Anti-Infective Drug Discovery, 2010, Vol. 1 i
PREFACE

The scientists invited to contribute short reviews to this first volume of book series,
“Frontiers in Anti-Infective Drug Discovery” were selected on the basis of their own
original contributions in this important field of health research. The chapters contain in this
volume are the updated version of articles published in Recent Patents on Anti-Infective
Drug Discovery. The reviews cover key aspects of infections caused by a variety of
organisms.

With the enhanced understanding of diseases at cellular and molecular levels, the search for
anti-infective agents is now more rational and strategically based on new tools and novel
techniques. Most of the reviews address the molecular mechanisms of infections and
development of inhibitors of these mechanisms. Several groups of existing anti-infective
agents have also been reviewed. The topics range from vaccines to clinical trials of
exploratory drugs, treatment by age-old anti-infective agents, and reviews on recent patents.
Each review is well-written and extensively referenced. We hope that volume 1 of this
series will be welcomed by of students and researchers and that it will lead to a broader
understanding of the current status of this subject.

We wish to express our profound gratitude to all authors for their excellent contributions.
We are also grateful to the management and the staff of the Bentham Science Publishers
(the Netherlands), especially Mr. Mahmood Alam (Managing Director), Ms. Samina Khan
(Senior Manager), Ms. Taqdees Malik (Assistant Manager) and Ms. Sadaf Idrees Khan
(Composer), for their help in compilation of the first volume of this important series of
books.

Prof. Dr. Atta-ur-Rahman, FRS
Prof. Dr. M. Iqbal Choudhary
Editors
ii Frontiers in Anti-Infective Drug Discovery, 2010, Vol. 1 Contributors

Contributors
Pieranna Chiarella Laboratory of Molecular Medicine and Biotechnology,
CIR, Campus Bio-Medico University of Rome, Via
Alvaro del Portillo 21 - 00128 Rome, Italy; Institute of
Neurobiology and Molecular Medicine, CNR, Via Fosso
del Cavaliere 100 - 00133 Rome, Italy
Emanuela Massi Laboratory of Molecular Medicine and Biotechnology,
CIR, Campus Bio-Medico University of Rome, Via
Alvaro del Portillo 21 - 00128 Rome, Italy; Institute of
Neurobiology and Molecular Medicine, CNR, Via Fosso
del Cavaliere 100 - 00133 Rome, Italy
Mariangela De Robertis Laboratory of Molecular Medicine and Biotechnology,
CIR, Campus Bio-Medico University of Rome, Via
Alvaro del Portillo 21 - 00128 Rome, Italy; Institute of
Neurobiology and Molecular Medicine, CNR, Via Fosso
del Cavaliere 100 - 00133 Rome, Italy
Vito M. Fazio Laboratory of Molecular Medicine and Biotechnology,
CIR, Campus Bio-Medico University of Rome, Via
Alvaro del Portillo 21 - 00128 Rome, Italy; Laboratory
of Oncology, Research Department, IRCCS H "Casa
Sollievo della Sofferenza" - 71013 S. Giovanni Rotondo
(FG), Italy
Emanuela Signori Institute of Neurobiology and Molecular Medicine, CNR,
Via Fosso del Cavaliere 100 - 00133 Rome, Italy
David Andrew Phoenix Deputy Vice Chancellor, University of Central
Lancashire, Preston, PR1 2HE, UK
Frederick Harris School of Forensic and Investigative Sciences,
University of Central Lancashire, Preston, PR1 2HE, UK
Mona Arabshahi Department of Cell Biology, Emory University School of
Medicine, Atlanta, GA, USA
Usha Bughani Department of Cell Biology, Emory University School of
Medicine, Atlanta, GA, USA
Surya N. Vangapandu Department of Cell Biology, Emory University School of
Medicine, Atlanta, GA, USA
Ritu Aneja Department of Cell Biology, Emory University School of
Medicine, Atlanta, GA, USA
Contributors Frontiers in Anti-Infective Drug Discovery, 2010, Vol. 1 iii
Ramesh Chandra Department of Chemistry and Dr. B. R. Ambedkar
Center for Biomedical Research, University of Delhi,
Delhi, India
Daniel Kalman Department of Pathology, Emory University School of
Medicine, Atlanta, GA, USA
Harish Joshi Department of Cell Biology, Emory University School of
Medicine, Atlanta, GA, USA
Ayman M. Noreddin School of Pharmacy, Hampton University, Hampton
Roads Bridge Tunnel, VA 23668, Hampton, USA
Walid F. El-Khatib College of Pharmacy, University of Minnesota, 4-101
Hanson Hall 1925 Fourth Street South Minneapolis, MN
55455, USA
Tommy R. Tong Department of Pathology, Montefiore Medical Center,
600 E 233 Street, Bronx, New York 10466, USA
Yolanda Sanz Instituto de Agroquímica y Tecnología de los Alimentos
(CSIC), P.O. Box 73 46100, 46100 Burjassot, Valencia,
Spain
Inmaculada Nadal Instituto de Agroquímica y Tecnología de los Alimentos
(CSIC), P.O. Box 73 46100, 46100 Burjassot, Valencia,
Spain
Ester Sánchez Instituto de Agroquímica y Tecnología de los Alimentos
(CSIC), P.O. Box 73 46100, 46100 Burjassot, Valencia,
Spain
Campo S. M. Antonio Gastroenterology and Digestive Endoscopy, “Nuovo
Regina Margherita” Hospital, Rome, Italy
Hassan Cesare Gastroenterology and Digestive Endoscopy, “Nuovo
Regina Margherita” Hospital, Rome, Italy
Burza Maria Antonietta Gastroenterology and Digestive Endoscopy, “Nuovo
Regina Margherita” Hospital, Rome, Italy
Ridola Lorenzo Gastroenterology and Digestive Endoscopy, “Nuovo
Regina Margherita” Hospital, Rome, Italy
Cristofari Francesca Gastroenterology and Digestive Endoscopy, “Nuovo
Regina Margherita” Hospital, Rome, Italy
Morini Sergio Gastroenterology and Digestive Endoscopy, “Nuovo
Regina Margherita” Hospital, Rome, Italy
iv Frontiers in Anti-Infective Drug Discovery, 2010, Vol. 1 Contributors
Zullo Angelo Gastroenterology and Digestive Endoscopy, “Nuovo
Regina Margherita” Hospital, Rome, Italy
Françoise Van Bambeke Unité de Pharmacologie Cellulaire et Moleculaire,
Université Catholique de Louvain, Brussels, Belgium
Jean-Marie Pagès EA2197 Enveloppe Bactérienne, Perméabilité et
Antibiotiques, Faculté de Médecine, Université de la
Méditerranée, Marseille, France
Ving J. Lee Adesis, Inc., New Castle, DE 19720, USA; Limerick
BioPharma, Inc., South San Francisco, CA 94080 USA
Marcus Vinícius Nora de Souza Instituto de Tecnologia em Fármacos-Far-Manguinhos,
Rua Sizenando Nabuco, 100, Manguinhos, 21041-250
Rio de Janeiro-RJ, Brazil
Marcelle de Lima Ferreira Instituto de Tecnologia em Fármacos-Far-Manguinhos,
Rua Sizenando Nabuco, 100, Manguinhos, 21041-250
Rio de Janeiro-RJ, Brazil
Raoni Schroeder B. Gonçalves Instituto de Tecnologia em Fármacos-Far-Manguinhos,
Rua Sizenando Nabuco, 100, Manguinhos, 21041-250
Rio de Janeiro-RJ, Brazil
Raúl N. Ondarza Department of Biochemistry, Faculty of Medicine,
National Autonomous University of Mexico (UNAM),
University City, Mexico 04510, USA; Center of
Research on Infectious Diseases, National Institute of
Public Health, Cuernavaca, Morelos, Mexico 62508,
USA; Center for Marine Biotechnology and
Biomedicine, Scripps Institution of Oceanography,
University of California, San Diego (UCSD), La Jolla,
CA 92093-0204, USA
Tsuyoshi Kasama Division of Rheumatology, Department of Medicine,
Showa University School of Medicine, 1-5-8 Hatanodai,
Shinagawa-ku, Tokyo 142-8666, Japan
Ryo Takahashi Division of Rheumatology, Department of Medicine,
Showa University School of Medicine, 1-5-8 Hatanodai,
Shinagawa-ku, Tokyo 142-8666, Japan
Michihito Sato Division of Rheumatology, Department of Medicine,
Showa University School of Medicine, 1-5-8 Hatanodai,
Shinagawa-ku, Tokyo 142-8666, Japan
Kuninobu Wakabayashi Division of Rheumatology, Department of Medicine,
Showa University School of Medicine, 1-5-8 Hatanodai,
Shinagawa-ku, Tokyo 142-8666, Japan
Contributors Frontiers in Anti-Infective Drug Discovery, 2010, Vol. 1 v
Li Li Department of Laboratory Medicine, First Hospital of
Shanghai, Shanghai, China
Shuhong Wu Department of Thoracic and Cardiovascular Surgery, The
University of Texas M. D. Anderson Cancer Center,
Houston, Texas 77030, USA
Wei Guo Department of Thoracic and Cardiovascular Surgery, The
University of Texas M. D. Anderson Cancer Center,
Houston, Texas 77030, USA
Bingliang Fang Department of Thoracic and Cardiovascular Surgery, The
University of Texas M. D. Anderson Cancer Center,
Houston, Texas 77030, USA
Virginia Bosó-Ribelles Pharmacy Department, Hospital La Fe, Valencia, Spain
Eva Romá-Sánchez Pharmacy Department, Hospital La Fe, Valencia, Spain
Jorge Carmena Infectious Diseases Department, Hospital Dr. Peset,
Valencia, Spain
Cristina Cáceres Infectious Diseases Department, Hospital Dr. Peset,
Valencia, Spain
Daniel Bautista Preventive Medicine Department, Hospital Dr. Peset,
Valencia, Spain
Sukhbir K. Shahid Consultant Pediatrician and Neonatologist, Mumbai-400
077, India
Monika I. Konaklieva Department of Chemistry, American University, 4400
Massachusetts Avenue, NW, Washington, DC 20016-
8014, USA
Balbina J. Plotkin Department of Microbiology and Immunology, CCOM,
Midwestern University, 555 31 St., Downers Grove, IL
60515, USA
Tze Shien Lo Section of Infectious Diseases, Veterans Affairs Medical
Center, Fargo, ND, USA
Justin M. Welch Pharmacy Department, Veterans Affairs Medical Center,
Fargo, ND, USA
Augusto M. Alonto Section of Infectious Diseases, MeritCare Medical
Center, Fargo, ND, USA
vi Frontiers in Anti-Infective Drug Discovery, 2010, Vol. 1 Contributors
Eileen Anne R. Vicaldo-Alonto Department of Internal Medicine, University of North
Dakota School of Medicine & Health Sciences, Fargo,
ND, USA
Junko Koyama Faculty of Pharmaceutical Sciences, Kobe
Pharmaceutical University, Higashinada-ku, Kobe 658-
8558, Japan
Vilma G. Duschak Instituto Nacional de Parasitología “Dr. Mario Fatala
Chabén”, ANLIS-Malbrán, Ministerio de Salud. Av.
Paseo Colon 568 (1063), Buenos Aires, Argentina
Alicia S. Couto CIHIDECAR (CONICET) Departamento de Química
Orgánica, Facultad de Ciencias Exactas y Naturales,
Universidad de Buenos Aires, Buenos Aires, CP 1428,
Argentina
Edward G. Saravolac Formulation Technology Consulting, 3 Essex St.,
Footscray, Victoria, 3011 Australia
Jonathan P. Wong Defence R&D Canada - Suffield, Biotechnology Section,
Box 4000 Main Station, Medicine Hat, Alberta, T1A
8K6 Canada