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Food and Chemical Toxicology An international journal published in association with TNO BIBRA International Ltd Volume 41 2003 Volume Contents and Author Index ase, ELSEVIER FOOD AND CHEMICAL TOXICOLOGY Founding Editor The late Leon Golberg Editors JOSEPH F. BORZELLECA HANS VERHAGEN Department of Pharmacology and Unilever Health Institute, Toxicology, Medical College of Virginia, Unilever R&D Vlaardingen, PO Box 114, Richmond, VA 23298-0613, USA 3130 AC Vlaardingen, The Netherlands Fax: + 1 804 284 1401; e-mail: [email protected] Fax: +31 10 460 5726; e-mail: [email protected] Review Editors SUSAN M. BARLOW TIMOTHY C. MARRS Harrington House, 8 Harrington Road, Food Standards Agency, Brighton, East Sussex BN] 6RE, UK Aviation House, 125 Kingsway, London WC2B 6NH, UK International Editorial Board Z. APOSTOLIDES, South Africa Y. HASHIMOTO, Japan J. J. RAFTER, Sweden O. ARUOMA, UK A. W. Hayes, USA D. Ray, UK A. BLACK, Australia J. M. Jones, USA F. REYES, Brazil A. BLack, UK S. Kacew, Canada M. ROBERFROID, Belgium A. R. Boosts, UK I. KIMBER, UK I. ROWLAND, Northern Ireland J. CALDWELL, UK S. KNASMULLER, Austria W.H. M. Saris, The Netherlands J. E. CHAMBERS, USA P. A. LACHANCE, USA R. C. SHANK, USA J. K. CHIPMAN, UK B. LAKE, UK M. SmitH, The Netherlands S. M. COHEN, USA R. W. LANE, USA T. SUGIMURA, Japan T. F. X. CoLuins, USA M. I. Luster, USA J. A. SWENBERG, USA J. VAN DELFT, The Netherlands H. '. MAIBACH, USA S. L. TayLor, USA D. J. DooLittLe, USA B. MEIER, Switzerland J. A. THomas, USA Y. P. DRAGAN, USA S. A. MILLER, USA J. TURESKY, Switzerland L. O. DRAGSTED, Denmark K. MorGAn, USA D. Tweats, UK J. G. Evans, UK M. Pariza, USA H. VAINIO, France L. FERGUSON, New Zealand G. PASCAL, France A. VISCONTI, Italy H. R. GLatT, German) B. POOL-ZOBEL, Germany J. H. WEISBURGER, USA W. H. GLINSMANN, USA H. E. POULSEN, Denmark G. WILLIAMSON, UK G. C. Harb, USA M. PRODANCHUK, Ukraine S. YANNAI, /srael ©) 2003 Elsevier Ltd. All rights reserved. Publication information: Food and Chemical Toxicology (ISSN 0278-6915). For 2003, volume 41 is scheduled for publication. Subscription prices are available upon request from the Publisher or from the Regional Sales Office nearest you or from this journal’s website (http://www.elsevier.com/locate/foodchemtox). Further information is available on this journal and other Elsevier products through Elsevier’s website: (http://wwav. elsevier.com). Subscriptions are accepted on a prepaid basis only and are entered on a calendar year basis. Issues are sent by standard mail (surface within Europe, air delivery outside Europe). Priority rates are available upon request. Claims for missing issues should be made within six months of the date of dispatch. Advertising information: Advertising orders and enquiries can be sent to: USA, Canada and South America: Mr Tino DeCarlo, The Advertising Department, Elsevier Inc., 360 Park Avenue South, New York, NY 10010-1710, USA; phone: (+ 1) (212) 633 3815; fax: (+ 1) (212) 633 3820; e-mail: [email protected]. Japan: The Advertising Department, Elsevier K.K., 4F Higashi-Azabu, 1-Chome Bldg, 1-9-15 Higashi-Azabu, Minato-ku, Tokyo 106-0044, Japan; phone: (+ 81) (3) 5561 5037; fax: (+81) (3) 5561 5047; e-mail: [email protected]. Europe and ROW: Commercial Sales Department, Elsevier Ltd., The Boulevard, Langford Lane, Kidlington, Oxford OXS 1GB, UK; phone: (+ 44) 1865 843016; fax: (+44) 1865 843976; e-mail: [email protected]. USA mailing notice: Food and Chemical Toxicology (ISSN 0278-6915) is published monthly by Elsevier Ltd (P.O. Box 211, 1000 AE Amsterdam, The Netherlands). Annual subscription price in the USA US$ 2160 (valid in North, Central and South America), including air speed delivery. Periodical postage rate paid at Jamaica, NY 11431. USA POSTMASTER: Send address changes to Food and Chemical Toxicology, Publications Expediting Inc., 200 Meacham Ave, Elmont, NY 11003. AIRFREIGHT AND MAILING in the USA by Publications Expediting Inc., 200 Meacham Ave, Elmont, NY 11003. LIST OF CONTENTS VOLUME 41 NUMBER | L. D. Karalliedde, P. Edwards and Variables influencing the toxic response to organophosphates in humans T. C. Marrs J. Fonseca de Oliveira, Assessment of the effect of Fucus vesiculosus extract on the labeling of blood M. B. Nunes de Oliveira, A. S. Avila, constituents with technetium-99m and the histological modifications on the shape of the A. C. S. Braga red blocd cells M. T. Jansen de Almeida Catanho, R. L. Cavalcanti Jales, V. N. Cardoso and M. Bernado-Filho R. Reynoso-Camacho, Purification and acute toxicity of a lectin extracted from tepary bean (Phaseolus acutifolius) E. Gonzalez de Mejia and G. Loarca-Pina J.-R. loset, G. E. Raoelison and Detection of aristolochic acid in Chinese phytomedicines and dietary supplements used K. Hostettmann as slimming regimens A. A. Al-Qarawi, B. H. Ali, Gastrointestinal transit in mice treated with various extracts of date (Phoeni v dactylifera S. A. Al-Mougy and H. M. Mousa L3 R. El Hamss, M. Idaomar, Antimutagenic properties of bell and black peppers A. Alonso-Moraga and A. Muroz Serrano F. R. Johannsen Toxicological profile of carboxymethyl inulin M. Friedman, P. R. Henika and Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant B. E. Macke) mice I. Costabeber and T. Emanuelli Influence of alimentary habits, age and occupation on polychlorinated biphenyl levels in adipose tissue C. Bindslev-Jensen, E. Sten, L. K. Earl, Assessment of the potential allergenicity of ice structuring protein type III HPLC 12 R. W. R. Crevel, U. Bindslev-Jensen, using the FAO/WHO 2001 decision tree for novel foods T. K. Hansen, P. Stahl Skov and L. K. Poulsen M. D. Rodriguez, R. Gamez, Lack of developmental toxicity of D-003: a mixture of long-chain fatty J. E. Gonzalez, H. Garcia, C. P. Acosta and E. Goicochea J.-E. Belgaied 5—98 Release of heavy metals from Tunisian traditional earthenware D. Bigot-Lasserre, F. Chuzel, 106 Tumorigenic potential of carbaryl in the heterozygous p53 knockout mouse model E. L. M. Debruyne, R. Bars and N. G. Carmichael H. Tryphonas, G. Bondy, M. Hodgen, Effects of cis-nonachlor, trans-nonachlor and chlordane on the immune system of L. Coady, M. Parenteau, C. Armstrong, Sprague-Dawley rats following a 28-day oral (gavage) treatment S. Hayward and V. Liston V. F. Agnes and M. A. Akbarsha Spermatotoxic effect of aflatoxin B, in the albino mouse K. Ohno, Y. Azuma, K. Date, S. Nakano, Evaluation of styrene oligomers eluted from polystyrene for estrogenicity in estrogen T. Kobayashi, Y. Nagao and T. Yamada receptor binding assay, reporter gene assay, and uterotrophic assay A. Shihadeh Investigation of mainstream smoke aerosol of the argileh water pipe Forthcoming Papers VOLUME 41 NUMBER 2 Review P. Ridgway, T. E. Nixon and J.-P. Leach Occupational exposure to organic solvents and long-term nervous system damage detectable by brain imaging, neurophysiology or histopathology Research section R. O. Alves de Lima, L. Azevedo, 189-192 Study on the mutagenicity and antimutagenicity of a natural food colour (annatto) in L. R. Ribeiro and D. M. F. Salvadori mouse bone marrow cells PII: $0278-6915(02)00251-X IV Volume Contents G. E. Neal, D. J. Judah, G. G. Hard and 200 Differences in ethoxyquin nephrotoxicity between male and female F344 rats N. Ito J. L. C. M. Dorne, K. Walton and 224 Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for 1. G. Renwick risk assessment J. L. C. M. Dorne, K. Walton and 25-245 Polymorphic CYP2C19 and N-acetylation: human variability in kinetics and pathway- i 1. G. Renwick related uncertainty factors Born, A. M. Api, R. A. Ford 247-258 Comparative metabolism and kinetics of coumarin in mice and rats efever and D. R. Hawkins {pi and R. A. Ford Evaluation of the dermal subchronic toxicity of diphenyl ether in the rat Meky, P. C. Turner, A. E. Ashcroft 2 ; Development of a urinary biomarker of human exposure to deoxynivalenol Miller, Y.-L. Qiao, M. J. Roth and P. Wild Orsiére, M. De Méo, P. Rathelot Implication of nitro group reduction in the mutagenic and chromosome damaging Pompili, M. Galas, M. Castegnaro, activities of 22 new 5-nitroisoquinolines by the Sa/monella mutagenicity test and the Vanelle and G. Dumeénil cytokinesis-blocked micronucleus assay G. Bondy, C. Armstrong, L. Coad : Toxicity of the chlordane metabolite oxychlordane in female rats: clinical and J. Doucet, P. Robertson, M. Feeley and histopathological changes VM. Barker S. B. Stanfill, A.M . Calafat, C. R. Brown 303 Concentrations of nine alkenylbenzenes, coumarin, piperonal and pulegone in Indian G. M. Polzin, J. M. Chiang, C. H. Watson bidi cigarette tobacco and D. L. Ashle) Forthcoming Papers VOLUME 41 NUMBER 3 Reviews C. C. DeMerlis and D. R. Schoneker 2 Review of the oral toxicity of polyvinyl alcohol (PVA) J. J. Hostynek 27 Factors determining percutaneous metal absorption Research section G. L. Erexson Lack of in vivo clastogenic activity of grape seed and grape skin extracts in a mouse micronucleus assay M. C.-M. de Kok, I. Zwingman 5 Analysis of oxidative DNA damage after human dietary supplementation with linoleic E. J. Moonen, P. A. E. L. Schilderman, acid E. Rhijnsburger, G. R. M. M. Haenen and J. C. S. Kleinjans E. Koyama, K. Kitazawa, Y. Ohori In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically O. Izawa, K. Kakegawa, A. Fujino and modified stevia in human intestinal microflora M. Ui 1. A. Yusuf, T. A. Arowolo and 3 Cadmium, copper and nickel levels in vegetables from industrial and residential areas of O. Bamgbose Lagos City, Nigeria 1. Pillai, L. Priya and S. Gupta 3 Effects of combined exposure to lead and cadmium on the hypothalamic—pituitary axis function in proestrous rats H. Tuschl and C. Schwab 85 3 Cytotoxic effects of the herbicide 2,4-dichlorophenoxyacetic acid in HepG2 cells V. Wenehed, A. Solyakov, I. Thylin Cytotoxic response of Aspergillus fumigatus-produced mycotoxins on growth medium, P. Hadggblom and A. Forsb) maize and commercial animal feed substrates D. R. Schoneker, C. C. DeMerlis and 3 Evaluation of the toxicity of polyvinylacetate phthalate in experimental animals J. F. Borzelleca 1. M. Saillenfait, F. Gallissot, G. Morel 5 Developmental toxicities of ethylbenzene, ortho-, meta-, para-xylene and technical and P. Bonnet xylene in rats following inhalation exposure M. Dayal, D. Parmar, A. Dhawan Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity M. Ali, U. N. Dwivedi and P. K. Seth induced by deltamethrin S. T. Larsen, R. M. Lund, P. Thygesen Investigation of the adjuvant and immuno-suppressive effects of benzyl butyl phthalate, O. M. Poulsen and G. D. Nielsen phthalic acid and benzyl alcohol in a murine injection model Forthcoming Papers Volume Contents VOLUME 41 NUMBER 4 Publisher's note Research Section M. R. Fielden, S. M. Samy, K. C. Chou Effect of human dietary exposure levels of genistein during gestation and lactation on and T. R. Zacharewski long-term reproductive development and sperm quality in mice C.-Y. Zhu and S. Loft Effect of chemopreventive compounds from Brassica vegetables on NAD(P)H:quinone reductase and induction of DNA strand breaks in murine hepalctic7 cells N. P. Okolie and C. U. Iroanya Some histologic and biochemical evidence for mitigation of cyanide-induced tissue lesions by antioxidant vitamin administration in rabbits J. H. Exon and E. H. South Effects of sphingomyelin on aberrant colonic crypt foci development, colon crypt cell proliferation and immune function in an aging rat tumor model B. Delaney, T. Carlson, S. Frazer, Evaluation of the toxicity of concentrated barley B-glucan in a 28-day feeding study in T. Zheng, R. Hess, K. Ostergren, Wistar rats K. Kierzek, J. Haworth, N. Knutson, K. Junker and D. Jonker M. J. Scotter, L. Castle, R. C. Massey, A study of the toxicity of five mineral hydrocarbon waxes and oils in the F344 rat, with P. G. Brantom and M. E. Cunninghame histological examination and tissue-specific chemical characterisation of accumulated hydrocarbon material M. W. Cook and H. V. Thygesen Safety evaluation of a hexose oxidase expressed in Hansenula polymorpha P. Akhter, N. Ashraf, D. Mohammad, Nutritional and radiological impact of dietary potassium on the Pakistani population S. D. Orfi and N. Ahmad J. Cao, Y. Zhao, J. Liu, R. Xirao, Brick tea fluoride as a main source of adult fluorosis S. Danzeng, D. Daji and Y. Yan T. Takamura-Enya, J. Ishihara, Analysis of estrogenic activity of foodstuffs and cigarette smoke condensates using a S. Tahara, S. Goto, Y. Totsuka, yeast estrogen screening method T. Sugimura and K. Wakabayashi S. E. Atawodi Occurrence of preformed volatile nitrosamines in preparations of some Nigerian medicinal plants: a preliminary report M. M. Sugui, P. L. Alves de Lima, Antimutagenic effect of Lentinula edodes (BERK.) Pegler mushroom and possible R. D. Delmanto, A. F. da Eira, variation among lineages D. M. F. Salvadori and L. R. Ribeiro Th. Wolf, ¢ Niehaus-Rolf and Investigating genotoxic and hematotoxic effects of N-nitrosodimethylamine, N-nitroso- N.-P. Luepke diethylamine and N-nitrosodiethanolamine in the hen’s egg—micronucleus test (HET MN) C. F. Daher, G. M. Baroody and Effect of a surfactant, Tween 80, on the formation and secretion of chylomicrons in the R. J. Howland rat A. M. Saillenfait, F. Gallissot and Developmental toxicity of N-methyl-2-pyrrolidone in rats following inhalation exposure G. Morel R. M. David, L. K. Lockhart and Lack of sensitization for trimellitate, phthalate, terephthalate and isobutyrate plastici K. M. Ruble zers in a human repeated insult patch test Brief Communication A. Salim, M. A. Hassanin and A. Zohair A simple procedure for reducing lead content in fish Letter to the Editor W. H. James 599-600 Phthalates, hormones and offspring sex ratios T. Tanaka 601-602 Offspring sex ratio in laboratory mice Forthcoming Papers VOLUME 41 NUMBER 5 H. Verhagen, O. I. Aruoma, 603-610 The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or J. H. M. van Delft, L. O. Dragsted, anticarcinogenic potential of test substances in in vitro experiments and animal studies L. R. Ferguson, S. Knasmiiller, in vivo B. L. Pool-Zobel, H. E. Poulsen, G. Williamson and S. Yannai VI Volume Contents Review M. E. Hurtt, G.D . Cappon and Proposal for a tiered approach to developmental toxicity testing for veterinary 1. Browning pharmaceutical products for food-producing animals Research Section Y-S. Ho, H-Y. Ma, H-Y. Chang Lipid peroxidation and cell death mechanisms in rats and human cells induced by B-L. Wei, C-C. Lee, S-Y. Ho, H-R. Guo chloral hydrate T-P. Wu, W-H. Chang and Y-J. Wang E. Bowey, H. Adlercreutz and I. Rowland Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats J-C. Kim, D-H. Shin, T-H. Ahn 26-Week repeated oral dose toxicity study of the new quinolone antibacterial DW-116 in S-S. Kang, S-W. Song, J. Han Sprague-Dawley rats C-Y. Kim, C-S. Haand M-K. Chung R. H. Lindecrona, A.-M. Molck, J. Gr) Subchronic oral toxicity study on the three flavouring substances: octan-3-ol, 2-methyl- M. Poulsen, R. Andersen and I. Thorup crotonic acid and oct-3-yl 2-methylcrotonate in Wistar rats 4. Schaeferhenrich, W. Sendt, J. Scheele, Putative colon cancer risk factors damage global DNA and 7P53 in primary human 4. Kuechler, T. Liehr, U. Claussen colon cells isolated from surgical samples 1. Rapp, K.-O. Greulich and B. L. Pool- Zobe l High levels of apoptosis induced by total body irradiation in mice fed a low protein—-low vitamin E diet P. J. Klein, T. R. Van Vleet, J. O. Hall Effects of dietary butylated hydroxytoluene on aflatoxin B,-relevant metabolic enzymes and R. A. Coulombe Jr in turkeys T. Okubo, Y. Yokoyama, K. Kano and Cell death induced by the phenolic antioxidant tert-butylhydroquinone and its metabolite I. Kano tert-butylquinone in human monocytic leukemia U937 cells 4. Buard, B. D. Carlton, F. Floch and Subchronic toxicity, mutagenicity and allergenicity studies of a cultured dextrose food G. S. Simon product E. F. Lhoste, V. Ouriet, S. Bruel The human colonic microflora influences the alterations of xenobiotic-metabolizing J.-P. Flinois, C. Brézillon, J. Magdalou, enzymes by catechins in male F344 rats C. Cheze and L. Nugon-Baudon R. W. Owen, R. Haubner, W. Mier Isolation, structure elucidation and antioxidant potential of the major phenolic and A. Giacosa, W. E. Hull, B. Spiegelhalder flavonoid compounds in brined olive drupes and H. Bartsch C. M. Kelly, C. C. DeMerlis Subchronic toxicity study in rats and genotoxicity tests with polyvinyl alcohol D. R. Schoneker andJ . F. Borzelleca D. E. Rodwell, C. M. Kelly Effects of polyvinyl alcohol administered in the diet to rats on fertility, early embryonic C. C. DeMerlis, D. R. Schoneker and development, growth and development J. F. Borzelleca W. J. Waddell Threshold for carcinogenicity of N-nitrosodiethylamine for esophageal tumors in rats Erratum 1. O. Gamer, J. Hellwig and Erratum to “Developmental toxicity of oral n-butylamine hydrochloride and inhaled n- B. van Ravenzwaa) butylamine in rats” Forthcoming Papers VOLUME 41 NUMBER 6 Special section: Flaxseed Papers (pp. 819-916) Research Section M. Nachshon-Kedmi, S. Yannai, A. Haj Indole-3-carbinol and 3,3’-diindolylmethane induce apoptosis in human prostate cancer and F. A. Fares cells Z. Sroka and W. Cisowski Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids T. Miura, S. Muraokanad Y. Fujimoto Inactivation of creatine kinase induced by quercetin with horseradish peroxidase and hydrogen peroxide: pro-oxidative and anti-oxidative actions of quercetin S M | D Zayed M Farghal\ and Fate of '*C-chlorpyrifos in stored soybeans and its toxicological potential to mice S. El-Maghraby Volume Contents VII M.S. Christian, S. Schulte and J. Hellwig 18: Developmental (embryo-fetal toxicity/teratogenicity) toxicity studies of synthetic crystalline lycopene in rats and rabbits L. R. Ferguson, S. Zhu and P. Kestell 85-792 Contrasting effects of non-starch polysaccharide and resistant starch-based diets on the disposition and excretion of the food carcinogen, 2-amino-3-methylimidazo[4.5-/] quinoline (IQ), in a rat model C. L. Kruger and S. W. Mann Safety evaluation of functional ingredients C. J. Smith, T. A. Perfetti, R. Garg and 307-817 IARC carcinogens reported in cigarette mainstream smoke and their calculated log P C. Hansch values Special section: Flaxseed Papers T. F. X. Collins, R. L. Sprando, 8 Effects of flaxseed and defatted flaxseed meal on reproduction and development in rats T. N. Black, N. Olejnik, P. W. Wiesenfeld, U. S. Babu, M. Bryant, T. J. Flynn and D. 1. Ruggles T. J. Flynn, T. F. X. Collins 35 Developmental effects of serum from flaxseed-fed rats on cultured rz R. L. Sprando, T. N. Black, D. 1. Ruggles P. W. Wiesenfeld and U. S. Babu P. W. Wiesenfeld, U. S. Babu, 855 Flaxseed increased x-linolenic and eicosapentaenoic ai T. F. X. Collins, R. Sprando, in serum and tissues of rat dams and offspring M. W. O'Donnell, T. J. Flynn, T. Black and N. Olejnik N. O. Wesley and H. 1. Maibach 857 Decreasing allergic contact dermatitis frequency through epidemiologic based intervention? S.-D. Ryu and W.-G. Chung 866 Induction of the procarcinogen-activating CYP1A2 by rats and humans B. W. Wolf and S. E. Weisbrod 67-87 Safety evaluation of an extract from Salacia oblong: E. Koyama, N. Sakai, ¥. Ohori, S—88 Absorption and metabolism of glycosidic sweetenerso f stevia mixture K. Kitazawa, O. Izawa, K. Kakegawa steviol, in rats and humans A. Fujino and M. Ui C. T. Jung, R. R. Wickett, P. B. Desai 85 In vitro and in vivo percutaneous absorption of catechol and R. L. Bronaugh R. J. Merritt, N. Auestad, C. Kruger and , Safety evaluation of sources of docosahexaenoic acid and arachidonic acid for use in S. Buchanan infant formulas in newborn piglets U. S. Babu, P. W. Wiesenfeld 15 Impact of high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell T. F. X. Collins, R. Sprando, T. J. Flynn subsets and fatty acid composition of spleen cells from pregnant and FI generation T. Black, N. Olejnik and R. B. Raybourne Spprraagg ue-Dawley 3 rats Forthcoming Papers VOLUME 41 NUMBER 7 Special issue: RIFM Toxicologic and Dermatologic Assessments of Linalool and Related Esters When Used as Fragrance Ingredients Editorial L. W. Smith and A. M. Api 7 Group summaries and fragrance material reviews Reviews The RIFM Expert Panel: D. Bickers 94? A toxicologic and dermatologic assessment of linalool and related esters when used as P. Calow, H. Greim, J. M. Hanifin, fragrance ingredients A. E. Rogers, J. H. Saurat, I. G. Sipes R. L. Smith and H. Tagami C. S. Letizia, J. Cocchiara, J. Lalko and 964 Fragrance material review on linalool A. M. Api C. S. Letizia, J. Cocchiara, J. Lalko and 976 Fragrance material review on linalyl acetate A. M. Api C. S. Letizia, J. Cocchiara, J. Lalko and Fragrance material review on linalyl benzoate A. M. Api Volume Contents occhiara, J. Lalko and 983-987 Fragrance material review on linalyl butyrate occhiara, J. Lalko and 989-993 Fragrance material review on linalyl cinnamate occhiara, J. Lalko and 995-—999 Fragrance material review on linalyl formate occhiara, J. Lalko and 1001-1004 Fragrance material review on linalyl hexanoate Lalko and 1005-1010 Fragrance material review on linalyl isobutyrate chiara, J.L alko and 1011-1015 Fragrance material review on linaly! isovalerate chiara, J. Lalko and 1017-1021 Fragrance material review on linalyl phenylacetate S. Letizia occhiara, J. Lalko and 1023-1027 Fragrance material review on linalyl propionate 1. M. Api Research section R. Géggel, W. Pittermann, W. Aulmann 1029-1033 Assessment of the acute pulmonary toxicity of lamp oil aspiration in the isolated and §. Uhlig perfused rat lung O. Takahashi and S. Oishi 1035-1044 Testicular toxicity of dietarily or parenterally administered bisphenol A in rats and mice Y. Cheng, H. L. Li, H. F. Wang, 1045-1050 Inhibition of nicotine-DNA adduct formation in mice by six dietary constituents H Sun, Y. F. Liu, S. X. Peng Y. Liu and Z. Y. Guo Forthcoming Papers VOLUME 41 NUMBER 8 R. Poon, I. Chu, G. LeBel, A. Yagminas 1051-1061 Effects of dibromoacetonitrile on rats following 13-week drinking water exposure and V. E. Valli K. Chun and H. G. Kang 1063-1076 Estimation of risks of pesticide exposure, by food intake, to Koreans Parmar, S. Yadav, M. Dayal 1077-1087 Effect of lindane on hepatic and brain cytochrome P450s and influence of P450 Johri, A. Dhawan and P. K. Seth modulation in lindane induced neurotoxicity Delaney, T. Carlson, G.-H. Zheng 1089-1102 Repeated dose oral toxicological evaluation of concentrated barley B-glucan in CD-1 Hess, N. Knutson, S. Fraze mice including a recovery phase Ostergren, M. van Zijverden Knippels, D. Jonker and A. Penninks Li, C. Wei, C. Zhang, M. Van Hulle, 1103 A survey of arsenic species in chinese seafood Cornelis and X. Zhang Takahashi, A. Nakamura, M. Kato Soluble soybean fiber: a 3-month dietary toxicity study in rats Maeda, R. C. Mandella Broadmeadow and S. A. Ruckman S. S. Anand, S. N. Murthy, V. S. Vaidya, Tissue repair plays pivotal role in final outcome of liver injury following chloroform and M.M. Mumtaz and H. M. Mehendale allyl alcohol binary mixture F. Grosso, S. Said, I. Mabrouk New data on the occurrence of ochratoxin A in human sera from patients affected or not J. M. Fremy, M. Castegnaro, by renal diseases in Tunisia M. Jemmali and S. Dragacci F. Catterall, N. J. McArdle, L. Mitchell, Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with 1. Papayanni, M. N. Clifford and black tea theafulvins and theaflavins C. Ioannides Y. Hamada, H. Tanaka, S. Ishizaki, 5 Purification, reactivity with IgE and cDNA cloning of parvalbumin as the major M. Ishida, Y. Nagashima and K. Shiomi allergen of mackerels 1. Hagiwara, N. Imai, T. Ichihara, A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color M. Sano, S. Tamano, H. Aoki extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats K. Yasuhara, T. Koda, M. Nakamura and T. Shirai Volume Contents 1X N. Wolff, U. Cogan, A. Admon, I. Dalal, Allergy to sesame in humans is associated primarily with IgE antibody to a 14 kDa 2S Y. Katz, N. Hodos, N. Karin and albumin precursor S. Yannai T. Stroheker, N. Cabaton, R. Berges, Influence of dietary soy isoflavones on the accessory sex organs of the Wistar rat V. Lamothe, J.-C. Lhuguenot and M.-C. Chagnon R. H. Dashwooadn d M. Xu The disposition and metabolism of 2-amino-3-methylimidazo-[4,5-/|quinoline in the F344 rat at high versus low doses of indole-3-carbinol D. D. Ngudi, Y.-H. Kuo and F. Lambein Cassava cyanogens and free amino acids in raw and cooked leaves J. L. Donovan, C. L. DeVane, Dietary levels of quinine in tonic water do not inhibit CYP2D6 in vivo D. Boulton, S. Dodd and J. S. Markowitz S. Cnattingius, A. Ekbom, F. Granath Letter to the Editor and A. Rane R. Black Response to Letter Forthcoming Papers VOLUME 41 NUMBER 9 Special Issue: RISK CHARACTERISATION OF CHEMICALS IN FOOD AND DIET Final part of FOOD SAFETY IN EUROPE (FOSIE): RISK ASSESSMENT OF CHEMICALS IN FOOD AND DIET In Memory of Dr. Berry Danse About ILSI/ILSI Europe A. Boenke 1209 Preface A. G. Renwick, S. M. Barlow, 1211 1271 Risk characterisation of chemicals in food and diet I. Hertz-Picciotto, A. R. Boobis, E. Dybing, L. Edler, G. Eisenbrand, J. B. Greig, J. Kleiner, J. Lambe, D. J. G. Miiller, M. R. Smith, A. Tritscher, S. Tuijtelaars, P. A. van denBrandt, R. Walker and R. Kroes Forthcoming Papers VOLUME 41 NUMBER 10 Review J. J. Hlywka, J. E. Reid and I. C. Munro 1273 1282 The use of consumption data to assess exposure to biotechnology-derived foods and the feasibility of identifying effects on human health through post-market monitoring Research Section G. Avantaggiato, R. Havenaar and 1283-1290 Assessing the zearalenone-binding activity of adsorbent materials during passage A. Visconti through a dynamic in vitro gastrointestinal model R. D. Snyder and P. J. Gillies 1291-1298 Reduction of genistein clastogenicity in Chinese hamster V79 cells by daidzein and other flavonoids L. Roza, N. de Vogel and 1299-1305 Lack of clastogenic effects in cultured human lymphocytes treated with hydroquinone J. H. M. van Delft J. Widestrand, T. Lundh, H. Pettersson 1307-1313 A rapid and sensitive cytotoxicity screening assay for trichothecenes in cereal samples and J. E. Lindberg X Volume Contents V. M. Breinholt, A.-M. Molck Effects of dietary antioxidants and 2-amino-3-methylimidazo[4,5-f]-quinoline (IQ) on G. W. Svendsen, B. Daneshvar preneoplastic lesions and on oxidative damage, hormonal status, and detoxification 4. M. Vinggaard, M. Poulsen and capacity in the rat L. O. Dragsted K. Khan and K. S. Awasthy Cytogenetic toxicity of neem Jo, H. S. Yook, M.S. Lee, J. H. Kim, Irradiation effects on embryotoxicity and oxidative properties of gossypol dissolved in P. Sone, J. S. Kwon and M. W. Byun methanol K. Kanki, A. Nishikawa, F. Furukawa, A 13-week subchronic toxicity study of paprika color in F344 rats Y. Kitamura, T. Imazawa, T. Umemura and M. Hirose P. Dilkin, P. Zorzete, C. A. Maiimann, Toxicological effects of chronic low doses of aflatoxin B,; and fumonisin B,-containing J.D. F. Gomes, C. E. Utivama Fusarium moniliforme culture material in weaned piglets L. L. Oetting and B. Corréa M. J. Spurgeon, A. K. Palmer and An investigation of the general, reproductive and postnatal developmental toxicity of P. A. Hepburn Betapol™, a human milk fat equivalent R. C. Borrelli, C. Mennella, F. Barba Characterization of coloured compounds obtained by enzymatic extraction of bakery M. Russo, G. L. Russo, K. Krome products H. F. Erbersdobler, \ Faist and V. Fogliano T. Arkaravichien, N. Sattayasai 1380 Dose-dependent effects of glutamate in pyridoxine-induced neuropathy S. Daduang and J. Sattayasai 4. T. Smolinsakndi J. J. Pestka 1390 Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb, (ginseng) and parthenolide (feverfew) M. B. Aguila and Aorta wall quantitative alterations due to different long-term high-fat diet in rats C. A. Mandarim-de-Lacerda O. Aust, N. Ale-Agha, L. Zhang 1399 Lycopene oxidation product enhances gap junctional communication H. Wollersen, H. Sies and W. Stahl 4. J. Hayes and B. Markovic 1409 Toxicity of Australian essential oil Backhousia citriodora (lemon myrtle) Part 2. Absorption and histopathology following application to human skin M. Col and C. Cél Environmental boron contamination in waters of Hisarcik area in the Kutahya Province of Turkey Y.-O. Son, J. Kim, J.-C. Lim, Y. Chung, Ripe fruits of Solanum nigrum L. inhibits cell growth and induces apoptosis in MCF-7 G.-H. Chung and J.-C. Lee cells T. Tanaka Effects of bis(2-ethylhexyl) phthalate (DEHP) on secondary sex ratio of mice in a cross- mating study Forthcoming Papers VOLUME 41 NUMBER 11 R Kroes, E J Sc hae fel R 1. Squire A review of the safety of DHA45-oil and G. M. Williams B. H. Ali Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: some recent research S. Fairhurst Hazard and risk assessment of industrial chemicals in the occupational context in eur- ope: some current issues Research Section M.-H. Lin, F.-P. Chou, H.-P. Huang The tumor promoting effect of lime-piper betel quid in JB6 cells J.-D. Hsu, M.-Y. Chou and C.-J. Wang A. Bocanegra, A. Nieto, B. Blas and Diets containing a high percentage of Nori or Konbu algae are well-accepted and F. J. Sanchez-Muniz efficiently utilised by growing rats but induce different degrees of histological changes in the liver and bowel N. Udilova, D. Jurek, B. Marian, L. Gille, 1489 Induction of lipid peroxidation in biomembranes by dietary oil components R. Schulte-Hermann and H. Nohl Y.-K. Huang, K.-H. Lin, H.-W. Chen, 1500 Arsenic species contents at aquaculture farm and in farmed mouthbreeder (Oreochromis C.-C. Chang, C.-W. Liu, M.-H. Yang mossambicus) in blackfoot disease hyperendemic areas and Y.-M. Hsueh

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