Table Of Content

PII: S0278-6915(98)00053-2 Index of Authors Abel S., 647 Campbell J. S., 1191 Feder P., 127, 167 Acosta D., 79 Cao J., 827 Feely W. F., 1085 Adams T. B., 739 Carr G., 67, 167 Feeney W. P., 1085 Agrawal R. C., 523, 1081 Cassani M., 567 Felton J. S., 433 Al-Shabanah O. A., 769 Castle L., 821 Fernie S., 1191 Alabaster O., 517 Catroux P., 159 Fernie S. M., 981 Albrecht R., 693 Cerniglia C. E., 897 Fielding I., 261 Albright K., 449 Chakrabarti J., 1177 Fitzpatrick D. W., 789 Alexander J., 945 Chamberlain M., 23, 845 Flynn T. J., 1135 Ames M. J., 881 Chan W., 459 Ford R. A., 739 Ando J., 1075 Chang S. S., 1001 Fordham P. J., 821 Angulo R., 621 Chang W. C., 1001 Fowler E. H., 869 Aranyi C., 683 Chen C., 1143 Frame S. R., 393 Armstrong C. L., 981 Chen Y.-C., 957 Freudenberger H., 501 Arnold D. L., 1191 Cherian K. M., 583 Friedman M., 639 Atkinson K., 67 Chirtel S. J., 1135 Fukushima S., 783 Atzpodien E., 465 Cholerton S., 903 Furukawa F., 387 Aughton P., 315 Chou C., 783 Augustsson K., 555 Chou F.-P., 1159 Gad S. C., 23 Chu C.-Y., 1159 Gandhi V. M., 583 Bagheri D., 1091 Chu I., 225 Garleb K. A., 1165 Bagley D. M., 39 Chung J. G., 1001, 1151 Gautheron P., 23 Baijal P. K., 789 Clapham P., 379 Gaworski C. L., 683 Bailey R. H., 807 Clarke D., 465, 909 Gelderblom W. C. A., 647 Baldrick P., 719 Coenen T. M. M., 315 Gembardt Chr., 859, 1041, 1061 Balls M., 165 Cohen A. J., 271 Gerberick G. F., 417 Bamford D. G., 719 Collins T. F. X., 881 Gerhart J. M., 683 Barker M. G., 981 Cookman G., 417 Gerner I., 159 Basketter D. A., 255, 261, 417, 845, Coroama M., 1099 Gettings S. D., 705, 1219 1099, 1209 Cottin M., 67, 159 Glynn A. W., 891 Baverel M., 1099 Cottrell S., 753 Gombar V. K., 1091 Becher G., 945 Crouch L. S., 1085 Goodman J. I., 739 Beck M. M., 991 Cumberbatch M.., 261 Grasso P., 753 Beekman M. J., 241 Curren R. D., 127 Gray G. C., 443 Bernal C. A., 1017 Green D. M., 705 Bernard L. G., 1023 Damant A. P., 821 Green S., 175 Beth-Hiibner M., 677 Dami N., 159 Greer I., 1191 te Biesebeek J. D., 615 Das M., 835 Griffiths H. A., 255, 845 Bird R. P., 789 David R. M., 1023 Gross G., 547 Black T. N., 881 Dearman R. J., 261, 1209 Gupta K., 175 Blain P. G., 1009 Deckardt K., 1041, 1061 Gupta K. C., 159 Blake B. W., 1091 Demichele S. J., 1165 Guzman R., 567 Blankemeyer J. T., 639 Diaz Barriga S., 567 Boink A. B. T. J., 615 Diembeck W., 1099 Hadidi H., 903 Bollard M., 933 Diersen-Schade D. A., 967 Hall J. D., 897 Bolognani F., 535 Doolittle D. J., 1107 Hall L. L., 697 Bomhard E. M., 753 Dossou K. G., 159 Hallagan J. B., 625 Bondy G. S., 981 Doull J., 739 Hamaide N., 417 Borzelleca J. F., 625 Downie R. H., 185, 199 Harakal C., 713 Botham P., 67 Doyle B. A., 459 Harbell J. W., 79 Bradlaw J., 175 Dozier M. M., 683 Hartway T., 513 Bradlaw J. A., | Dressler W. E., 705 Haug M., 219 Brain K. R., 705, 1219 Dyer Jr W. M., 1023 Hayward S., 1191 Brandt R. B., 459 Heck J. D., 683 Bremmer J. N., 753 Edenharder R., 357, 373 Hellwig J., 489, 501, 677, 859 Brennecke L. H., 683 Eisenbrand G., 219 Hempenius R. A., 573 Briand G., 693 Emerole G. O., 975 Henderson L., 207 Bruner L. H., 165 Enami T., 387 Herderich M., 777 Bryce F., 1191 Engman J., 891 Hermansky S&S. J., 1031 Buc Calderon P. M., 669 Enslein K., 1091 Hierlihy S. L., 981 Bullerman L. B., 991 Evdokimova E., 669 Hildebrand B., 1041, 1061 Burns R. A., 967 Hill D. L., 589 i Butryee C., 213 Faber W. D., 1023 Hill R., 175 t Fahey Jr G. C., 1165 Hill R. N., 159, 165 | Caldwell J., 409, 933 Falke H. E., 337, 349 Hilton J., 261, 1209 } Campbell J. M., 1165 Farombi E. O., 975 Hinton R. H., 753 | j XIII XIV Index of Authors Hlywka J. J., 991 Lina B. A. R., 309, 573 Pariza M., 449 Hofer H., 39 Lind Y., 891 Pélissier M. A., 693 Holzhiitter H.-G., 39, 167 Lin Wu H.-W., 1159 Phillips T. D., 807 Hosono M., 783 Lipman J. M., 39 Philo M. R., 821 Hostynek J. J., 839, 109] Liu T.-Y., 957 Plattner R. D., 807 Hotchkiss S. A. M., 409 Liu W., 449 Pohlmeyer-Esch G., 909 Howes D., 705, 1009, 1219 Liu J., 827 Poland J. L., 459 Hsieh S. E., 1151 Livingston S. D., 1107 Poon R., 225 Huber W. W., 647 Lo H. H., 1151 Portoghese P. S., 739 Huggett A. C., 547 Lomax L. G., 393 Potokar M., 417 Hughes M. F., 697 Lovell D., 79, 167 Pozo R., 621 Price S. C., 753 Idle J. R., 903 Machino S., 783 Prinsen M., 573 lijima K., 1143 Madrigal-Bujaidar E., 567 Prinsen M. K., 23, 337, 923 lijima T., 1075 Maekawa A., 1075 Pritts I. M., 869 Imaizumi K., 663 Maibach H. I., 513, 1091 Procter B. G., 225 Imazawa T., 387, 799 Makino S., 783 Putnam J. M., 625 Ishihara R., 1075 Manoonphol K., 213 Iyer V. J., 583 Martos M., 669 Radhofer-Welte S., 465, 909 Martinez M. P., 621 Rafii F., 897 Jaccaud E., 547 Matsui H., 597 Rajendran N., 683 Jackh R., 489, 501 Matthies W., 1099 Ramchandani S., 835 Jagerstad M., 555 Matula T. I., 185, 199 Rasmussen T., 945 James V. J., 705, 1219 Mayura K., 807 Régnier J.-F., 127 Janzowski C., 219 McFadden J., 255 Reistad R., 945 Jodral M., 621 McFarlane M., 753 Robinson M. K., 255 Johnson K. A., 241 McKenzie K. S., 807 Roe F. J. C., 271, 1041, 1061 Johnson I. T., 379 Mehdi N., 465, 909 Rogers T. D., 807 Jorhem L., 891 Mehrotra N. K., 523, 1081 Roguet R., 159 Ju H.-R., 663 Metzler M., 605 Romijn T., 923 Meulenbelt J., 615 Roper C. S., 1009 Kang J.-J., 957 Miller D., 1191 Rorie J., 881 Kangsadalampai K., 213 Miller D. R., 807 Roscher R., 777 Kao E.-S., 1159 van Miller J. P., 481 Rossland O. J., 945 Kasahara K., 387 Miltenburger H., 39 RGthlisberger R., 1099 Kataoka S., 449 Mitchell S., 933 Rowland I. R., 535 Katz G. V., 1023 Mitsui M., 387 Rowson M., 845 Kelling C. K., 705 Mitsumori K., 475, 799 Rumney C. J., 535 Kelly C. M., 967 Mizusawa K., 207 Khanna S. K., 835 Mocchiutti N. O., 1017 Sahu S. C., 443 Ki M., 663 Moldenhauer F., 39 Salmon C. P., 433 Kikuchi M., 207 Mori S., 783 Sarkar (Datta) D., 657 Kim H-C., 387 Mota P., 567 Sarr A. B., 807 Kimber I., 261, 1209 Mougin D., 1099 Sattar N., 1209 Kimoto T., 323 Moulton R. A., 1023 Savard M. E., 981 Kitamura T., 1075 Mueller R., 225 Savouré N., 693 Kitaura K., 475 Mukerji B., 583 Scala R. A., 13 Klassen R., 185, 199 Mukherjee A., 1177 Schlede E., 159 Klimisch H.-J., 677, 1041. 1061 Mukherjee P., 657 Schreier P., 777 Knize M. G., 433 Mulky M. J., 583 Schwab W., 777 Koch H., 777 Munro I. C., 739 Seibel H. R., 459 Kolb E., 219 Murai T., 783 Sekijima M., 1143 Koontz S. W., 79 Murphy S. R., 859 Serranzana S., 513 Kraus A. L., 1219 Musk S. R. R., 379 Sharma A., 657 Krivanek N. D., 393 Shibuya T., 323 Kruszewski F. H., 127 Nasseri-Sina P., 409 Shigeoka T., 589 Kubena L. F., 807 Neeper-Bradley T. L., 869 Shimo T., 475 Kulling S. E., 605 Nera E. A., 1191 Shiobara S., 323 Kuper C. F., 349 Newberne P., 739 Shivapurkar N., 517 Kiittler K., 1041, 106] Nishikawa A., 387 Shoda T., 331, 597, 799, 1181 Nishimura S., 1075 Shukla Y., 523 La Du B. N., 625 Nishizono S., 663 Sicard C., 159 Lane R. W., 207 Noker P. E., 589 Sigman C. C., 1091 Latva-Kala K. J., 945 Norred W. P., 807 de Silva O., 39, 159 Lau B. P.-Y., 185, 199 Nwankwo J. O., 975 Sina J. F., 127 Lecavalier P., 225 Skog K., 555 Lee I-S., 387 O’Donnell M., 881 Smith C. J., 1107 Leung H.-W., 481 Okumiya M., 663 Smith R. L., 739 Leung H. W., 1031 Onodera H., 475, 799 Smith M., 207 Lewis D., 185, 199 Osborne R., 67, 127 Smits-Van Prooije A. E., 309 Lewis R. W., 79 Smuts C. M., 647 Liebsch M., 39 Pape W. J. W., 39 Snoeij N. J., 923 Lin T.-H., 589 Pariza M. W., 625 Snyman §S. D., 647 Index of Authors Spencer P. J., 241 Tolnai G., 1191 Wang C.-J., 1159 Spielmann H., 39, 159 Tomera J. F., 713 Wang H. H., 1001 Spira H., 165 Toufic A., 159 Wang H.-W., 957 Sprando R. L., 881 Toulon M., 1219 Wang S.-D., 1143 Springer J., 13, 167 Toyoda K., 331, 597, 1181 Wang X. M., 255 Stack M. E., 1135 Troy A. L., 1135 Watanabe T., 799 Stapley R., 1191 Tseng T.-H., 1159 Watkinson A. C., 705, 1219 Stavric B., 185, 199 Tyler T. R., 869 Weil C. S., 739 Steiling W., 39 Wester R. C., 513 Steineck G., 555 Ueng T.-H., 957 White J. B., 639 Stenberg M., 555 Ueno Y., 1143 Whittle E., 845 Storkson J., 449 Uneyama C., 331, 597, 799, 1181 Wibert G. J., 967 Stott W. T., 241 Wilcox N., 175 Upreti R. K., 835 Stribbling S., 933 Wilcox N. L., 1 Stringer B. K., 639 Wilhelm K.-P., 255 Valli V. E., 225 Sugano M., 663 Willems M. I., 337 Van Buskirk R. G., 67 Sugiura Y., 1143 Williams F. M., 1009 Van de Kuil A., 615 Suzuki C. A. M., 981 Woods L. A., 739 Van Delft J. M. H., 573 Swanevelder S., 647 Wrzesinski C. L., 1085 Van der Westhuizen L., 647 Wu L. T., 1001 Verhagen H., 315 Takada K., 331, 597, 1181 Vetter A., 219 Takahashi M., Vikse R., 945 Yamakoshi J., 207 Takahashi M., 331, 387, 475, 597, 799, Vlaovic M. S., 1023 Yasuhara K., 475, 799 1075, 1181 Vleeming W., 615 Yea ¥. 3. 213i Takegawa K., 799 Voss K. A., 807 York M., 255, 845 Tanaka T., 1143 Yoshida M., 1075 Tanakamaru Z., 387 Yu S.-Z., 1143 Tang X., 373, 357 Waalkens-Berendsen D. H., 309 Tang Z., 517 Wagner B. M., 739 Teetsel N. M., 1219 Walker A. P., 1099 Zahlsen K., 903 Til H. P., 337, 349 Walters K. A., 705, 1219 Zhao Y., 827 PII: S0278-6915(98)00054-4 Index of Subjects Acesulfame-K genotoxicity in mice 1177 Antioxidants activity of Hibiscus sabdariffa L. extracts on Acetone TLV 1230 oxidative stress in rat hepatocytes 1159 N-Acetyltransferase vitamin C effect on bacterial activity Anti-tumour activity flavonoids 928 1151 Apple flavonoids cancer 1132 Acid Green 16 genotoxicity 1134 Apricot oil safety assessment of wild type 583 Acrylic acid effects of oral administration on two gener- Arachidonic acid oral safety study of algal and fungal ation reproduction/fertility toxicity study 859 ... foetal single cell sources 967 ... safety assessment of Mortier- development toxicity study by inhalation in NZ white ella alpina enriched oil 573 rabbits 869 Aroclor 1254 post-reproduction toxicology studies in Adrenal effects no-observed-effect level (NOEL) by Rhesus monkeys 1181 nitrite-induced 349 Aromatic herbs occupational asthma 181 Air pollution mortality studies 858 Arsenic genotoxicity 432 Arylamine N-acetyltransferase emodin inhibition on ac- Alcohol cancer and consumption 633 ... consumption tivity in strains of H. pylori in peptic ulcer patients 1001 and hormone replacement therapy (HRT) 302 ... intake Asbestos similarity of silicon carbides and silicon nitrides and breast cancer 854 ... spermatogenesis 1232 ... use 532 in pregnancy and newborn cleft lip 298 L-Ascorbic acid lack of promotion of urinary bladder Alcohols differential prenatal toxicity of straight and cancer in rats 783 branched chain primary alcohols 489 Aspartame brain cancer in children 927 ... dental caries Algae oral safety study of single cell sources of docosa- 297 hexaenoic acid and arachidonic acid 967 Aspergillus oryzae safety evaluation of tannase prep- Alicyclic flavouring substances FEMA GRAS assessment aration 207 program 297 Asthma aromatic herbs 181 ... 1,2-benzisothiazolin-3-one Allergens immunogenicity induced in mice by proteins 856 ... COSHH and occupational preventive measures 1209 ... International standard series 738 ... Patch test 533 ... diphenylmethane diisocyanate and mortality 635 chambers size 1232 ... fish handlers 930 ... isothiazolinones exposure 1229 Allergy ackee fruit 300 ... ammonium bisulfite 180 ... ninhydrin 1230 nitrogen dioxide 637 carrot 853 ... chicory 181, 928 ... cumin 853 ... occupational contact to food enzymes 430 ... occu- detergent-disinfectant combination 1134 ... gelatin in pational exposure to amylase 1229 ... occupational use vaccines 427 ... gold: review of the growing significance of lactase 635 ... roasted coffee beans 181 as an allergen 839 ... gold and pierced ears 858 ... gold Atherosclerosis phytosterols protection in mice 528 contact 1134 ... tert-butyl hydroquinone reaction Atopic status human patch test evaluation 182 threshold 1134 ... iodopropynylbutylcarbamate 738 Atrazine genotoxicity 429 ... jackfruit 735 ... lanolin 737 ... latex 858 ... latex Azamethiphos contact dermatitis 429 in children 532 ... latex (natural) in air 182 ... latex Azo dyes mutagenic activity and reduction by azoreduc- (natural) rubber 306 methylhexahydrophthalic tase producing human intestinal tract bacteria 897 anhydride 430 ... methylol phenols 1133 ... mite- Azoreductase mutagenic activity and human intestinal contaminated flour 928 ... mushroom Boletus sp. 928 tract bacteria reduction of azo dyes 897 . non-ionic emulsifier in liquid deodorant 738 ... Azoxymethane phase I/II drug metabolizing enzymes peanut oil 635 ... phenol-formaldehyde resins 1133 ... effect on colon-specific carcinogen 789 pistachio nuts 427 ... pumpkin seeds 634 ... rosins 304 . Saffron 853 ... sesame seed 301 ... sesame seed, increasing numbers of patients 427 ... spathe flower 533 BAC-ester chloride allergic contact dermatitis from dental ... textile dyes 431 ... whey protein hydrolysates in rats material 180 663 ... wool wax alcohols 737 Beer dangers of binge drinking 1228 Alligator environmental oestrogens 430 Bendroflumethiazide occupational dermatitis 304 Allyl isothiocyanate disposition in the rat and mouse 933 Benzene benzene oxide importance in carcinogenesis 931 Alternative test methods validation with cosmetics 182 ... haematological cancers 931 Aluminium 857 ... Alzheimer’s disease 857 ... neuro- Benzene butyl phthalate breast cancer reduction 931 toxicity in premature babies 857 Benzene oxide importance in carcinogenesis of benzene Aluminium phosphide acute toxicity in humans 302 931 Alzheimer’s disease aluminium 857 Benzidine liver cancer 303 Ametryn embryotoxicity in rats 530 1,2-Benzisothiazolin-3-one occupational asthma 856 Amines (see also Heterocyclic aromatic amines) ... acute Benzothiophene short-term toxicity 431 and subacute toxicity 337 ... short-term toxicity studies 3,4-Benzpyrene generations sexual behaviour 1231 855 Bioassays_ to assess toxicity of fumonisin B1 991 Aminopentol embryotoxicity of fumonisin Bl hydrolysis Biogenic amines acute and subacute toxicity 337 product 1135 Birth defects maternal occupational exposure to glycol Ammonium bisulfite allergy 180 ethers 929 Amylase occupational asthma 1229 Bis(2-(dimethylamino)ethyl) ether acute toxicity and irri- Anaphylaxis cereal-induced following exercise 735 tancy 1231 Animal bedding toxicity 931 Bisphenol A stimulates prolactin 854 XVII XVIII Index of Subjects Black pepper sister chromatid exchanges induced by Cardiovascular disease caffeine risk factor 428 extract 567 dietary intake of fish and risk factors 179 ... homo- Black tea effects of clastogens combination on chromo- cysteine plasma levels risk factor 427 ... protective some abberations 657 ... heart disease 1132 effect of dietary fibre 428 Blood pressure dietary effects 298, 634 ... elderly and salt Carnosol contact dermatitis 1229 1228 ... multiple linear regression analysis of calcium/ B-Carotene dietary supplements and lung cancer 298 ... cadmium effect on hypertensive states 713 ... nitrite heart disease protective role 853 effect in rats 615 ... sour milk consumption 300 Carpet assay for neurotoxicity of volatile organic com- Body temperature genotoxicity increase in mice 858 pound emissions 241 Boric acid developmental toxicity in rabbits 301 Carrot allergy 853 Brain tumours aspartame consumption by children 927 ... Cassia gum_ review for GRAS status 625 childhood and maternal dietary intake of sodium nitrite Cats dietary sodium requirements 736 179 Cell-function assays IRAG Working group 3 report on Breast soy protein effect in premenopausal female 298 assays of eye irritation 67 Breast cancer alcohol intake 854 ... environmental effects Central nervous system Jet fuel effects 1133 On oestrogenic activity 854... erythrosine 853 ... trans- Chemical-induced toxicity modulatory effect of yam fatty acids 1228 ... low-fat eating pattern 633 ... meat browned flour diet 975 intake risk factor 1131 ... organic solvents 736 ... Chemical mixtures exposure assessment, hazard identifi- phytoestrogens 1228 polyunsaturated fatty acids cation and risk characterisation 533 inhibit 633 ... reduction with benzene butyl phthalate Chicken marination and heterocyclic aromatic amines 931... tofu intake 298 ... water consumption 1131 carcinogen formation 433 Brick tea consumption and dental fluorosis among Chicken embryo screening test to assess toxicity of Chinese children 827 fumonisin Bl 991 Brine shrimp test to assess toxicity of fumonisin B, 991 Chicory allergy 928 ... occupational allergy 181 Brominated dibenzo-p-dioxins review 531 Children brain cancer and aspartame consumption 927... Bromodichloromethane mutagenicity 737 cancer and parental cigarette smoking 532 ... drinking 2-Bromopropane reproductive toxicity 857, 1231 water nitrate levels and chromosome damage 432 ... 2-Butin-1,4-diol developmental toxicity 1133 latex allergy 532 n-Butyl acetate acute inhalation toxicity levels 1133 Chlorinated hydrocarbons comet assay 306 Butylated hydroxytoluene foetal development in rats 753 Chlorohydrins cancer epidemiology 930 fert-Butyl hydroquinone allergy reaction threshold 1134 5-Chloro-1-methyl-4-nitroimidazole occupational contact dermatitis 430 4-Chloro-o-toluidine genotoxicity 180 Cadaverine acute and subacute toxogenicity 337 Chlorophenates exposure and effect on male reproductive Cadmium accumulation in mouse liver and kidney after system 180 continuous exposure 891 ... multiple linear regression Cholesterol diterpenes from coffee affect levels 529 ... analysis of effect on blood pressure in hypertensive effect of dietary changes 429 ... medium-chain fatty States 713 acids 428 ... garlic, lowering properties 300 ... infant Cafestol analysis of content of diterpenes in coffee brews formulas 299 ... legumes, lowering effect 928 ... oat 547 fibre decreases levels 528 .. . rice bran oil, lowering effect Caffeine cardiac arrest 1232... cardiovascular disease risk 928 ... shrimps, effect of on high cholesterol diets 300 factor 428 consumption during pregnancy and . Soy protein isoflavones, lowering effect 428 reduced birth weight 529 ... delays conception 529 ... Chorion allantoic membrane (CAM) IRAG Working effects on pre-existing heart disease 735 ... spermato- Group 2 report on assays of eye irritation 39 genesis 1232 Chromosome aberrations effects of clastogens black tea Calcium multiple linear regression analysis of effect on infusion combinations 657 blood pressure in hypertensive states 713 Cidial placental barrier 530 Canada heterocyclic aromatic amines content in pre- Cigarettes (see also Tobacco smoke) ... literature survey processed meat cuts 199 of IARC Group 1 carcinogens (review) 1107 Cancer (see also specific cancers) alcohol consumption 633 maternal smoking and limb malformations 532 . apple flavonoids 1132 ... chlorohydrins epidemiol- mentholated brands health risks 302 ... mentholated ogy 930 ... colon tumours, inhibition of by wheat bran smoke inhalation, toxicity study 683 ... oesophageal 517... gastric risk, dietary salt intake and 271 ... green cancer 1134... parental smoking and childhood cancer tea lowers risk 529 ... liver tumour, promoting effects in 532 ... women smokers risk of lung disease 858 rats of oxfendazole 799 ... passive smoking 1232... Clastogens black tea infusion combination, effects of on protective effects of resveratrol 301 ... review of food chromosome abberations 657 association 633 ... urinary bladder, lack of promotion Cleft lip alcohol use in pregnancy 298 by sodium bicarbonate and L-ascorbic acid in rats 783 Clenbutarol residue contaminated meat 1133 . Vitamin and mineral supplements 1227 Cocamidopropylbetaine non-sensitizer pure preparation Carcinogen broccoli source of glutathione S-transferase 305 for detoxification 429 ... dichloroacetic acid effect on Cocoamphodipropionate, disodium dermatitis from con- liver 298 furanocoumarin enzyme inhibitor of tact lens cleaning solutions 305 activity in grapefruit 429 ... influence of lactic acid- Coffee analysis of brew content of cafestol and kahweol producing bacteria on dietary binding and mutagenicity 547 ... consumption and risk of coronary heart disease 535 ... mixtures and DNA damage 182 ... phase I/II 300 ... consumption raises homocysteine plasma levels drug metabolizing enzymes effect on colon-specific 428 ... mutagenicity of trigonelline constituent 928 azoxymethane 789 ... phenolphthalein 305 ... PhIP Coffee beans occupational asthma 181 prostate carcinogen in rats 527 silicon carbide Cognitive impairment dietary linoleic acid 429 inhalation 303 Cold hypoxia fructose protective effect on stored hepato- Carcinogenicity (see also Oncogenicity) . . . oral toxicity of cytes 669 lornoxicam in rats 909 ... potential of cyanoguanidine Colitis royal jelly 1228 475 ... study of B-cyclodextrin 331 Colon cancer (see also Colorectal cancer) ... animal fat Cardiac arrest caffeine and smoking 1232 dietary intake 927 dietary sugar 1227 diet- Index of Subjects induced differences 638 ... folate role 735 ... genistein Dietary fibre See Fibre enhancement 1228 ... heterocyclic amines in meat 633 Diethylene glycol monoethyl ether subchronic inhalation ... vegetable and fibre intake 927 ... ‘Western style’ diet 1231 effect 299 Diethylenetriamine 2HCI] (DETA) dose toxicity and diet- Colorectal cancer (see also Colon cancer ... Rectal cancer) ary exposure 481 ... diet and risk 298 ... risk decrease with MTHFR gene Diethylstilboestrol multigeneration carcinogenicity 636 mutation 299 Diisonony! phthalate chronic toxicity and carcinogenicity Colour vision styrene impairment 180 636 Comet assay Chlorinated hydrocarbons 306 liver 2,5-Dimethyl-4-hydroxy-3|2A]furanone B-p-glucuronide carcinogens 931 identification as metabolite of strawberry flavour Contact lens dermatitis from cleaning solutions contain- constituent 777 ing disodium cocoamphodipropionate in 305 N,N-Dimethylethanolamine developmental study 303 Copper sulfate acute human toxicity 301 2,4-Dinitrothiocyanobenzene skin sensitizing properties Coronary heart disease coffee consumption and risk 300 261 . environmental tobacco smoke 182 ... fatty acids Dinoterb skin whitening effect 736 intake 179 Dioxins exposure and tumours to brominated forms 531 Cosmetics alternative test methods validation 182 ... ... herbicides contaminated 928 human skin penetration of N-nitroso-N-methyldodecyl- Diphenylmethane diisocyanate asthma and mortality 635 amine contaminants 705 ... local lymph node assay Disodium cocoamphodipropionate dermatitis from contact regulatory recognition 307 skin tolerance test lens cleaning solutions 305 guidelines for assessment in man of potentially irritant Disodium ricinoleamido MEA-sulfosuccinate shampoo ingredients 1099 contact dermatitis 304 COSHH _ occupational asthma preventive measures 533 Diterpenes analysis of content of cafestol and kahweol in Coumarin cytochrome P450 CYP2A6 polymorphism and coffee brews 547 ... from coffee affect cholesterol levels hydroxylation 903 ... mutagenicity inhibition of 1- 529 nitropyrene, 2-nitrofluorene and 3-nitrofluoranthene Dithiocarbamates immunity altered 429 357 Diuron genotoxicity 302 Coumoestrol genotoxicity of phytoestrogens 605 DNA adduct levels Omega-6 polyunsaturated fatty acids Cow’s milk (see also Milk) ... infant diets and develop- 1131 ment of diabetes 179 DNA damage carcinogen mixtures 182 ... induction with Cumene no foetotoxicity 737 morin and naringenin 443 Cumin allergy 853 DNOP subchronic toxicity 636 Cyanide exposure effect on thyroid function 736 Docosahexaenoic acid oral safety study of algal and Cyanoguanidine carcinogenic potential 475 fungal single cell sources 967 B-Cyclodextrin carcinogen 855 ... carcinogenicity studies Drinking water genotoxicity of chlorination contaminants 331 737 ... genotoxicity studies of fluoridation 857 ... Cytochrome P-450 CYP2A6 polymorphism and coumarin nitrate levels and chromosome damage in children 432 hydroxylation 903 ... geniposide inhibition in rat liver 957 Cytotoxicity allyl sulfides 379 Ears allergy to gold piercing 858 Cytotoxicity assays IRAG Working Group 4 report on Eczema _ lactose intolerance 1134 assays for eye irritation 79 Egg lysozyme risk to allergy sufferers 635 Elderly infection and vitamin and mineral supplements 1227 ... mortality, vitamin supplements 181... salt and DEHP subchronic toxicity 636 blood pressure 1228 Denitrification nitrosamine prevention after biological Emamectin benzoate developmental neurotoxicity 929... treatment of red beet juice 219 skin penetration in the rhesus monkey 1085 Dental caries aspartame 297 ... sodium trimetaphosphate Embryotoxicity fumonisin Bl hydrolysis product amino- usage and incidence 299 pentol 1135 ... isomaltulose studies in rats 309 Dental disinfectant wipes contact dermatitis 304 Emodin inhibition of arylamine N-acetyltransferase ac- Dental fillings lichen planus 738 tivity in strains of H. pylori in peptic ulcer patients 1001 Dental fluorosis brick tea consumption among Chinese Epoxy resin renal damage 1230 children 827 Ergometrine maleate subacute toxicity 297 Dentin bonding agents mutagenicity 1231 Erythritol dietary safety 297 Deodorant allergy to non-ionic emulsifier in liquid prep- Erythrosine breast cancer 853 arations 738 Ether, bis(2-(dimethylamino)ethyl) acute toxicity and irri- Dermatitis azamethiphos 429 BAC-ester chloride tancy 1231 dental material 180 ... bendroflumethiazide and hydra- Ethylene dioxide percutaneous absorption from fabric 513 lazine occupational exposure 304 ... carnosol 1229... Ethylene glycol monobutyl ether mutagenicity 180 disodium cocoamphodipropionate in contact lens clean- Ethylene glycol monomethyl ether spermatogenesis in ing solutions 305 ... dental disinfectant wipes 304 ... rabbits 530 ETMDQ 304 ... fatty alcohols 304 ... Irgarol 1051 5-Ethylidene-2-norbornene toxicity 931 occupational use 856 ... occupational contact with 5- Ethyl-tert-butyl ether repeated inhalation study 931 chloro-l-methyl-4-nitroimidazole 430 phthalates ETMDQ contact dermatitis 304 from computer mouse plasticizers 180 ... disodium European Union OELs 637 ricinoleamido MEA-sulfosuccinate shampoo 304 Evening primrose oil protective effect against gastric Detergent—disinfectant combination allergy 1134 ulceration and secretion 769 Detoxification organophosphate pesticides 302 Eye damage xylene induced 856 Diabetes mellitus cow’s milk in infant diets 179 Eye irritation industry, public interest and government protective effect of dietary fibre 428 perspectives on alternative tests (review) 165 ... IRAG Dibenzofurans review 531 Working Group 1 organotypic models for the assess- Dichloroacetic acid effect as liver carcinogen 298 ment and prediction 23 ... IRAG Working Group 2 1,1-Dichloro-1-fluoroethane mortality 1229 report on chorion allantoic membrane (CAM ) based Index of Subjects assays 39 ... IRAG Working Group 3 report on cell- embryotoxicity of hydrolysis product aminopentol 1135 function based assays 67 ... IRAG Working Group 5 ... toxicity study in mice 981 report on assays 127 ... IRAG Working Group 6 Fumonisins hepatocarcinogenesis from corn harvested in criteria for data submission for alternative tests 13 ... China 1143 statistical analysis and tier testing strategies of assays Functional foods beneficial effects of modified starches in 159 ... statistical planning and analysis in evaluation of 1131 testing alternatives to whole animal use 167 ... work- Fungi oral safety study of single cell sources of docosa- shop on practical applications of non-whole animal hexaenoic acid and arachidonic acid 967 testing alternatives 1, 175 Fungicides potential mutagenicity of thiram 523 EYTEX assay IRAG Working Group 5 report 127 Furanocoumarin enzyme inhibitor of carcinogen activity in grapefruit 429 Furfural FEMA GRAS assessment for use as a flavour ingredient 739 Fabric percutaneous absorption of ethylene dioxide 513 Furfuryl alcohol subchronic inhalation toxicity 930 Fats colon cancer and dietary intake 927 Fatty acids coronary artery disease progression 179 ... dietary intake and prostatic cancer 297 ... fumonisin B1 effect on composition of rat liver lipids 647 ... heart Garlic cholesterol lowering properties 300 ... cytotoxicity disease 854 ... medium-chain structures and cholesterol and genotoxicity of allyl sulfides 379 ... extracts prevent 428 ... n-3, dietary fish oils and oligosaccharides in growth of Helicobacter pylori 528 ... lectin toxicity 528 humans 1165 ... n-6, DNA adduct levels 1131 ... Garlic/fish oil combination reduction of serum lipids and polyunsaturated inhibit breast cancer 633 lipoproteins 528 Trans-fatty acids breast cancer 1228 Gastric cancer dietary salt intake and risk 27] Fatty alcohols contact dermatitis 304 heterocyclic amines from meat 634 FEMA GRAS assessment furfural use as a flavour Gastric ulceration protective effect of evening primrose oil ingredient 739 769 Fibre colon cancer and diet 927 ... protective effect Gelatin allergy from vaccines 427 against cardiovascular disease 428 ... protective effect Geniposide inhibition of cytochrome P-450 in rat liver 957 of diet in development of diabetes 428 ... rat maternal Genistein colon cancer enhanced 1228 dietary intake and hernias in offspring 299 Genotoxicity acesulfame-K 1177... acid green 16 1134... Finland abnormal spermatogenesis in male population allyl sulfides 379 ... arsenic 432 ... atrazine 429 ... 305 atrazine and trifluraline 429 ... body temperature effect Fish dietary consumption and heart disease 30 yr study in mice 858 ... of chlorination contaminants in drinking 634 ... dietary intake and risk factors for cardiovascular water 737 ... diuron 302 ... fluoridation of drinking disease 179 ... polar and non-polar heterocyclic amines water 857 ... formaldehyde 636 ... glyphosate (Round- in pan residues 555 ... thyroid cancer and consumption up) 856 ... 2-trans-hexenal 853 ... miconazole 1229 ... 1227 phytoestrogens (coumoestrol) 605 ... piperine 301 ... Fish handlers occupational asthma 930 4-chloro-o-toluidine 180 ... trifluraline 429 ... vehicle Fish oils n-3 fatty acids and oligosaccharides in humans exhaust catalytic converter complexes 43] 1165 VITOTOX test 638 Flavonoids anti-tumour activity 928 mutagenicity Genotoxicity of chlorination contaminants drinking water inhibition of 1-nitropyrene, 2-nitrofluorene and 3- 737 nitrofluoranthene 357 Germ cell genotoxicity formaldehyde 636 Flavonols heart disease 528 Glutathione potential protectant against free radicals in Flavours alicyclic GRAS assessment program 297 ... the skin of vitamin A deficient mice 693 anticarcinogenic properties in soy sauce 449 Glutathione S-transferase broccoli source for detoxifica- identification of 2,5-dimethyl-4-hydroxy-3[2H]furanone tion of carcinogens 429 B-D-glucuronide as metabolite of strawberry flavour Glycine conjugating activity in skin xenobiotic metab- constituent 777 ... mutagenicity of aromatic hetero- olism 409 cyclic amines in processed food samples 185 Glycoalkaloids effect of «-tomatine and tomatidine on Flour mite-contaminated, allergy 928 ... toxicity, mod- membrane potential 639 ulatory effect of yam browned flour diet 975 Glycol ethers birth defects after maternal occupational Fluorosis brick tea consumption among Chinese children exposure 929 827 Glyphosate (Roundup) genotoxicity 856 Foetal development butylated hydroxytoluene exposure in Gold contact allergy 1134 ... pierced ears allergy 858 ... rats 753 ... cumene 737 ... study of acrylic acid review of the growing significance as an allergen 839 inhalation in NZ white rabbits 869 Golf course herbicide 2,4-D induced hepatitis 929 Foetal mortality inorganic mercury vapour 929 Grapefruit furanocoumarin enzyme inhibitor of carcino- Folate role in colon cancer 735 ... variations in dietary gen activity 429 ... inherited aversion to bitter taste requirements 853 1132 Food-contact materials styrene oxide concentration, mi- GRAS status alicyclic flavouring substances 297 ... gration and stability 821 furfural use as a flavour ingredient assessed by FEMA Food enzymes occupational contact asthma 430 739 ... review of cassia gum 625 Formaldehyde germ cell genotoxicity 636 naso- Green tea lowers risk of cancer 529 pharyngeal cancer studies 1133 ... relaxation of TLV Guinea pig maximization test quantitative structure— health restrictions proposed 532 ... sensitivity threshold toxicity relationships (QSTR) 1091 ... skin sensitization 432 and SDS rechallenging 923 Foundry workers | silicosis incidence 303 Gulf War syndrome symptom classification and categor- Free radicals potential protectant of glutathione in the ization 306 ... synergy of chemicals 306 skin of vitamin A deficient mice 693 Fructose protective effect on hepatocytes under cold hypoxic storage 669 Haematological cancers benzene 931 Fumonisin B1 bioassays to assess toxicity 991 ... effect on Hairdressers reproductive risk 930 fatty acid composition of selected rat liver lipids 647 ... Halogenated hydrocarbons presence in environment 305 Index of Subjects XXI HCFC-123 reproductive toxicity studies 305 Interagency Regulatory Alternatives Group (IRAG) eye HCFC-123/124 liver disease 932 irritation testing workshop summary 1, 175... Working HCFC-225ca/-225cb inhalation toxicity in marmosets Group 1l-organotypic models for the assessment/predic- 1133 tion of eye irritation 23 ... Working Group 2-CAM Hearing loss toluene 1229 based assays of eye irritation 39 ... Working Group 3- Heart disease (see also Cardiovascular disease) ... black cell-function based assays of eye irritation 67 ... tea 1132 ... dietary consumption of fish 30 yr study 634 Working Group 4-cell cytotoxicity assays of eye ... effects of caffeine on pre-existing 735 ... trans fatty irritation 79 ... Working Group 5-eye irritation assays acids 854 ... flavonols 528 ... homocysteine risk factor 127 ... Working Group 6-eye irritation alternative tests 854 ... low-fat, high carbohydrate diets effect 735 ... criteria for data submission 13 passive cigarette smoking 637, 1232 ... a-tocopherol International Agency for Research on Cancer mainstream and f-carotene protective role 853 ... vitamin C 528 cigarette smoke literature survey of IARC group 1 Heart rate after consumption of Sauropus androgynus carcinogens (review) 1107 weight reducing vegetable 300 Intestinal tract bacteria mutagenic activity and reduction Heavy metals multiple linear regression analysis of of azo dyes by azoreductase production 897 accumulation on blood pressure in hypertensive states Intestine cancer (see also Colon cancer) ... sugar intake 713 and incidence 527 Helicobacter pylori emodin inhibition of arylamine N- Intolerance monosodium glutamate 927 acetyltransferase 1001 ... growth prevention by garlic Iodopropynylbutylcarbamate allergy 738 extracts 528 Irgarol 1051 occupational dermatitis 856 Hepatitis 2,4D induced from golf course herbicide 929 ... Iron supplements and mental performance in adolescent thiourea induced 858 girls 181 Herbicides dioxin contaminated 928 Isobutylidenediurea developmental toxicity 1133 ... pre- Hernia rat maternal dietary fibre and problems in off- natal toxicity of oral doses 669 spring 299 Isoflavones soy protein cholesterol lowering effect 428 Heterocyclic aromatic amines content in pre-processed Isomaltulose embryotoxicity/teratogenicity studies in rats meat cuts from Canada 199 ... in human _ urine 309 ... reproductive toxicity 855 following a fried meat meal 945 ... marination and Isopropanol non-carcinogenic in rodents 737 carcinogen formation in grilled chicken 433 ... muta- Isothiazolinones asthma 1229 genic activity in processed food flavour samples 185 ... polar and non-polar pan residues in cooked fish and meat products 555 ... stomach cancer from meat 634 Jackfruit allergy 735 B-Hexachlorocyclohexane oestrogenic action 430 Jet fuel CNS effects 1133 ... effects on immune system 2-trans-Hexenal human genotoxicity 853 1231 Hibiscus sabdariffa L. activity of extracts as antioxidants in rat hepatocytes 1159 Hip fracture risk in female smokers 1232 Kahweol analysis of content of diterpenes in coffee brews Homocysteine coffee consumption raises plasma levels 428 547 ... heart disease risk factor 854 ... plasma levels risk Kathon biocide mutagenicity from use in cosmetics 180 factor for cardiovascular disease 427 Kidney see Renal Hormone replacement therapy (HRT) alcohol consumption 302 Human detoxification organophosphate pesticides 302 Lactase occupational asthma 635 Hydralazine occupational dermatitis 304 Lactic acid-producing bacteria influence of dietary carci- Hydrofluoric acid lung damage 637 nogen binding and mutagenicity 535 Hydrogen fluoride low concentration irritant 531 Lactose inhalation toxicity 1134 ... toxicological review Hydrogen sulfide validity of OEL 636 to support clinical administration by inhalation 719 Hypoxia fructose protective effect on stored hepatocytes Lactose intolerance severe chronic eczema 1134 669 Lanolin allergy 737 Latex airborne allergy 182 ... allergens in tyre dust 306 ... allergy 858 ... children allergy 532 ... natural rubber allergy 306 ILSI Europe Novel Food Task force safety assessment Latex gloves low-protein sensitization 431 guidelines for novel foods 306 Lectin toxicity of garlic form 528 Immune system jet fuel effects 1231 ... oral dosing method Legumes _ cholesterol lowering effect 928 and seasonal variation 1233 ... vitamin E 735 Leukaemia nutritionally unbalanced slimming diets 1131 Immunity altered by dithiocarbamates 429 Lichen planus dental fillings 738 Immunogenicity induced in mice by protein allergens 1209 Licorice antioxidant activity 1132 ... effects on mineral Indium phosphate lung inflammation 530 metabolism 300 ... excessive consumption 527 Indole-3-carbinol male reproductive abnormalities 302 ... Lindane reproductive toxicity in rats 529 modulation of mutagenic potential of propoxur 1081... Linoleic acid cognitive impairment and dietary intake 429 urine levels 854 Lipase Rhizopus oryzae: safety evaluation from toxico- Infant formulas cholesterol content 299 logical data 315 ... toxicity studies 855 Infection vitamin and mineral supplements in the elderly Lipid peroxidation induction with morin and naringenin 1227 443 Inhalation studies diethylene glycol monoethyl ether sub- Lipids reduction with garlic/fish oil combination 528 chronic toxicity 1231 ... ethyl-fert-butyl ether 931 ... Lipoproteins di(2-ethylhexyl)phthalate effect on removal physical restraint of mice 638 and secretion in rats 1017 ... reduction with garlic/fish Inhalation toxicity n-butyl acetate 1133 ... furfuryl oil combination 528 f alcohol 930 ... lactose 1134 ... long-term N-vinylpyr- Liquid paraffin assessment of carcinogenic potential of j rolidone-2 vapours 1041 ... methyl methacrylate 393, orally administered medium-viscosity product 1181 | 857 ... study of water-dispersible polyester in rats 1023 Liver cancer benzidine 303 ... fumonisins from corn | ... Styrene 530 harvested in China 1143 XXII Index of Subjects Liver carcinogens Comet assay 931 Milk health risks of organochlorine pesticides in pasteur- Liver disease (see also Hepatitis) ... cadmium accumu- ized product 621 ... infant diets and development of lation in mouse after continuous exposure 891 ... effects diabetes 179 ... sour, consumption and blood pressure of polychlorinated naphthalene 930 ... HCFCs 123/124 300 ... testicular cancer and consumption 181 932 Mineral metabolism licorice effects 300 Local lymph node assay metal salt sensitization 738 ... Mineral supplements cancer 1227 regulatory recognition in cosmetics testing 307 Mint essential oil genotoxic 928 Lornoxicam chronic oral toxicity and carcinogenicity in Mite-contaminated flour allergy 928 rats 909 ... oral toxicity 465 Mollusc shell dust pneumonitis 856 Low-fat eating pattern breast cancer 633 Monoamine oxidase inhibitors (MAO) reduction with Lung cancer /f-carotene and «a-tocopherol dietary sup- smoking 302 plements 298 ... vitreous fibres 856 Monosodium glutamate intolerance 927 Lung disease (see also Respiratory function) ... women Monoterpenes effect on respiratory function 737 cigarette smokers 858 Morin lipid peroxidation and DNA damage induction Lung inflammation indium phosphate 530 443 Lung toxicity hydrofluoric acid 637 ... 3-methylindole Mortierella alpina safety assessment of arachidonic acid 738 enriched oil 573 Lycopene bioavailability from tomatoes 1132 Mouse micronucleus test carcinogenicity prediction 533 Lysozyme risk to egg allergy sufferers 635 Multiple linear regression analysis calcium/cadmium effect on blood pressure in hypertensive states 713 Mushroom Boletus sp. allergy 928 Musk nitro forms non-genotoxic 637 Malathion low dose effect 1229 Mutagenicity bromodichloromethane 737 dentin Marination heterocyclic aromatic amine carcinogen for- bonding agents 1231 ... ethylene glycol monobutyl mation in grilled chicken 433 ether 180 ... heterocyclic aromatic amines in processed Marine bunker fuel components toxicity of syntower food flavour samples 185 Kathon biocide in bottoms 531 cosmetics 180 nitroarenes inhibition 357 Maternal dietary intake sodium nitrite and childhood 2-nitrofluoranthene 638 ... polycyclic aromatic hydro- brain tumours 179 carbons in nitrite treated broiled food 213 ... styrene Meat breast cancer risk factor 1131 clenbutarol 303 ... thiram 523 ... trigonelline constituent of coffee residue contamination 1133 ... heterocyclic aromatic 928 amines content in pre-processed cuts from Canada 199 Mycotoxins novel source of ozone for degradation and ... heterocyclic aromatic amines in human urine 945... detoxification 807 polar and non-polar heterocyclic amines in pan residues 555 Membrane potential effect of a-tomatine and tomatidine Naphthalene 2-methyl naphthalene carcinogenicity 636... glycoalkaloids 639 polychlorinated liver effects 930 Mental performance dietary iron supplements in adoles- Narinenin lipid peroxidation and DNA damage induction cent girls 181 443 Menthol cigarettes health risks 302 ... toxicity study of Nasopharyngeal cancer formaldehyde studies 1133 smoke inhalation 683 Neurotoxicity aluminium, in premature babies 857 ... Mercury inorganic vapour and foetal mortality 929 ... assay for carpet volatile organic compounds emissions role in environmental illness 1231 241 ... emamectin benzoate 929 ... PCB exposure 736 Metal fume fever zinc oxide 1230 Ninhydrin asthma 1230 Metal particles exposure in hard metal industry 531 Nitrate drinking water levels and chromosome damage in Metal toxicity copper, magnesium and zinc sulfate 301 ... children 432 local lymph node assay measure of sensitization 738 Nitrite effect on blood pressure in rats 615 ... mutageni- Metanil yellow phase I/II drug metabolizing enzymes city of polycyclic aromatic hydrocarbons in broiled induction 835 food 213 ... no-observed-effect level (NOEL) by nitrite- Methacrylonitrile developmental toxicity 302 induced adrenal effects in rats 349 Methane diisocyanate sensitization potential increased by Nitroarenes mutagenicity inhibition by phenolic com- phenyl isocyanate 303 pounds 357 Methiocarb — skin sensitization 856 2-Nitrofluoranthene mutagenicity 638 Methoxy polyethylene glycol-350 cutaneous toxicity stu- 3-Nitrofluoranthene mutagenicity inhibition by flavo- dies 1031 noids, coumarins and quinones 357 ... mutagenicity Methyl bromide chronic poisoning 529 inhibition by vitamins and porphyrins 357 Methylene tetrahydrofolate reductase (MTHFR) colo- 2-Nitrofluorene mutagenicity inhibition by flavonoids, rectal cancer risk decrease with gene mutation 299 coumarins and quinones 357 ... mutagenicity inhibition Methyl ethyl ketone TLV 1230 by vitamins and porphyrins 357 Methylhexahydrophthalic anhydride allergy 430 Nitrogen dioxide asthma 637 3-Methyl indole lung toxicity 738 1-Nitropyrene mutagenicity inhibition by flavonoids, cou- Methyl methacrylate chronic inhalation toxicity 857 ... marins and quinones 357 chronic inhalation toxicity and oncogenicity 393 Nitrosamines prevention by biological denitrification in 2-Methyl naphthalene carcinogenicity 636 red beet juice 219 ... tobacco specific 532 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) N-Nitrosobis(2-oxopropyl)amine (BOP) NNAL _ pro- promotional effects on BOP initiated carcinogenesis 387 motional effects on carcinogenesis 387 Methylol phenols allergy 1133 N-Nitroso-N-methyldodecylamine penetration of human Methyl-tert-butyl ether toxicity in petrol 431 ... toxicity skin of cosmetics contaminants 705 study 857 Nivalenol kidney disease 855 Miconazole genotoxicity 1229 NOAEL (no observed adverse effect level) simultaneous Microsomes trichloroethylene rates of metabolism 531 chemical exposure 637 Microtox assay IRAG Working Group 5 report 127 Non-steroidal anti-inflammatory drugs (NSAIDs) oral Migraine vanilla trigger 527 toxicity of lornoxicam 465