Food Allergy: Expert Consult Basic

323 Pages·2011·11.17 MB·English

by  John M James

Food
ALLERGY
Commissioning Editor: Sue Hodgson
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Editorial Assistant: John Leonard
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Food
ALLERGY
John M. James, MD
Colorado Allergy and Asthma Centers, P.C.
Private Clinical Practice
Fort Collins, CO, USA
Wesley Burks, MD
Professor and Chief
Pediatric Allergy and Immunology
Duke University Medical Center
Durham, NC, USA
Philippe Eigenmann, MD
Head, Pediatric Allergy Unit
Department of Child and Adolescent
University Hospitals of Geneva
Geneva, Switzerland
Edinburgh  London  New York  Oxford  Philadelphia  St Louis  
Sydney  Toronto  2012
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British Library Cataloguing in Publication Data
Food allergy.
1. Food allergy.
I. James, John. II. Burks, Wesley. III. Eigenmann, Philippe.
616.9’75-dc22
ISBN-13: 9781437719925
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Preface
We take great pride in presenting an exciting new textbook entitled Food Allergy: Practical Clinical Approaches
to Diagnosis and Management. Our main goal was to create a practical, relevant and clinically-based
resource for food allergy and related adverse reactions to foods. The specific target audience was allergy
specialists, medical residents and fellows-in-training, general pediatricians, family physicians, nutritionists
and other health professionals with an interest in this important topic. Our hope was that the individual
chapters in this textbook would provide the reader with ready access to pertinent information. The chap-
ters have been specifically templated with boxed key points, clinical pearls and case studies to help illus-
trate key teaching points. In addition, an accompanying web-based version of this textbook will be
available to all readers via secure access, with searchable text, images for download to use in presentation
and links to other online resources.
Food allergy is an important public health problem that affects children and adults and appears to be
increasing in prevalence. The impact of food allergy in the community is commonly underestimated.
Besides the few patients with potentially life-threatening reactions to trace amounts of foods, there are
large numbers of patients on eviction diets based on unclear diagnosis. Also because patients frequently
confuse nonallergic food reactions, such as food intolerance, with food allergies, there is an unfounded
belief among the public that food allergy prevalence is higher than the reality. The medical care team
works in the chasm between the public perception and scientific reality of food allergy. The rapid growth
in knowledge in this clinical area has been staggering and continues to be gratifying as reflected in the
topics covered in this textbook. While there is no current cure for food allergy (i.e. the disease can only
be managed by allergen avoidance or treatment of symptoms), there are exciting new developments in
potential new therapies. Topics addressed in this textbook include mucosal immunity and oral tolerance,
basic science of food antigens, epidemiology, diagnosis and management of food allergy, GI tract and
food allergy, natural history, as well as the management of food allergy and anaphylaxis. Hopefully, this
textbook will help to identify key gaps in the current scientific knowledge to be addressed through future
research, but also supply to the primary care provider clear guidelines on how to address a patient with
suspected food allergy.
The development and creation of this new textbook on food allergy would not have been possible
without the expert assistance of our contributing authors, as well as the excellent guidance and editorial
assistance from the expert staff at Elsevier Ltd. We certainly hope that the reader will find this resource
to be useful and practical in dealing with patients with food allergy and other adverse reactions to foods.
John M. James MD
Wesley Burks MD
and
Philippe Eigenmann MD
vii

List of contributors
Yuri Alexeev, PhD Jesús F. Crespo, MD, PhD
Project Scientist Allergy Specialist
Institute of Food Research Servicio de Alergia
Norwich Hospital Universitario 12 de Octubre
UK Instituto de Investigación Hospital 12 de Octubre
Madrid
Katrina J. Allen, MBBS, BMedSc, FRACP, PhD
Spain
Associate Professor
Paediatric Gastroenterologist/Allergist George Du Toit, MBBCh, MSc, FCP, FRCPCH
Department of Paediatrics Consultant in Paediatric Allergy
University of Melbourne Royal Children’s Hospital King’s College London
Group Leader The Medical Research Council and Asthma UK
Gut and Liver Research Group Centre in Allergic Mechanisms of Asthma
Infection, Immunity & Environment Division of Asthma, Allergy and Lung Biology
Murdoch Children’s Research Institute Guy’s and St Thomas’ National Health Service
The Royal Children’s Hospital Foundation Trust
Parkville, VIC London
Australia UK
Cristiana Alonzi, MD Motohiro Ebisawa, MD, PhD
Assistant Professor Department of Allergy
Food Allergy Referral Centre Clinical Research Center for Allergology and
Department of Pediatrics Rheumatology
Padua General University Hospital Sagamihara National Hospital
Padua Sagamihara, Kanagawa
Italy Japan
Dan Atkins, MD Philippe Eigenmann, MD
Professor of Pediatrics Head, Pediatric Allergy Unit
National Jewish Health Department of Child and Adolescent
Associate Professor of Pediatrics University Hospitals of Geneva
University of Colorado Medical School Geneva
Denver, CO Switzerland
USA
Mary Feeney, MSc, RD
Debra D. Becton, MD Clinical Research Dietitian
Assistant Professor of Pediatrics King’s College London and
University of Arkansas for Medical Sciences Guy’s and St Thomas’ National Health Service
Arkansas Children’s Hospital Foundation Trust
Little Rock, AR London
USA UK
S. Allan Bock, MD Glenn T. Furuta, MD
Research Affiliate Professor of Pediatrics
Department of Pediatrics University of Colorado Denver School of Medicine
National Jewish Health Department of Pediatrics
Department of Pediatrics Digestive Health Institute, Section of Pediatric
University of Colorado Denver Gastroenterology, Hepatology and Nutrition
Denver, CO Director, Gastrointestinal Eosinophilic Diseases
USA Program
The Children’s Hospital
National Jewish Health
Denver, CO
USA
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