Food Allergy and Anaphylaxis PDF
Preview Food Allergy and Anaphylaxis
Food Allergy and Anaphylaxis Professor Mimi Tang The Royal Children’s Hospital, Melbourne Murdoch Childrens Research Institute, Melbourne University of Melbourne, Australia Food Allergy and Anaphylaxis • Terminology • Epidemiology • Food Allergy • Anaphylaxis WAO Nomenclature: Allergic Disease • Reproducible reactions to foods = hypersensitivity – Objectively reproducible symptoms or signs initiated by exposure to a defined stimulus at a dose tolerated by normal persons – Any reproducible reaction to a food – Controversial terminology – not widely accepted, best to use the term ‘reproducible reaction to food’ WAO Nomenclature 2003 • Allergy – Reaction initiated by specific immunological mechanisms • Intolerance – Reaction initiated by NON-immunological mechanisms Food Hypersensitivity (All reproducible reactions) Food Allergy Food Intolerance Immunologically NON-Immunologically mediated mediated IgE Mixed IgE and NON-IgE NON-IgE mediated mediated mediated Anaphylaxis • ASCIA Anaphylaxis Working Party… “Generalised allergic reaction that involves respiratory or cardiovascular systems or both” • Most severe presentation of an IgE mediated allergic reaction • A life-threatening allergic reaction Anaphylaxis Sampson HA et al. Second symposium on the definition and management of anaphylaxis: Summary report - Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium. J Allergy Clin Immunology 2006;117;391-7. Rising Prevalence of Immune Disorders Bach, NEJM 2002;347: 911-920 Rising Rates of Food Allergy Incidence of Food Allergy increased >10-fold from 1990-2004 Mullins R, Dear K, Tang MLK. J Allergy Clin Immunol 2009 Exponential Rise in Food Anaphylaxis +250% +230% +350% Liew WK, Williamson E, Tang MLK. J Allergy Clin Immunol 2009;123:434-42
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