Focused Ultrasound

294 Pages·2014·9.01 MB·English

ISTU 2014 Program Covers_0214 2/28/14 9:35 AM Page 1
International Society for Therapeutic Ultrasound
14th International Symposium
on Therapeutic Ultrasound
Final Program and Abstracts Book
April 2–5, 2014
Caesars Palace | Las Vegas, Nevada, USA
www.istu.org
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2 FDA approvals
Wed
 April
 2 Thurs
 April
 3
Pre-­‐Mee3ng
 Educa3onal
 Sessions Scien3fic
 Sessions
 Day
 1
Clinical
 Track
  Basic
 Science
 Track

Floren.ne
 Ballroom
 III/IV Floren.ne
 Ballroom
 I/II
MR-­‐Guided
 IFU
 Therapy:

Plenary
 Lectures:
 MRgFUS
 in
 the
 Clinical
 Se8ng

8:00
 AM Clinical
 Introduc.on

  Science
 Primer
 on
 Therapeu.c

Young-­‐Sun
 Kim,
 MD Ultrasound:
 Wave
 Physics
 and
  Pompeian
 Ballroom
Bioeffects

US
 IMAGING
 IN
 CLINICAL
 FUS
  Vera
 Khokhlova,
 PhD
 and

Plenary
 Lecture
 -­‐-­‐
 Wady
 Gedroyc,
 MD

8:30
 AM TREATMENTS

  Jean-­‐François
 Aubry,
 PhD 8:30
 AM
MRgFUS
 of
 the
 Body
Shin-­‐ichiro
 Umemura,
 MD
Can
 We
 Unleash
 the
 Power
 of
 An.-­‐ Plenary
 Lecture
 -­‐-­‐
 Jeff
 Elias,

 MD

9:00
 AM HIFU
 for
 Prostate
 cancer:
 Current
  9:00
 AM
Tumor
 Immunity
 Through
 Thermal/ Transcranial
 MRgFUS
 for
 the
 Treatment
 of
 Neurologic
 Disease
Status
 and
 Future
 Trends

Ultrasound
 Therapies?

Chris.an
 Chaussy,
 MD
Elizabeth
 Repasky,
 PhD
9:30
 AM 9:30
 AM Coffee
 Break
10:00
 AM Tips
 and
 Trick
 for
 Successful
 Focused

Ultrasound
 Treatment
 of
 Symptoma.c
  FUS:
 Principles
 and
 Instrumenta.on

 Scien.fic
 Sessions:
  Scien.fic
 Sessions:

Uterine
 Fibroids

  Design

10:30
 AM Elizabeth
 Stewart,
 MD
 and

  Kullervo
 Hynynen,
 PhD
  Clinical
 Applica.ons
  Therapeu.c
 Agent

Gina
 Hesley,
 MD and
 Treatment
  Deliv!ery

10:00
 AM
Assess!ment
  !
11:00
 AM Delivering
 the
 Right
 Dosage
 in
 US

Ultrasonic
 Imaging
 in
 Clinical
 Focused

Treatments:
 Measurements
 and

Ultrasound
 Treatments

  Floren.ne
 Ballroom
 I/II Floren.ne
 Ballroom
 III/IV
Standards

11:30
 AM Lian
 Zhang,
 MD
Gail
 ter
 Haar,
 PhD
12:00
 PM
Lunch
 Provided
 in
 the
 Exhibit
 Hall 12:00
 PM Break
 for
 Lunch
12:30
 PM
1:00
 PM
HIFU
 for
 Emerging
 Applica.ons-­‐
  Cavita.on
 and
 its
 Role
 in
 Therapeu.c
  Poster
 Se!ssion
 1

Overview

 U

 l
 t
 r
 asound

 1

 :
 1

 5

 PM
1:30
 PM Yael
 Inbar,
 MD Larry
 Crum,
 PhD Roman
 Ballroom
 I/II
2:00
 PM Enabling
 Targeted
 Drug
 Delivery
 to
 the

Treatment
 of
 Painful
 Bone
 Metastases
  Scien.fic
 Sessions:
  Scien.fic
 Sessions:

BBB
 Via
 US-­‐Induced
 BBB
 Disrup.on,

Using
 MR
 Guided
 High
 Intensity

and
 Sonothrombolysis

  Pros!tate
  Using,
 Monitoring,
 and

Focused
 Ultrasound

2:30
 PM Nathan
 McDannold,
 PhD
 and

  2:15
 PM ! Enhancing
 !Cavita.on

Pejman
 Ghanouni,
 MD
Stephen
 Meairs,
 MD
Floren.ne
 Ballroom
 I/II Floren.ne
 Ballroom
 III/IV
3:00
 PM
MR
 Guided
 Focused
 Ultrasound
 for

Current
 Neurosurgical
 Indica.ons
 and
  US-­‐Mediated
 Drug
 and
 Gene
 Delivery

Future
 Poten.al
 for
 Other
 Indica.ons

  Kathy
 Ferrara,
 PhD
3:30
 PM 3:35
 PM Coffee
 Break
Stephen
 Monteith,
 MD
Microbubbles
 as
 Carrier
 Systems:

Applica.on
 for
 Ultrasound-­‐Triggered

4:00
 PM
Drug
 and
 Gene
 Delivery

 Alexander

Lithotripsy:
 State
 of
 the
 Art

  Klibanov,
 PhD
 Scien.fic
 Sessions:
  Scien.fic
 Sessions:

Robin
 Cleveland,
 PhD Bra!in
  Transd!ucers

4:00
 PM
US
 Therapy
 at
 Low
 Intensity:
 Non-­‐
4:30
 PM Thermal
 Bioeffects
 and
 Biophysics

Floren.ne
 Ballroom
 I/II Floren.ne
 Ballroom
 III/IV
Alfred
 Yu,
 PhD
5:00
 PM
Q&A

 With
 the
 Speakers
5:30
 PM
5:30
 PM Adjourn
6:00
 PM Reception
Fri
 April
 4 Sat
 April
 5
Scien0fic
 Sessions
 Day
 2 Scien0fic
 Sessions
 Day
 3
8:30
 AM Announcement
 of
 2014
 Lizzi
 and
 Fry
 Award
 Winners 8:30
 AM Announcement
 of
 Student
 Awards
Plenary
 Lectures:

 From
 Basic
 Science
 to
 The

2013
 ISTU
 Award
 Plenary
 Lectures

Clinical
 Future

Pompeian
 Ballroom
Pompeian
 Ballroom
2013
 Lizzi
 Award
 Lecture
 -­‐-­‐
 Hao
 Li
 Liu,
 Ph.D.

  Plenary
 Lecture
 -­‐-­‐
 Mark
 Dewhirst,
 D.V.M.,
 Ph.D.

8:40
 AM 8:40
 AM
FUS
 BBB
 Opening
 and
 CNS
 Drug
 Delivery:
 An
 Overview
 Combining
 ThermosensiSve
 Liposomes
 with
 Ultrasound

2013
 Fry
 Award
 Lecture
 -­‐-­‐
 Feng
 Wu
 ,
 MD

  Plenary
 Lecture
 -­‐-­‐

 Willem
 Mali,
 M.D.,

9:10
 AM 9:10
 AM
Is
 HIFU
 Therapy
 an
 Emerging
 Discipline
 in
 Medicine? HIFU

 Amidst
 other
 minimal
 and
 non-­‐invasive
 treatments

9:40
 AM Coffee
 Break 9:40
 AM Coffee
 Break

 ScienSfic
 Sessions:
  ScienSfic
 Sessions:

Other
 Hardware
 and
  Sonothrombolysis

ScienSfic
 Sessions:
  ScienSfic
 Sessions:

Syste!ms
  and
 Other

10:10
 AM
Monitoring!
 Methods
  BBB
 Op!ening

10:10
 AM ! Microbubble-­‐
Enhanced
 Therapies

FlorenSne
 Ballroom
 I/II FlorenSne
 Ballroom
 III/IV
FlorenSne
 Ballroom
 I/II FlorenSne
 Ballroom
 III/IV
Hot
 Topic
 Debates

1)
 US
 vs
 MR-­‐guidance
 for
 extracranial
 HIFU
 ApplicaSons

11:30
 AM Kullervo
 Hynynen
 vs.
 Larry
 Crum

12:00
 PM Break
 for
 Lunch 2)
 HIFU
 is
 an
 appropriate
 modality
 to
 treat
 Localized

Breast
 Cancer

 David
 Brenin/Dennis
 Parker
 vs.

Alessandro
 Napoli/Chrit
 Moonen
Poster
 Se!ssion
 2
  12:30 Adjourn
1:15
 PM
Roman
 Ballroom
 I/II
ScienSfic
 Sessions:
  ScienSfic
 Sessions:

Mode!ling
  Sonopo!raSon

2:15
 PM
FlorenSne
 Ballroom
 I/II FlorenSne
 Ballroom
 III/IV
3:35
 PM Coffee
 Break
ScienSfic
 Sessions:
  ScienSfic
 Sessions:

Lithotripsy
 and
  Treatment!
 Planning

4:00
 PM Histot!ripsy
  !
FlorenSne
 Ballroom
 I/II FlorenSne
 Ballroom
 III/IV
5:30
 PM Adjourn
18:00 Dinner
 Gala
 at
 the
 Stratosphere
Dear ISTU Colleagues and Friends,

It is a great pleasure and privilege to welcome you to the 14th International Symposium on
Therapeutic Ultrasound (ISTU’14) in Las Vegas on April 2 – 5, 2014. Our Annual meeting
provides an excellent forum for basic scientists, clinicians, and physicists/engineers from
industry to meet face-to-face, exchange ideas, and renew friendships. We are proud of the
high level of participation by students and young scientists and engineers at this meeting.
We hope that our young scientists will take advantage of this meeting to develop their
professional networks as they enrich the meeting with their fresh ideas that will define the
future of the field.

ISTU continues to attract members from all parts of the world with major participation from
Asia, Europe, and North America. Our meeting this year is held in coordination with the
AIUM Annual Convention following a very successful experiment in 2011. We believe this
will be a beneficial model for the memberships of ISTU and AIUM as well as the larger
biomedical ultrasound community. For this first time this year, ISTU’14 will feature a pre-
meeting educational day covering physical principles and clinical aspects of therapeutic
ultrasound. Dr. Butts-Pauly initiated and planned this meeting with help from Dr. Arik
Hananel and Dr. Alfred Yu. The Society is grateful for these efforts and we hope this
becomes a permanent feature of ISTU meetings in the future.

Meetings like ISTU’14 are the fruit of volunteer work of many individuals who give
generously of their time and energy. ISTU is fortunate to have the outstanding efforts of Dr.
Kim Butts Pauly, the ISTU’14 Chair and the Organizing Committee, Dr. Joo-Ha Hwang
(Sponsorship/Exhibits Chair), Dr. Jean-Francois Aubry (Student Travel Award Chair), our
AIUM support team and many others who continue to work towards a successful completion
of ISTU’14.

ISTU’14 promises to be one of our most successful meetings in terms of providing an
excellent integration between of basic science, engineering, and clinical practice. The
addition of the educational day on April 2 will provide an opportunity for students and
practitioners alike to develop a deeper understanding of the physics, bioeffects, and clinical
aspects of focused ultrasound. This event is included in the registration fee and outstanding
speakers in the field will present the lectures. We encourage you to take advantage of this
excellent opportunity.

Finally, we hope that you will enjoy the venue and the other activities including the welcome
reception and the ISTU Special Event Dinner. I am looking forward to seeing many of you
in Las Vegas.

Emad S Ebbini
President of the International Society for Therapeutic Ultrasound
Professor of Electrical and Computer Engineering
University of Minnesota
Dear Colleagues, !
Welcome to the 2014 ISTU Meeting in Las Vegas! !
This meeting has been in the planning for over a year. I’d like to thank the many people who
helped make it possible. This includes the program committee members, the reviewers, the
education course speakers, and the moderators. Thank you all. !
In addition, I’d like to thank the AIUM/ISTU office for their contributions, including Jenny
Clark, Brenda Kinney, Danielle Delanko, and Angela Marinelli. !
Most importantly, I’d like to thank my assistant Kellison Pack who did yeoman’s work pulling
together the program book on the very tight schedule.!
Please enjoy the meeting, including the Friday party at the Stratosphere, which should be
thrilling. !
-­‐Kim Butts Pauly

!
Program
 Commi+ee

Alfred Yu Dennis Parker Mike Marx Urvi Vyas
Arik Hananel Emad Ebbini Nathan McDannold Vera Khokhlova
Beat Werner Feng Wu Patrick Ye Viola Rieke
Brian Fowlkes Guofeng Shen Rachelle Bitton Wen-Shiang Chen
Chris Diederich Jean-François Aubry Ron Watkins Yoichiro Matsumoto
Chrit Moonen Joo Ha Hwang Sham Sokka Yufeng Zhou
Cyril Lafon Juan Plata Stephen Meairs
!
Reviewers

Adam Maxwell David Cranston Kathy Ferrarra Rajiv Chopra
Adam Shaw Dennis Parker Kullervo Hynynen Rares Salomir
Alfred Yu Doug Christiansen Larry Crum Robert Staruch
Allison Payne Eitan Kimmel Leonid Gavrilov Robin Cleveland
Arik Hananel Emad Ebbinni Lili Chen Ron Watkins
Aurea Pascal-Tenorio Ernst Martin Mario Ries Seung-Schik Yoo
Beat Werner Feng Wu Mathieu Pernot Sham Sokka
Bradford Wood Gail ter Haar Matsumoto Yoichiro Stephen Meairs
Brian Fowlkes Gerald Harris Max Wintermark Urvi Vyas
Charles Cain Greg Clement Michael Bailey Vera Khokhlova
Chris Diederich Hao-Li Liu Michael Canney Viola Rieke
Christy Holland Jahan Tavakkoli Nathan McDannold Volker Wilkens
Chrit Moonen Jason Stafford Nick Todd Wayne Kreider
Chuck Dumoulin Jean Yves Chapelon Nico de Jong Will Grissom
Constantin Coussios Jean-Francois Aubry Oleg Sapozhnikov WS Chen
Craig Meyer Joo Ha Hwang Patrick Ye
Cyril Lafon Juan Plata Rachelle Bitton

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(cid:115)(cid:47)(cid:38)(cid:104)(cid:883)(cid:1006)(cid:1004)(cid:1004)(cid:1004)
Pre-Clinical High Intensity Focused Ultrasound (HIFU) System
Key Advantages:
(cid:3) (cid:891)(cid:3)Ultrasound guided non-invasive procedure
(cid:3) (cid:891)(cid:3)Real-time monitoring
(cid:115)(cid:47)(cid:38)(cid:104)(cid:3)(cid:1006)(cid:1004)(cid:1004)(cid:1004)
(cid:3) (cid:891) Precise targeting for accurate treatment
(cid:904)Dry(cid:905)
(converged by ALPINION’s proprietary HIFU and
imaging transducer technologies)
(cid:3) (cid:891)(cid:3)Wet or Dry platform to accommodate various
applications (easy and fast switching between Wet
and Dry platform, depending on types of study)
(cid:3) (cid:891)(cid:3)Turnkey bench-top system ideally designed for
laboratory
Applications:
(cid:3) (cid:891)(cid:3)Solid tumor ablation
Imaging Platform
(cid:3) (cid:891)(cid:3)Cavitation effect study (E-Cube 9)
(cid:3) (cid:891)(cid:3)Histotripsy (cid:115)(cid:47)(cid:38)(cid:104)(cid:3)(cid:1006)(cid:1004)(cid:1004)(cid:1004)
(cid:3) (cid:891) In-vivo / Ex-vivo study (cid:904)Wet(cid:905)
(cid:3) (cid:891)(cid:3)Animal treatment
(cid:3) (cid:891)(cid:3)Enhanced drug delivery study
(cid:3) (cid:891)(cid:3)Opening the blood brain barrier (BBB)
For more information: www.AlpinionUSA.com/VIFU