Fmoc-Amino Acids Attached to Wang Resin

160 Pages·2008·0.61 MB·English

Table of Contents

Abbreviations....................................................................................................................................................3
N-Protecting Reagents......................................................................................................................................6
Peptide Coupling Reagents...............................................................................................................................8
Linkers for Solid Phase Synthesis....................................................................................................................11
Other Reagents...............................................................................................................................................12
Amino Acids and Derivatives...........................................................................................................................15
Unusual Amino Acids.......................................................................................................................................43
N-Methyl Amino Acids.....................................................................................................................................70
Boc-Amino Acids and Derivative.....................................................................................................................73
Fmoc-Amino Acids and Derivatives.................................................................................................................87
Z-Amino Acids and Derivatives.....................................................................................................................102
Amino Alcohols...............................................................................................................................................111
Fmoc-Amino Acids Attached to Wang Resin..................................................................................................118
Amino Acids 2-Chlorotrityl Resin...................................................................................................................121
Other Resin and Derivatives.........................................................................................................................124
Mass Spectrometry Analysis.........................................................................................................................126
Custom Peptide Synthesis............................................................................................................................127
Alphabetical Index.........................................................................................................................................130
Catalogue Number Index..............................................................................................................................143
Custom Synthesis & Manufacturing..............................................................................................................156
QA/QC...........................................................................................................................................................157
Ordering Information.....................................................................................................................................158
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GL Biochem (Shanghai) Ltd. Abbreviations

Abbreviations
Symbol Structure Name Formula MW
O
Acm C AcetamidOMethyl C H ON 72.1
H C N 3 6
3 H

O
Z O
Benzyloxycarbonyl C H O 135.1
(CBZ) 8 7 2

CH O
3
Boc H C O C t-Butoxycarbonyl C H O 101.1
3 5 9 2
CH
3
CH
3
tBu H C t-Butyl C H 57.1
3 4 9
CH
3
OMe
DMT 4,4’-Dimethoxytrityl C H O 303.3
MeO 21 19 2

O
Fmoc O Fluorenylmethoxy-carbonyl C H O 223.3
15 11 2

H C
3 CH
3
H C O 2,2,4,6,7-
3
Pbf O S Pentamethyldihydrobenzofu C H O S 253.3
13 17 3
O ran-5-sulfonyl
H C CH
3 3
Trt Trityl C H 243.3
19 15

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Abbreviations GL Biochem(Shanghai) Ltd.

Symbol Structure Name Formula MW
NH
2
OH Alanine
Ala C H NO 89.1
(丙氨酸) 3 7 2
O
NH
H 2
Arginine
H N N OH
Arg 2 （精氨酸） C6H14N4O2 174.2
NH O
O NH
2
Asparagine
OH
Asn C H N O 132.1
H2N （天冬酰胺） 4 8 2 3
O
O NH
2
Aspartic acid
OH
Asp C H NO 133.1
HO （天冬氨酸） 4 7 4
O
NH
2
Citrulline
H N NH
Cit 2 COOH （胍氨酸） C6H13N3O3 175.2
O
NH
2
Cysteine
HS OH
Cys C H NO S 121.2
（半胱氨酸） 3 7 2
O
NH
2
OH Glutamic acid
Glu C H NO 147.1
HOOC （谷氨酸） 5 9 4
O
NH
2
Glutamine
H N OH
Gln 2 （谷氨酰胺） C5H10N2O3 146.2
O O
OH
Glycine
H N
Gly 2 （甘氨酸） C2H5NO2 75.07
O

O
Histidine
His HN OH （组氨酸） C6H9N3O2 155.2
N NH2
CH O
3
H C OH Isoleucine
Ile 3 C H NO 131.2
（异亮氨酸） 6 13 2
NH
2

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GL Biochem (Shanghai) Ltd. Abbreviations

Symbol Structure Name Formula MW
O
H C Leucine
Leu 3 OH （亮氨酸） C6H13NO2 131.2
CH NH
3 2
O
H N Lysine
Lys 2 OH （赖氨酸） C6H14N2O2 146.2
NH
2
NH
2
Methionine
Met H C OH C H NO S 149.2
3 S （蛋氨酸） 5 11 2
O
NH
2
Phenylalanine
OH
Phe C H NO 165.2
（苯丙氨酸） 9 11 2
O
NH
2
H N OH Ornithine
Orn 2 C H N O 132.1
（鸟氨酸） 5 12 2 2
O
O
Proline
Pro OH C H NO 115.1
（脯氨酸） 5 9 2
N
H
O
Serine
Ser HO OH （丝氨酸） C3H7NO3 105.1
NH
2
O
Threonine
Thr HO OH （苏氨酸） C4H9NO3 119.1
NH
2
NH
2
OH Tryptophan
Trp C H N O 204.2
O （色氨酸） 11 12 2 2
N
H
NH
2
OH Tyrosine
Tyr C H NO 181.2
HO （酪氨酸） 9 11 3
O
O
Valine
Val OH （缬氨酸） C5H11NO2 117.1
NH
2
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N-protecting Reagents GL Biochem(Shanghai) Ltd.
Cat# Product MW QTY US$

N-Protecting Reagents
00501 tert-Butyldimethylsilyl Chloride 150.7 100g 24.00
[18162-48-6] 250g 48.00
C H ClSi
6 15

00201 Boc Anhydride 218.3 100ml 25.00
[24424-99-5] 500ml 100.00
C H O
10 18 5

00202 Boc-ON 246.3 25g 20.00
2-t-Butyloxycarbonyloxyimino-2- 100g 60.00
phenyl acetonitrile
[58632-95-4]
C H N O
13 14 2 3

00301 CBZ-Cl (Z-Cl) 170.6 100ml 28.00
[501-53-1] 500ml 88.00
C H ClO
8 7 2

00302 CBZ-OSu (Z-OSu) 249.2 50g 27.00
[13139-17-8] 100g 43.00
C H NO
12 11 5

00401 DMT-Cl 338.8 25g 30.00
[40615-36-9] 100g 90.00
C H ClO
21 19 2

00305 DSC 256.2 25g 72.00
N,N’-Disuccinimidyl carbonate 100g 214.00
[74124-79-1]
C H N O
9 8 2 7

00101 9-Fluorenylmethanol 196.2 50g 20.00
[24324-17-2] 100g 30.00
C H O
14 11

00102 Fmoc-Cl 258.7 25g 22.00
[28920-43-6] 100g 67.00
C H ClO
15 11 2

00104 Fmoc-NH 239.3 25g 100.00
2
[84418-43-9] 100g 304.00
C H NO
15 13 2

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GL Biochem(Shanghai) Ltd. N-protecting Reagents
Cat# Product MW QTY US$

00103 Fmoc-OSu 337.3 50g 24.00
[82911-69-1] 100g 30.00
C H NO
19 15 5

00402 Trityl Chloride 278.8 100g 22.00
[76-83-5] 250g 44.00
C H Cl
19 15

00304 Z(2-Br)-OSu 328.1 25g 32.00
[128611-93-8] 100g 115.00
C H BrNO
12 10 5

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eessppeecciiaallllyy rreeccoommmmeennddeedd..
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Peptide Coupling Reagents GL Biochem(Shanghai) Ltd.
Cat# Product MW QTY US$

Peptide Coupling Reagents

00701 BOP reagent, 99% min. 442.3 25g 24.00
[56602-33-6] 100g 72.00
C H F N OP
12 22 6 6 2

00808 BOP-Cl 254.6 5g 25.00
[68641-49-6] 25g 110.00
C H ClN O P
6 8 2 5

00801 CDI 25g 30.00
162.2
N,N’-Carbonyldiimidazole 50g 45.00

[530-62-1]
C H N O
7 6 4

00802 DCC 100g 14.00
206.3
N,N’-Dicyclohexylcarbodiimide 500g 57.00
[538-75-0]
C H N
13 22 2

00606 DEPBT 299.2 25g 111.00
3-(Diethoxy-phosphoryloxy)-3H- 100g 333.00
benzo[d][1,2,3] triazin-4-one
[165534-43-0]
C H N O P
11 14 3 5

00803 DIC 126.2 100ml 45.00
N,N’-Diisopropylcarbodiimide 500ml 135.00
[693-13-0]
C H N
7 14 2

00805 EDC•HCl 191.7 25g 44.00
[25952-53-8] 100g 131.00
C H N ·HCl
8 17 3

00703 HATU 380.2 5g 30.00
[148893-10-1] 25g 118.00
C H F N OP
10 15 6 6

00702 HBTU 50g 30.00
379.2
[94790-37-1] 100g 46.00

C H F N OP
11 16 6 5

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GL Biochem (Shanghai) Ltd. Peptide Coupling Reagents
Cat# Product MW QTY US$

00601 HOAt 25g 115.00
136.1
[39968-33-7] 100g 288.00
C H N O
5 4 4

00602 HOBt (anhydrous) 100g 17.00
135.1
[2592-95-2] 500g 68.00

C H N O
6 5 3

00605 HOOBt 25g 73.00
163.1
[28230-32-2] 100g 217.00
C H N O
7 5 3 2

00706 HCTU 25g 125.00
413.8
[330645-87-9] 100g 380.00
C H ClF N OP
11 15 6 5

00604 Cl-HOBt 25g 80.00
169.6
[26198-19-6] 100g 280.00
C H ClN O
6 4 3

00809 PyAOP 521.4 25g 200.00
[156311-83-0] 100g 600.00
C H F N OP
17 27 6 7 2

00804 PyBOP 25g 60.00
520.4
[128625-52-5] 100g 128.00
C H F N OP
18 28 6 6 2

00806 PyBrOP 25g 188.00
466.2
Bromo-tris-pyrrolidino- 100g 450.00
phosphoniumhexafluorophosphate
[132705-51-2]
C H N P BrF
12 24 3 2 6

00704 TATU 322.1 50g 243.00
C H BF N O 100g 365.00
10 15 4 6

00705 TBTU 50g 34.00
321.1
[125700-67-6] 100g 52.00

C H BF N O
11 16 4 5

00710 TCFH 280.6 100g 80.00
[94790-35-9] 250g 150.00
C H ClF N P
5 12 6 2

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Peptide Coupling Reagents GL Biochem(Shanghai) Ltd.
Cat# Product MW QTY US$

00708 TDBTU 25g 188.00
349.1
2-(3,4-Dihydro-4-oxo-1,2,3- 100g 450.00
benzotriazin-3-yl)-N,N,N',N'-
tetramethyluronium
tetrafluoroborate
[125700-69-8]
C H BF N O
12 16 4 5 2

00711 TOTU 328.08 25g 90.00
O-[(Ethoxycarbonyl) 100g 230.00
cyanomethylenamino]-N,N,N,N-
tetra methyluronium
tetrafluoroborate
[136849-72-4]
C H BF N O
10 17 4 4 3

00712 TPTU 297.06 5g 65.00
[125700-71-2] 25g 250.00
C H BF N O
10 16 4 3 2

00707 TSTU 25g 116.00
301.1
O-(N-Succinimidyl)-1,1,3,3- 100g 352.00
tetramethyl uranium
tetrafluoroborate
[105832-38-0]
C H BF N O
9 16 4 3 3

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uuppddaatteedd wweebbssiittee:: wwwwww..ggllsscchhiinnaa..ccoomm
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