Table Of Content

This page intentionally left blank USM LE STEP1 2 0 1 9 TAO LE, MD, MHS VIKAS BHUSHAN, MD Associate Clinical Professor Boracay Chief, Section of Allergy and Immunology Department of Medicine University of Louisville School of Medicine MATTHEW SOCHAT, MD JORDAN ABRAMS Fellow, Department of Hematology/Oncology St George's University School of Medicine St. Louis University School of Medicine Class of 2020 YASH CHAVDA, DO MEHBOOB KALANI, MD Chief Resident, Department of Emergency Medicine Chief Resident, Department of Internal Medicine St. Barnabas Hospital, New York Allegheny Health Network Medical Education Consortium Fellow, ALL NYC EM VAISHNAVI VAIDYANATHAN, MD KIMBERLY KALLIANOS, MD Resident, Department of Pediatric Neurology Assistant Professor. Department of Radiology and Biomedical Imaging Barrow Neurological Institute at Phoenix Children's Hospital University of California, San Francisco School of Medicine New York I Chicago I San Francisco I Athens I London I Madrid I Mexico City Milan I New Delhi I Singapore I Sydney /Toronto Copyright <D 2019 by Tao Le and Vikas Bhushan. All rights reserved. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a database or retrieval system, without the prior written permission of the publisher. ISBN: 978-1-26-014368-3 MHID: 1-26-014368-6 The material in this eBook also appears in the print version of this title: ISBN: 978-1-26-0I4367-6, MHID: 1-26-014367-8. eBook conversion by codeMantra Version I.0 All trademarks are trademarks of their respective owners. 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This page intentionally left blank Contents Contributing Authors vii General Acknowledgments xiii Associate Authors viii How to Contribute xvii Faculty Ad vi so rs ix How to Use This Book xix Preface xi Selected USMLE Laboratory Values xx Special Acknowledgments xii First Aid Checklist for the USMLE Step 1 xxi i ~ SECTION I GUIDE TO EFFICIENT EXAM PREPARATION 1 Introduction 2 Test-Taking Strategies 22 USMLE Step 1-The Basics 2 Clinical Vignette Strategies 23 Defining Your Goal 12 If You Think You Failed 24 Learning Strategies 13 Testing Agencies 24 Timeline for Study 16 References 25 Study Materials 20 ~ SECTION I SUPPLEMENT SPECIAL SITUATIONS 27 ~ SECTION II HIGH-YIELD GENERAL PRINCIPLES 29 How to Use the Database 30 Pathology 205 Biochemistry 33 Pharmacology 231 Immunology 95 Public Health Sciences 255 Microbiology 123 v ~ SECTION Ill HIGH-YIELD ORGAN SYSTEMS 269 Approaching the Organ Systems 270 Neurology and Special Senses 477 Cardiovascular 273 Psychiatry 541 Endocrine 321 Renal 565 Gastrointestinal 351 Reproductive 597 Hematology and Oncology 395 Respiratory 645 Musculoskeletal, Skin, and Connective Tissue 437 Rapid Review 673 ~ SECTION IV TOP-RATED REVIEW RESOURCES 689 How to Use the Database 694 Cell Biology and Histology 698 Question Banks 696 Microbiology and Immunology 699 Question Books 696 Pathology 699 Web and Mobile Apps 696 Pharmacology 700 Comprehensive 697 Physiology 700 Anatomy, Embryology, and Neuroscience 697 Abbreviations and Symbols 701 Behavioral Science 698 Image Acknowledgments 709 Biochemistry 698 Index 731 About the Ed ito rs 793 vi Contributing Authors MAJED H. ALGHAMDI, MBBS PRASHANK SHREE NEUPANE, MBBS King Abdulaziz University College of Medicine KIST Medical College HUMOOD BOQAMBAR, MB BCh BAO ERIKA J. PARISI, MD Farwaniya Hospital Resident, Department of Medicine Massachusetts General Hospital JOHN E.CODA BRIAN H. PARK, MD Penn State College of Medicine Class of 2019 Resident, Department of Anesthesiology Brigham and Women's Hospital KRISTINA DAMISCH VIVEK PODDER University of Iowa Carver College of Medicine Class of 2020 Tairunnessa Memorial Medical College and Hospital, Bangladesh Class of 2019 YUMI KOVIC CONNIE QIU University ofC onnecticut School of Medicine Class of 2019 Lewis Katz School of Medicine at Temple University MD/PhD Candidate, Class of 2021 LAUREN N. LESSOR, MPH, MD SARAH SCHIMANSKY, MB BCh BAO Resident, Department of Pediatrics Mercy Health - St. Vincent Medical Center Resident, Department ofO phthalmology Gloucestershire Hospitals NHS Foundation Trust IMAGE AND ILLUSTRATION TEAM MATTHEW HO ZHI GUANG RENATA VELAPATINO, MD University College Dublin (MD). DFCI (PhD) San Martin de Porres University School of Medicine MD/PhD Candidate, Class of 2020 Hospitalist, Clinica Internacional VICTOR JOSE MARTINEZ LEON, MD ALI REZA ZAND IF AR, MD Central University of Venezuela Research Fellow Isfahan University of Medical Sciences, Iran AIDA K. SARCON, MD St. George's University School of Medicine vii Associate Authors HUZAIFA AHMAD, MBBS VASILY OVECHKO Aga Khan University Medical College Pirogov Russian National Research Medical University Class of 2018 Class of 2019 JESSE CHAIT BASHAR RAMADAN, MBBS NYIT College of Osteopathic Medicine Mutah University, Faculty of Medicine Class of 2020 Class of 2018 ANUP CHALISE, MBBS ROSHUN D. SANGANI House Officer, Department ofG eneral Surgery and Digestive Diseases Drexel University College of Medicine Nepal Mediciti Hospital Class of 2019 SCOTT MOORE, DO GANNAT SHALAN Assistant Professor of Medical Laboratory Sciences Rowan University School ofO steopathic Medicine Weber State University Class of 2019 Assistant Dean of Clinical Affairs Rocky Vista University College ofO steopathic Medicine MATTHEW WELLS Lake Erie College ofO steopathic Medicine Class of 2019 IMAGE AND ILLUSTRATION TEAM BENJAMIN F. COMORA, DO, MBA PARTH R. JANI, MBBS Resident, Department of Radiology Pandit Deendayal Upadhyay Medical College Albert Einstein Medical Center PRIYESH THAKURATHI, MBBS JACQUELINE BEKHIT, MD B.P. Koirala Institute of Health Sciences, Nepal Xavier University School of Medicine Class of 2020 NIKHIL YEGYA-RAMAN Rutgers Robert Wood Johnson Medical School TAYLOR MANEY Class of 2019 New York Medical College Class of 2019 viii