Findings of Drug Abuse Research - Archives - National Institute on

431 Pages·2002·2.09 MB·English

FINDINGS OF
DRUG ABUSE
RESEARCH
An annotated bibliography of NIMH
and NIDA-supported extramural grant
research 1967-74 in two volumes
Volume 1
July 1975
National Institute on Drug Abuse
11400 Rockville Pike
Rockville, Maryland 20852
The NIDA Research Monograph Services is property by the
Division of Research of the National Institute on Drug Abuse. Its
primary objective is to provide critical reviews of research problem
areas and techniques, the content of state-of-the-art conferences,
integrative research reviews and significant original research. Its
dual publication emphasis is rapid and targeted dissemination to the
scientific and professional community.
EDITORIAL ADVISORY BOARD
Avram Goldstein, M.D. Addiction Research Foundation
Palo Alto, California
Jerome Jaffe, M.D. College of Physicians and Surgeons
Columbia University, New York
Reese T. Jones, M.D. Langley Porter Neuropsychiatric Institute
University of California
San Francisco, California
William McGlothlin, Ph.D. Department of Psychology, UCLA
Los Angeles, California
Jack Mendelson, M.D. Alcohol and Drug Abuse Research Center
Harvard Medical School
McLean Hospital
Belmont, Massachusetts
Helen Nowlis, Ph.D. Office of Drug Education, DHEW
Washington, D.C.
Lee Robins, Ph.D. Washington University School of Medicine
St. Louis, Missouri
NIDA RESEARCH MONOGRAPH series
Robert DuPont, M.D. DIRECTOR, NIDA
William Pollin, M.D. DIRECTOR, DIVISION OF RESEARCH, NIDA
Robert C. Petersen, Ph.D. EDITOR-IN-CHIEF
Eunice L. Corfman, M.A. EDITOR
Rockwall Building 11400 Rockville Pike Rockville, Maryland, 20852
PREFACE
Nearly eight years have elapsed since the inauguration of a
high priority Federal research program directed toward better
understanding and coping with drug abuse. When that program
was begun, estimates of the extent of drug abuse were more
frequently based on speculation than on hard data. The basic
materials for studying such drugs as marihuana were frequently
lacking and research was in its infancy. Opiate research,
while it had a much longer history through pioneering work of
the Addiction Research Center, the U.S. Public Health Hospitals
at Lexington and Fort Worth a and other programs, also underwent
a much needed expansion.
The research infant has now become a strapping adolescent.
While much remains to be learned, this bibliography comprising
some 3,500 titles and abstracts attests to the productivity
of over 650 researchers whose work was directly supported
through grants from the National Institute on Drug Abuse and
its predecessor program in the National Institute of Mental
Health. Its publication represents an attempt to give some
sense of the diversity and scope of the Federal impact on drug
abuse research. It is our hope that it will prove to be a
valuable source of scientific information in itself and will
also serve as a source document for later analysis of the
Federal role in its extramural grant program towards shaping
and contributing to the overall drug abuse literature.
Preparation of these volumes inevitably leaves us indebted to
many individuals and organizations. First and foremost, special
thanks are owed to the hundreds of researchers who took time
from their busy schedules to give us detailed accounting of the
papers they have published arising from our grant support.
Without their generous cooperation a reasonably complete account-
ing would not have been possible. Thanks are also due to the
staffs of some twenty libraries, information services and
clearinghouses which provided assistance in many ways.
The actual production of the volumes demands thanks to many
individuals whose commitment to the detailed preparation
required testifies to their fine level of professionalism.
Special thanks are due to the staff of Koba Associates, Inc.,
particularly to Georgette Semick, the project director, ably
assisted by Carol Tuckerman and to their research assistants
Tina Lindegren and Kath Nesper. Susan Lachter, Acting Chief
of the National Clearinghouse for Drug Abuse Information here
at NIDA provided necessary assistance as did other members of
the NIDA staff.
Robert C. Petersen
Assistant Director, Research Division
NATIONAL INSTITUTE ON DRUG ABUSE
iii
Introduction
PURPOSE under NIMH-NIDA grants during the
period 1967-1974. the first major task
Since September, 1973, the Division of was to identify the relevant grants and
Research of the National Institute on their principal investigators (PIs).
Drug Abuse (NIDA) has been responsible The methodology for collecting the mat-
for the coordination of extramural, erials was based on the assumptions
grant-supported research into tke that the Principal Investigator would,
effects of drug use/abuse and for fund- at minimum, be familiar witk the lit-
ing projects to examine possibe pre- erature produced as a result of his/her
vention and treatment modalities for grant and in most cases would also have
its control. NIDA-supported work has copies of that literature. Lists of
its origins in the research program principal investigators were developed
supported and coordinated since the by utilizing NIMH and NIDA files of
1960’s by the National Institute of grantees and the Research Grants Index
Mental Health. The bulk of the Feder- published by tire Public Health Service.
ally funded research has been under- Each identified Principal Investigator
taken since 1967 and the results have tken received a personally addressed
been documented in numerous journals, letter explaining the project and re-
books and other scientific publications. questing lists (and copies) of litera-
ture produced as a result of drug use/
A listing of published drug abuse lit- abuse grants for which s/he was desig-
erature including synopses of the con- nated as PI.
tent was considered necessary in order
to provide NIDA with a resource for PIs were also asked to identify in a
planning future research directions and preliminary way which of ten program
for examining the impact of this liter- areas of drug use/abuse research would
ature on the scientific community. best classify their literature. By
Thus, the purpose of tkis annotated receiving this additional information
bibliography is twofold: 1) to kelp from the PIs themselves, the project
NIDA program personnel review the find- staff was provided with a firmer founda-
ings of previous drug abuse grants in tion for designing the final product.
order to plan future research strate-
gies, and 2) to serve as a retro- The first request to PIs yielded an
spective indication of the findings approximate 50 percent response rate
from supported research that have been within a period of one month. To aug-
disseminated to the scientific community ment, these responses the project staff
and the general public. sent outfollow-up reminders to non-
respondents while concurrently contact-
The publication, Findings of Drug Abuse ing information resources such as the
Research 1967-1974, is a two-volume National Clearing House for Drug Abuse
work that lists the drug abuse research Information, the Student Association
literature supported by NIMH and NIDA for the Study of Hallucinogens, Inc.
and provides abstracts or summaries of (STASH) and the Addiction Research
the articles when these are provided Foundation to obtain lists of articles/
by the author. Each volume may be used books published by those PIs who were
independently and each is indexed. not located by the principal contact
method, Final response was from approx-
PREPARATION OF THE BIBLIOGRAPHY imately 60 percent of all PIs.
These’ sources produced the remainder.
Having defined the scope of the final To monitor tke communication with PIs
product as research literature produced and other information sources and to
organize information received, detailed Following the entry‘s bibliographic
recordkeeping systems were developed. information the author-prepared ab-
File systems recorded the number of stract or summary is included.
articles identified and submitted, class-
ified or unclassified, and listed the Whenever possible, author-prepared
literature identified but not accompan- summaries, abstracts or short conclu-
ied by abstracts or articles. Litera- sions are used to describe the articles,
ture received was checked for complete books and proceedings. Since author-
publication information and filed by prepared abstracts are not always re-
its appropriate classification category. quired by the publisher, both annotated
and nonannotated citations are found in
Using the prepared resource list of rug the bibliography. The intended use of
abuse research and medical libraries, the bibliography required that the
information services and clearinghouses, findings be consistently validated.
the project staff attempted to locate There fore, when no author-prepared
the several hundred articles which PIs abstract was available, the project
identified but which were not forwarded staff did not attempt to summarize the
or classified by the investigators. findings. In the same vein, no attempt
Once found, these were screened, class- has been made to change or edit the
ified and filed in accordance with abstracts and summaries for consistent
project specifications. language; thus, words such as ‘our’ and
‘I’ still remain.
Following the’ collection of all identi-
fied articles and/or books, the final Missing abstracts are not available for
classification system and entry format a number of reasons: the articles are
were defined. Each entry was then out of print; literature is now “in
formatted (accompanied by its author- press”; papers presented at meetings,
prepared abstract or summary where conferences and symposia have not to
available), cross-referenced where date been published; short summaries
necessary and prepared for final sub- were never required. In such cases the
mission to NIDA. unannotated bibliographic information
has, nonetheless, been provided.
FORMAT AND ANNOTATION SYSTEM
CLASSIFICATION OF ENTRIES
In order to create a bibliography of
optimal use, several questions were The classification system was designed
kept in mind throughout the design to dovetail with the-primary intended
stages : “What format most readily use of the bibliography; to review the
would facilitate the bibliography‘s progress of the NIMH-NIDA supported
use ?” and “What information about each drug abuse research programs. Thus,
item is necessary for subsequent loca- the sections of the bibliography
tion by users?” These questions were parallel the program areas of ‘NIDA re-
carefull considered throughout the search: To determine whether the ele-
bibliography design process. ven categories are descriptive of the
existing literature, the PIs were re-
The format design reflects the bibliog- quested to indicate which of the
raphy‘s principal, in tended use (i.e., suggested categories were most applic-
for program planning and evaluation) by able for their articles and abstracts.
organizing the material into program/ Suggestions of alternative classifica-
subject areas. Within each category tion categories and systems were
the entries are organized alphabetic- encouraged. A review of the replies
ally by author. To facilitate identifi- received from the PIs showed that, for
cation of new entries and location of the most part, the program areas also
cross-references, the author’s(s‘) adequately classified the grant-
name(s) appears in capital letters. supported literature.
Publication and descriptive information
about each item is provided in a stand- The ten subject-program categories
ard bibliographic format which supplies that correspond with the first ten
information about the author(s) or sections of the bibliography are:
editor(s), title of the chapter or art- I. Methodology of Drug Research
icle, source (book, proceedings or II. Drug Chemistry and Metabolism
journal) including volume numbers and III. Mechanisms of Action of
pages where applicable, book’s publisher Different Drugs
and dates of publication or presentation. IV. Behavioral Studies
v
V. Adverse Effects, Toxicity and INDEXES
Genetic Effects
VI. Drug Use/Abuse Prevention To increase the usefulness of the
VII. Treatment-Related Research bibliography, indexes have been pro-
VIII. Psychosocial Studies vided for author/editor and for
IX. Education subject/drugs, So that the two vol-
X. Epidemiological Studies and umes may be used independently, these
Surveys indexes have been inserted at the end
of both volumes. Virtually all index
The eleventh section, “Peripherally and cross references are to sections
Related”, was included to list those within the same volume.
materials that do not pertain exclusive-
ly to drug abuse research, but which CONTENTS OF VOLUME 1
are produced as an offshoot of NIMH and
NIDA-supported drug abuse projects. The first volume of Findings of Drug
For this reason entries in this category Abuse Research offers three sections of
include references to subcategories such entries pertaining to the methodology
as therapeutic aspects of various abus- of drug abuse research and findings of
able drugs, analytical techniques for basic research into the chemical and
more generalized behavioral research metabolic characteristics of drugs and
and the body’s receptors for psycho- their mechanisms of action.
active drugs.
CONTENTS OF VOLUME 2
CROSS REFERENCES
The second volume of Findings of Drug
Because many of the articles and books Abuse Research includes entries on the
summarize findings related to several behavioral and clinical aspects of
of the ten program areas, a cross- drug abuse research including results
reference system was developed. In of studies of adverse effects, preven-
this way entries could be included in tion and treatment systems and the
all relevant subject categories with- literature on human and psychosocial
out duplicating the abstracts for each factors of drug abuse research (i.e.,
listing. The annotation for any cross- psychosocial studies, education and
referenced entry can be found with the epidemiology of drug abuse).
first citation. In subsequent categor-
ies the entry includes complete biblio- The final section, entitled “Peripher-
graphic information; however, for the ally Related”, contains findings from
abstract the reader is then referred NIDA-supported drug abuse projects
to the earlier section. which do not pertain exclusively to
that subject.
CONTENTS
VOLUME 1
Preface iii
Introduction iv
I. Methodology of Drug Research 5
II. Drug Chemistry and Metabolism 79
III. Mechanisms of Action of Different Drugs 185
Index 324i
Author/Editor
Subject/Drugs
VOLUME 2
Preface iii
Introduction iv
IV. Behavioral Studies 385
V. Adverse Effects, Toxicity and Genetic Effects 523
VI. Drug Use/Abuse Prevention 585
VII. Treatment - Related Research 595
VIII. Psychosocial Studies 627
IX. Education 661
X. Epidemiological Studies and Surveys 665
XI. Peripherally Related 691
Index 729
Author/Editor
Subject/Drugs

I
Methodology of
Drug Research