Final Abstract book (e-pdf) - World Glaucoma Association

1329 Pages·2013·11.3 MB·English

by  World Glaucoma Association

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© 2013 World Glaucoma Association
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Table of Contents
Glaucoma Society Symposiums 4
Symposiums 16
Courses 56
Grand Rounds 101
Video Sessions 121
Poster Abstracts 152
Blood flow 153
Drug and gene delivery systems 159
Drug delivery: iris-ciliary body/intraocular fluids/posterior segment 163
Ganglion cell structure and function 168
Glaucoma: biochemistry and molecular biology, genomics and proteomics 173
Glaucoma: biomechanics 191
Glaucoma: clinical drug studies and clinical trials 220
Glaucoma: electrophysiology 291
Glaucoma: epidemiology 299
Glaucoma: genetics 378
Glaucoma: IOP measurement and characterization 406
Glaucoma: laser therapy 485
Glaucoma: neuroprotection 541
Glaucoma: ocular blood flow 554
Glaucoma: pharmacological intervention or cellular mechanism 575
Glaucoma: structure/function relationships 596
Glaucoma: surgery or wound healing 655
Glaucoma: trabecular meshwork and ciliary body 924
Glaucoma: visual fields and psychophysics 942
Glial cells 980
Health care delivery and economic research 982
Image post processing and analysis methodologies 999
Imaging: glaucoma 1013
Imaging: new technologies and techniques 1096
Intraocular pressure/physiology pharmacology 1130
Nanomedicine, nanopharmaceuticals, nanotherapy 1142
Ocular surface health and disease 1148
Optic nerve 1167
Stem cells 1180
Visual function and quality of life 1184
Additional Posters 1195
Index of Authors 1260
Index of Abstracts 1290
GlAuCOmA
SOCIeTy
SymPOSIumS
WGC 2013 Abstract Book Glaucoma Society Symposiums
GS1 CeNTRAl CORNeAl THICKNeSS IN PATIeNTS WITH
PSeuDOeXFOlIATIVe GlAuCOmA
S. Ivanova1
1Alexandrovska Hospital, Sofia, Bulgaria
Wednesday July 17, 2013 • 8.00 – 9.45 am
GS
Background: To make a comparative study of the Central Cor-
neal Thickness (CCT) between patients with pseudoexfoliative S
glaucoma (PEG) and healthy people of the same age group.
C
methods: CCT is measured to 60 eyes with PEG with the help of
ultrasound pachymeter. The intraocular pressure (IOP) is mea-
GR
sured by the standard automatic Goldmann applanation tonom-
eter. All other routine diagnostic methods used in the ophthal-
VS
mological practice were made: biomicroscopy, ophthalmoscopy,
gonioscopy, computer perimetry, optical coherence tomography
(OCT). A comparative research of the records was made, as the P
results were compared with those of the same number of healthy
people at the same age. I
Results: The results have been analyzed and compared between
them and with those of other authors.
Conclusions: The relevant conclusion is made for the signifi-
cance of CCT as a risk factor for patients with PEG.
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WGC 2013 Abstract Book Glaucoma Society Symposiums
GS2 meASuRemeNT OF TOP FIVe TOPOGRAPHIC
PARAmeTeRS OF THe OPTIC DISK uSING HeIDelBeRG
ReTINA TOmOGRAPH II IN PRImARy OPeN-ANGle
GlAuCOmA PATIeNTS IN VARIOuS STAGeS OF PeRImeTRIC
CHANGeS
A. Toshev1, B. Anguelov1
1UMBAL ‘Alexandrovska’ Hospital, Sofia, Bulgaria GS
Wednesday July 17, 2013 • 8.00 – 9.45 am S
Background: То determine the values of the top five topographic
C
parameters of optic nerve head measured by Heidelberg reti-
na tomograph II in healthy volunteers and patients with primary
GR
open-angle glaucoma in various stages of perimeter changes.
VS
methods: 73 eyes (38 volunteers at the age of 56 years ± 13,
11 men and 27 women) and 170 eyes (90 patients at the age
of 66 years ± 12, 33 men and 57 women) were examined. We P
performed the comprehensive ophthalmic examination, standard
automated perimetry and measurement of the top five topograph- I
ic parameters of optic disk - rim area, rim volume, cup shape
measure, height variation contour and mean RNFL thickness. For
the purpose of this study we used Heidelberg retina tomograph
II(software version 3.1.2.).
Results: We determine the values of the investigated topo-
graphic parameters of the optic disk for healthy volunteers (rim
area=1.68 ± 0.22, rim volume=0.44 ± 0.07, cup shape mea-
sure=-0.2 ± 0.06, height variation contour=0.38 ± 0.08 and mean
RNFL thickness=0.24 ± 0.03) and for the patients with primary
open-angle glaucoma in various stages of perimeter changes
(early stage: rim area=1.52 ± 0.47, rim volume=0.38 ± 0.17, cup
shape measure=-0.14 ± 0.1, height variation contour=0.36 ± 0.09
and mean RNFL thickness=0.22 ± 0.11; moderate stage: rim
area=1.21 ± 0.46, rim volume=0.27 ± 0.17, cup shape mea-
sure=-0.09 ± 0.1, height variation contour=0.36 ± 0,17 and mean
RNFL thickness=0.16 ± 0.12; severe stage: rim area=0.97 ± 0.01,
rim volume=0.18 ± 0.17, cup shape measure=-0.06 ± 0.1, height
6
WGC 2013 Abstract Book Glaucoma Society Symposiums
variation contour=0,28 ± 0,11 and mean RNFL thickness=0.17 ±
0.11). Hodapp-Parrish-Anderson staging system includes three
separate levels (early, moderate and severe) of glaucoma accord-
ing to visual field defects. Each stage is additionally characterized
by the values of the top five topographic parameters of the optic
nerve head.
GS
Conclusions: Early diagnosis, staging and follow-up of primary
open-angle glaucoma are based on both function and structure S
assessment. The determined value for the top five topographic
parameters of the optic nerve head for healthy volunteers and
C
patients in different perimetric stages of glaucoma helps and sup-
ports their right classification. Patients with different level changes
GR
require different kind of treatment at different price. In this respect
the acquired data is an initial step at the development of primary
VS
open-angle glaucoma staging system based on the topographic
parameters of optic nerve head obtained by Heidelberg retina
tomograph II. P
I
7
WGC 2013 Abstract Book Glaucoma Society Symposiums
GS3 COmPARISON OF TWO ReTINAl NeRVe FIBeR lAyeR
THICKNeSS meASuRemeNTS ASSeSSeD By OPTICAl
COHeReNCe TOmOGRAPHy IN PRImARy OPeN-ANGle
GlAuCOmA PATIeNTS
K. Petrova1, B. Anguelov1
1Alexandrovska Hospital, Sofia, Bulgaria
GS
Wednesday July 17, 2013 • 8.00 – 9.45 am
S
Background: To evaluate the degree of correlation and agree-
ment between two retinal nerve fibre layer thickness measure-
C
ment patterns (RNFL 3.45 and ONH map), obtained with optical
coherence tomography, in primary open-angle glaucoma (POAG)
GR
patients.
VS
methods: In this study were enrolled of 76 primary open-angle
glaucoma patients (109 eyes). All subjects had comprehensive
clinical examination, including standard automated perimetry and P
optical coherence tomography. RNFL was measured with two
different measurement patterns - RNFL 3.45 (RNFL 1) and ONH I
(RNFL 2). For this comparison Pearson’s correlation coefficient
was calculated and paired T-test and Bland-Altman analysis was
made. Additionally, ganglion cell complex (GCC) was evaluated
and compared with RNFL 2.
Results: The analysis showed that there was statistically signifi-
cant (p<0.0001) positive correlation between RNFL 1 and RNFL 2
and Pearson’s correlation coefficient was R = 0.905. Paired T-test
found no statistically significant difference between measurements
t = 0.362 p>0.05. Bland-Altman analysis showed that measure-
ments of retinal nerve fibre layer thickness by RNFL 1 and RNFL
2 are in good agreement (from all 109 eyes, only 5 are out of the
interval from -9.19 to 9.52). We found a good correlation between
GCC and RNFL 2 (R = 0.678, р < 0.0001).
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WGC 2013 Abstract Book Glaucoma Society Symposiums
Conclusions: RNFL 3.45 is with operator-dependent centring,
while ONH scan has automatic centring and with 3D disk refer-
ence gives the contour of the disc automatically. Although these
differences in the way the two patterns are performed, we found
that they have high correlation and good agreement. The GCC
measurements seem to be valuable addition to RNFL thickness
measurements, according to these results. Therefore, the combi- GS
nation of diagnostic parameters may help to improve the diagnos-
tic accuracy of POAG. S
C
GR
VS
P
I
9
WGC 2013 Abstract Book Glaucoma Society Symposiums
GS4 APPeARANCe OF eXFOlIATION SyNDROme IN THe
PROGReSS OF PRImARy OPeN ANGle GlAuCOmA - A
DIFFeReNT WAy FOR DeVelOPmeNT OF eXFOlIATIVe
GlAuCOmA
M. Kostianeva1
1Medical University, Plovdiv, Bulgaria, Plovdiv, Bulgaria
GS
Wednesday July 17, 2013 • 8.00 – 9.45 am
S
Background: Many studies have demonstrated that exfoliative
glaucoma (XFG) develops as a consequence of exfoliation syn-
C
drome (XFS). A progressive intraocular accumulation of exfoliation
deposits may lead to glaucoma development in 40-60% of patients
GR
with XFS. However, the elevation of intraocular pressure (IOP)
and glaucoma onset may precede the detection of clinically visible
VS
XFS and affected glaucomatous eyes may initially diagnosed as
having primary open-angle glaucoma (POAG). The aim of this
study is to describe another way of XFG development - clinical ap- P
pearance of exfoliation syndrome in patients previously diagnosed
to have POAG. I
methods: We present a series of 20 patients with diagnose POAG
(5 male, 15 female, mean age 71 ± 7 years) that reveal exfoliation
material on anterior lens surface and pupillary border of the iris in
the progress of disease. The patients included in the study group
have a long history of glaucoma disease - from 3 to 16 years
(mean 9±3 years)
Results: The exfoliation syndrome is established after period of
7±3 years (range 2-15 years) from the beginning of the disease’s
treatment. Twelve patients present bilateral exfoliations, and 9
- unilateral. The mean age of XFS appearance is 69 ± 7 years.
Fifteen patients (75%) have underdone trabeculectomy and /or
phacoemulsification before XFS identification. During follow-up
period 3 patients have only medical treatment. At the time of XFS
discovery 15 patients demonstrate IOP elevation and the rest 5
patients show a progress of glaucoma disease (optic disc or visual
field changes).
10