Fertility Challenges and Solutions in Women with Cancer PDF
Preview Fertility Challenges and Solutions in Women with Cancer
Fertility Challenges and Solutions in Women with Cancer Hatem A. Azim Jr Isabelle Demeestere Fedro A. Peccatori Editors 123 Fertility Challenges and Solutions in Women with Cancer Hatem A. Azim Jr • Isabelle Demeestere Fedro A. Peccatori Editors Fertility Challenges and Solutions in Women with Cancer Editors Hatem A. Azim Jr Isabelle Demeestere School of Medicine CUB-Erasme, Fertility Clinic Tecnologico de Monterrey Université Libre de Bruxelles Monterrey Brussels Mexico Belgium Fedro A. Peccatori Division of Gynecologic Oncology European Institute of Oncology Milan Italy ISBN 978-3-030-24085-1 ISBN 978-3-030-24086-8 (eBook) https://doi.org/10.1007/978-3-030-24086-8 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Preface This book addresses a highly controversial and challenging subject, which is related to fertility management of young women with cancer. In light of the improvement in cancer survival and the rising trend of delaying childbearing over the past decade, an increasing number of oncologists and fertility specialists are often faced with young women with cancer inquiring into fertility-related issues in routine clinical practice. Over the past decade, the field of fertility management of cancer patients has evolved enormously moving from managing patients based on anecdotes and per- ceptions to counseling based on evidence, thanks to a large amount of clinical and experimental research that has been generated and published by several groups around the globe. This book gathers worldwide experts who have made important contributions in the field of fertility management of young cancer patients. Several subjects are dis- cussed spanning from understanding the feasibility and safety of pregnancy in can- cer survivors to the various fertility preservation methods that could be used, in addition to fertility counseling of special subgroups of patients like those with germline mutations or with endocrine sensitive tumors. The book also addresses controversies related to the role of ovarian tissue cryopreservation and LHRH analogues. We strongly believe that this book will fulfill its aim in providing busy clinicians with a valuable resource in counseling their patients in routine clinical practice. Monterrey, Mexico Hatem A. Azim Jr Brussels, Belgium Isabelle Demeestere Milan, Italy Fedro A. Peccatori v Contents Part I O verview on Pregnancy in Cancer Survivors and Fertility Preservation Options 1 Epidemiology and General Considerations of Pregnancy Following Cancer Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Barbara Buonomo, Hatem A. Azim Jr, Carlo Alviggi, and Fedro A. Peccatori 2 Safety and Challenges of Pregnancy in Women with a History of Endocrine-S ensitive Breast Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Hatem A. Azim Jr 3 Pregnancy After Gynecological Cancer . . . . . . . . . . . . . . . . . . . . . . . . . 17 Marieke van der Zalm, Frederic Amant, and Joris van Drongelen 4 Overview of Fertility Preservation Approaches in Cancer Patients . . . 25 Isabelle Demeestere 5 Fertility Preservation in Women with Hematological Malignancies . . 43 Javier Domingo and Antonio Pellicer Part II C hallenges to Fertility Preservation in Women with Cancer 6 Organizational Strategies to Overcome Barriers to Addressing Fertility Preservation in the Oncology Setting . . . . . . . . . . . . . . . . . . . . 57 Joanne Frankel Kelvin 7 Impact of Systemic Anticancer Therapy on Fertility . . . . . . . . . . . . . . . 67 Antonio Di Meglio, Ines Vaz-Luis, and Barbara Pistilli 8 Fertility Counseling in Routine Practice: Why, When, and How? . . . . 81 Sukhkamal B. Campbell and Terri L. Woodard 9 Challenges in Fertility Counseling of Cancer Patients: A Developing Nation Perspective . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 Ghina Ghazeeri and Dalia Khalife vii viii Contents Part III Controversial Topics in Fertility Counseling of Breast Cancer Patients 10 Ovarian Stimulation in Women with Breast Cancer . . . . . . . . . . . . . . . 105 Volkan Turan and Kutluk Oktay 11 Role of GnRH Agonists for Fertility Preservation in Breast Cancer . . 117 Cynthia Villarreal-Garza, Edna A. Lopez-Martinez, and Hatem A. Azim Jr 12 Fertility and Pregnancy Counseling of Breast Cancer Patients with Germline BRCA Mutations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131 Margherita Condorelli and Matteo Lambertini About the Editors Hatem A. Azim Jr, MD, PhD is a medical oncologist and an adjunct professor at the School of Medicine of the Monterrey Institute of Technology and the American University of Beirut. He also serves as faculty for the European Society for Medical Oncology (ESMO) and the European School of Oncology. He holds a master’s degree from the University of Newcastle Upon Tyne (UK) and a PhD from the Université Libre de Bruxelles (Belgium). Dr. Azim has published more than 120 peer-reviewed articles, contributed to 10 books, and been an invited speaker at the major oncology conferences. In recognition to his research in the field of breast cancer in young women and its relation to pregnancy and fertility, Dr. Azim has received the American Society of Clinical Oncology Merit Award, the ESMO Translational Research Award, and the University of Padua Breast Cancer Research Award. Isabelle Demeestere, MD, PhD is a gynecologist at the fertility clinic in Erasme Hospital (Brussels, Belgium) and the Director of the Research Laboratory on Human Reproduction at the Université Libre de Bruxelles (ULB). After earning a PhD in fertility preservation for cancer patients, she completed her research training at McGill University, Canada, and became research associate at the FNRS. She was among the earliest innovators in the fertility preservation field and is responsible for the oncofertility unit at Erasme Hospital. She is a member of several scientific soci- eties and author or coauthor of over 60 articles and book chapters in the field. Fedro Alessandro Peccatori, MD, PhD is a specialist in Medical Oncology and Obstetrics & Gynecology. He acts as Director of the Fertility and Pregnancy Unit at the European Institute of Oncology (IEO) and Scientific Director of the European School of Oncology (ESO) Milan, Italy. Fertility and pregnancy issues in young women with cancer are his main research interests. He has published more than 190 peer-reviewed articles in international journals and has been the editor or author of more than 10 books on cancer and reproduction. He has been invited as speaker for ASCO, ESGO, and ESMO, where he is part of the Adolescent and Young Adults working group. ix Part I Overview on Pregnancy in Cancer Survivors and Fertility Preservation Options Epidemiology and General 1 Considerations of Pregnancy Following Cancer Diagnosis Barbara Buonomo, Hatem A. Azim Jr, Carlo Alviggi, and Fedro A. Peccatori Introduction Nowadays, there is a rising trend of delaying childbearing for personal, educational, and professional reasons. Given that cancer incidence increases with age, more women inquire into the feasibility and safety of pregnancy following cancer diagno- sis [1]. In addition, several concerns exist regarding the impact of cancer therapy on pregnancy outcome and the possibility of adverse effects among their offspring. However, it is not only the oncologic treatment that may have a potential negative impact on reproductive rates among cancer survivors. These patients may choose not to start a family for concerns related to the risk of transmitting predisposing genetic mutations to offsprings, for worries about cancer relapse and for the potentially increased risks of obstetric and perinatal complications [2]. Cancer sur- vivors often suffer sexual health problems as well, which could be partly related to psychological challenges [3]. It was shown that decreased arousal, pleasure, and B. Buonomo (*) Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy Fertility and Procreation Unit, Division of Gynecologic Oncology, European Institute of Oncology IRCCS, Milan, Italy e-mail: [email protected] H. A. Azim Jr Tecnologico De Monterrey, School of Medicine, Monterrey, Mexico C. Alviggi Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy F. A. Peccatori Fertility and Procreation Unit, Division of Gynecologic Oncology, European Institute of Oncology IRCCS, Milan, Italy © Springer Nature Switzerland AG 2020 3 H. A. Azim Jr et al. (eds.), Fertility Challenges and Solutions in Women with Cancer, https://doi.org/10.1007/978-3-030-24086-8_1
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