Female and Male Climacteric: Current Opinion 1978

155 Pages·1979·4.15 MB·English

by  M. P. Flint, A. Holte, P. A. van Keep, B. Maoz, H. Musaph (auth.), D. M. Serr, R. B. Greenblatt (eds.)

Female-l M I
anu ae
Climacteric
Female WD
ana Male
Climacteric
Current Opinion 1978
Edited b~ PA.van Keep,
D. M. Serr and R. B.Greenblatt
The Workshop Moderators' Reports presented at the
Second International Congress on the Menopause
held in Jerusalem. June 1978, under the auspices of
The American Geriatrics Society
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MTPPR~S LIMITED
International Medical Publishers
Published by
MTP Press Limited
Falcon House
Lancaster, England
Copyright ~:) 1979 MTP Press Limited
All rights reserved. No part of this publication
may be reproduced, stored in a retrieval
system, or transmitted in any form or by any
means, electronic, mechanical, photocopying,
recording or otherwise, without prior
permission from the publishers.
ISBN 978-94-011-9722-9 ISBN 978-94-011-9720-5 (eBook)
DOl 10.1007/978-94-011-9720-5
Mather Bros (Printers) Limited, Preston
fSSj Contents
Page
Preface vii
List of contributing participants IX
1 Sociology and anthropology of the menopause
M. P. Flint
2 Psychology of the menopause 9
B. Maoz and N. Durst
3 The ageing ovary 17
H. Peters
4 The climacteric syndrome 23
J. W. W. Studd
5 Hypothalamic-pituitary-ovarian relationships
around the menopause 35
M. Ben-David and P. F. A. van Look
6 Effects, side-effects, and dosage schemes of various
sex hormones in the peri- and post-menopause 43
H. Kopera
7 Oestrogen and progesterone receptors 69
A. M. Kaye
8 Metabolic changes due to menopause and their
response to oestrogen 89
W. H. Utian and G. S. Gordan
9 Clotting factors and oestrogen replacement therapy 103
M. Notelovitz
10 The endometrium in the menopause 111
S. Campbell and M. I. Whitehead
v
CONTENTS
Page
11 Management of the patient, including the high-risk
patient 121
C. Lauritzen
12 The male climacteric 133
E. Nieschlag
Other communications 140
Index 144
VI
!SSJ Preface
The decision taken during the First International Congress on the
Menopause in June 1976 to repeat the exercise 2 years later turned
out to be a good one.
In the last few years much work has been done on the subject of
the menopause. I t is, of course, a subject of many facets, but of
particular importance recently has been the work done as a result
of the reports appearing in 1975 and 1976 alleging an increase in
the incidence of endometrial carcinoma in women who had used
oestrogens, and of other effects, some beneficial others deleterious,
reportedly seen when oestrogens were administered. 1978 seemed
the right time to re-assess the situation, and the Second Inter-
national Congress on the Menopause provided a good platform.
The congress was held in Jerusalem in June 1978. It took the
form of a series of 12 workshops, each of which, within a prescribed
framework, was planned and presided over by a moderator experi-
enced in that particular field. The 12 moderators were free to
organize their sessions in whichever way they wished, and to invite
whoever they wished to present papers and to join in the discussions.
In addition the workshops were open to anyone who wished to
attend.
Several of the workshops were held simultaneously so it was not
possible for the participants to attend all of them. On the last after-
noon, however, all participantsjoined together to hear the modera-
tors summarize what had been said in the workshops they had
chaired, and it is these summaries which are reproduced in this
book.
This format, of course, does not lead to a clear consensus of
opinion. Indeed, as will be seen in the following pages, the opinions
expressed in one workshop were sometimes contradictory to those
expressed in another. When this occurs it is clear that more research
is needed in order to clarify the matter.
The theme of the congress was 'The Female and Male Climac-
teric' but only one workshop dealt with the male climacteric. The
VB
PREFACE
OpInIOn of the partIcIpants of this workshop was that the male
climacteric as such probably does not exist, but it is the opinion of
many that far more research is needed in this connection.
A number of papers read during the workshop meetings and
presented during the free communications sessions have been sub-
mitted to Maturitas and will appear in that journal in due course.
We, the editors, are extremely grateful to the workshop modera-
tors, all of whom worked hard to make the congress a success, and
who supplied the reports which form this book. We are also grateful
to Pamela Freebody who assisted with the editing task.
Our thanks are also due, and are hereby extended, to the
Honorary President of the Congress, Professor Michel Albeaux-
Fernet, upon whose instigation the first, and so second, congress in
this series was held. Professor Menashe Ben-David, Professor Dan
Hertz, Professor Bruno Lunenfeld, Dr Benjamin Maoz, and Pro-
fessor Jacob Menczel joined Pieter van Keep as members of the
programme committee and it is largely the enthusiasm and com-
bined efforts of this group that resulted in the gathering together of
such an interesting group of people. Finally, our thanks are due to
all those, the un-named as well as the named, who attended this
congress, and who, through their presence, showed the extent to
which the subject of the menopause is gaining importance in the
eyes of scientists of many different disciplines.
P. A. van Keep, International Programme Co-ordinator
D. M. Serr, Secretary General
R. B. Greenblatt, Chairman
Vlll
ISSJ List of contributing participants
Inclllded ill tlzis list arc IIzI' /lIm/{'s IIlld addrl'.l.l('s oj' Ihl' (OII.!',re.l.\' Olli(ill!.l, lite
1.f)orkslwjI IllOtil'mlor.l, 11u: jlarLieijlalll.1 .ljJ(ujical(v illlliled 10 conlribule Lo lite /('ork-
shoji.\', anti the first-named authors (if' the jlapers presented ill the free communication
sessiolls, a list of which begins on page 140, It should be noted that, whilst most (if'
these free communications were presented by thefirst-Ilamed authors, some were not;
the first-named authors are given here in order that a point (if contact may be
established,
T. ABE C. BABUNA
Department of Obstetrics and Department of 0bstetrics and
Gynecology, Gynecology,
Tohoku University School of Istanbul University,
Medicine, Istanbul, Turkey
1-1 Seiryo-machi,
Sendai 980, Japan S. BALLINGER
Department of Behavioural Sciences
in Medicine,
M. F. AKSU University of Sydney,
Department of Endocrinology, Sydney, NSW, Australia
Medical College of Georgia,
Augusta, Georgia, USA M. L. BATRINOS
Department of Experimental
Pharmacology of the University
S. ANDERMAN of Athens,
Department of Obstetrics and 'Vassileus Pavlos' Hospital,
Gynecology, Athens, Greece
Hillel Jaffa Memorial Hospital,
Hadera, Israel M. BEN-DAVID
Department of Pharmacology,
P. ASCHHEIM The Hebrew University,
Unite de Recherches Hadassah Medical School,
Gerontologiques, PO Box 1172,
U, 118, 29 rue Wilhem, Jerusalem, Israel
75016 Paris, France
C. BENGTSSON
University of Gothenburg,
M. ASSAEL Department of Medicine II,
Kaplan Hospital, Sahlgrenska Sjukhuset,
Rehovot, Israel Gothenburg SV, Sweden
IX
LIST OF CONTRIBUTING PARTICIPANTS
O. BENKERT M.DHONT
Psychiatrische Klinik der Department of Gynaecology,
Universitat Munchen, Akademisch Ziekenhuis,
Nussbaumstrasse 7,
De Pintelaan 115,
8000 Munich, West Germany
B 9000 Ghent. Belgium
J. BONNAR
Y. Z. DIAMANT
Trinity College Unit,
Hadassah Medical Relief
Rotunda Hospital,
Association,
Dublin, Ireland
Department of Obstetrics and
Gynecology,
R. BORENSTEIN
Kiryat Hadassah,
Medical College of Georgia,
Jerusalem, Israel
Augusta, Georgia, USA
F. DIENSTL
S. CAMPBELL
Cardiology Intensive Care Unit.
Department of Obstetrics and
Anichstrasse 35,
Gynaecology,
6020 Innsbruck,
King's College Hospital Medical
Austria
School,
University of London,
Denmark Hill, P. DOERR
London SE5 8RX, United Kingdom Max Planck Institute for Psychiatry,
Kraepelinstrasse 10,
M. J. CASEY 8 Munich 40, West Germany
Department of Gynecologic
Oncology,
Z. DURMUS
The University of Connecticut
Ankara Maternity Hospital,
Health Center,
Talatpasa Bulvari,
Farmington, Connecticut, USA
Cebeci, Ankara, Turkey
F. COMHAIRE
Academisch Ziekenhuis, N. DURST
135 De Pintelaan, Geha Psychiatric Hospital,
B 9000 Ghent, Belgium Petah-Tiqvah, Israel
D. W. CRAMER
M. EUSTRATIADES
The Menopause Clinic,
The Laboratories of Cytology and
Boston Hospital for Women,
Pathology of the 1 st Department
Boston, Massachusetts, USA
of Obstetrics and Gynecology of
the University of Athens,
J. A. DAVIES
Alexandra Hospital,
Department of Medicine,
Athens, Greece
Martin Wing, General Infirmary,
Leeds, United Kingdom
M. P. FLINT
L. DENNERSTEIN Department of Anthropology,
Department of Psychiatry, Human Biology,
University of Melbourne, Montclair State College,
c/o PO Royal Melbourne Hospital, Upper Montclair,
Victoria 3050, Australia New Jersey 070043, USA
x
LIST OF CO:-\TRIBUTI:-\G PARTICIPA:\TS
M. FURUHJELM D. HERTZ
Sabbatsbergs Kvinnoklinik, Department of Psychiatry,
Stockholm Va, Sweden Hadassah Medical Center,
Jerusalem, Israel
R. D. GAMBRELL Jr
B. HOCHSTADT
903 15th Street.
The Amran Harofe Medical
Augusta,
Laboratory,
Georgia 30901, USA
Rechov Balfour 3,
Haifa, Israel
S. GELLER
Centre d'Exploration Fonctionnelle A. HOLTE
et d'Etude de la Reproduction I nstitute for Psychology,
Humaine, University of Oslo,
Laboratoire d'Hormonologie, PO Box 1094,
21, rue Edmond- Rostand, Blindern, Oslo 3, Norway
13006 Marseille, France
J. HUSTIN
Institut de Morphologie
J. A. GOLDMAN
Pathologique,
Department of Obstetrics-
B 6270 Loverval, Belgium
Gynecology,
Hasharon Municipal Hospital,
H. S. JACOBS
Tel-Aviv University Medical School,
Obstetric Unit,
Petah-Tiqvah, Israel
St Mary's Hospital,
Paddin'gton,
G. S. GORDAN London, United Kingdom
Department of Medicine,
University of California Medical
H. JACOBSON
Center,
Albany Medical College,
San Francisco, California, USA
Albany, New York, USA
R. B. GREENBLATT L. B. JASZMANN
Medical College of Georgia, Department of Obstetrics and
School of Medicine, Gynecology,
Augusta, Georgia, USA Regional Protestant Hospital,
6720 GA-Bennekom,
The Netherlands
A. A. HAS PELS
Universiteitskliniek voor
H. JICK
Gynecologie en Verloskunde,
Boston Collaborative Drug
Academisch Ziekenhuis Utrecht,
Surveillance Program,
Catharijnesingel 101,
400 Totten Pond Road,
Utrecht, The Netherlands
Waltham, Massachusetts, USA
J. HEIDENREICH S. J. JOEL-COHEN
Frauenklinik, Department of Obstetrics and
Universitiit Dusseldorf, Gynecology,
Moorenstrasse 5, The Beilinson Medical Center,
4 Dusseldorf 1, Tel-Aviv University Medical School,
West Germany Petah-Tiqvah, Israel
Xl