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Feed Your Genes Right: Eat to Turn Off Disease-Causing Genes and Slow Down Aging PDF

274 Pages·2005·1.57 MB·english
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ffirs.qxd 11/22/04 9:45 AM Page i Feed Your Genes Right ffirs.qxd 11/22/04 9:45 AM Page ii ffirs.qxd 11/22/04 9:45 AM Page iii Feed Your Genes Right Eat to Turn Off Disease-Causing Genes and Slow Down Aging Jack Challem John Wiley & Sons, Inc. ffirs.qxd 11/22/04 9:45 AM Page iv Copyright © 2005 by Jack Challem.All rights reserved Published by John Wiley & Sons,Inc.,Hoboken,New Jersey Published simultaneously in Canada Design and composition by Navta Associates,Inc. No part of this publication may be reproduced,stored in a retrieval system,or transmitted in any form or by any means,electronic,mechanical,photocopying,recording,scanning, or otherwise,except as permitted under Section 107 or 108 of the 1976 United States Copy- right Act,without either the prior written permission of the Publisher,or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center, 222 Rosewood Drive,Danvers,MA 01923,(978) 750-8400,fax (978) 646-8600,or on the web at www.copyright.com.Requests to the Publisher for permission should be addressed to the Permissions Department,John Wiley & Sons,Inc.,111 River Street,Hoboken,NJ 07030, (201) 748-6011,fax (201) 748-6008. Limit of Liability/Disclaimer of Warranty:While the publisher and the author have used their best efforts in preparing this book,they make no representations or warranties with respect to the accuracy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose.No warranty may be created or extended by sales representatives or written sales materials.The advice and strategies contained herein may not be suitable for your situation.You should consult with a professional where appropriate.Neither the publisher nor the author shall be liable for any loss of profit or any other commercial damages,including but not limited to special, incidental,consequential,or other damages. For general information about our other products and services,please contact our Customer Care Department within the United States at (800) 762-2974,outside the United States at (317) 572-3993 or fax (317) 572-4002. Wiley also publishes its books in a variety of electronic formats.Some content that appears in print may not be available in electronic books.For more information about Wiley prod- ucts,visit our web site at www.wiley.com. Library of Congress Cataloging-in-Publication Data: Challem,Jack. Feed your genes right :eat to turn off disease-causing genes and slow down aging / Jack Challem. p. cm. Includes bibliographical references and index. ISBN 0-471-47986-1 1.Nutrition–Genetic aspects.2.DNA damage–Prevention.3.Diet in disease.I.Title. QP143.7.C48 2005 613.2–dc22 2004024636 Printed in the United States of America 10 9 8 7 6 5 4 3 2 1 ffirs.qxd 11/22/04 9:45 AM Page v I dedicate this book to DeWitt Garrett,who first taught me about the health benefits of vitamins and nutrition. ffirs.qxd 11/22/04 9:45 AM Page vi ftoc.qxd 11/22/04 9:47 AM Page vii C O N T E N T S Foreword by Kilmer S. McCully, M.D. ix Preface xiii Acknowledgments xvii PART I The Nutrition-Gene Connection 1 1 Your Genes Depend on Good Nutrition 3 2 DNA Damage,Aging,and Disease 11 3 Conflicts between Ancient Genes and Modern Foods 27 PART II Gene-Enhancing Nutritional Supplements 39 4 Nutrients That Enhance Energy and Prevent DNA Damage 41 5 Nutrients That Make and Repair DNA 57 6 Nutrients That Protect DNA from Damage 68 PART III Gene-Enhancing Eating Plans 91 7 Dietary Guidelines for Feeding Your Genes Right 93 8 Recipes,Menu Plans,and Guidelines for Eating Out 117 PART IV Nutrition Plans for Protecting and Enhancing Your Genes 139 9 Stress,Genes,and Nutrition 141 10 Nutritional Recommendations for Specific Diseases,A to Z 153 Afterword 209 vii ftoc.qxd 11/22/04 9:47 AM Page viii viii CONTENTS Appendix A Genetic and Nutrition Testing 211 Appendix B Resources for Supplements, Food, and Additional Information 217 Selected References 225 Index 243 fbetw.qxd 11/22/04 9:51 AM Page ix F O R E W O R D T he study of DNA in heredity and disease has led to a great many heady scientific discoveries and,ironically,to some humbling acknowl- edgments of ancient medical wisdom. Scientists discovered nucleic acids, the general chemical building blocks of DNA (deoxyribonucleic acid) and genes,in the 1890s.Within several decades, biochemists and biologists had gained an impressive understanding of how nucleic acids were involved in heredity,and by 1950 experiments with bacteria had proven that DNA transmits inher- ited traits from one generation to the next. Perhaps the single most dramatic event to ignite the imagination and enthusiasm of biologists was the 1953 discovery by James Watson and Francis Crick of the double-helix structure of DNA. All that remained,or so it seemed at the time,was to decipher and describe the genetic code in terms of its four-letter chemical alphabet. But unraveling the details of DNA and its role in health and disease has turned out to be a far more complex and,at times,vexing process. As it turned out, the new millennium coincided with the complete decoding of the human genome,and this catalog of all human genes has led to many new insights into the function of DNA.Unfortunately,the promise of turning these discoveries into practical ways of preventing and treating disease has so far been disappointing.Cardiovascular dis- eases remain the leading cause of death in the United States and most of the developed world,while the scourge of cancer continues to take its relentless toll despite minor advances in treatment and prevention. Gene therapy has proven dangerous and difficult and has had few sig- nificant successes.Despite our current understanding of cancer-causing oncogenes and the details of how genes function, researchers have devised few new and effective therapies for cancer patients. ix

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