Fanaroff and Martin’s Neonatal-Perinatal Medicine, 2-Volume Set Diseases of the Fetus and Infant

1883 Pages·2014·4.37 MB·English

by  Richard J. Martin, Avroy A. Fanaroff, Michele C. Walsh

10TH EDITION VOLUME ONE
FANAROFF AND
MARTIN’S NEONATAL-
PERINATAL MEDICINE
Diseases of the Fetus and Infant
Richard J. Martin, MBBS, FRACP
Professor, Pediatrics, Reproductive Biology, and Physiology and Biophysics
Case Western Reserve University School of Medicine
Drusinsky/Fanaroff Chair in Neonatology
Rainbow Babies and Children’s Hospital
Cleveland, Ohio
Avroy A. Fanaroff, MD, FRCPE, FRCPCH
Emeritus Professor, Pediatrics and Reproductive Biology
Case Western Reserve University School of Medicine
Emeritus Eliza Henry Barnes Chair in Neonatology
Rainbow Babies and Children’s Hospital
Cleveland, Ohio
Michele C. Walsh, MD, MSE
Professor, Pediatrics
Case Western Reserve University School of Medicine
William and Lois Briggs Chair in Neonatology
Chief, Division of Neonatology
Rainbow Babies and Children’s Hospital
Cleveland, Ohio
1600 John F. Kennedy Blvd.
Ste 1800
Philadelphia, PA 19103-2899
FANAROFF & MARTIN’S NEONATAL-PERINATAL MEDICINE ISBN: 978-1-4557-5617-9
Volume 1 part number: 9996098133
Volume 2 part number: 9996098192
Copyright © 2015 by Saunders, an imprint of Elsevier Inc.
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Library of Congress Cataloging-in-Publication Data
Fanaroff and Martin’s neonatal-perinatal medicine : diseases of the fetus and infant / [edited by]
Richard J. Martin, Avroy A. Fanaroff, Michele C. Walsh.—10th edition.
p. ; cm.
Neonatal-perinatal medicine
Includes bibliographical references and index.
ISBN 978-1-4557-5617-9 (2 v. set : hardcover : alk. paper)
I. Martin, Richard J. (Richard John), 1946-, editor. II. Fanaroff, Avroy A., editor. III. Walsh,
Michele C., editor. IV. Title: Neonatal-perinatal medicine.
[DNLM: 1. Fetal Diseases. 2. Infant, Newborn, Diseases. 3. Perinatal Care. 4. Pregnancy
Complications. WS 420]
RJ254
618.92’01–dc23
2014023366
Senior Content Strategist: Kate Dimock
Content Development Specialist: Kelly McGowan
Publishing Services Manager: Jeff Patterson
Senior Project Manager: Clay S. Broeker
Design Direction: Ellen Zanolle
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
To our spouses
Patricia Martin and Roslyn Fanaroff
to the Martin children and grandchildren
Scott, Molly, William, and Adelaide Martin;
Sonya Martin; and Peter, Mateo, and Soren Graif
to the Fanaroff children and grandchildren
Jonathan, Kristy, and Mason Fanaroff;
Jodi, Peter, Austin, and Morgan Tucker;
and Amanda, Jason, Jackson, and Raya Hirsh
to the Walsh children
Sean and Ryan
with love, admiration, and deep appreciation
for their continued support and inspiration
Contributors
Steven A. Abrams, MD A. Rebecca Ballard, MD
Professor, Pediatrics, Baylor College of Medicine, Assistant Clinical Professor, Pediatrics, Texas A&M
Houston, Texas Health Science Center, College of Medicine, McLane
Disorders of Calcium, Phosphorus, and Magnesium Children’s Hospital, Baylor Scott and White Health,
Metabolism in the Neonate Temple, Texas
Normal Mother-Infant Attachment; Attachment
Johan Agren, MD, PhD Challenges with Premature or Sick Infants
Faculty Member, Department of Women’s and
Children’s Health, Uppsala University; Attending Eduardo H. Bancalari, MD
Neonatologist, Division of Neonatology, University Professor, Pediatrics, Director, Division of Neonatology,
Children’s Hospital, Uppsala, Sweden University of Miami Miller School of Medicine;
The Thermal Environment of the Intensive Care Nursery Chief, Newborn Services, Holtz Children’s Hospital at
University of Miami/Jackson Memorial Medical
Sareea Al Remeithi, MBBS Center, Miami, Florida
Pediatric Endocrinologist, Department of Pediatrics, Bronchopulmonary Dysplasia in the Neonate
Sheikh Khalifa Medical City, Abu Dhabi, United Arab
Emirates Manish Bansal, MD
Disorders of Sex Development Assistant Professor of Pediatrics, Pediatric Cardiology,
Texas Children’s Hospital, Baylor College of
James E. Arnold, MD Medicine, Houston, Texas
The Julius W. McCall Professor, Program Director, Cardiovascular Problems of the Neonate
Otolaryngology and Head and Neck Surgery, Pediatric
Otolaryngology, Rainbow Babies and Children’s Nancy Bass, MD
Hospital, University Hospitals Case Medical Center; Associate Professor, Pediatrics and Neurology, Case
Professor, Otolaryngology, Case Western Reserve Western Reserve University, Rainbow Babies and
University School of Medicine, Cleveland, Ohio Children’s Hospital, Cleveland, Ohio
Upper Airway Lesions in the Neonate Hypotonia and Neuromuscular Disease in the Neonate
Ravi Ashwath, MD, FAAP Cynthia F. Bearer, MD, PhD
Assistant Professor of Pediatrics, Pediatric Cardiology, Mary Gray Cobey Endowed Professor of Neonatology,
Case Western Reserve University, Rainbow Babies and Associate Chair of Research, Chief, Division of
Children’s Hospital, Cleveland, Ohio Neonatology, Pediatrics, University of Maryland
Congenital Defects of the Cardiovascular System School of Medicine, Baltimore, Maryland
Adverse Exposures to the Fetus
Komal Bajaj, MD, FACOG
Reproductive Geneticist, North Bronx Healthcare William E. Benitz, MD
Network; Assistant Professor, Albert Einstein College Philip Sunshine Professor in Neonatology, Chief,
of Medicine, New York, New York Division of Neonatal and Developmental Medicine,
Genetic Aspects of Perinatal Disease and Prenatal Department of Pediatrics, Stanford University School
Diagnosis of Medicine, Stanford, California; Chief, Neonatology
Service, Lucile Packard Children’s Hospital, Palo Alto,
Jill E. Baley, MD California
Medical Director, Rainbow 4, University Hospitals Patent Ductus Arteriosus
Rainbow Babies and Children’s Hospital; Professor,
Pediatrics, Associate Professor, Obstetrics and John T. Benjamin, MD
Gynecology, Case Western Reserve University School Assistant Professor, Pediatrics, Division of Neonatology,
of Medicine, Cleveland, Ohio Vanderbilt University, Nashville, Tennessee
Perinatal Viral Infections; Schedule for Immunization of Developmental Immunology
Preterm Infants
v
vi CONTRIBUTORS
Isaac Blickstein, MD Moira A. Crowley, MD
Professor, Obstetrics and Gynecology, Kaplan Medical Assistant Professor, Pediatrics, Case Western Reserve
Center, Rehovot, Israel; The Hadassah-Hebrew University School of Medicine; Co-Director, Neonatal
University School of Medicine, Jerusalem, Israel ECMO Program, Division of Neonatology, Rainbow
Diabetes Mellitus During Pregnancy; Fetal Effects of Babies and Children’s Hospital, Cleveland, Ohio
Autoimmune Disease; Obstetric Management of Multiple Neonatal Respiratory Disorders; Therapy for
Gestation and Birth; Post-Term Pregnancy Cardiorespiratory Failure in the Neonate
Kara L. Calkins, MD Joshua D. Dahlke, MD
Assistant Professor of Pediatrics, Pediatrics, Fellow, Maternal Fetal Medicine, Women and Infants
Neonatology, and Developmental Biology, David Hospital of Rhode Island, Warren Alpert Medical
Geffen School of Medicine at University of School of Brown University, Providence, Rhode Island
California—Los Angeles; Physician, Pediatrics, Mattel Immune and Nonimmune Hydrops Fetalis
Children’s Hospital, University of California—Los
Angeles, Los Angeles, California Peter Davis, MBBS, MD
Intrauterine Growth Restriction; Developmental Origins of Professor, Neonatology, University of Melbourne, Royal
Adult Health and Disease Women’s Hospital, Melbourne, Victoria, Australia
Role of Positive Pressure Ventilation in Neonatal
Bryan Cannon, MD Resuscitation
Associate Professor, Pediatrics, Pediatric Cardiology
Fellowship Program Director, Departments of Linda S. de Vries, MD, PhD
Cardiovascular Diseases, Children’s Center, and Professor, Neonatal Neonatology, Department of
Pediatric and Adolescent Medicine, Mayo Clinic, Neonatology, University Medical Center Utrecht,
Rochester, Minnesota Wilhelmina Children’s Hospital, Utrecht, The
Disorders of Cardiac Rhythm and Conduction in Netherlands
Newborns Intracranial Hemorrhage and Vascular Lesions in the
Neonate; Hypoxic-Ischemic Encephalopathy
Michael Caplan, MD
Chairman, Department of Pediatrics, NorthShore Katherine MacRae Dell, MD
University HealthSystem, Evanston, Illinois; Clinical Associate Professor, Pediatrics, Case Western Reserve
Professor, Pediatrics, University of Chicago, Pritzker University; Director, Clinical and Translational
School of Medicine, Chicago, Illinois Research, Pediatric Institute, Cleveland Clinic
Neonatal Necrotizing Enterocolitis Foundation, Cleveland, Ohio
Fluids, Electrolytes, and Acid-Base Homeostasis; The
Waldemar A. Carlo, MD Kidney and Urinary Tract of the Neonate
Edwin M. Dixon Professor of Pediatrics, University of
Alabama at Birmingham; Physician, Neonatology, Sherin U. Devaskar, MD
University of Alabama Hospital, Children’s of Distinguished Professor of Pediatrics, Pediatrics,
Alabama Hospital, Birmingham, Alabama Neonatology, and Developmental Biology, David
Assessment of Neonatal Pulmonary Function Geffen School of Medicine at University of
California—Los Angeles; Physician, Pediatrics, Mattel
Gisela Chemlinsky, MD Children’s Hospital, University of California—Los
Professor, Pediatrics, Medical College of Wisconsin, Angeles, Los Angeles, California
Milwaukee, Wisconsin Intrauterine Growth Restriction; Developmental Origins of
Disorders of Digestion in the Neonate Adult Health and Disease; Disorders of Carbohydrate
Metabolism in the Neonate
Janet Chuang, MD
Pediatric Endocrinologist, Nationwide Children’s Juliann M. Di Fiore, BSEE
Hospital, Columbus, Ohio Research Engineer, Department of Medicine, Case
Thyroid Disorders in the Neonate Western Reserve University; Research Engineer,
Division of Neonatology, Rainbow Babies and
Alan R. Cohen, MD, FACS, FAAP Children’s Hospital, Cleveland, Ohio
Neurosurgeon-in-Chief, Chairman, Department of Biomedical Engineering Aspects of Neonatal
Neurosurgery, Boston Children’s Hospital; Franc D. Cardiorespiratory Monitoring; Assessment of Neonatal
Ingraham Professor of Neurosurgery, Harvard Medical Pulmonary Function
School, Boston, Massachusetts
Disorders in Head Shape and Size; Myelomeningocele
and Related Neural Tube Defects
CONTRIBUTORS vii
Yaser Diab, MBBS Ross M. Fasano, MD
Director, Thrombosis Program, Children’s National Director, Chronic Transfusion Program, Hematology,
Medical Center; Assistant Professor, Pediatrics, George Children’s National Medical Center, Washington, DC
Washington University School of Medicine and Blood Component Therapy for the Neonate
Health Sciences, Washington, DC
Hematologic and Oncologic Problems in the Fetus and Smadar Friedman, MD, PhD
Neonate Senior Lecturer in Pediatrics, The Hebrew University
School of Medicine; Director, Neonatology Unit,
Katherine Dobbs, MD Hadassah University Medical Center, Jerusalem, Israel
Fellow, Pediatric Infectious Diseases and Rheumatology, Fetal Effects of Autoimmune Disease
Case Western Reserve University School of Medicine,
Cleveland, Ohio Meena Garg, MD
Postnatal Bacterial Infections Professor of Pediatrics, Pediatrics, Neonatology, and
Developmental Biology, David Geffen School of
Steven M. Donn, MD Medicine at University of California—Los Angeles;
Professor, Pediatrics, Division of Neonatal-Perinatal Physician, Pediatrics, Mattel Children’s Hospital,
Medicine, C. S. Mott Children’s Hospital, University University of California—Los Angeles, Los Angeles,
of Michigan Health System, Ann Arbor, Michigan California
Assisted Ventilation and Its Complications Disorders of Carbohydrate Metabolism in the Neonate
Elizabeth A. Dubil, MD Allison Gilmore, MD
LT MC USN Fellow, National Capital Consortium Assistant Professor, Pediatric Orthopaedics, Division of
Fellowship in Gynecologic Oncology, Walter Reed Pediatric Orthopaedics, Case Medical Center,
National Military Medical Center, Washington, Rainbow Babies and Children’s Hospital, Cleveland,
District of Columbia Ohio
Amniotic Fluid Volume Bone and Joint Infections in Neonates
Richard A. Ehrenkranz, MD Jay P. Goldsmith, MD
Professor, Pediatrics and Obstetrics, Gynecology and Elsie Schaefer Professor, Pediatrics, Chief, Section of
Reproductive Sciences, Interim Chief, Neonatal- Neonatology, Tulane University, New Orleans,
Perinatal Medicine, Section of Neonatal-Perinatal Louisiana
Medicine, Department of Pediatrics, Yale School of Overview and Initial Management of Delivery Room
Medicine; Interim Director, Neonatal Intensive Care Resuscitation; Chest Compression, Medications, and Special
Unit, Yale–New Haven Children’s Hospital, New Problems in Neonatal Resuscitation
Haven, Connecticut
Nutrient Requirements and Provision of Nutritional Blanca E. Gonzalez, MD
Support in the Premature Neonate Assistant Professor, Pediatrics, Center for Pediatric
Infectious Diseases, Cleveland Clinic Lerner College
Alison J. Falck, MD of Medicine, Case Western Reserve University,
Assistant Professor, Pediatrics, Division of Neonatology, Cleveland Clinic Children’s, Cleveland, Ohio
University of Maryland School of Medicine, Perinatal Viral Infections
Baltimore, Maryland
Adverse Exposures to the Fetus Jeffrey B. Gould, MD, MPH
Robert L. Hess Professor in Pediatrics, Director,
Avroy A. Fanaroff, MD, FRCPE, FRCPCH Perinatal Epidemiology and Health Outcomes
Emeritus Professor, Pediatrics and Reproductive Biology, Research Unit, Division of Neonatal and
Case Western Reserve University School of Medicine; Developmental Medicine, Stanford University School
Emeritus Eliza Henry Barnes Chair in Neonatology, of Medicine; Director, California Perinatal Quality
Rainbow Babies and Children’s Hospital, Cleveland, Care Collaborative, Stanford, California
Ohio Evaluating and Improving the Quality and Safety of
Epidemiology for Neonatologists; The Organization of Neonatal Intensive Care
Perinatal Services; Obstetric Management of Prematurity
Pierre Gressens, MD, PhD
Jonathan M. Fanaroff, MD, JD Professor of Foetal and Neonatal Neurology, Centre for
Associate Professor, Pediatrics, Case Western Reserve the Developing Brain and Department of Biomedical
University School of Medicine; Director, Rainbow Engineering, Division of Imaging Sciences, King’s
Center for Pediatric Ethics; Co-Director, Neonatal College London, The Rayne Institute, St Thomas’
Intensive Care Unit, Rainbow Babies and Children’s Hospital, London, United Kingdom; Director,
Hospital, Cleveland, Ohio Inserm–Université Paris Diderot, Département
Medical Ethics in Neonatal Care; Legal Issues in Hospitalo–Universitaire PROTECT, Hôpital Robert
Neonatal-Perinatal Medicine Debré, Paris, France
Normal and Abnormal Brain Development; White Matter
Damage and Encephalopathy of Prematurity
viii CONTRIBUTORS
Florin Grigorian, MD Susan Hatters Friedman, MD, BA
Assistant Professor, Pediatric Ophthalmology, Case Associate Professor, Psychiatry and Pediatrics, Case
Western Reserve University, University Hospitals Case Western Reserve University School of Medicine,
Medical Center, Cleveland, Ohio Cleveland, Ohio; Associate Professor of Psychological
Examination and Common Problems of the Neonatal Eye Medicine, University of Auckland, Auckland,
New Zealand
Floris Groenendaal, MD, PhD Parental Mental Health Issues
Associate Professor of Neonatology, Department of
Neonatology, Wilhelmina Children’s Hospital, Yenon Hazan, MD
University Medical Center Utrecht, Utrecht, The Department of Obstetrics and Gynecology, Kaplan
Netherlands Medical Center, Rehovot, Israel
Hypoxic-Ischemic Encephalopathy Diabetes Mellitus During Pregnancy
Susan J. Gross, MD Anne Hellström, MD, PhD
Professor, Clinical Obstetrics and Gynecology and Professor, Pediatric Ophthalmology, Institute of
Women’s Health, Pediatrics, and Clinical Genetics, Neuroscience and Rehabilitation, Sahlgrenska
Chair, Department of Obstetrics and Gynecology and Academy, Gothenburg University, Gothenburg,
Women’s Health, North Bronx Healthcare Network, Sweden
Albert Einstein School of Medicine, Yeshiva Retinopathy of Prematurity
University, Bronx, New York
Genetic Aspects of Perinatal Disease and Prenatal Anna Maria Hibbs, MD, MSCE
Diagnosis Associate Professor, Pediatrics, Case Western Reserve
University; Attending Neonatologist, Rainbow Babies
Bhaskar Gurram, MD and Children’s Hospital, Cleveland, Ohio
Assistant Professor, Medical College of Wisconsin; Gastroesophageal Refux and and Gastroesophageal Refux
Pediatric Gastroenterologist, Children’s Hospital of Disease in the Neonate
Wisconsin, Milwaukee, Wisconsin
Disorders of Digestion in the Neonate James Adam Hill, MD, FAAP, FACC
Interventional Pediatric/Congenital Cardiologist,
Iris Gutmark-Little, MD Division of Pediatric Cardiology, Rainbow Babies and
Assistant Professor, Pediatric Endocrinology, Cincinnati Children’s Hospital, University Hospitals Case
Children’s Hospital Medical Center, Cincinnati, Ohio Medical Center; Assistant Professor, Pediatrics, Case
Thyroid Disorders in the Neonate Western Reserve University School of Medicine,
Cleveland, Ohio
David N. Hackney, MD, MS Principles of Medical and Surgical Management of the
Assistant Professor, Obstetrics and Gynecology, Neonate
University Hospitals Case Medical Center, Cleveland,
Ohio Susan R. Hintz, MD, MS Epi
Estimation of Fetal Well-Being Professor, Pediatrics, Division of Neonatal and
Developmental Medicine, Stanford University School
Louis P. Halamek, MD of Medicine; Medical Director, Center for Fetal and
Professor and Associate Chief, Education and Training, Maternal Health, Lucile Packard Children’s Hospital,
Division of Neonatal and Developmental Medicine, Palo Alto, California
Department of Pediatrics, Stanford University; Role of Imaging in Neurodevelopmental Outcomes of
Director, Center for Advanced Pediatric and Perinatal High-Risk Neonates
Education; Attending Neonatologist, Lucile Packard
Children’s Hospital at Stanford, Palo Alto, California Shinjiro Hirose, MD
Simulation in Neonatal-Perinatal Medicine Associate Professor of Clinical Surgery, Division of
Pediatric Surgery, Fetal Treatment Center, University
Aaron Hamvas, MD of California—San Francisco School of Medicine,
Raymond and Hazel Speck Barry Professor of San Francisco, California
Neonatology and Head, Division of Neonatology, Surgical Treatment of the Fetus
Ann and Robert H. Lurie Children’s Hospital of
Chicago, Northwestern University Feinberg School of Steven B. Hoath, MD
Medicine, Chicago, Illinois Professor Emeritus, Department of Pediatrics
Respiratory Distress Syndrome in the Neonate (Neonatology), University of Cincinnati; Attending
Neonatologist, Cincinnati Children’s Hospital
Medical Center, Cincinnati, Ohio
The Skin of the Neonate
CONTRIBUTORS ix
Jeffrey D. Horbar, AB, MD Suhas G. Kallapur, MD
Jerold F. Lucey Professor of Neonatal Medicine, Professor, Pediatrics and Neonatology, University of
Pediatrics, University of Vermont; Chief Executive and Cincinnati, Cincinnati Children’s Hospital,
Scientifc Offcer, Vermont Oxford Network, Cincinnati, Ohio
Burlington, Vermont Lung Development and Maturation
Evaluating and Improving the Quality and Safety of
Neonatal Intensive Care Michael Kaplan, MB ChB
Emeritus Director of Neonatology, Shaare Zedek
McCallum R. Hoyt, MD, MBA Medical Center; Professor of Pediatrics, Faculty of
Director of Anesthesia, Hillcrest Hospital; Director of Medicine, Hebrew University, Jerusalem, Israel.
Obstetrical Anesthesia, Anesthesiology Institute, Neonatal Jaundice and Liver Diseases
Cleveland Clinic Foundation, Cleveland, Ohio
Anesthesia for Labor and Delivery David A. Kaufman, MD
Professor, Pediatrics, Division of Neonatology,
Mark L. Hudak, MD Department of Pediatrics, University of Virginia
Professor and Chairman, Pediatrics, University of Medical School; Physician, Neonatal Medicine,
Florida College of Medicine—Jacksonville, University of Virginia Children’s Hospital,
Jacksonville, Florida Charlottesville, Virginia
Infants with Antenatal Exposure to Drugs Perinatal Fungal and Protozoal Infections
Petra S. Hüppi, MD Kathleen A. Kennedy, MD, MPH
Professor, Pediatrics and Newborn Medicine, Division Professor, Pediatrics, Division of Neonatal-Perinatal
of Development and Growth, University of Geneva, Medicine, University of Texas Medical School at
Children’s Hospital, Geneva, Switzerland Houston, Houston, Texas
Normal and Abnormal Brain Development; White Matter Practicing Evidence-Based Neonatal-Perinatal Medicine
Damage and Encephalopathy of Prematurity
Peter C. Kouretas, MD, PhD
Corey W. Iqbal, MD, FAAP Associate Professor, Surgery and Pediatrics, Case
Chief, Section of Fetal Surgery, Children’s Mercy Western Reserve University; Chief, Division of
Hospital Fetal Health Center; Assistant Professor of Pediatric Cardiothoracic Surgery, Rainbow Babies and
Surgery, University of Missouri—Kansas City School Children’s Hospital, Cleveland, Ohio
of Medicine, Kansas City, Missouri Principles of Medical and Surgical Management of the
Surgical Treatment of the Fetus Neonate
Lucky Jain, MD, MBA Oleg Kovalenko, MD
Richard W. Blumberg Professor and Executive Vice Assistant Professor of Pediatrics, Pediatric Cardiology,
Chairman, Department of Pediatrics, Emory Director, Pediatric Electrophysiology, Women and
University; Executive Medical Director, Children’s Children’s Hospital of Buffalo, State University of
Healthcare of Atlanta Faculty Practices, Atlanta, New York at Buffalo, Buffalo, New York
Georgia Disorders of Cardiac Rhythm and Conduction in
The Late Preterm Infant Newborns
Arun Jeyabalan, MD, MS Catherine Larson-Nath, MD
Associate Professor, Maternal-Fetal Medicine, Instructor of Pediatrics, Pediatric Gastroenterology,
Department of Obstetrics, Gynecology, and Medical College of Wisconsin, Milwaukee, Wisconsin
Reproductive Sciences, University of Pittsburgh Disorders of Digestion in the Neonate
School of Medicine, Pittsburgh, Pennsylvania
Hypertensive Disorders of Pregnancy Noam Lazebnik, MD
Professor, OBGYN and Radiology, Associate Professor,
Alan H. Jobe, MD, PhD Genetics, Case Western Reserve University School of
Professor of Pediatrics, Pulmonary Biology and Medicine; Senior Physician, Obstetrics, Gynecology,
Neonatology, Cincinnati Children’s Hospital Medical and Maternal Fetal Medicine, University Hospitals
Center, Cincinnati, Ohio Case Medical Center, Cleveland, Ohio
Lung Development and Maturation Perinatal Imaging
Nancy E. Judge, MD
Associate Professor, Obstetrics, Gynecology, and
Women’s Health, Albert Einstein College of Medicine,
Yeshiva University, New York, New York
Perinatal Imaging
x CONTRIBUTORS
Hanmin Lee, MD Naomi L. C. Luban, MD, FAAP
Michael R. Harrison Endowed Chair and Professor, Professor, Pediatrics and Pathology, Division of
Surgery, Pediatrics, Ob-Gyn and Reproductive Health Laboratory Medicine, Department of Pediatrics,
Services, Chief, Division of Pediatric Surgery, Director, George Washington University School of Medicine
Fetal Treatment Center, Surgeon-in-Chief, University and Health Sciences; Attending Hematologist,
of California—San Francisco Benioff Children’s Director of Transfusion Medicine, Chair of IRB,
Hospital; Vice-Chair, Department of Surgery, Children’s National Medical Center, Washington, DC
University of California—San Francisco School of Blood Component Therapy for the Neonate
Medicine, San Francisco, California
Surgical Treatment of the Fetus Lori Luchtman-Jones, MD
Hematologist, Center for Cancer and Blood Disorders,
Henry C. Lee, MD Children’s National Medical Center; Associate
Assistant Professor, Pediatrics, Division of Neonatal and Professor, Pediatrics, George Washington University
Developmental Medicine, Stanford University School Medical School, Washington, DC
of Medicine, Lucile Packard Children’s Hospital at Hematologic and Oncologic Problems in the Fetus and
Stanford; Director of Research, California Perinatal Neonate
Quality Care Collaborative, Stanford, California
Evaluating and Improving the Quality and Safety of Everett F. Magann, MD
Neonatal Intensive Care Professor, Obstetrics and Gynecology, University of
Arkansas for the Medical Sciences, Little Rock,
Liisa Lehtonen, MD, PhD Arkansas
Professor, Pediatrics, Turku University; Head, Division Immune and Nonimmume Hydrops Fetalis; Amniotic
of Neonatology, Department of Pediatrics, Turku Fluid Volume
University Hospital, Turku, Finland
Assessment and Optimization of Neurobehavioral Akhil Maheshwari, MD
Development in Preterm Infants Professor, Pediatrics and Molecular Medicine, Pamela
and Leslie Muma Chair in Neonatology, Chief,
Ethan G. Leonard, MD Division of Neonatology, Assistant Dean, Graduate
Associate Professor, Pediatrics, Pediatric Infectious Medical Education, University of South Florida
Diseases and Rheumatology, Case Western Reserve Health Morsani College of Medicine, Tampa, Florida
University School of Medicine; Chief Medical Offcer Developmental Immunology
and Vice Chair for Quality, University Hospitals
Rainbow Babies and Children’s Hospital, Cleveland, Henry H. Mangurten, MD
Ohio Professor, Pediatrics, Rosalind Franklin University of
Postnatal Bacterial Infections Medicine and Science, The Chicago Medical School,
North Chicago, Illinois; Chairman Emeritus,
Tom Lissauer, MB, BChir, FRCPCH Pediatrics, Director, Pediatric Palliative Care,
Honorary Consultant Neonatologist, Imperial College Pediatrics, Advocate Children’s Hospital, Park Ridge,
Healthcare Trust; Consultant Paediatric Programme Illinois; Medical Director, Pediatrics, Journey Care for
Director in Global Health, Imperial College London, Children, Barrington, Illinois
London, Great Britain Birth Injuries
Physical Examination of the Newborn
Paolo Manzoni, MD
Raymond W. Liu, MD Associate Professor of Pediatrics and Neonatology,
Assistant Professor, Pediatric Orthopaedic Surgery, Case Neonatology and NICU, S. Anna Hospital, Torino,
Western Reserve University School of Medicine, Italy
Rainbow Babies and Children’s Hospitals, Cleveland, Perinatal Fungal and Protozoal Infections
Ohio
Musculoskeletal Disorders in Neonates Kara Beth Markham, MD
Associate Professor, Obstetrics, Gynecology, and
Suzanne M. Lopez, MD Maternal Fetal Medicine, Ohio State University,
Associate Professor, Pediatrics, Division of Neonatology, Columbus, Ohio
Director, Neonatal Perinatal Medicine Fellowship Obstetric Management of Pregnancy
Program, University of Texas Health Science Center at
Houston, Houston, Texas
Practicing Evidence-Based Neonatal-Perinatal Medicine
Timothy E. Lotze, MD
Associate Professor, Pediatrics and Neurology, Section
of Child Neurology, Texas Children’s Hospital, Baylor
College of Medicine, Houston, Texas
Hypotonia and Neuromuscular Disease in the Neonate