Familial Cancer Control

117 Pages·1992·3.903 MB·English

by  W. Weber (auth.), Priv.-Doz. Dr. Walter Weber (eds.)

Monographs
Series Editor: U.Veronesi
The European School of Oncology gratefully acknowledges financial support for the Seminar on Familial
Cancer Control received from the Swiss Cancer League ~
W. Weber (Ed.)
Familial
Cancer Control
With 29 Figures and 29 Tables
Springer-Verlag
Berlin Heidelberg New York
London Paris Tokyo
Hong Kong Barcelona
Budapest
Priv.-Doz. Dr. WALTER WEBER
Swiss Cancer League
MonbijoustraBe 61
3001 Bern, Switzerland
Library of Congress Cataloging-in-Publication Data
Familial cancer control IW. Weber (ed.).
(Monographs I European School of Oncology)
Includes bibliographical references and index.
ISBN-13: 978-3-642-77584-0 e-ISBN-13 978-3-642-77582-6
001: 10.1007/978-3-642-77582-6
1. Cancer-Genetic aspects. 2. Cancer-Epidemiology. 3. Cancer-Etiology. 4. Cancer-Prevention. I. Weber, W. (Walter) II.
Series. III. Series: Monographs (European School of Oncology) [DNLM: 1. Neoplasms-genetics. 2. Neoplasms-prevention
& control. az 202 F198] RC267.4.F35 1992 616.99'-dc20 DNLM/DLC
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Softcover reprint of the hardcover 1s t edition 1992
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Foreword
The European School of Oncology came into existence to respond to a need for informa
tion, education and training in the field of the diagnosis and treatment of cancer. There are
two main reasons why such an initiative was considered necessary. Firstly, the teaching of
oncology requires a rigorously multidisciplinary approach which is difficult for the Univer
sities to put into practice since their system is mainly disciplinary orientated. Secondly, the
rate of technological development that impinges on the diagnosis and treatment of cancer
has been so rapid that it is not an easy task for medical faculties to adapt their curricula
flexibly.
With its residential courses for organ pathologies and the seminars on new techniques
(laser, monoclonal antibodies, imaging techniques etc.) or on the principal therapeutic
controversies (conservative or mutilating surgery, primary or adjuvant chemotherapy,
radiotherapy alone or integrated), it is the ambition of the European School of Oncology
to fill a cultural and scientific gap and, thereby, create a bridge between the University and
Industry and between these two and daily medical practice.
One of the more recent initiatives of ESO has been the institution of permanent study
groups, also called task forces, where a limited number of leading experts are invited to
meet once a year with the aim of defining the state of the art and possibly reaching a
consensus on future developments in specific fields of oncology.
The ESO Monograph series was designed with the specific purpose of disseminating the
results of these study group meetings, and providing concise and updated reviews of the
topic discussed.
It was decided to keep the layout relatively simple, in order to restrict the costs and make
the monographs available in the shortest possible time, thus overcoming a common
problem in medical literature: that of the material being outdated even before publication.
UMBERTO VERONESI
Chairman Scientific Committee
European School of Oncology
Contents
Introduction
W. WEBER .
Introduction to the Seminar
G. NOSEDA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 3
Aetiology and Epidemiology
Markovian Models as a Tool in Epidemiology
M. GEBHARDT, M. BUSER, W. WEBER, S. MOSIMANN, J. TORHORST and Hj. MOLLER 7
Familial Adenomatous Polyposis: Current Status in Switzerland
R.J. SCOTT, M. SPYCHER, W. WEBER and Hj. MOLLER . . . . . . .. . ......... 13
Down-Regulation of a Cell-Surface Glycoprotein Correlated with
Rearrangement of Chromosome 1 in Human Breast Cancer Cells
S. A. IMAM, L. A. MILLS, S. PATHAK and C. R. TAYLOR . . . . . . . . . . . . . . . . . 17
Gastric Cancer in Hawaii Japanese: A Family Study
G. N. STEMMERMANN ................ . . .... 23
Increased Number of Multiple Melanomas in Sporadic and Familial Variants
of Dysplastic Naevus Syndrome
CH. SIGG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . .... 27
Family History in Clinical Trials: Experience of the IBCSG and the SAKK
M. CASTIGLIONE-GERTSCH ................................ 31
Aetiology and Epidemiology - Report of Rapporteur
R. H. SIJMONS ..................................... 35
Lynch Syndromes
Lynch Syndromes I and II - Natural History, Diagnosis and Control Strategies
H. T. LYNCH, J. F. LYNCH and G. CRISTOFARO .................. . ... 39
Cost-Benefit Implications in the Surveillance of Lynch Syndrome Subjects
G. CRISTOFARO, E. CARROZZO, F. GENTILE and E. DI GIULIO . . . . . . . . . . . . . . . . 45
VIII Contents
Treatment
Is Endoscopy Still Controversial in Secondary Prevention of Colon Cancer?
R. MEIER and K. GYR ................................. 53
Preventive Surgery
M. ZUBER, U. LAFFER and F HARDER ..... ..... 59
-
Desmoids in Gardner's Syndrome: A Challenge for Surgeons
S. MARTINOLl, L. MARIANI and A. GOLDHIRSCH ...................... 65
Radiation and Cancer Prevention
J. M. HAEFLIGER ........................... 69
Chemoprevention
W. WEBER and S. KUBBA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
Familial Cancer Control
Cancer Prevention Through Genetic Counselling
Hi. MOlLER ................... . . .. 77
Identification of Persons at High Risk for Cancer: A Delay in UV-Induced DNA
Repair is Correlated with Multiple Skin Cancer
M. ROTH, Hi. MOLLER, u. w. SCHNYDER, F PELLONI, J. M. BOYLE and C. SIGG ... 79
The Nurse's Role in Familial Cancer
H. STOLL .............. . . ................... 87
Screening for Colorectal Neoplasia in Families
B. M. STEPHENSON, V.A. MURDAY, P. J. FINAN and D. T. BISHOP ............... 91
Risk Assessment in Hereditary Breast Cancer
S.A. NAROD ................. . . .. 95
A Screening Programme for Medullary Thyroid Carcinoma and Breast Cancer
for Families at High Risk
H. SOBOL ....................................... 99
Familial Cancer Control-Report of Rapporteur
P. A. DALY .................. .................. 10 3
A Clinical Study of Familial Cancer in Japan
T. NOMIZU, R. ABE, A. TSUCHIYA, J. UTSUNOMIYA, F WATANABE and Y. YAMAKI . . . . . . . . 105
DNA Diagnosis in Families with Hereditary Forms of Cancer
H. FA. VASEN, Hi. MOLLER and P. MEERA KHAN ........ . 113
Contents IX
Ulee Strategy Meeting
Familial Cancer Among Cancer Patients Registered at the Aichi Cancer Registry -
Heterogeneity of Aggregation of Familial Cancer
K. AOKI and H. OGAWA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 119
Report of the First UICC Strategy Meeting on Familial Cancer
W. WEBER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 123
Participants
Chairmen: Dr. G. CRISTOFARO
Director
Hereditary Gastrointestinal
Prof. K. AOKI
Cancer Prevention Center
Chairman
Via de Terribile 9
UICC Epidemiology and
72100 Brindisi, Italy
Prevention Programme
President
Aichi Cancer Center Dr. P A. DALY
1-1 Kanokoden Medical Oncologist
Chikusa-Ku St. James's Hospital
Nagoya 464, Japan James's Street PO. Box 580
Dublin 8, Ireland
Prof. M. M. BORGER
UICC Treasurer Dr. L.-J. D'OREY MANOEL
Chairman Tr. Abarracamento
UICC Tumour Biology Programme Peniche 13-2
Director 1200 Lisboa, Portugal
Friedrich-Miescher-Institut
PO. Box 2543
Prof. W. F. DOE
4002 Basel, Switzerland
Division of Clinical Sciences
John Curtin School of Medical Research
PD Dr. W. WEBER PO. Box 334
Medical Oncology Canberra City Act 2601, Australia
Scientific Secretary
Swiss Cancer League
Dr. M. GEBHARDT
Monbijoustrasse 61
Genetic Epidemiologist
3001 Bern, Switzerland
Labor Humangenetik
Dept. Forschung
Kantonsspital
Participants: 4031 Basel, Switzerland
Dr. D. T. BISHOP Dr. R. GILLON
Head Director
ICRF Genetic Epidemiology Laboratory Imperial College Health Service
at the University of Leeds Visiting Professor in Medical Ethics
3K Springfield House St. Mary's Hospital Medical School
Hyde Terrace 14, Princes Gardens
Leeds LS2 9LU, UK London SW7 1 NA, UK
XII Participants
PO Dr. J. CL. GIVEL Dr. R. MEIER
Service de Chirurgie A Oberarzt Gastroenterologie
Chuv Medizinische Klinik
1011 Lausanne, Switzerland Kantonsspital
4410 Liestal, Switzerland
Dr. J.-M. HAEFLIGER
PO Dr. H.J. MOLLER
Medecin-Chef
Head
Service de Radiotherapie et d'Oncologie
Labor Humangenetik
H6pital
Dept. Forschung
Rue du Chasseral 20
Kantonsspital
2300 La Chaux-de-Fonds, Switzerland
4031 Basel, Switzerland
Mrs. CH. HAROCOPOS Prof. J.-J. MULVIHILL
ICRF Colorectal Cancer Unit Dep. of Human Genetics
St. Mark's Hospital University of Pittsburgh
City Road Graduate School of Public Health
London EC1 V2PS, UK 130 Desoto Street
Pittsburgh, PA 15261, USA
Dr. F. JORIS
Dr. V.A. MURDAY
Medecin-Chef de I'lnstitut Central
Consultant Clinical Geneticist
des Hopitaux Valaisans
ICRF Genetic Epidemiology Laboratory
Grand-Champsec
at the University of Leeds
1950 Sion, Switzerland
3K Springfield House
Hyde Terrace
Dr. S. KUBBA
Leeds LS2 9LU, UK
Master in Surgery Research Fellow
Clinical Etiology Unit
Dr. S. NAROD
Heuberg 16 Department of Medicine
4051 Basel, Switzerland
Division of Medical Genetics
The Montreal General Hospital
Prof. H. T. LYNCH 1650 Ave Cedar
Creighton University Montreal, Quebec H3G 1A4, Canada
School of Medicine
Department of Preventive Medicine and Dr. T. NOMIZU
Public Health Director
California at 24th Street Department of Surgery
Omaha, Nebraska 68178, USA Hoshi General Hospital
2-1-160machi
Koriyama 963, Japan
Prof. P. M. LYNCH
Section of Gastrointestinal
Prof. G. NOSEDA
Oncology and Digestive Diseases
President, Swiss Cancer League
M. D. Anderson Cancer Center
Primario di Medicina
1515 Holcombe Blvd.
Ospedale della Beata Vergine
Houston, TX 77030, USA
6850 Mendrisio, Switzerland
PO Dr. S. MARTI NOLI Dr. G. RENNERT
Primario, Reparto di Chirurgia Dept. of Community Health
Ospedale Civico Carmel Hospital
Via Tesserete 46 7 Michal Street
6900 Lugano, Switzerland Haifa 34362, Israel