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P. Marco Fisichella Editor Failed Anti- Reflux Therapy Analysis of Causes and Principles of Treatment 123 Failed Anti-Reflux Therapy P. Marco Fisichella Editor Failed Anti-Reflux Therapy Analysis of Causes and Principles of Treatment Editor P. Marco Fisichella Department of Surgery VA Boston Healthcare System Brigham and Women’s Hospital Harvard Medical School West Roxbury, MA USA ISBN 978-3-319-46884-6 ISBN 978-3-319-46885-3 (eBook) DOI 10.1007/978-3-319-46885-3 Library of Congress Control Number: 2017932747 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland To Barbara Jericho Preface A fundoplication is very effective in controlling the symptoms of gastro- esophageal reflux disease (GERD) in most patients. However, the procedure proves ineffective in 10–15% of patients. In these patients, symptoms of GERD recur or they experience dysphagia. Some of these patients eventually need a second operation. However, the chances of success of a second opera- tion are inferior to the outcome of primary surgery. Hence, the management of patients who fail antireflux surgery is complex, and the indications for reoperation are far from straightforward. This book will cover the compre- hensive evaluation and treatment of failed antireflux therapy. Pathophysiology, diagnostic evaluation, treatment, and strategies are included and based both on evidence-based data and the experience of the contributors. Each chapter will describe a very specific aspect of the analysis of causes and principles of treatment for failed medical and surgical therapy, by a known expert. In addi- tion, this book will outline the current diagnostic and management strategies of failures, as well as the simplified re-operative approaches with relevant technical considerations. I thank all the contributors for their efforts, André Tournois for his help as the editorial assistant, and Julia Megginson and Melissa Morton, from Springer, for their continued and relentless support. West Roxbury, MA, USA P. Marco Fisichella vii Contents 1 History of Medical and Surgical Antireflux Therapy . . . . . . . . . . 1 Fernando A.M. Herbella and Ana Cristina C. Amaral 2 Establishing the Diagnosis of GERD . . . . . . . . . . . . . . . . . . . . . . . 13 Wai-Kit Lo and Hiroshi Mashimo 3 Medical Management of GERD: Algorithms and Outcomes . . . 19 Wai-Kit Lo and Hiroshi Mashimo 4 Principles of Successful Surgical Antireflux Procedures . . . . . . 25 Rafael Melillo Laurino Neto and Fernando A.M. Herbella 5 Diagnosis and Treatment of the Extraesophageal Manifestations of Gastroesophageal Reflux Disease . . . . . . . . . . 33 Feroze Sidwa, Alessandra Moore, Elaine Alligood, and P. Marco Fisichella 6 Acute Complications of Antireflux Surgery . . . . . . . . . . . . . . . . . 51 Talar Tatarian, Michael J. Pucci, and Francesco Palazzo 7 Management of Complications: After Paraesophageal Hernia Repair . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 Nisha Dhanabalsamy, Melissa M. Carton, and Carlos Galvani 8 Persistent Symptoms After Antireflux Surgery and Their Management . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 Lawrence F. Borges and Walter W. Chan 9 Technical Surgical Failures: Presentation, Etiology, and Evaluation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83 Chase Knickerbocker, Devendra Joshi, and Kfir Ben-David 10 Symptoms After Antireflux Surgery: Not Everything Is Caused By Surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 Meredith C. Duke and Timothy M. Farrell 11 The Medical and Endoscopic Management of Failed Surgical Anti-reflux Procedures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 Aparna Repaka and Hiroshi Mashimo ix x Contents 12 Reoperation for Failed Antireflux Surgery . . . . . . . . . . . . . . . . 111 Luigi Bonavina 13 Short Esophagus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121 Verónica Gorodner, Rudolf Buxhoeveden, Federico Moser, and Santiago Horgan 14 Esophagectomy for Failed Anti- reflux Therapy: Indications, Techniques, and Outcomes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131 Daniela Treitl, Robert Grossman, and Kfir Ben-David Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139 1 History of Medical and Surgical Antireflux Therapy Fernando A.M. Herbella and Ana Cristina C. Amaral Introduction an exclusive surgical anatomy: (1) access routes to the esophagus may be variable and multiple; Those who cannot remember the past are con- (2) oncologic margins are elusive; and (3) organs demned to repeat it. need to be prepared in order to replace it [4]. The Life of Reason, Volume 1, 1905 Also, the esophagus has a distinctive physiology: George Santayana (1863–1952), Spaniard/ American philosopher (1) it is a digestive organ without known absorp- tive or endocrine functions; (2) it is bounded by Initial and scarce attempts to operate the two sphincters; and (3) it exhibits a motility pat- esophagus have been described since the sev- tern only at feed and different from other diges- enteenth century, mostly due to traumatic injury tive segments. Moreover, esophageal diagnostic [1]; however, the real history of esophageal tests such as esophageal function tests and even surgery is relatively young compared to other esophagoscopy are recent achievements. All this organs. According to Fogelman and Reinmiller lead to unsuccessful tries and fears to operate the [2], esophageal surgery was both uncommon and esophagus and consequently delay in the devel- poorly performed prior to the nineteenth century. opment of procedures even though esophageal This may be attributed to the fact that the esopha- diseases have odd characteristics too: (1) they gus is a peculiar organ. It has a unique anatomy: frequently affect other organs, either through (1) important organs surround the esophagus in neoplastic dissemination or regurgitation of its entire length; (2) the esophagus crosses the esophageal refluxed contents; (2) they mimic neck, the chest, and the abdomen; (3) it lacks a diseases from other organs; and (3) they bring serosa and its own artery, and (4) the lymphatic severe suffering, e.g., gastroesophageal reflux drainage is abundant and erratic [3]. This leads to disease (GERD) burdens quality of life in levels comparable to or greater than that observed in other chronic conditions, such as diabetes, arthri- F.A.M. Herbella, MD (*) tis or congestive heart failure [5]. Department of Surgery, Escola Paulista de Medicina, This book focuses on the failure of antireflux Federal University of Sao Paulo, Sao Paulo, Brazil therapy. The understanding that a collective and Department of Surgery, Escola Paulista de Medicina, historical experience may help prevent the rep- Rua Diogo de Faria 1087 cj 301, Sao Paulo, SP etition of errors is essential. Although esopha- 04037-003, Brazil geal surgery is still in the infancy, some lessons e-mail: [email protected] from the past are frequently ignored and those A.C.C. Amaral, MD who cannot remember the past are condemned to Department of Medicine, Escola Paulista de Medicina, Federal University of Sao Paulo, Sao Paulo, Brazil repeat it. © Springer International Publishing AG 2017 1 P.M. Fisichella (ed.), Failed Anti-Reflux Therapy, DOI 10.1007/978-3-319-46885-3_1 2 F.A.M. Herbella and A.C.C. Amaral Gastroesophageal Reflux Disease symptoms relieve after 20 years, with 49% of radiologic recurrence of the hernia [12], a rate The surgical history of GERD, or “ante-mortem below paraesophageal mesh-reinforced hiato- digestion of the esophagus” [6] was associated plasty and fundoplication in modern series [13]. for a long time with esophagitis and hiatal hernia Latter, it was acknowledged that GERD could (HH), since they were considered synonyms. exist without an associated HH and Allison Esophagitis was firstly describe by Quincke procedure was also carried out successfully in 1859 [7] (Fig. 1.1) but Winkelstein is usually in these patients [14]. From this time, became given the credit for first describing peptic esoph- clear that fixing the HH and performing a hiato- agitis as a new clinical entity only in 1935 [8]. plasty were essential parts of the surgical treat- Postmortem description of diaphragmatic hernias ment for GERD. In fact, modern authors learned can be found in Hippocrates works, but Morgagni that the absence of a hiatoplasty leads to much in 1769 described HH as it is known nowadays worse outcomes [15]. This fact culminated (Fig. 1.2). In the clinical scenario, Eppinger diag- with the use of prosthetic reinforcement of the nosed the first HH in a live patient and Mayo did hiatus to make this part of the procedure even the first operation for this condition in 1909 [9]. stronger, actually not a modern idea but dating The initial therapy for GERD consisted in replacing the stomach to the abdomen and repairing and tightening the esophageal hiatus. Philip Rowland Allison (1908–1974) (Fig. 1.3), a British surgeon [10], initiated the modern era of antireflux surgery. He published in 1951 [11] a series of patients that, utilizing a transthoracic approach, the stomach were reduced to the abdo- men and the crural fibers were closed behind the esophagus. He believed these crural fibers functioned as a pinchcock to prevent reflux. He had good long term results with over 80% of Fig. 1.2 Joannes Baptista Morgagnus. First description of a hiatal hernia (Source: National Library of Medicine Images from the History of Medicine) Fig. 1.1 Heinrich Quincke. First description of esophagi- Fig. 1.3 Philip Rowland Allison. Initiator of the modern tis (Source: National Library of Medicine Images from antireflux surgery (Reproduced from Bani-Hani and Bani- the History of Medicine) Hani [90] with permission)

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This multiauthored text provides information on the pathophysiology of GERD, appropriate medical management, and proper indications for and performance of surgical and endoscopic procedures for GERD. Thousands of patients will experience inadequate relief from medical therapy or will develop complic
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