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FACTORIZATIONS AND HARDY–RELLICH-TYPE INEQUALITIES FRITZGESZTESYANDLANCELITTLEJOHN 7 1 Dedicated with great pleasure toHelge Holden on the occasion of his60th birthday. 0 2 Abstract. Theprincipalaimofthisnoteistoillustratehowfactorizationsofsingular, n even-orderpartialdifferentialoperatorsyieldanelementaryapproachtoclassicalinequal- a itiesofHardy–Rellich-type. Moreprecisly,introducingthetwo-parametern-dimensional J homogeneousscalardifferentialexpressionsTα,β :=−∆+α|x|−2x·∇+β|x|−2,α,β∈R, 1 x∈Rn\{0}, n∈N, n≥2, and itsformaladjoint, denoted byT+ ,we show that non- 3 negativityofTα+,βTα,β onC0∞(Rn\{0})impliesthefundamentalαi,nβequality, P] [(∆f)(x)]2dnx≥[(n−4)α−2β] |x|−2|(∇f)(x)|2dnx ZRn ZRn A −α(α−4) |x|−4|x·(∇f)(x)|2dnx (0.1) h. ZRn at +β[(n−4)(α−2)−β]ZRn|x|−4|f(x)|2dnx, f ∈C0∞(Rn\{0}). m A particular choice of values for α and β in (0.1) yields known Hardy–Rellich-type [ inequalities,includingtheclassicalRellichinequalityandaninequalityduetoSchmincke. Bylocality,theseinequalitiesextendtothesituationwhereRnisreplacedbyanarbitrary 1 opensetΩ⊆Rn forfunctionsf ∈C∞(Ω\{0}). 0 v Perhaps more importantly, we will indicate that our method, in addition to being 9 elementary,isquiteflexiblewhenitcomestoavarietyofgeneralizedsituationsinvolving 2 theinclusionofremaindertermsandhigher-ordersituations. 9 8 0 . 1 1. Introduction 0 7 We dedicate this note with great pleasure to Helge Holden, whose wide range of contri- 1 butions to a remarkable variety of areas in mathematical physics, stochastics, partial differ- : v ential equations, and integrable systems, whose exemplary involvement with students, and i whose tireless efforts on behalf of the mathematical community, deserve our utmost respect X and admiration. Happy Birthday, Helge, we hope our modest contribution toHardy–Rellich- r a type inequalities will give some joy. The celebrated (multi-dimensional) Hardy inequality, |(∇f)(x)|2dnx≥[(n−2)/2]2 |x|−2|f(x)|2dnx, f ∈C∞(Rn\{0}), n∈N, n≥3, ZRn ZRn 0 (1.1) and Rellich’s inequality, |(∆f)(x)|2dnx≥[n(n−4)/4]2 |x|−4|f(x)|2dnx, f ∈C∞(Rn\{0}), n∈N, n≥5, ZRn ZRn 0 (1.2) Date:February1,2017. 2010 Mathematics Subject Classification. Primary: 35A23,35J30; Secondary: 47A63,47F05. Keywordsandphrases. Hardyinequality,Rellich-typeinequality,factorizationsofdifferentialoperators. 1 2 F.GESZTESYANDL.L.LITTLEJOHN the first two inequalities in an infinite sequence of higher-order Hardy-type inequalities, received enormous attention in the literature due to their ubiquity in self-adjointness and spectraltheoryproblemsassociatedwithsecondandfourth-orderdifferentialoperatorswith strongly singular coefficients, respectively (see, e.g., [2], [3], [6], [10], [15, Sect. 1.5], [16, Ch.5],[28],[31],[32],[35],[38]–[42],[54,Ch.II],[57]). WerefertoRemark2.11foraselection of Rellich inequality references and some pertinent monographs on Hardy’s inequality. As one of our principal results we will derive the following two-parameter family of in- equalities (a special case of inequality (1.5) below): If either α ≤ 0 or α ≥ 4, and β ∈ R, then, |(∆f)(x)|2dnx≥[α(n−α)−2β] |x|−2|(∇f)(x)|2dnx ZRn ZRn +β[(n−4)(α−2)−β] |x|−4|f(x)|2dnx, (1.3) ZRn f ∈C∞(Rn\{0}), n∈N, n≥2. 0 Aswillbeshown,(1.3)containsRellich’sinequality(1.2),andSchmincke’sone-parameter family of inequalities, |(∆f)(x)|2dnx≥−s |x|−2|(∇f)(x)|2dnx ZRn ZRn +[(n−4)/4]2 4s+n2 |x|−4|f(x)|2dnx, (1.4) (cid:0) (cid:1)ZRn s∈ −2−1n(n−4),∞ , (cid:2) (cid:1) as special cases. By locality, the inequalities (1.1)–(1.4) naturally extend to the case where Rn is replaced by an arbitrary open set Ω ⊂ Rn for functions f ∈ C∞(Ω\{0}) (without 0 changing the constants in these inequalities). Our approach is based on factorizing even-order differential equations. More precisely, focusingonthe 4th-ordercaseforsimplicity,weintroducethe two-parametern-dimensional homogeneous scalar differential expressions T := −∆+α|x|−2x·∇+β|x|−2, α,β ∈ R, α,β x ∈ Rn\{0}, n ∈ N, n ≥ 2, and its formal adjoint, denoted by T+ . Nonnegativity of α,β T+ T on C∞(Rn\{0}) then implies the fundamental inequality, α,β α,β 0 [(∆f)(x)]2dnx≥[(n−4)α−2β] |x|−2|(∇f)(x)|2dnx ZRn ZRn −α(α−4) |x|−4|x·(∇f)(x)|2dnx (1.5) ZRn +β[(n−4)(α−2)−β] |x|−4|f(x)|2dnx, f ∈C∞(Rn\{0}), ZRn 0 which in turn contains inequality (1.3) as a special case. We conclude our note with a series of remarks putting our approachinto proper context by indicating that our method is elementary and very flexible in handling a variety of generalized situations involving the inclusion of remainder terms and higher even-order differential operators. 2. Factorizations and Hardy–Rellich-type Inequalities The principal inequality to be proven in this note is of the following form: HARDY–RELLICH-TYPE INEQUALITIES 3 Theorem 2.1. Let α,β ∈R, and f ∈C∞(Rn\{0}), n∈N, n≥2. Then, 0 [(∆f)(x)]2dnx≥[(n−4)α−2β] |x|−2|(∇f)(x)|2dnx ZRn ZRn −α(α−4) |x|−4|x·(∇f)(x)|2dnx (2.1) ZRn +β[(n−4)(α−2)−β] |x|−4|f(x)|2dnx. ZRn In addition, if either α≤0 or α≥4, then, |(∆f)(x)|2dnx≥[α(n−α)−2β] |x|−2|(∇f)(x)|2dnx ZRn ZRn +β[(n−4)(α−2)−β] |x|−4|f(x)|2dnx. (2.2) ZRn Proof. Given α,β ∈ R and n ∈ N, n ≥ 2, we introduce the two-parameter n-dimensional homogeneous scalar differential expressions T :=−∆+α|x|−2x·∇+β|x|−2, x∈Rn\{0}, (2.3) α,β and its formal adjoint, denoted by T+ , α,β T+ :=−∆−α|x|−2x·∇+[β−α(n−2)]|x|−2, x∈Rn\{0}. (2.4) α,β Assumingf ∈C∞(Rn\{0})throughoutthisproof,employingelementarymulti-variabledif- 0 ferentialcalculus,weproceedtothecomputationofT+ T (which,whileentirelystraight- α,β α,β forward, may well produce some tears in the process), (T+ T f)(x)=(∆2f)(x)+[(n−4)α−2β]|x|−2(∆f)(x) α,β α,β n +α(4−α)|x|−4 x x f (x) j k xj,xk jX,k=1 + −(n−3)α2+2(n−2)α+4β |x|−4x·(∇f)(x) +(cid:2)β2+2(n−4)β−(n−4)αβ |x(cid:3)|−4f(x). (2.5) (cid:2) (cid:3) Thus, choosingf ∈C∞(Rn\{0})real-valuedfromthis point on andintegrating by parts 0 (observing the support properties of f, which results in vanishing surface terms) implies 0≤ [(T f)(x)]2dnx= f(x)(T+ T f)(x)dnx ZRn α,β ZRn α,β α,β = [(∆f)(x)]2dnx+[(n−4)α−2β] |x|−2f(x)(∆f)(x)dnx ZRn ZRnZRn n +α(α−4) |x|−4f(x)x x f (x)dnx jX,k=1ZRn j k xj,xk + −(n−3)α2+2(n−2)α+4β |x|−4f(x)[x·(∇f)(x)]dnx (cid:2) (cid:3)ZRn + β2+2(n−4)β−(n−4)αβ |x|−4f(x)2dnx. (2.6) (cid:2) (cid:3)ZRn 4 F.GESZTESYANDL.L.LITTLEJOHN To simplify and exploit expression (2.6), we make two observations. First, a standard integration by parts (again observing the support properties of f) yields |x|−2f(x)(∆f)(x)dnx=2 |x|−4f(x)(x·(∇f)(x)dnx ZRn ZRn (2.7) − |x|−2|(∇f)(x)|2dnx. ZRn Similarly, one confirms that n x x f(x)f (x)=−(n−3) |x|−4f(x)[x·(∇f)(x)]dnx jX,k=1ZRn j k xj,xk ZRn (2.8) − |x|−4[x·(∇f)(x)]2dnx. ZRn Combining (2.6)–(2.8) then yields (2.1). Since by Cauchy’s inequality, − |x|−4[x·(∇f)(x)]2dnx≥− |x|−2|(∇f)(x)|2dnx, (2.9) ZRn ZRn one concludes that as long as α(α−4) ≥ 0, that is, as long as either α ≤ 0 or α ≥ 4, one can further estimate (2.1) from below and thus arrive at inequality (2.2). (cid:3) As a special case of (2.2) one obtains Rellich’s classical inequality in its original form as follows: Corollary 2.2. Let n∈N, n≥5, and f ∈C∞(Rn\{0}). Then, 0 |(∆f)(x)|2dnx≥[n(n−4)/4]2 |x|−4|f(x)|2dnx. (2.10) ZRn ZRn Proof. Choosing β =α(n−α)/2 in (2.2) results in |(∆f)(x)|2dnx≥G (α) |x|−4|f(x)|2dnx, (2.11) n ZRn ZRn with G (α)=α(n−α){(n−4)(α−2)−[α(n−α)/2]}/2. (2.12) n Maximizing G (α) with respect to α (it is advantageous to introduce the new variable n a=α−2) yields maxima at α =2± n2/2 −2n+4 1/2, (2.13) ± (cid:2)(cid:0) (cid:1) (cid:3) and taking the constraints α≤0 or α≥4 into account results in n≥5. The fact G (α )=[n(n−4)/4]2, (2.14) n ± then yields the Rellich inequality (2.10). (cid:3) Inequality (2.1) also implies the following result: Corollary 2.3. Let n∈N and f ∈C∞(Rn\{0}). Then, 0 |(∆f)(x)|2dnx≥ n2/4 |x|−2|(∇f)(x)|2dnx, n≥8, (2.15) ZRn (cid:0) (cid:1)ZRn and |(∆f)(x)|2dnx≥4(n−4) |x|−2|(∇f)(x)|2dnx, 5≤n≤7. (2.16) ZRn ZRn HARDY–RELLICH-TYPE INEQUALITIES 5 In addition, |(∆f)(x)|2dnx≥ n2/4 |x|−4|x·(∇f)(x)|2dnx, n≥2. (2.17) ZRn (cid:0) (cid:1)ZRn Proof. Again, we chose f ∈ C∞(Rn\{0}) real-valued for simplicity throughout this proof. 0 The choice β =(n−4)(α−2) in (2.1) then results in |(∆f)(x)|2dnx≥(n−4)(4−α) |x|−2|(∇f)(x)|2dnx ZRn ZRn (2.18) −α(α−4) |x|−4|x·(∇f)(x)|2dnx. ZRn If in addition α < 0, then applying Cauchy’s inequality to the 2nd term on the right-hand side of (2.18) yields |(∆f)(x)|2dnx≥H (α) |x|−2|(∇f)(x)|2dnx, (2.19) n ZRn ZRn whereH (α)=(n−4+α)(4−α). MaximizingH withrespecttoαsubjecttotheconstraint n n α<0yieldsamaximumatα =(8−n)/2,withH ((8−n)/2)=n2/4,implying inequality 1 n (2.15) for n≥9. On the other hand, choosing α=0 in (2.18) yields |(∆f)(x)|2dnx≥4(n−4) |x|−2|(∇f)(x)|2dnx. (2.20) ZRn ZRn Since 4(n−4)=n2/4 for n=8, this proves (2.15). Actually, one can arriveat (2.15) much quicker,butsincewewillsubsequentlyuse(2.18),wekepttheaboveargumentinthisproof: Indeed, choosing β =0 in (2.2) yields |(∆f)(x)|2dnx≥α(n−α) |x|−2|(∇f)(x)|2dnx. (2.21) ZRn ZRn Maximizing F (α) = α(n − α) with respect to α yields a maximum at α = n/2, and n 1 subjecting it to the constraint α≥4 proves (2.15). Choosing α=4, β =0 in (2.1) yields (2.16). For n ≥ 2 and (4−n) < α < 4, applying Cauchy’s inequality to the 1st term on the right-hand side of (2.18) now yields |(∆f)(x)|2dnx≥K (α) |x|−4|x·(∇f)(x)|2dnx, (2.22) n ZRn ZRn whereK (α)=−(α+n−4)(α−4). MaximizingK subjecttotheconstraint(4−n)<α<4 n n yields a maximum at α =(8−n)/2, with K ((8−n)/2)=n2/4, implying (2.17). (cid:3) 1 n We conclude with a series of remarks that put our approach into proper context and point out natural continuations into various other directions. Remark2.4. (i)Theconstantininequality(2.10)isknowntobeoptimal,see,forinstance, [6, p. 222], [17], [47], [50], [58], [61]. (ii)Asequenceofextensionsof (2.15),validforn≥5,andforboundeddomainscontaining 0, was derived by Tertikas and Zographopoulos [58, Theorem 1.7]. Moreover, an extension of inequality (2.15) valid for n=4 and for bounded open domains containing 0 was proved by [1, Theorem 2.1(b)]. An alternative inequality whose special cases also imply Rellich’s inequality (2.10) and inequality (2.15) appeared in [14]. Thus, while the constant n2/4 in (2.15) is known to be optimal (cf. [58] for n≥5), the constant4(n−4) in (2.16) is not, the sharp constant being known to be n2/4 (also for n=4, cf. [1]). ⋄ Next, we comment on a special case of inequality (2.2) originally due to Schmincke [56]: 6 F.GESZTESYANDL.L.LITTLEJOHN Remark 2.5. The choice β =2−1(n−4)[α−2−4−1(n−4)], and the introduction of the new variable s=s(α)=α2−4α−2−1n(n−4), (2.23) renders the two-parameter inequality (2.2) into Schmincke’s one-parameter inequality |(∆f)(x)|2dnx≥−s |x|−2|(∇f)(x)|2dnx ZRn ZRn +[(n−4)/4]2 4s+n2 |x|−4|f(x)|2dnx, (2.24) (cid:0) (cid:1)ZRn s∈ −2−1n(n−4),∞ . (cid:2) (cid:1) Here the requirements α≤0, equivalently, α≥4, both yield the range requirementfor s in the form s∈ −2−1n(n−4),∞ . Inequality (2.24) is precisely the content of Lemma 2 in Schmincke [56(cid:2)], in particular, (2(cid:1).2) thus recovers Schmincke’s result. Moreover, assuming n ≥ 5 (the case n = 4 being trivial) permits the value s = 0 and hence implies Rellich’s inequality (2.10). If n ≥ 8, the value s = −n2/4 is permitted, yielding inequality (2.15). Finally, for 5 ≤ n ≤ 7, s ∈ −2−1n(n−4),∞ and 4s+n2 ≥ 0 permit one to choose s=−n(n−4)/2 and hence to(cid:2)conclude (cid:1) |(∆f)(x)|2dnx≥2−1n(n−4) |x|−2|(∇f)(x)|2dnx ZRn ZRn +[(n−4)/4]2 4s+n2 |x|−4|f(x)|2dnx(2.21) (2.25) (cid:0) (cid:1)ZRn ≥2−1n(n−4) |x|−2|(∇f)(x)|2dnx, 5≤n≤7, (2.26) ZRn but inequality (2.16) is strictly superior to (2.26). Hence the two-parameter version (2.2) yields the better result (2.16), eventhough, the latter is not optimaleither as mentioned in the previous Remark 2.4(ii). ⋄ Remark 2.6. Since all differential expressions employedare local, and only integrationby parts was involvedin deriving (2.6) (cf., e.g., [39, Remark 4] in this context), the estimates (2.1), (2.2), (2.10), (2.15)–(2.17), (2.24), all extend to the case where Rn is replaced by an arbitrary open set Ω ⊂ Rn for functions f ∈ C∞(Ω\{0}) (without changing the constants 0 in these inequalities). ⋄ Remark 2.7. Since C∞(Rn\{0}) is dense in H2(Rn) if and only if n ≥ 4, equivalently, 0 −∆ is essentially self-adjoint in L2(Rn) if and only if n ≥ 4 (see, e.g., [21, C0∞(Rn\{0}) p. 4(cid:12)12–413], see also [41], [56]), Rellich’s inequality (2.10) extends from C∞(Rn\{0}) to (cid:12) 0 H2(Rn) for n≥5, and inequalities (2.15), and (2.17) extend from C∞(Rn\{0}) to H2(Rn) 0 for n≥4. ⋄ Remark 2.8. This factorization approach was originally employed in the context of the classicalHardyinequality in [31](and someof its logarithmicrefinements in [28]). Without repeatingthe analogousstepsindetailwe justmentionthatgivenn∈N, n≥3, α∈R,one introduces the one-parameter family of homogeneous vector-valued differential expressions T :=∇+α|x|−2x, x∈Rn\{0}, (2.27) α with formal adjoint, denoted by T+, α T+ =−div(·)+α|x|−2x·, x∈Rn\{0}, (2.28) α such that (e.g., on C∞(Rn\{0})-functions), 0 T+T =−∆+α(α+2−n)|x|−2. (2.29) α α HARDY–RELLICH-TYPE INEQUALITIES 7 Thus, for f ∈C∞(Rn\{0}), 0 0≤ |T f)(x)|2dnx= f(x)(T+T f)(x)dnx ZRn α ZRn α α (2.30) = |(∇f)(x)|2dnx+α(α+2−n) |x|−2|f(x)|2dnx, ZRn ZRn and hence, |(∇f)(x)|2dnx≥α[(n−2)−α] |x|−2|f(x)|2dnx. (2.31) ZRn ZRn Maximizing α[(n−2)−α] with respect to α yields the classical Hardy inequality, |(∇f)(x)|2dnx≥[(n−2)/2]2 |x|−2|f(x)|2dnx, f ∈C∞(Rn\{0}). (2.32) ZRn ZRn 0 Again, it is well-known that the constant in (2.32) is optimal (cf., e.g., [61]). ⋄ Actually,ourfactorizationapproachalsoyieldsaknownimprovementofHardy’sinequal- ity (see, e.g.,[6, Theorem1.2.5],specializing it to p=2, ε=0). Next, we briefly sketchthe corresponding argument. Remark 2.9. Given n ∈ N, n ≥ 3, α ∈ R, one introduces the following modified one- parameter family of homogeneous vector-valued differential expressions T := |x|−1x ·∇+α|x|−1, x∈Rn\{0}, (2.33) α (cid:0) (cid:1) with formal adjoint, deneoted by T +, α (cid:0) (cid:1) T + =− |x|−1xe ·∇+(α−n+1)|x|−1, x∈Rn\{0}. (2.34) α (cid:0) (cid:1) (cid:0) (cid:1) Exploiting the ideentities (for f ∈C∞(Rn\{0}), for simplicity), 0 n |x|−1x·∇ |x|−1x·(∇f)(x) =|x|−2 x x f (x), x∈Rn\{0}, (2.35) j k xj,xk (cid:2) (cid:3)(cid:2) (cid:3) jX,k=1 x·∇ |x|−1f(x) =|x|−1[x·(∇f)(x)]−|x|−1f(x), x∈Rn\{0}, (2.36) (cid:0) (cid:1) one computes (e.g., on C∞(Rn\{0})-functions), 0 n T +T =−|x|−2 x x ∂ ∂ −(n−1)|x|−2[x·(∇f)(x)]+α(α+2−n)|x|−2, α α j k xj xk (cid:0) (cid:1) jX,k=1 e e x∈Rn\{0}. (2.37) Thus, appropriate integration by parts yield 0≤ T f (x) 2dnx= f(x) T +T f (x)dnx α α α ZRn(cid:12)(cid:0) (cid:1) (cid:12) ZRn (cid:0)(cid:0) (cid:1) (cid:1) (cid:12) e (cid:12)n e e =− |x|−2 x x f(x)f (x)+(n−1)f(x)[x·(∇f)(x)] ZRn (cid:26)jX,k=1 j k xj,xk −α(α−n+2)|f(x)|2 dnx, (cid:27) = |x|−2 |[x·(∇f)(x)]|2+α(α−n+2)|f(x)|2 , f ∈C∞(Rn\{0}). (2.38) ZRn (cid:26) (cid:27) 0 8 F.GESZTESYANDL.L.LITTLEJOHN Here we used n |x|−2x x f(x)f (x)dnx=− |x|−2|[x·(∇f)(x)]|2dnx jX,k=1ZRn j k xj,xk ZRn (2.39) −(n−1) |x|−2f(x)[x·(∇f)(x)]dnx, f ∈C∞(Rn\{0}). ZRn 0 Thus, |x|−1x·∇f](x) 2dnx≥α[(n−2)−α] |x|−2|f(x)|2dnx. (2.40) ZRn(cid:12)(cid:2) (cid:12) ZRn Maximizing α[(n(cid:12)−2)−α] with re(cid:12)spect to α yields the improved Hardy inequality, |x|−1x·∇f](x) 2dnx≥[(n−2)/2]2 |x|−2|f(x)|2dnx. (2.41) ZRn(cid:12)(cid:2) (cid:12) ZRn (cid:12) (cid:12) (By Cauchy’s inequality, (2.41) implies the classical Hardy inequality (2.32).) Again, it is known that the constant in (2.41) is optimal (cf., e.g., [6, Theorem 1.2.5]). ⋄ Remark 2.10. The case of Rellich (and Hardy) inequalities in the half-line case is com- pletely analogous (and much more straightforward): Consider the differential expressions d2 α d β d2 α d α+β T =− + + , T+ =− − + , (2.42) dx2 xdx x2 dx2 xdx x2 with α,β ∈R, which are formal adjoints to each other. One verifies, d4 α−α2−2β d2 2α2−2α+4β d 3αβ+β2−6β T+T = + + + , (2.43) dx4 x2 dx2 x3 dx x4 and hence upon some integrations by parts, ∞ ∞ 0≤ (Tf)(x)2dx= f(x)(T+Tf)(x)dx Z Z 0 0 ∞ ∞ [f′(x)]2 = [f′′(x)]2dx− α−α2−2β dx Z Z x2 0 (cid:0) (cid:1) 0 ∞ f(x)2 +β(3α+β−6) dx, f ∈C∞((0,∞)), (2.44) Z x4 0 0 choosing f real-valued (for simplicity and w.l.o.g.). Thus, one obtains, ∞ ∞ |f′(x)|2 |f′′(x)|2dx≥ α−α2−2β dx Z Z x2 0 (cid:0) (cid:1) 0 ∞ |f(x)|2 +β(6−β−3α) dx, (2.45) Z x4 0 f ∈C∞((0,∞)), α,β ∈R. 0 Choosing β = α−α2 /2 yields the Rellich-type inequality ∞ (cid:0) (cid:1) ∞ |f(x)|2 |f′′(x)|2dx≥ 3α−(19/4)α2+2α3−(1/4)α4 dx, Z Z x4 0 (cid:2) (cid:3) 0 f ∈C∞((0,∞)). (2.46) 0 Introducing F(α) = 3α−(19/4)α2 +2α3 −(1/4)α4 = −(1/4)(α−4)(α−3)(α−1)α, α∈R, one verifies that F(2+γ)=F(2−γ), γ ∈R, and factors its derivative as F′(α)=3−(19/2)α+6α2−α3 (2.47) =−(α−2) α−2+(5/2)1/2 α−2−(5/2)1/2 . (cid:0) (cid:1)(cid:0) (cid:1) HARDY–RELLICH-TYPE INEQUALITIES 9 One notes that α = 2 yields a local minimum with F(2) = −1, α = 2−(5/2)1/2 and 1 2 α = 2+(5/2)1/2 both yield local maxima of equal value, that is, F(α ) = F(α ) = 9 . 3 2 3 16 Thus, one obtains Rellich’s inequality for the half-line in the form ∞ 9 ∞ |f(x)|2 |f′′(x)|2dx≥ dx, f ∈C∞((0,∞)). (2.48) Z 16Z x4 0 0 0 We refertoBirman[13,p.46](see alsoGlazman[34,p.83–84]),who presentsasequenceof higher-orderHardy-typeinequalities on(0,∞)whose secondmember coincides with (2.48). For a variantof (2.48)on the interval(0,1)we refer to [16, p.114];the case of higher-order Hardy-typeinequalitiesforgeneralintervalisalsoconsideredin[52]. Wewillreconsiderthis sequence of higher-order Hardy-type inequalities in [30]. In addition, choosing β =0 or β =6−3α and subsequently maximizing with respect to α yields in either case ∞ 1 ∞ |f′(x)|2 |f′′(x)|2dx≥ dx, f ∈C∞((0,∞)), (2.49) Z 4Z x2 0 0 0 however, this is just Hardy’s inequality [36], [37], with f replaced by f′. ⋄ Remark 2.11. WhilewebasicallyfocusedoninequalitiesinL2(Rn)(see,however,Remark 2.6), muchof the recentworkonRellich andhigher-orderHardyinequalities aims at Lp(Ω) for open sets Ω ⊂ Rn (frequently, Ω is bounded with 0 ∈ Ω), p ∈ [1,∞), appropriate remainderterms(the latteroftenassociatedwithlogarithmicrefinementsorwithboundary terms), higher-order Hardy–Rellich inequalities, and the inclusion of magnetic fields. The enormous number of references on this subject, especially, in the context of Hardy-type inequalities, makes it impossible to achieve any reasonable level of completeness in such a short note as the underlying one. Hence we felt we had to restrict ourselves basically to Rellich and higher-order Hardy inequality references only and thus we refer, for instance, to [1], [2], [4], [5], [6, Ch. 6], [7], [8], [9], [11], [12], [17], [18], [19], [20], [22], [23], [24], [25], [26], [27], [33], [40], [45], [46], [48], [49], [52], [53], [55], [58], [59], [60], andthe extensive literaturecitedtherein. ForthecaseofHardy-typeinequalitiesweonlyrefertothestandard monographs such as, [6], [43], [44], and [51]. Inthiscontextweemphasizeonceagainthatthefactorizationmethodisentirelyindepen- dent of the choice of domain Ω. Indeed, factorizations in the context of Hardy’s inequality in balls with optimal constants and logarithmic correction terms were already studied in [28], [31], based on prior work in [38], [41], and [42], although this appears to have gone unnoticed in the recent literature on this subject. For instance, one can introduce iterated logarithms of the form for γ >0, x∈Rn, |x|<γ, (−ln(|x|/γ)) =1, 0 (−ln(|x|/γ)) =(−ln(|x|/γ)), 1 (−ln(|x|/γ)) =ln((−ln(|x|/γ)) ), k ∈N, (2.50) k+1 k 10 F.GESZTESYANDL.L.LITTLEJOHN and replace ∇ by T , where αm,y m j T =∇+2−1|x−y|−2 (n−2)+ [(−ln(|x−y|/γ)) ]−1 αm,y (cid:26) k Xj=1kY=1 m −α [(−ln(|x−y|/γ)) ]−1 (x−y), (2.51) m k (cid:27) kY=1 0<|x|<r, r<γ, α ≥0, m∈N, m T =∇+2−1(n−2−α )|x−y|−2(x−y), 0<|x|<r, α ≥0, m=0. (2.52) α0,y 0 0 Then with T+ the formal adjoint of T , one obtains for f ∈C∞(B (y;r)\{y}) αm,y αm,y 0 n (T+ T f)(x)=(−∆f)(x)−4−1|x−y|−2 (n−2)2 (2.53) αm,y αm,y (cid:26) m j m + [(−ln(|x−y|/γ)) ]−2f(x)−α2 [(−ln(|x−y|/γ)) ]−2 f(x), m∈N, k m k (cid:27) Xj=1Xk=1 kY=1 (T+ T f)(x)=(−∆f)(x)−4−1 (n−2)2−α2 |x−y|−2f(x), m=0. (2.54) α0,y α0,y 0 (Here B (x ;r ) denotes the open bal(cid:2)l in Rn with c(cid:3)enter x ∈ Rn and radius r > 0.) In n 0 0 0 0 particular, letting r ↓0 and r ↑r in [28, Lemma 1] implies 0 1 0≤ |(T f)(x)|2 = |(∇f)(x)|2−4−1|x−y|−2 (n−2)2 Z αm,y Z (cid:26) (cid:20) B(y;r) B(y;r) m j m + [(−ln(|x−y|/γ)) ]−2−α2 [(−ln(|x−y|/γ)) ]−2 |f(x)|2 dnx, (2.55) k m k (cid:21) (cid:27) Xj=1Xk=1 kY=1 0<r <γ, f ∈C∞(B(y;r)\{y}), m∈N∪{0}, 0 and hence (with α =0), m |(∇f)(x)|2dnx≥4−1 |x−y|−2 (n−2)2 Z Z (cid:26) B(y;r) B(y;r) m j + [(−ln(|x−y|/γ)) ]−2 |f(x)|2dnx, (2.56) k (cid:27) Xj=1kX=1 0<r <γ, f ∈C∞(B(y;r)\{y}), m∈N∪{0}. 0 (Following standard practice, a product, resp., sum over an empty index set is defined to equal 1, resp., 0.) In analogy to Remark 2.6, inequality (2.56) extends to arbitrary open bounded sets Ω⊂Rn as longas γ is chosensufficiently large(e.g., largerthan the diameter of Ω). The constants in (2.55) are best possible as it is well-known that the operators (2.53), (2.54) are nonnegative if and only if α2 ≥ 0, m ∈ N∪{0} (cf., e.g., [28, p. 99] or m [32, Theorem 2.2]). (They are unbounded from below for α2 <0, m∈N∪{0}, permitting m temporarily a continuation to negative values of α2 on the right-hand sides of (2.53) and (2.54).) For the special half-line case we also refer to [32]. Higher-order logarithmic refinements of the multi-dimensional Hardy–Rellich-type in- equality appeared in [1, Theorem 2.1], and a sequence of such multi-dimensional Hardy– Rellich-type inequalities, with additional generalizations, appeared in [58, Theorems 1.8– 1.10]. ⋄

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