Anil T.Ahuja, MD, FRCR Winnie C.W. Chu, MBChB, FRCR Professor Professor Department of Diagnostic Radiology & Organ h;naging Department of Diagnostic Radiology & Organ Imaging The Chinese University of Hong Kong The Chinese University of Hong Kong Hong Kong, China Hong Kong, China James F.Griffith, MBBCh, FRCR Deborah levine, MD Professor Associate Radiologist-in-Chief of Academic Affairs Department of Diagnostic Radiology & Organ Imaging Co-Chief of Ultrasound The Chinese University of Hong Kong Director of Ob/Gyn Ultrasound Hong Kong, China Beth Israel Deaconess Medical Center Professor of Radiology Harvard Medical School Gregory E.Antonio, MD, FRANZCR Boston, Massachusetts Honorary Professor Department of Diagnostic Radiology & Organ Imaging Stella S.Y.Ho, PhD, ROMS The Chinese University of Hong Kong Adjunct Associate Professor Hong Kong, China Department of Diagnostic Radiology & Organ Imaging The Chinese University of Hong Kong Hong Kong, China K.T.Wong, MBChB, FRCR Honorary Clinical Associate Professor Bhawan K. Paunipagar, MO, ONB Department of Diagnostic Radiology & Organ Imaging Clinical Tutor The Chinese University of Hong Kong Department of Diagnostic Radiology & Organ Imaging Hong Kong, China The Chinese University of Hong Kong Hong Kong, China Yolanda Y.P.lee, MBChB, FRCR Simon S.M. Ho, MBBS, FRCR Honorary Clinical Assistant Professor Honorary Assistant Professor Department of Diagnostic Radiology &Organ Imaging Department of Diagnostic Radiology &Organ Imaging The Chinese University of Hong Kong The Chinese University of Hong Kong Hong Kong, China Hong Kong, China ,. AMIRSYS" Names you know. Content you trust.® iii • ...---.,.... •.•® AMIRSYS® Names you know. Content you trust.@ First Edition Copyright 2010 Amirsys, Inc. Allrights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or media or by any means, electronic, mechanical, photocopying, recording, or otherwise, without prior written permission from Amirsys, Inc. Composition by Amirsys, Inc., Salt Lake City, Utah Printed in Canada by Friesens, Altona, Manitoba, Canada ISBN: 978-1-931884-14-3 Notice and Disclaimer The information inthis product ("Product") isprovided asareference forusebylicensed medical professionals and no others. Itdoesnot and should not beconstrued as any form ofmedical diagnosis orprofessional medical advice on any matter. Receipt oruseofthis Product, inwhole orinpart, doesnot constitute orcreate adoctor·patient, therapist-patient, orother healthcare professional relationship between Amirsys Inc. ("Amirsys") and any recipient. This Product may not reflect the most current medical developments, and Amirsys makes no claims, promises, orguarantees about accuracy, completeness, oradequacy ofthe information contained inorlinked tothe Product. The Product isnot asubstitute fororreplacement ofprofessional medical judgment. 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ISBN978-1-931884-14-3 1. Diagnostic ultrasonic imagingnAtlases. 2. Diagnosis, Differential--Atlases. I.Ahuja, Ani! T.II.Title: Ultrasound. [DNLM: 1. UltrasonographynHandbooks. 2. Diagnosis, Differential--Handbooks. WN 39 £96 2009] RC78.7.U4E972009 616.07'S43--dc22 2009019984 CONTRIBUTING AUTHORS Chander Lulla, MO, OMRO Consultant Sonologist RIAClinic Mumbai, India Vivian Y.F.Leung, PhO, ROMS Adjunct Associate Professor Department of Diagnostic Radiology &Organ Imaging The Chinese University of Hong Kong Hong Kong, China Eric K.H. Liu, PhO, ROMS Adjunct Assistant Professor Department of Diagnostic Radiology &Organ Imaging The Chinese University of Hong Kong Hong Kong, China Nicole Roy,MO Associate Professor of Breast and Body Imaging University of Utah School of Medicine Salt Lake City, Utah vii Once the appropriate technical protocols have been delineated, the best quality images obtained, and the cases queued up on PACS,the diagnostic responsibility reaches the radiology reading room. The radiologist must do more than simply "lay words on" but reach a real conclusion. Ifwe cannot reach a definitive diagnosis, we must offer a reasonable differential diagnosis. Alist that's too long isuseless; a list that's too short may be misleading. Tobe useful, a differential must be more than a rote recitation from some dusty book or a mnemonic from a lecture way back when. Instead, we must take into account key imaging findings and relevant clinical information. With these considerations in mind, we at Amirsys designed our Expert Differential Diagnoses series- EXPERTddxfor short. Leading experts in every subspecialty of radiology identified the top differential diagnoses in their respective fields, encompassing specific anatomic locations, generic imaging findings, modality-specific findings, and clinically based indications. Our experts gathered multiple images, both typical and variant, for each EXPERTddx. Each features at least eight beautiful images that illustrate the possible diagnoses, accompanied by captions that highlight the pertinent imaging findings. Hundreds more are available in the eBook feature that accompanies every book. Inclassic Amirsys fashion, each EXPERTddxincludes bulleted text that distills the available information to the essentials. You'll find helpful clues for diagnoses, ranked by prevalence as Common, LessCommon, and Rarebut Important. Our EXPERTddxseries is designed to help radiologists reach reliable-indeed, expert-conclusions. Whether you are a practicing radiologist or a resident/fellow in training, we think the EXPERTddxseries will quickly become your practical "go-to" reference. Anne G. Osborn, MD Executive Vice President and Editor-in-Chief, Amirsys, Inc. Paula]. Woodward, MD Executive Vice President and Medical Director, Amirsys, Inc. H. RicHarnsberger, MD CEO, Amirsys, Inc. ix PREFACE Despite the advances of teleradiology, in most cases ultrasound diagnosis is made on real-time examination. Because of its real-time nature, ultrasound demands a high level of skill and meticulous attention to detail. EXPERTddx: Ultrasound is the third Amirsys book designed specifically for the practicing sonologist. Our first book, Diagnostic Imaging: Ultrasound, discussed the sonographic appearances of conditions commonly encountered in clinical practice. The second, Diagnostic and Surgical Imaging Anatomy: Ultrasound, covered key anatomy that should be familiar to any sonologist. In EXPERTddx: Ultrasound, we focus on the building blocks of ultrasound diagnosis. The book looks at the discrete sonographic characteristics of a mass or lesion. Isit hypoechoic, calcified, vascular, or solid? The presence and arrangement of these discrete sonographic features enables the characterization of involved tissues, making it possible to arrive at a sonographic diagnosis/differential diagnosis. Relating this sonographic diagnosis to the clinical presentation then provides the most likely final diagnosis. It is important to realize that a diagnosis is rarely based on one sonographic characteristic alone. Typically, any lesion shows a plethora of sonographic features, each of which provides a clue to the nature of the tissue being examined. For example, a liver mass may be hypoechoic, noncalcified, vascular, and solid all at the same time. This combination of features leads us to a differential diagnosis that includes hepatocellular carcinoma. The presence of cirrhosis, ascites, weight loss, and elevated alpha-fetoprotein narrows the possible diagnosis to hepatocellular carcinoma. When you read EXPERTddx: Ultrasound, please consider each feature as a starting point in a chain of thought. Very soon you will put these features and thoughts together to rapidly arrive at a definitive diagnosis. Although dedicated to ultrasound, this book also includes images from other modalities. This isto emphasize that ultrasound is not a standalone modality. Information gained by ultrasound can frequently complement or be supported by information obtained from other imaging modalities. Please note that this book does not discuss obstetric ultrasound, as the topic has been covered in a separate book in the same series. Iam grateful to Drs. RicHarnsberger, Anne Osborn, and Paula Woodward for giving me the opportunity to work on this project and patiently guiding me along the process. Iremain humbled by their continuing patience and faith. The production team at Amirsys has been great and contributed significantly toward the completion of this book. Finally, a book such as this would not have been possible without the contribution of all members of the department. Once again, Ihave been fortunate to work with a wonderful group of colleagues interested in ultrasound. Despite their significant clinical and academic duties, they have worked hard on this project and contributed their cases, knowledge, and time. Iremain forever grateful. The journey has been hard work but also good fun. The effort has been more than compensated by the privilege of working with friends and learning from them. Ihope this book will help you in your daily clinical practice. Anil T.Ahuja, MD, FRCR Professor Department of Diagnostic Radiology & Organ Imaging The Chinese University of Hong Kong xi ACKNOWLEDGMENTS Text Editing KellieJ. Heap Arthur G. Gelsinger, MA Katherine Riser Image Editing Jeffrey J. Marmorstone Terence Y.W.Lam Kevin K.W.Leung Abby Y.T.Tong Medical Text Editing Paula]. Woodward, MO Marc Tubay, MO Art Direction and Design Lane R.Bennion, MS Richard Coombs, MS Contributors Alex H.C. Chan James S.W.Cheung Carmen Cho, MBChB Ann King, FRCR William K.M. Kong Aniruddha Kulkarni, MO Pramod Lonikar, MBBS,OMRO Tom W.K.Lee AsHMomin, MO, ONB Oarshana Rasalkar, MBBS,FRCR Sanjay Vaid Cina Tong, MBChB KiWang, FRCR Simon C.H. Yu,FRCR Associate Editor Ashley R.Renlund, MA Production lead Melissa A.Hoopes xiii SECTIONS Head and Neck Thyroid/Parathyroid Liver Biliary System Pancreas Spleen Adrenal Gland Kidney Abdominal Wall/Peritoneal Cavity Bladder Prostate Scrotum Female Pelvis Vascular Musculoskeletal Breast xv SECTION 1 Head and Neck S_E_CL_iTv_eIOr_N_3 _ ----------------------- 11 Midline Neck Mass 1-2 Hepatomegaly 3-2 Yolanda Y.P.Lee,MBChB, FRCR&Ani! T.Ahuja, MD, GregoryE.Antonio, MD, FRANZCR FRCR Hyperechoic Liver, Diffuse 3-6 Cystic Neck Mass 1-8 GregoryE.Antonio, MD, FRANZCR Yolanda Y.P.Lee,MBChE, FRCR&Anil T.Ahuja, MD, EricK.H. Liu, PhD, RDMS &Michael P.Federle,MD, FRCR FACR Non-Nodal Solid Neck Mass 1-14 Heterogeneous Liver Echopattern 3-8 Yolanda Y.P.Lee,MEChE, FRCR&Ani! T.Ahuja, MD, GregoryE.Antonio, MD, FRANZCR FRCR Simple Anechoic Liver Mass 3-10 Solid Neck Lymph Node 1-20 GregoryE.Antonio, MD, FRANZCR Yolanda Y.P.Lee,MEChE, FRCR&Anil T.Ahuja, MD, Complex Cystic Liver Mass 3-14 FRCR GregoryE.Antonio, MD, FRANZCR &Cina Tong,MEChE Necrotic Neck Lymph Node 1-26 Hypoechoic Liver Mass 3-18 Yolanda Y.P.Lee,MEChE, FRCR&Anil T.Ahuja, MD, FRCR GregoryE.Antonio, MD, FRANZCR &Carmen Cho, MEChB Diffuse Salivary Gland Enlargement 1-28 Isoechoic Liver Mass 3-22 Yolanda Y.P.Lee,MEChE, FRCR&Anil T.Ahuja, MD, FRCR GregoryE.Antonio, MD, FRANZCR &Cina Tong,MEChE Focal Salivary Gland Mass 1-34 Echogenic Liver Mass 3-26 GregoryE.Antonio, MD, FRANZCR Yolanda Y.P.Lee,MEChE, FRCR&Anil T.Ahuja, MD, FRCR EricK.H.Liu, PhD, RDMS &Michael P.Federle,MD, FACR Target Lesions in Liver 3-32 SECTION 2 GregoryE.Antonio, MD, FRANZCR Thyroid/Parathyroid Irregular Border Liver Mass 3-34 GregoryE.Antonio, MD, FRANZCR Multiple Hepatic Masses 3-38 Diffuse Thyroid Enlargement 2-2 GregoryE.Antonio, MD, FRANZCR &Carmen Cho, Yolanda Y.J~Lee,MEChE, FRCR&Ani! T.Ahuja, MD, MEChE FRCR Hepatic Mass with Central Scar 3-42 lso-/Hyperechoic Thyroid Nodule 2-8 GregoryE.Antonio, MD, FRANZCR Yolanda Y.P.Lee,MEChB, F/~CR&Anil T.Ahuja, MD, FRCR Hepatic Lesion with Posterior Shadowing 3-44 GregoryE.Antonio, MD, FRANZCR Hypoechoic Thyroid Nodule 2-10 Yolanda Y.P.Lee,MEChE, F1~CR&Anil T.Ahuja, MD, Periportal Lesion 3-46 FRCR GregoryE.Antonio, MD, FRANZCR Cystic Thyroid Nodule 2-16 Irregular Hepatic Surface 3-50 Yolanda Y.P.Lee,MEChE, FRCR&Anil T.Ahuja, MD, GregoryE.Antonio, MD, FRANZCR FRCR Perihepatic Cyst/Fluid Collection 3-52 Calcified Thyroid Nodule 2-20 GregoryE.Antonio, MD, FRANZCR Yolanda Y.P.Lee,MBChE, FRCR&Anil T.Ahuja, MD, Portal Vein Abnormality 3-56 FRCR GregoryE.Antonio, MD, FRANZCR Enlarged Parathyroid Gland 2-24 Mass in Porta Hepatis 3-58 Yolanda Y.P.Lee,MEChE, FRCR&Anil T.Ahuja, MD, GregoryE.Antonio, MD, FRANZCR &Carmen Cho, FRCR MEChE XVI
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