Experimental Hematology Today—1985: Selected Papers from the 14th Annual Meeting of the International Society for Experimental Hematology, July 14–18, 1985, Jerusalem, Israel PDF
Preview Experimental Hematology Today—1985: Selected Papers from the 14th Annual Meeting of the International Society for Experimental Hematology, July 14–18, 1985, Jerusalem, Israel
Experimental Hematology Today Experimental Hematology Today 1985 Selected Papers from the 14th Annual Meeting of the International Society for Experimental Hematology, July 14-18, 1985, Jerusalem, Israel Edited by S. J. Baum D. H. Pluznik L. A. Rozenszajn With 65 Illustrations Springer-Verlag New York Berlin Heidelberg Tokyo S. J. Baum Physiology Department Uniformed Services University of the Health Sciences Bethesda, MD 20814, USA D. H. Pluznik Laboratory of Microbiology and Immunology National Institute of Dental Research, NIH Bethesda, MD 29782, USA L. A. Rozenszajn Department of Life Sciences Bar-Han University, Ramat-Gan Israel and Department of Medical Laboratories Meir Hospital Kfar-Sava Israel ISSN 0251-0170 LCCN 79-641222 © 1986 by Springer-Verlag New York Inc. Softcover reprint of the hardcover 1st edition 1986 All rights reserved. No part of this book may be translated or reproduced in any form without written permission from Springer-Verlag, 175 Fifth Avenue, New York, New York 10010, USA. The use of general descriptive names, trade names, trademarks, etc., in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. While the advice and information of this book is believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no war- ranty, express or implied, with respect to material contained herein. Printed and bound by Edwards Brothers, Inc., Ann Arbor, Michigan. Printed in the United States of America. 9876543 2 ISBN-l3: 978-0-387-96273-3 e-ISBN-13: 978-1-4612-4920-7 DOl: 10.1007/978-1-4612-4920-7 Preface Experimental Hematology Today-1985 is a memento to the superb 14th Annual Meeting of the International Society for Experimental Hematology, held in Jerusa- lem, Israel in July 1985. It represents a selection of the best presentations at the meeting. The manuscripts were selected by the local scientific committee and care- fully reviewed by the editors. The yearbook is divided into five parts and represents the most recent advances in the basic sciences and clinical applications. Part I, under the leadership of Dr. L. A. Rozenszajn, is entitled "Hematopoietic Regulators." Papers in this section discuss the most recent discoveries on the phys- iological regulation of hematopoiesis. Part II, "Hematopoietic Microenvironment," introduced by Dr. J. S. Greenberger, deals with the involvement ofthe hematopoietic microenvironment in the control of hematopoiesis. Dr. M. Saito leads Part Ill, "Dif- ferentiation of Normal and Leukemic Cells," while Part IV, "Leukemic Cells in Leukemogenesis," is introduced by Dr. A. Raghavacher. The important discussions on recent advances in "Bone Marrow Transplantation," Part V, are headed by Dr. M. M. Bortin. Recent findings in many disciplines in experimental and clinical hematology are presented in this yearbook. It should be of considerable value to experimental and clinical scientists. The Editors v Contents Part I. Hematopoietic Regulators L. A. Rozenszajn 1. Role of T-Lymphocyte Colony Enhancing Factor, TLCEF, in the Induction of CFU- TL L. A. Rozenszajn, 1. Goldman, H. Poran, M. M. Werber, D. Shoham, and 1. Radnay ........................... . 2. Thymic Hormones in Thymus Recovery from Radiation Injury R. Neta, G. N. Schwartz, T. 1. MacVittie, and S. D. Douches. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3. Early Biochemical Steps in Colony Stimulating Factor (CSF) Generation are Induced by Synergy between Phorbol Esters and Calcium Ionophores D. H. Pluznik and S. E. Mergenhagen . . . . . . . . . . . . . . . . . . . 14 4. Dependence of CFU-S Proliferation on the CFU-S Population B. I. Lord. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 5. Interaction of Interleukin 3 with Pluripotent Hematopoietic Stem Cells 1. L. Spivak, R. R. L. Smith, and 1. N. Ihle. . . . . . . . . . . . . . 27 6. In Vivo Effects of Urinary Extracts of Patients with Aplastic Anemia on Rat Platelet Production and Megakaryocyte Progen- itors in Murine Spleen and Bone Marrow S-I. Kuriya, Y. Ishida, F. Ali-Osman, C. Mantel, and M. 1. Murphy lr. .................................... 33 7. Inhibitor(s) of Biologically Active Erythropoietin in Concen- trated Human Sera 1. Barone-Varelas, C. Morley, and W. Fried . . . . . . . . . . . . . . 39 Part II. Hematopoietic Microenvironment 1. S. Greenberger 8. Establishment of Bone Marrow Stromal Cell Cultures and Per- manent Clonal Stromal Cell Lines from Osteopetrotic (mi/mi) and Steel Mutant (Sl/Sld) Mice: Studies of Bone Resorption by vii viii Engrafted Hemopoietic Stem Cells In Vitro J. S. Greenberger, L. Key, C. Daugherty, J. Schwartz, and M. A. Sakakeeny .................................... 42 9. Monoclonal Antibodies Identify Specific Determinants on Re- ticular Cells in Murine Embryonic and Adult Hemopoietic Stroma A. H. Piersma, R. E. Ploemacher, K. G. M. Brockbank, and C. P. E. Ottenheim. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 10. Stromal Cell Lines from Mouse Bone Marrow: A Model Sys- tem for the Study of the Hemopoietic Microenvironment D. Zipori . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 Part III. Differentiation of Normal & Leukemic Cells M. Saito 11. Glycosphingolipids as Specific Differentiation-Markers and Differentiation-Inducers for Human Myelogenous Leukemia Cells: A Monosialyl Glycosphingolipid, Ganglioside GM3, is Highly Potent for Induction of Monocytic Differentiation of Human Myeloid and Monocytoid Cell Lines, HL-60 and U937 Cells M. Saito, H. Nojiri, and Y. Miura. . . . . . . . . . . . . . . . . . . . . . 64 12. Properties of a T-Lymphocyte Derived Differentiation Inducing Factor (OIF) for the Myeloid Leukemic Cell Line HL-60 U. Gullberg, E. Nilsson, and I. Olsson .................. 75 13. Interactions of Differentiation Inducing Agents In Vitro Provide Insight into Molecular Mechanisms of Differentiation and Iden- tify Synergistic Combinations Effective In Vivo G. E. Francis and J. J. Berney. . . . . . . . . . . . . . . . . . . . . . . . . 82 Part IV. Leukemic Cells in Leukemogenesis A. Raghavachar 14. Immunoglobulin and T-Cell Receptor Gene Rearrangements in Human Acute Leukemias A. Raghavachar, C. R. Bartram, and B. Kubanek. . . . . . . . . . 90 15. Immunological and Molecular Classification of Human Leu- kemias R. Foa, N. Migone, M. C. Giubellino, M. T. Fierro, P. Lusso, F. Lauria, G. Pizzolo, G. Basso, G. Cattoretti, and F. Gavosto . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95 16. Oncogenes in Chronic Myelogenous Leukemia R. P. Gale and E. Cannani ............................ 102 17. Response to an Active Vitamin D3 Metabolite of Transplantable Human Myeloid Leukemic Cell Lines in Adult Nude Mice G. K. Potter, A. N. Mohamed, N. C. Dracopoli, S. L. B. Groshen, R. N. Shen, and M. A. S. Moore. ... . .. 106 Part V. Bone Marrow Transplantation M. M. Bortin 18. Risk Factors for Acute Graft-vs-Host Disease in Humans M. M. Bortin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 114 ix 19. Autologous Marrow Transplantation for Malignant Lymphoma F. R. Appelbaum, K. M. Sullivan, E. D. Thomas, C. D. Buckner, R. A. Clift, H. J. Deeg, A. Fefer, N. Flournoy, R. Hill, J. E. Sanders, P. Stewart, and R. Storb . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 122 20. The Influence of T-Cell Depletion by Monoclonal Antibodies on Repopulating Hemopoietic Stem Cells and Their Efficacy in Preventing GvHD in Rhesus Monkeys W. R. Gerritsen, M. Jonker, G. Wagemaker, and D. W. van Bekkum..... ... ... ....... . . ... ... .... . . ... 128 21. Review of the Effects of Anti-T-Cell Monoclonal Antibodies on Major and Minor GvHR in the Mouse J/. P. OKunewick. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 133 Contributors F. Ali-Osman, Hipple Cancer Research Center, Dayton, Ohio, and Wright State University, Dayton, Ohio, USA Frederick R. Appelbaum, Division of Oncology, University of Washington School of Medicine, and the Fred Hutchinson Cancer Research Center, Seattle, Wash- ington, USA J. Barone-Varelas, Departments of Biochemistry and Medicine, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois, USA C. R. Bartram, DRK-Blutspendezentrale, University of Ulm, D-7900 Ulm, Federal Republic of Germany Giuseppe Basso, Dipartimento di Pediatria, University of Padova, Padova, Italy J. J. Berney, Department of Haematology, Royal Free Hospital, London, Great Britain Mortimer M. Bortin, Medical College of Wisconsin, Milwaukee, Wisconsin, USA K. G. M. Brockbank, Department of Cell Biology and Genetics, Erasmus Univer- sity, 3000 DR Rotterdam, The Netherlands C. Dean Buckner, Division of Oncology, University of Washington School of Med- icine, and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Eli Cannani, Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel Giorgio Cattoretti, Laboratorio di Ematologia, I.c.P., Milano, Italy Reginald A. Clift, Division of Oncology, University of Washington School of Med- icine, and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Cathie Daugherty, Department of Radiation Oncology, University of Massachusetts Medical Center, Worcester, Massachusetts, and Joint Center for Radiation xi xii Therapy, Department of Radiation Therapy, Harvard Medical School, and Dana- Farber Cancer Institute, Boston, Massachusetts, USA H. Joachim Deeg, Division of Oncology, University of Washington School of Med- icine, and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Susan D. Douches, Experimental Hematology Department, Armed Forces Radio- biology Research Institute, Bethesda, Maryland, USA Nicholas C. Dracopoli, Human Cancer Serology Laboratory, Sloan-Kettering Insti- tute for Cancer Research, New York, New York, USA Alexander Fefer, Division of Oncology, University of Washington Schooi of Med- icine, and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Maria T. Fierro, Clinica Medica A, University of Torino, Torino, Italy Nancy Flournoy, Division of Oncology, University of Washington School of Med- icine, and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Robert Foa, Clinica Medica A, University of Torino, Torino, Italy G. E. Francis, Department of Haematology, Royal Free Hospital, London, Great Britain W. Fried, Departments of Biochemistry and Medicine, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois, USA Robert P. Gale, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA Felice Gavosto, Clinic a Medica A, University of Torino, Torino, Italy W. R. Gerritsen, Radiobiological Institute TNO, Rijswijk, The Netherlands, and Primate Center TNO, Rijswijk, The Netherlands Maria C. Giubellino, Clinica Medica A, University of Torino, Torino, Italy J. Goldman, Department of Life Sciences, Bar-Han University, Ramat-Gan, Israel, and Department of Medical Laboratories, Meir Hospital, Kfar-Sava, Israel Joel S. Greenberger, Department of Radiation Oncology, University of Massachu- setts Medical Center, Worcester, Massachusetts; Joint Center for Radiation Ther- apy, Department of Radiation Therapy, Harvard Medical School; and Dana-Farber Cancer Institute, Boston, Massachusetts, USA Susan L. B. Groshen, Biostatistics Laboratory, Sloan-Kettering Institute for Cancer Research, New York, New York, USA Urban Gullberg, Division of Hematology, Department of Medicine, University of Lund, 221 85 Lund, Sweden Roger Hill, Division of Oncology, University of Washington School of Medicine, and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA xiii James N. Ihle, The National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland, USA Y. Ishida, Hipple Cancer Research Center, Dayton, Ohio, and Wright State Uni- versity, Dayton, Ohio, USA M. Jonker, Primate Center TNO, Rijswijk, The Netherlands Lyndon Key, Department of Pediatrics, Children's Hospital Medical Center, Boston, Massachusetts, USA Bernhard Kubanek, DRK-Blutspendezentrale, University of Ulm, D-7900 Ulm, Fed- eral Republic of Germany S-I. Kuriya, Hipple Cancer Research Center, and Wright State University, Dayton, Ohio, USA Francesco Lauria, Istituto di Ematologia "L. and A. Seragnoli," University of Bo- logna, Bologna, Italy B. I. Lord, Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, Great Britain Paolo Lusso, Clinica Medica A, University of Torino, Torino, Italy Thomas J. MacVittie, Experimental Hematology Department, Armed Forces Radio- biology Research Institute, Bethesda, Maryland, USA C. Mantel, Hipple Cancer Research Center, Dayton, Ohio, and Wright State Uni- versity, Dayton, Ohio, USA Stephan E. Mergenhagen, Laboratory of Microbiology and Immunology, National Institute of Dental Research, NIH, Bethesda, Maryland, USA Nicola Migone, Istituto di Genetica Medica, University of Torino, Torino, Italy Yasusada Miura, Division of Hemopoiesis, Institute of Hematology, and Division of Hematology, Department of Medicine, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi-machi, Kawachi-gun, Tochigi-ken 329-04, Japan Anwar N. Mohamed, Division of Neuro-Oncology, Sloan-Kettering Institute for Cancer Research, New York, New York, USA Malcolm A. S. Moore, Laboratory of Developmental Hematopoiesis, Sloan-Ketter- ing Institute for Cancer Research, New York, New York, USA C. Morley, Departments of Biochemistry and Medicine, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois, USA M. J. Murphy, Jr., Hipple Cancer Research Center, Dayton, Ohio, and Wright State University, Dayton, Ohio, USA Ruth Neta, Experimental Hematology Department, Armed Forces Radiobiology Re- search Institute, Bethesda, Maryland, USA
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