Evolutionary Bioinformatics

494 Pages·13.263 MB·English

by  Forsdyke, Donald R

Donald R. Forsdyke
Evolutionary
Bioinformatics
Third Edition
Evolutionary Bioinformatics

Donald R. Forsdyke
Evolutionary Bioinformatics
Third Edition
Donald R. Forsdyke
Department of Biomedical and Molecular Sciences
Queen’s University
Kingston , ON , Canada
ISBN 978-3-319-28753-9 ISBN 978-3-319-28755-3 (eBook)
DOI 10.1007/978-3-319-28755-3
Library of Congress Control Number: 2016931596
Springer Cham Heidelberg New York Dordrecht London
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In memory of Erwin Chargaff whose studies
of the base composition ‘accent’
of DNA underlie everything in this book,
and of Susumo Ohno who fi rst understood
that DNA ‘speaks’ in palindromic verses;
with many thanks to Vinay Prabhu whose
neat little 1993 paper showed the way.

Erwin Chargaff (1905-2002)

Contents
Note on the Third Edition .............................................................................. xvii
Note on the Second Edition ............................................................................ xix
Abbreviations .................................................................................................. xxi
Prologue: To Select is Not To Preserve .......................................................... xxiii
Part I Information and DNA
1 Memory: A Phenomenon of Arrangement ............................................ 3
Priorities .................................................................................................... 3
Textual and Hereditary Information .......................................................... 5
Mental Information ................................................................................... 6
Periodical Rhythms ................................................................................... 9
Food .......................................................................................................... 11
Informational Macromolecules ................................................................. 12
Translation ................................................................................................ 16
Variation .................................................................................................... 18
Latency ...................................................................................................... 21
Summary ................................................................................................... 22
References ................................................................................................. 22
2 Chargaff’s First Parity Rule .................................................................. 25
Error-Detection ......................................................................................... 25
In-Parallel Redundancy ............................................................................. 26
DNA Structure .......................................................................................... 26
Turnover and Channeling .......................................................................... 32
Promiscuous DNA .................................................................................... 33
Haploidy and Diploidy .............................................................................. 34
In-Series Redundancy ............................................................................... 35
Bits and Bats ............................................................................................. 36
Accidents and Non-Accidents ................................................................... 39
Summary ................................................................................................... 40
References ................................................................................................. 41
ix