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Evaluation of certain food additives : seventy-first report of the joint FAO/WHO expert committee on food additives PDF

2010·2.2 MB·English
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Preview Evaluation of certain food additives : seventy-first report of the joint FAO/WHO expert committee on food additives

WHOTechnicalReportSeries EVAIUATION OF CERTAIN FOOD ADDITIVES Seventy-firstreportofthe JointFAO/WHOExpertCommitteeon FoodAdditives FoodandAgriculture WorldHealth OUrngiatneidzNaattioinonosfthe Organization World Health Organization WHOTechnicalReportSeries EVALUATION OF CERTAIN FOOD ADDITIVES Seventy-firstreportofthe JointFAO/WHOExpertCommitteeon FoodAdditives FoodandAgriculture Organizationofthe UnitedNations World Health Organization EVALUATION OF CERTAIN FOOD ADDITIVES Seventy-firstreportofthe JointFAO/WHOExpertCommitteeon FoodAdditives FoodandAgriculture WorldHealth Organizationofthe Organization UnitedNations WHOLibraryCataloguing-in-PublicationData JointFAOA/VHOExpertCommitteeonFoodAdditives.Meeting(71st:2009:Geneva,Switzeriand) oSanfeFtoyodevAadlduiattiivoens.ofcertainfoodadditives:seventy-firstmeetingoftheJointFAO/WHOExpertCommittee (WHOtechnicaireportseries;956) t1o.xiFcoiotyd.a5d.dRiitsikveass-setosxsicmietny.t.2.IF.oJooidntcFonAtOam/iWnaHtOioEnx.pSe.rFtiCavoomrmiintgtaegeenotnsF-oaondaiAydsdiist.i4v.esF.iaMveoreitnigngagents- (71st:2009:Geneva,Switzerland).II.InternationalProgrammeonChemicalSafety.III.Series. ISBN9789241209564 (NLMClassification:WA712) ISSN0512-3054 ©WorldHealthOrganization2010 AWfplauolxbr:llri+dic4gah1tHtise2oa2nlrste7-hs9e1wnOh/r4eeg8dta5.hn7ei;zPraueftb-oilmroiasncilaa,:[email protected],itHa)e1.la2i1dRti1eshqtruGOieerbsugnttaeisnovinfazo-art2spi7heo,ornumSlicwdsaisbntizeoenbaredltdaoonrrbdeetspas(riteeonldd.e;udtco+efW4ro1HormOt2r2WaPnrHs7el9Osa1st,eP3Wart2eH6st4shO;,e aboveaddress(fax:+41227914806;e-mail:[email protected]). Thedesignationsemployedandthepresentationofthematerialinthispublicationdonotimplytheexpression ofanyopinionwhatsoeveronthepartoftheWorldHealthOrganizationconcerningthelegalstatusofany cDooutntterdy,litneersriotonrym,aciptsyorreparreesaenortoafppitrsoaxuitmhoartietibeos,rdoerrcloinnceserfnorinwghitchhedtehleirmeitmaatiyonnootfiytestfrboentfiuellrsagorrebeomuenndta.ries. Thementionofspecificcompaniesorofcertainmanufacturers’productsdoesnotimplythattheyareendorsed omrenrteiconoemdm.enErdreodrsbayntdheomWiosrslidonHseaelxtchepOtregda,nitzhaetinoanmiensproeffeprreopnrcieettaoryotphreordsuocftsaasriemildairstniantguurieshtehdatbyareinintioatl capitalletters. AllreasonableprecautionshavebeentakenbytheWorldHealthOrganizationtoverifytheinformation containedinthispublication.However,thepublishedmaterialisbeingdistributedwithoutwarrantyofanykind, eIintnheoreevxepnrtesshsaeldlotrheimWpolrieldd.HTehaeltrhesOprognsainbiizlaittiyofnorbteheliianbtleerfporretdataimoangaensduarsiesionfgtfhreommatietsriuasle.lieswiththereader. Thispublicationcontainsthecollectiveviewsofaninternationalgroupofexpertsanddoesnotnecessarily representthedecisionsorthepoliciesoftheWorldHealthOrganization. TypesetinIndia PrintedinIndia Contents 1. Introduction 1 1.1 Declarationsofinterests 1 2. Generalconsiderations 3 2.1 Modificationoftheagenda 3 2.2 Reportfromtheforty-firstsessionoftheCodexCommittee onFoodAdditives(CCFA) 4 2.3 Principlesgoverningtheevaluationofcompoundson theagenda 5 2.3.1 CodexGSFA-relatedquestions 5 2.3.2 JECFAperiodicre-evaluationoffoodadditives 6 2.3.3 Dataadjustmentusingfoodfrequencyquestionnaires tobetteraccountforlong-termdietaryexposure 7 2.3.4 Guidelinesforthesafetyevaluationofenzymes producedbygeneticallymodifiedmicroorganisms 8 2.4 Flexanes 8 3. Specificfoodadditives 9 3.1 Safetyevaluations 9 3.1.1 BranchingglycosyltransferasefromRhodothermus obamensisexpressedinBacillussubtllis 9 3.1.2 Cassiagum 11 3.1.3 Cyclamicacidanditssalts:dietaryexposure assessment 15 3.1.4 Cyclotetraglucoseandcyclotetraglucosesyrup 21 3.1.5 Ferrousammoniumphosphate 22 3.1.6 Glycerolesterofgumrosin 27 3.1.7 Glycerolesteroftalloilrosin 31 3.1.8 Lycopenefromallsources 35 3.1.9 Lycopeneextractfromtomato 38 33..11..1110aOMcinntdeerncaylllasossiulcII(Iclionwicanacdidmemdodiiufmievdisgcuosmitayr)acbliacssII 4400 3.1.12Sodiumhydrogensulfate 43 3.2 3R.e1v.i1s3ionSuocfrsopseeciofliicgaoteisotnserstypeIandtypeII 4469 3.2.1 Diacetyltartaricandfattyacidestersofglycerol 49 3.2.2 Ethyllauroylarginate 50 3.2.3 Glycerolesterofwoodrosin 50 3.2.4 Nisinpreparation 50 3.2.5 Nitrousoxide 51 3.2.6 Pectins 51 3.2.7 Starchsodiumoctenylsuccinate 51 3.2.8 Tannicacid 52 3.2.9 Titaniumdioxide 52 3.2.10Triethylcitrate 52 Mi 4. Futurework 53 5. Recommendation 55 Acknowledgement 57 References 59 Annex1 oRfeptohretJsoianntdFoAtOhe/rWdHoOcuEmxepenrttsCroemsmulittitnegefroonmFporoedviAodudsitmieveetsings 61 Annex2 Acceptabledailyintakes,othertoxicologicalinformationand informationonspecifications 73 Annex3 Furtherinformationrequiredordesired 79 Seventy-firstmeetingoftheJointFAO/WHOExpert CommitteeonFoodAdditives Geneva,16-24June2009 Members ProfessorJ. Bend, Departmentof Pathology, Siebens-Drake MedicalResearchInstitute,SchulichSchoolofMedicine& Dentistry, UniversityofWesternOntario, London,Ontario, Canada(Unabletoparticipate) DrY.Kawamura,DivisionofFoodAdditives,NationalInstituteof HealthSciences,Tokyo,Japan DrA.G.A.C.Knaap,Bilthoven,Netherlands DrP.M.Kuznesof,SilverSpring,MD,UnitedStatesofAmerica (USA)(Unabletoparticipate) DrJ.C.Larsen,NationalFoodInstitute,TechnicalUniversityof Denmark,Soborg,Denmark(JointRapporteur) DrA.Mattia,CenterforFoodSafetyandAppliedNutrition,Food andDrugAdministration,DepartmentofHealthandHuman Services,CollegePark,MD,USA(Vice-Chairperson) MrsI.Meyland,NationalFoodInstitute,TechnicalUniversityof Denmark,Soborg,Denmark(Chairperson) Dr Z. Olempska-Beer, Center for Food Safety and Applied Nutrition,FoodandDrugAdministration,DepartmentofHealth andHumanServices,CollegePark,MD,USA Dr J. Schlatter, Nutritional and Toxicological Risks Section, FederalOfficeofPublicHealth,Zurich,Switzerland DrM.VeerabhadraRao,DepartmentofChemistry,Collegeof Science,UnitedArabEmiratesUniversity,AlAin,UnitedArab Emirates DrP.Verger,FrenchNationalInstituteforAgriculturalResearch (INRA)-AgroParisTech,Paris,France ProfessorR.Walker,SchoolofBiomedicalandHealthSciences, UniversityofSurrey,Guildford,Surrey,UnitedKingdom MrsH.Wallin,NationalFoodSafetyAuthority(Evira),Helsinki, Finland{JointRappoiieut) DrB.Whitehouse,Bowdon,Cheshire,UnitedKingdom Secretariat MsJ.Baines,FoodStandardsAustraliaNewZealand,Canberra, ACT,Australia{FAOExpert) DrA.Bruno,JointFAO/WHOFoodStandardsProgramme,Food andAgricultureOrganizationoftheUnitedNations,Rome, Italy{FAOCodexSecretariat) DrJ.Chen,ChairmanoftheCodexCommitteeonFoodAdditives (CCFA), National Institute of Nutrition and Food Safety, Beijing,China{WHOTemporaryAdviser) DrM.Choi,DepartmentofFoodSafetyandZoonoses,World Health Organization, Geneva, Switzerland {WHO Staff Member) DrR.P.Danam,CenterforFoodSafetyandAppliedNutrition, Foodand DrugAdministration, DepartmentofHealth and HumanServices,CollegePark,MD,USA{WHOTemporary Adviser) ProfessorM.C.deFigueiredoToledo,FacultyofFoodScience, StateUniversityofCampinas,Campinas,SaoPaulo,Brazil {FAOExpert) DrM.DiNovi,CenterforFoodSafetyandAppliedNutrition,Food andDrugAdministration,DepartmentofHealthandHuman Services,CollegePark,MD,USA{WHOTemporaryAdviser) DrY. Fan, DepartmentofFoodSafetyandZoonoses,World Health Organization, Geneva, Switzerland {WHO Staff Member) DrR.Harrison,FoodStandardsAgency,London,UnitedKingdom {WHOTemporaryAdviser) DrS.M.F.Jeurissen,CentreforSubstancesandIntegratedRisk Assessment, National Institute for Public Health and the Environment, Biithoven, Netheriands {WHO Temporary Adviser) DrH.Lee,NationaiInstituteofToxicologicaiResearch,Korea Food and Drug Administration, Seoul, Republic of Korea (WHOTemporaryAdviser) ProfessorS.M.Mahungu,DairyandFoodScienceandTechnol- ogyDepartment,EgertonUniversity,Njoro,Kenya(FAOEx- pert) Dr U.W. Mueller, Food Standards Australia New Zealand, Canberra,ACT,Australia(WHOTemporaryAdviser) ProfessorS.Rath,DepartmentofAnalyticalChemistry,Institute ofChemistry,StateUniversityofCampinas,Campinas,Sao Paulo,Brazil(FAOExpert) MsM.Sheffer,Ottawa,Canada(WHOEditor) Professor I. Stankovic, Institute of Bromatology, Faculty of Pharmacy, Universityof Belgrade, Belgrade, Serbia(FAO Expert) DrA.Tritscher.DepartmentofFoodSafetyandZoonoses,World Health Organization, Geneva, Switzerland (WHO Joint Secretary) DrT. Umemura, BiologicalSafetyResearchCenter, National InstituteofHealthSciences,Tokyo,Japan(WHOTemporary Adviser) DrA.Wennberg,NutritionandConsumerProtectionDivision, Food andAgriculture Organization ofthe United Nations, Rome,Italy(FAOJointSecretary) vii aMtoinoonsgraarpehasvaoiolnatbalienfirngomsWumHmOariuensdeorftrheeletivtalne;tdataandtoxicologicalevalu- Safetyevaluationofcertainfoodadditives.WHOFoodAdditivesSeries, No.62,2010, SpecificationsareissuedseparatelybyFAOunderthetitle: Compendiumoffoodadditivespecifications.FAOJECFAMonographs7, 2009.

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