Table Of Content

European Journal of Pharmacology — Molecular Pharmacology Section, 227 (1992) 455-458 © 1992 Elsevier Science Publishers B.V. All rights reserved 0922-/4921 /0$056.0 0 Author index Aasen, A., see Waelbroeck, M. (227) 33 Bryson, S.E., see Wintersgill, H.P. (227) 283 Abbracchio, M.P., Fogliatto, G., Paoletti, A.M., Rovati, G.E. and Burbach, J.P.H. and Meijer, O.C. Cattabeni, F. The structure of neuropeptide receptors (227) 1 Prolonged in vitro exposure of rat brain slices to adenosine analogues: selective desensitization of adenosine A, but not A, Cadoni, C. and Gee, K.W. receptors (227) 317 Complex interactions between the steroid derivative RU 5135 Abe, T., see Tokumaru, H. (227) 363 and the GABA ,-receptor complex (227) 147 Abrahams, T.P. and Schofield, G.G. Campbell, A.K., see Bazan, E. (227) 343 Norepinephrine-induced Ca?* current inhibition in adult rat Camus, J., see Waelbroeck, M. (227) 33 sympathetic neurons does not require protein kinase C activation Caspar Ruegg, J., see Strauss, J.D. (227) 437 (227) 189 Casteels, R., see Missiaen, L. (227) 391 Aikawa, J., see Namiki, A. (227) 339 Cattabeni, F., see Abbracchio, M.P. (227) 317 Akil, H., see Mansour, A. (227) 205 Chan-Yeung, M., see Howard, S. (227) 123 Akiyoshi, J., see Lesch, K.P. (227) 233 Chang, C.-H., Yu, Z.-N. and Song, D.-L. Aly, M.H.M., see Mohamed, A.S. (227) 181 Formycin triphosphate as a probe for the ATP binding site Anzai, K., see Tokumaru, H. (227) 363 involved in the activation of guanylate cyclase (227) 229 Appenheimer, M., see Ko, Y. (227) 215 Chen, G., see Manji, H.K. (227) 275 Arakawa, M., see Suzuki, S. (227) 395 Chevillard, C., see Diochot, S. (227) 427 Aulakh, C.S., see Lesch, K.P. (227) 109 Chiasson, B.J., Hooper, M.L., Murphy, P.R. and Robertson, H.A. Aulakh, C.S., see Lesch, K.P. (227) 233 Antisense oligonucleotide eliminates in vivo expression of c-fos in mammalian brain (227) 451 Baganoff, M.P., see Davies, M.S. (227) 51 Chiavaroli, C., Vacher, P. and Schlegel, W. Ball, S.G., see Wintersgill, H.P. (227) 283 Modulation of Ca** influx by protein phosphorylation in single Ballesta, J.J. and Orts, A. intact clonal pituitary cells (227) 173 Interaction of opioid drugs with human platelet a,-adrenoceptors Chiu, A.T., see Leung, K.H. (227) 63 (227) 349 Christophe, J., see Delporte, C. (227) 247 Balmforth, A.J., see Wintersgill, H.P. (227) 283 Christophe, J., see Waelbroeck, M. (227) 33 Baraban, J.M., see Bhat, R.V. (227) 447 Chuang, D.-M., see Lesch, K.P. (227) 233 Basile, A.S., Paul, 1.A. and De Costa, B. Civelli, O., see Mansour, A. (227) 205 Differential effects of cytochrome P-450 induction on ligand Civelli, O., see Seeman, P. (227) 139 binding to o receptors (227) 95 Couture, R., see Hasséssian, H. (227) 103 Bast, A., see Voss, H.-P. (227) 403 Criscuoli, M., see Brown, M.C.S. (227) 163 Bazan, E., Campbell, A.K. and Rapoport, R.M. Protein kinase C activity in blood vessels from normotensive and spontaneously hypertensive rats (227) 343 Daly, J.W., see Murata, M. (227) 43 Bergmann, J.S., see Johnson, K.M. (227) 411 Davies, M.S., Baganoff, M.P., Grishin, E.V., Lanthorn, T.H., Volkova, Bertacco, S., see Muccioli, G. (227) 293 T.M., Watson, G.B. and Wiegand, R.C. Bettini, E., see Spreafico, E. (227) 353 Polyamine spider toxins are potent un-competitive antagonists of Bhat, R.V. and Baraban, J.M. rat cortex excitatory amino acid receptors (227) 51 High basal expression of zif268 in cortex is dependent on intact De Costa, B., see Basile, A.S. (227) 95 noradrenergic system (227) 447 De Costa, B., see Reith, M.E.A. (227) 417 Biagi, M., see Brown, M.C.S. (227) 163 DeHaven-Hudkins, D.L., Fleissner, L.C. and Ford-Rice, F.Y. Bidlack, J.M., Saripalli, L.D. and Lawrence, D.M.P. Characterization of the binding of [*H)(+)-pentazocine to o «k-Opioid binding sites on a murine lymphoma cell line (227) 257 recognition sites in guinea pig brain (227) 371 Bitran, J.A., see Manji, H.K. (227) 275 Delporte, C., Poloczek, P., Tastenoy, M., Winand, J. and Christophe, Brands, J., see Stam, N.J. (227) 153 J. Briggs, R.S.J., see Porter, R.H.P. (227) 83 Atrial natriuretic peptide binds to ANP-R, receptors in neuro- Brogrs, O., see Stokke, M. (227) 379 blastoma cells or is degraded extracellularly at the Ser-Phe bond Brown, M.C.S., Biagi, M., Renzetti, A.R., Rovero, P., Criscuoli, M. (227) 247 and Mizrahi, J. Demchyshyn, L., see Miller, K.J. (227) 99 ['*>]]His-neurokinin A binds selectively to NK, receptors of the De Smedt, H., see Missiaen, L. (227) 391 B-type in rat small intestine smooth muscle membranes (227) 163 Diamond, J., see Langlands, J.M. (227) 131 Bruinvels, A.T., Landwehrmeyer, B., Moskowitz, M.A. and Hoyer, Di Carlo, R., see Muccioli, G. (227) 293 D. Dijkema, R., see Stam, N.J. (227) 153 Evidence for the presence of 5-HT,, receptor messenger RNA in Diochot, S., Vittet, D., Mathieu, M.-N., Launay, J.-M. and Chevil- neurons of the rat trigeminal ganglia (227) 357 lard, C. 456 Effects of endothelins on the human megakaryoblastic cell line Ishikawa, M., see Namiki, A. (227) 339 MEG-01 (227) 427 Iso, Y., see Harada, J. (227) 301 Donnell, D., see Voss, H.-P. (227) 403 Droogmans, G., see Missiaen, L. (227) 391 Jacobson, A.E., see Reith, M.E.A. (227) 417 Diising, R., see Ko, Y. (227) 215 Jiang, H., see Yamamoto, S. (227) 113 Johnson, K.M., Bergmann, J.S. and Kozikowski, A.P. Eiger, S., see Lameh, J. (227) 19 Cocaine and dopamine differentially protect [*H]mazindol bind- El-Fakahany, E.E., see Mohamed, A.S. (227) 181 ing sites from alkylation by N-ethylmaleimide (227) 411 Joyce, J.N., see Murray, A.M. (227) 443 Faunce, D.M., see Sawutz, D.G. (227) 309 Fleissner, L.C., see DeHaven-Hudkins, D.L. (227) 371 Kase, H., see Miki, I. (227) 199 Fogliatto, G., see Abbracchio, M.P. (227) 317 Kato, R., see Yamamoto, S. (227) 113 Folger, W.H., Halushka, P.V., Wilcox, C.S. and Guzman, N.J. King, A., see Miller, K.J. (227) 99 Characterization of rat glomerular thromboxane A, receptors: Kirino, Y., see Tokumaru, H. (227) 363 comparison to rat platelets (227) 71 Ko, Y., Gorg, A., Appenheimer, M., Wieczorek, A.J., Dusing, R.., Ford-Rice, F.Y., see DeHaven-Hudkins, D.L. (227) 371 Vetter, H. and Sachinidis, A. Forray, C., see Mohamed, A.S. (227) 181 Losartan inhibits the angiotensin II-induced stimulation of the Fredholm, B.B., see Kontny, E. (227) 333 phosphoinositide signalling system in vascular smooth muscle Fukazawa, M., see Namiki, A. (227) 339 cells (227) 215 Kondo, Y., see Tada, S. (227) 25 Garcia-Sainz, J.A., Macias-Silva, M., Olivares-Reyes, A. and Kontny, E., Kvanta, A. and Fredholm, B.B. Romero-Avila, M.T. Activation of protein kinase C and elevation of cAMP interact Histamine activates phosphorylase and inositol phosphate pro- synergistically to raise c-Fos and AP-1 activity in Jurkat cells duction in guinea pig hepatocytes (227) 325 (227) 333 Garcia-Sainz, J.A., Romero-Avila, M.T., Olivares-Reyes, J.A. and Kozikowski, A.P., see Johnson, K.M. (227) 411 Macias-Silva, M. Krause, K.-H., Van Delden, C., Huggler, E., Monod, A. and Lew, Guinea pig hepatocyte a,,-adrenoceptors: characterization, sig- D.P. nal transduction and regulation (227) 239 Differential effects on neutrophil activation of staurosporin and Gee, K.W., see Cadoni, C. (227) 147 its protein kinase C-selective derivative cgp 41231 (227) 221 Gorg, A., see Ko, Y. (227) 215 Kristensen, P., see Thomsen, C. (227) 361 Grishin, E.V., see Davies, M.S. (227) 51 Kvanta, A., see Kontny, E. (227) 333 Guan, H.-c., see Seeman, P. (227) 139 Gusovsky, F., see Manji, H.K. (227) 275 Lambrecht, G., see Waelbroeck, M. (227) 33 Gusovsky, F., see Murata, M. (227) 43 Lameh, J., Eiger, S. and Sadée, W. Guzman, N.J., see Folger, W.H. (227) 71 Interaction among p-opioid receptors and a,-adrenoceptors on SH-SY5Y human neuroblastoma cells (227) 19 Hagelin, E.M., see Stokke, M. (227) 379 Haldeman, B., see Thomsen, C. (227) 361 Landwehrmeyer, B., see Bruinvels, A.T. (227) 357 Halushka, P.V., see Folger, W.H. (227) 71 Langlands, J.M. and Diamond, J. Harada, J., Ueda, H., Iso, Y. and Satoh, M. Translocation of protein kinase C in bovine tracheal smooth Affinity cross-linked 6-opioid receptor in NG108-15 cells is low muscle strips: the effect of methacholine and isoprenaline (227) molecular weight (25 kDa) and coupled to GTP-binding proteins 131 (227) 301 Lanthorn, T.H., see Davies, M.S. (227) 51 Hasséssian, H., Prat, A. and Couture, R. Launay, J.-M., see Diochot, S. (227) 427 Anaesthetic doses of pentobarbital antagonize phosphatidylinosi- Lawrence, D.M.P., see Bidlack, J.M. (227) 257 tol hydrolysis induced by substance P or carbachol in the spinal Lesch, K.P., Aulakh, C.S., Wolozin, B.L., Hill, J.L. and Murphy, D.L. cord and cerebral cortex of the rat (227) 103 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid decreases Haycock, D., see Sawutz, D.G. (227) 309 NMDA receptor mRNA (227) 109 Healy, D.P., see Ye, M.-Q. (227) 79 Lesch, K.P., Hough, C.J., Aulakh, C.S., Wolozin, B.L., Tolliver, T.J., Hill, J.L., see Lesch, K.P. (227) 109 Hill, J.L., Akiyoshi, J., Chuang, D.-M. and Murphy, D.L. Hill, J.L., see Lesch, K.P. (227) 233 Fluoxetine modulates G protein a,, a, and a, subunit MRNA Hirata, Y., see Namiki, A. (227) 339 expression in rat brain (227) 233 Holopainen, I., Rau, C. and Wojcik, W.J. Leung, K.H., Roscoe, W.A., Smith, R.D., Timmermans, P.B.M.W.M. Proposed antagonists at GABA, receptors that inhibit adenylyl and Chiu, A.T. cyclase in cerebellar granule cell cultures of rat (227) 225 Characterization of biochemical responses of angiotensin II (AT,) Hooper, M.L., see Chiasson, B.J. (227) 451 binding sites in the rat pheochromocytoma PC12W cells (227) 63 Houck, W.T., see Sawutz, D.G. (227) 309 Lew, D.P., see Krause, K.-H. (227) 221 Hough, C.J., see Lesch, K.P. (227) 233 Liu, Y., see Von Euler, G. (227) 449 Lomasney, J.W., see Schwinn, D.A. (227) 433 Howard, S., Chan-Yeung, M., Martin, L., Phaneuf, S. and Salari, H. Polyphosphoinositide hydrolysis and protein kinase C activation in guinea pig tracheal smooth muscle cells in culture by Machii, K., see Namiki, A. (227) 339 leukotriene D, involve a pertussis toxin sensitive G-protein (227) Macias-Silva, M., see Garcia-Sainz, J.A. (227) 239 123 Macias-Silva, M., see Garcia-Sainz, J.A. (227) 325 Hoyer, D., see Bruinvels, A.T. (227) 357 Maggi, A., see Spreafico, E. (227) 353 Huggler, E., see Krause, K.-H. (227) 221 Mais, D.E., True, T.A. and Martinelli, M.J. Characterization by photoaffinity labelling of the human platelet Ishihara, M., see Yamamoto, S. (227) 113 thromboxane A,/prostaglandin H, receptor: evidence for N- Ishii, A., see Miki, I. (227) 199 linked glycosylation (227) 267 Maksay, G. Pollio, G., see Spreafico, E. (227) 353 Modification of benzodiazepine receptors supports the distinctive Poloczek, P., see Delporte, C. (227) 247 role of histidine residues (227) 57 Porter, R.H.P., Briggs, R.S.J. and Roberts, P.J. Manji, H.K., Chen, G., Bitran, J.A., Gusovsky, F. and Potter, W.Z. Modulation of [*H]3-(( + )-2-carboxypiperazin-4-yl)propyl-1-phos- Idazoxan down-regulates B-adrenoceptors on C6 glioma cells in phonic acid ((7HJCPP) binding by ligands acting at the glycine vitro (227) 275 and the polyamine sites of the rat brain NMDA receptor complex Mansour, A., Meng, F., Meador-Woodruff, J.H., Taylor, L.P., Civelli, (227) 83 O. and Akil, H. Potter, W.Z., see Manji, H.K. (227) 275 Site-directed mutagenesis of the human dopamine D, receptor Poulsson, C., see Stokke, M. (227) 379 (227) 205 Prat, A., see Hasséssian, H. (227) 103 Martin, L., see Howard, S. (227) 123 Rapoport, R.M., see Bazan, E. (227) 343 Martinelli, M.J., see Mais, D.E. (227) 267 Rau, C., see Holopainen, I. (227) 225 Mathieu, M.-N., see Diochot, S. (227) 427 Reiser, G. Meador-Woodruff, J.H., see Mansour, A. (227) 205 Nitric oxide formation caused by Ca** release from internal Meijer, O.C., see Burbach, J.P.H. (227) 1 stores in neuronal cell line is enhanced by cyclic AMP (227) 89 Meng, F., see Mansour, A. (227) 205 Reith, M.E.A., De Costa, B., Rice, K.C. and Jacobson, A.E. Miki, I., Kase, H. and Ishii, A. Differences in activities of thromboxane A, receptor antagonists Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter (227) 417 in smooth muscle cells (227) 199 Rengel, I., Sinowatz, F. and Schulz, R. Miller, K.J., King, A., Demchyshyn, L., Niznik, H. and Teitler, M. Opioid-controlled adenylate cyclase in the guinea-pig myenteric Agonist activity of sumatriptan and metergoline at the human plexus is confined to nerve somata (227) 385 S-HT pg receptor: further evidence for a role of the 5-HT,p Renzetti, A.R., see Brown, M.C.S. (227) 163 receptor in the action of sumatriptan (227) 99 Rice, K.C., see Reith, M.E.A. (227) 417 Missiaen, L., De Smedt, H., Droogmans, G. and Casteels, R. Roberts, P.J., see Porter, R.H.P. (227) 83 2,5-Di-(tert-butyl)-1,4-benzohydroquinone and cyclopiazonic acid Robertson, H.A., see Chiasson, B.J. (227) 451 decrease the Ca”* permeability of endoplasmic reticulum (227) Romero-Avila, M.T., see Garcia-Sainz, J.A. (227) 239 391 Romero-Avila, M.T., see Garcia-Sainz, J.A. (227) 325 Mitsui, Y., see Tada, S. (227) 25 Roscoe, W.A., see Leung, K.H. (227) 63 Mizrahi, J., see Brown, M.C.S. (227) 163 Rovati, G.E., see Abbracchio, M.P. (227) 317 Mohamed, A.S., Forray, C., Aly, M.H.M. and El-Fakahany, E.E. Rovero, P., see Brown, M.C.S. (227) 163 Lack of intrinsic activity and significant subtype selectivity of SR Ryoo, H., see Murray, A.M. (227) 443 95639A at muscarinic receptors (227) 181 Monod, A., see Krause, K.-H. (227) 221 Sachinidis, A., see Ko, Y. (227) 215 Moroi, M., see Namiki, A. (227) 339 Sadée, W., see Lameh, J. (227) 19 Moskowitz, M.A., see Bruinvels, A.T. (227) 357 Sakatume, M., see Suzuki, S. (227) 395 Muccioli, G., Scordamaglia, A., Bertacco, S. and Di Carlo, R. Salari, H., see Howard, S. (227) 123 Effect of S-adenosyl-L-methionine on brain muscarinic receptors Saripalli, L.D., see Bidlack, J.M. (227) 257 of aged rats (227) 293 Sato, H., see Suzuki, S. (227) 395 Mulvihill, E., see Thomsen, C. (227) 361 Satoh, M., see Harada, J. (227) 301 Murata, M., Gusovsky, F., Yasumoto, T. and Daly, J.W. Sawutz, D.G., Faunce, D.M., Houck, W.T. and Haycock, D. Selective stimulation of Ca* flux in cells by maitotoxin (227) 43 Characterization of bradykinin B, receptors on human IMR-90 Murphy, D.L., see Lesch, K.P. (227) 109 lung fibroblasts: stimulation of *Ca** efflux by D-Phe’ substi- Murphy, D.L., see Lesch, K.P. (227) 233 tuted bradykinin analogues (227) 309 Murphy, P.R., see Chiasson, B.J. (227) 451 Schjelderup, L., see Waelbroeck, M. (227) 33 Murray, A.M., Ryoo, H. and Joyce, J.N. Schlegel, W., see Chiavaroli, C. (227) 173 Visualization of dopamine D,-like receptors in human brain with Schofield, G.G., see Abrahams, T.P. (227) 189 [!*>Tepidepride (227) 443 Schulz, R., see Rengel, I. (227) 385 Mutschler, E., see Waelbroeck, M. (227) 33 Schwinn, D.A. and Lomasney, J.W. Pharmacologic characterization of cloned a,-adrenoceptor sub- Namiki, A., Hirata, Y., Fukazawa, M., Ishikawa, M., Moroi, M., types: selective antagonists suggest the existence of a fourth Aikawa, J., Yamaguchi, T. and Machii, K. subtype (227) 433 Granulocyte-colony stimulating factor stimulates immunoreactive Scordamaglia, A., see Muccioli, G. (227) 293 endothelin-1 release from cultured bovine endothelial cells (227) Seeman, P., Guan, H.-c., Civelli, O., Wan Tol, H.H.M., Sunahara, 339 R.K. and Niznik, H.B. Nishikawa, K., see Yamamoto, S. (227) 113 The cloned dopamine D, receptor reveals different densities for Niznik, H., see Miller, K.J. (227) 99 dopamine receptor antagonist ligands. Implications for human Niznik, H.B., see Seeman, P. (227) 139 brain positron emission tomography (227) 139 Sinowatz, F., see Rengel, I. (227) 385 Okajima, F., see Tada, S. (227) 25 Smith, R.D., see Leung, K.H. (227) 63 Olijve, W., see Stam, N.J. (227) 153 Song, D.-L., see Chang, C.-H. (227) 229 Olivares-Reyes, A., see Garcia-Sainz, J.A. (227) 325 Spreafico, E., Bettini, E., Pollio, G. and Maggi, A. Olivares-Reyes, J.A., see Garcia-Sainz, J.A. (227) 239 Nucleotide sequence of estrogen receptor cDNA from Sprague- Orts, A., see Ballesta, J.J. (227) 349 Dawley rat (227) 353 Stam, N.J., Van Huizen, F., Van Alebeek, C., Brands, J., Dijkema, Paoletti, A.M., see Abbracchio, M.P. (227) 317 R., Tonnaer, J.A.D.M. and Olijve, W. Paul, I.A., see Basile, A.S. (227) 95 Genomic organization, coding sequence and functional expres- Phaneuf, S., see Howard, S. (227) 123 sion of human 5-HT, and 5-HT,, receptor genes (227) 153 458 Stokke, M., Hagelin, E.M., Poulsson, C. and Br@grs, O. Vetter, H., see Ko, Y. (227) 215 Ca** modulates the inhibition of (+)-[*H]isradipine binding by Vittet, D., see Diochot, S. (227) 427 amiloride and quinacrine (227) 379 Volkova, T.M., see Davies, M.S. (227) 51 Strauss, J.D., Zeugner, C. and Caspar Riegg, J. Von Euler, G. and Liu, Y. The positive inotropic calcium sensitizer EMD 53998 antagonizes The glutamate- and glycine-induced reduction of [7H]MK-801 phosphate action on cross-bridges in cardiac skinned fibers (227) binding in the presence of Mg** is reversed at low pH (227) 449 437 Voss, H.-P., Donnell, D. and Bast, A. Strohmann, C., see Waelbroeck, M. (227) 33 Atypical molecular pharmacology of a new long-acting B,-adre- Sugai, K., see Suzuki, S. (227) 395 noceptor agonist, TA 2005 (227) 403 Sunahara, R.K., see Seeman, P. (227) 139 Suzdak, P.D., see Thomsen, C. (227) 361 Waelbroeck, M., Camus, J., Tastenoy, M., Mutschler, E., Strohmann, Suzuki, S., Sugai, K., Sato, H., Sakatume, M. and Arakawa, M. C., Tacke, R., Schjelderup, L., Aasen, A., Lambrecht, G. and Inhibition of active oxygen generation by dipyridamole in human Christophe, J. polymorphonuclear leukocytes (227) 395 Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, Tacke, R., see Waelbroeck, M. (227) 33 with four muscarinic receptors (227) 33 Tada, S., Okajima, F., Mitsui, Y., Kondo, Y. and Ui, M. Wang, J.C., see Yamamoto, S. (227) 113 P, purinoceptor-mediated cyclic AMP accumulation in bovine Warburton, P., see Wintersgill, H.P. (227) 283 vascular smooth muscle cells (227) 25 Watson, G.B., see Davies, M.S. (227) 51 Tastenoy, M., see Delporte, C. (227) 247 Wieczorek, A.J., see Ko, Y. (227) 215 Tastenoy, M., see Waelbroeck, M. (227) 33 Wiegand, R.C., see Davies, M.S. (227) 51 Taylor, L.P., see Mansour, A. (227) 205 Wilcox, C.S., see Folger, W.H. (227) 71 Teitler, M., see Miller, K.J. (227) 99 Winand, J., see Delporte, C. (227) 247 Thomsen, C., Kristensen, P., Mulvihill, E., Haldeman, B. and Suz- Wintersgill, H.P., Warburton, P., Bryson, S.E., Ball, S.G. and Balm- dak, P.D. forth, A.J. L-2-Amino-4-phosphonobutyrate (L-AP4) is an agonist at the Characterization of the angiotensin II receptor expressed by the type IV metabotropic glutamate receptor which is negatively human hepatoma cell line, PLC-PRF-5 (227) 283 coupled to adenylate cyclase (227) 361 Wojcik, W.J., see Holopainen, I. (227) 225 Timmermans, P.B.M.W.M., see Leung, K.H. (227) 63 Wolozin, B.L., see Lesch, K.P. (227) 109 Tokumaru, H., Anzai, K., Abe, T. and Kirino, Y. Wolozin, B.L., see Lesch, K.P. (227) 233 Purification of the cardiac 1,4-dihydropyridine receptor using immunoaffinity chromatography with a monoclonal antibody Yamaguchi, T., see Namiki, A. (227) 339 against the a,6 subunit of the skeletal muscle dihydropyridine receptor (227) 363 Yamamoto, S., Jiang, H., Nishikawa, K., Ishihara, M., Wang, J.C. and Kato, R. Tolliver, T.J., see Lesch, K.P. (227) 233 Protein kinase C-dependent and -independent actions of a potent Tonnaer, J.A.D.M., see Stam, N.J. (227) 153 protein kinase C inhibitor, staurosporine (227) 113 True, T.A., see Mais, D.E. (227) 267 Yasumoto, T., see Murata, M. (227) 43 Ye, M.-Q., Yuan, L.-X. and Healy, D.P. Ueda, H., see Harada, J. (227) 301 Effects of intracerebroventricular captopril on angiotensin-con- Ui, M., see Tada, S. (227) 25 verting enzyme and angiotensinogen mRNA levels in rat brain (227) 79 Vacher, P., see Chiavaroli, C. (227) 173 Yu, Z.-N., see Chang, C.-H. (227) 229 Van Alebeek, C., see Stam, N.J. (227) 153 Yuan, L.-X., see Ye, M.-Q. (227) 79 Van Delden, C., see Krause, K.-H. (227) 221 Van Huizen, F., see Stam, N.J. (227) 153 Van Tol, H.H.M., see Seeman, P. (227) 139 Zeugner, C., see Strauss, J.D. (227) 437 European Journal of Pharmacology — Molecular Pharmacology Section, 227 (1992) 459-467 © 1992 Elsevier Science Publishers B.V. All rights reserved 0922-/4921 /0$056.0 0 Key word index Acetylcholine release a@ ,,-Adrenoceptors SR 95639A; Muscarinic receptor agonists (selective); Muscarinic Adrenoceptors; Phosphoinositide turnover; Phosphorylase (Garcia- receptor subtypes; Phosphoinositides; cAMP (Mohamed, A.S. (227) Sainz, J.A. (227) 239) 181) a,-Adrenoceptors Action potentials Clonidine; Norepinephrine; Morphine; u-Opioid receptors; Adenylyl Ca**; Pituitary; Protein kinase A; Protein kinase C; Okadaic acid cyclase inhibition; Neuroblastoma SH-SYSY cells; Retinoic acid (Chiavaroli, C. (227) 173) (Lameh, J. (227) 19) Adenosine receptors a ,-Adrenoceptors Phorbol esters; Adenylyl cyclase; Gene transcription; T-lymphocytes Platelets (human): Opioids (Ballesta, J.J. (227) 349) (Kontny, E. (227) 333) B-Adrenoceptors Adenosine A, receptors Idazoxan; Antidepressants; Adenylyl cyclase; C6 glioma cells; Protein Adenosine A, receptors; Neuroprotection; Brain (rat); Desensitiza- kinase C (Manji, H.K. (227) 275) tion (agonist induced) (Abbracchio, M.P. (227) 317) Affinity cross-linking Adenosine A, receptors Opioid receptors; G-proteins; NG108-15 cells (Harada, J. (227) 301) Adenosine A, receptors; Neuroprotection; Brain (rat); Desensitiza- tion (agonist induced) (Abbracchio, M.P. (227) 317) Aging S-Adenosyl-L-methionine; Brain; Muscarinic receptors; Striatum; S-Adenosyl-L-methionine Hippocampus (Muccioli, G. (227) 293) Brain; Aging; Muscarinic receptors; Striatum; Hippocampus (Muc- cioli, G. (227) 293) Amiloride 3,4-Dichlorobenzamil; Quinacrine; Ca?*; Ca** channel blockers; Adenylate cyclase L-type Ca?* channels (Stokke, M. (227) 379) Myenteric plexus (guinea-pig); -Opioid receptors (pre- and post- synaptic) (Rengel, I. (227) 385) L-2-Amino-4-phosphonobutyrate (L-AP4) Metabotropic glutamate receptors; cAMP (Thomsen, C. (227) 361) Adenylyl cyclase Idazoxan; Antidepressants; B-Adrenoceptors; C6 glioma cells; Pro- cAMP tein kinase C (Manji, H.K. (227) 275) P, Purinoceptors; Smooth muscle cells (vascular) (Tada, S. (227) 25) Phorbol esters; Adenosine receptors; Gene transcription; T-lympho- 5-HT receptors; Sumatriptan; 5-HT,pg receptors (Miller, K.J. (227) cytes (Kontny, E. (227) 333) 99) Adenylyl cyclase inhibition SR 95639A; Muscarinic receptor agonists (selective); Muscarinic Clonidine; Norepinephrine; a,-Adrenoceptors; Morphine; ,.-Opioid receptor subtypes; Phosphoinositides; Acetylcholine release (Mo- receptors; Neuroblastoma SH-SY5Y cells; Retinoic acid (Lameh, J. hamed, A.S. (227) 181) (227) 19) GABA , receptors; GABA (y-aminobuteric acid); Adenylyl cyclase Adenylyl cyclase (inhibition) (inhibition); Baclofen; Cerebellar granule cells (Holopainen, I. (227) GABA g receptors; GABA (y-aminobuteric acid); cAMP; Baclofen; 225) Cerebellar granule cells (Holopainen, I. (227) 225) Metabotropic glutamate receptors; L-2-Amino-4-phosphonobutyrate B,-Adrenoceptor agonists (long acting) (L-AP4) (Thomsen, C. (227) 361) Ternary complex; Tight agonist binding; Tracheal smooth muscle relaxation (Voss, H.-P. (227) 403) AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) Spider toxins; Excitatory amino acid receptors; NMDA (N-methyl- Adrenoceptors D-aspartic acid); Kainate (Davies, M.S. (227) 51) a,,-Adrenoceptors; Phosphoinositide turnover; Phosphorylase (Garcia-Sainz, J.A. (227) 239) d-Amphetamine Dopamine transport; N-Ethylmaleimide alkylation; Cocaine; [>H]- Catecholamines; Inositol phosphates (Schwinn, D.A. (227) 433) Mazindol binding (Johnson, K.M. (227) 411) 460 Anesthesia Brain (guinea pig) Substance P; Inositol phosphates; Spinal cord; Cerebral cortex; Pen- o Receptors; Radioreceptor assay; (+)-Pentazocine (DeHaven- tobarbital (Hasséssian, H. (227) 103) Hudkins, D.L. (227) 371) Angiotensin-converting enzyme Brain (rat) Converting enzyme inhibitors; Captopril; Angiotensinogen; Solution Adenosine A, receptors; Adenosine A, receptors; Neuroprotection; hybridization /RNase protection (Ye, M.-Q. (227) 79) Desensitization (agonist induced) (Abbracchio, M.P. (227) 317) Angiotensin II receptors Bronchodilators PLC-PRF-5; Hepatoma cells; (Radioligand binding); (Receptor sub- Protein kinase C; Trachealis (bovine); Smooth muscle contraction; types) (Wintersgill, H.P. (227) 283) Cholinomimetics (Langlands, J.M. (227) 131) Angiotensin II receptor subtypes BTCP (N[1-(2-benzo[b]thiophenyl)cyclpoihpeerxiydlin]e ) GBR PC12W; Signal transduction pathways (Leung, K.H. (227) 63) 12935 [SH]CFT (2B-carbomethoxy-38-(4-fluorophenyl)-tropane) binding; Angiotensinogen Cocaine; Dopamine uptake inhibitors; Striatum (rat) (Reith, M.E.A. Angiotensin-converting enzyme; Converting enzyme inhibitors; Cap- (227) 417) topril; Solution hybridization /RNase protection (Ye, M.-Q. (227) 79) 2,3-Butanedione ANP-R, receptors Benzodiazepine receptors (central); Modification of receptors; [*H]- cGMP; Neutral metalloendopeptidase; Human neuroblastoma cell Ro 15-4513 binding; GABA , receptors (a subunits); Diethylpyrocar- line NB-OK1 (Delporte, C. (227) 247) bonate (Maksay, G. (227) 57) Antidepressants Ca*+ Idazoxan; B-Adrenoceptors; Adenylyl cyclase; C6 glioma cells; Pro- Action potentials; Pituitary; Protein kinase A; Protein kinase C; tein kinase C (Manji, H.K. (227) 275). Okadaic acid (Chiavaroli, C. (227) 173) A7r5 aortic cells Smooth muscle (vascular); Protein kinase C activity (cytosolic, partic- 2,5-Di-(tert-butyl)-1,4-benzohydroquinone; Cyclopiazonic acid; Ca** ulate); Phorbol esters (Bazan, E. (227) 343) permeability (Missiaen, L. (227) 391) Amiloride; 3,4-Dichlorobenzamil; Quinacrine; Ca** channel block- ATP ers; L-type Ca**+ channels (Stokke, M. (227) 379) Formycin A triphosphate (FTP); Guanylate cyclase; Atrial natri- uretic factor (ANF); cGMP (Chang, C.-H. (227) 229) Endothelins; Megakaryoblastic cells; Inositol phosphates (Diochot, S. (227) 427) Atrial natriuretic factor (ANF) Formycin A triphosphate (FTP); Guanylate cyclase; ATP; cGMP Ca** channel blockers (Chang, C.-H. (227) 229) ‘ Amiloride; 3,4-Dichlorobenzamil; Quinacrine; Ca**; L-type Ca?* channels (Stokke, M. (227) 379) Baclofen GABA, receptors; GABA (y-aminobuteric acid); Adenylyl cyclase Ca?* channels (inhibition); cAMP; Cerebellar granule cells (Holopainen, I. (227) Maitotoxin; Cation blockers; Liposomes (Murata, M. (227) 43) 225) Dihydropyridine receptors; Monoclonal antibodies; Purification; Benzodiazepine receptors (central) Cardiac sarcolemma (Tokumaru, H. (227) 363) Modification of receptors; [*H]Ro 15-4513 binding; GABA, 4 recep- tors (a subunits); Diethylpyrocarbonate; 2,3-Butanedione (Maksay, L-type Ca7* channels G. (227) 57) Amiloride; 3,4-Dichlorobenzamil; Quinacrine; Ca**; Ca** channel blockers (Stokke, M. (227) 379) Bradykinin cGMP; Endothelin; EDRF (endothelium-derived relaxing factor); Ca?* concentrations (intracellular) Forskolin; 5-HT (serotonin) (Reiser, G. (227) 89) Thromboxane A.,/prostaglandin H, receptors (TXA,/PGH, re- ceptors); Smooth muscle cells (vascular); Thromboxane A, receptor Bradykinin receptors; Bradykinin receptor antagonists; IMR-90 cells antagonist (KW-3635 and BM-13505) (Miki, I. (227) 199) (Sawutz, D.G. (227) 309) Ca?* current Bradykinin receptor antagonists Norepinephrine; Protein kinase C; 1,2-Dioctanoylglycerol; Whole-cell Bradykinin; Bradykinin receptors; IMR-90 cells (Sawutz, D.G. (227) voltage clamp; Sympathetic ganglia (Abrahams, T.P. (227) 189) 309) Ca’** permeability Bradykinin receptors 2,5-Di-(tert-butyl)-1,4-benzohydroquinone; Cyclopiazonic acid; A7r5 Bradykinin; Bradykinin receptor antagonists; IMR-90 cells (Sawutz, aortic cells (Missiaen, L. (227) 391) D.G. (227) 309) Captopril Brain Angiotensin-converting enzyme; Converting enzyme inhibitors; An- S-Adenosyl-L-methionine; Aging; Muscarinic receptors; Striatum; giotensinogen; Solution hybridization /RNase protection (Ye, M.-Q. Hippocampus (Muccioli, G. (227) 293) (227) 79) 461 Cardiac muscle (skinned) [SHICPP ([°H]3-((+ )-2-carboxypiperazin-4-yl) propyl-1-phosphonic Ca** sensitization; Muscle regulation; Inorganic phosphate; EMD acid) binding 53998 (Strauss, J.D. (227) 437) NMDA receptors; HA-966; Glycine; Polyamines (Porter, R.H.P. (227) 83) Cardiac sarcolemma Dihydropyridine receptors; Ca** channels; Monoclonal antibodies; Cyclopiazonic acid Purification (Tokumaru, H. (227) 363) 2,5-Di-(tert-butyl)-1,4-benzohydroquinone; Ca** permeability; A7r5 aortic cells (Missiaen, L. (227) 391) Ca’* sensitization Cardiac muscle (skinned); Muscle regulation; Inorganic phosphate; Cytochrome P-450 EMD 53998 (Strauss, J.D. (227) 437) ao Receptors; Phenobarbital; 3-Methylcholanthrene (Basile, A.S. (227) 95) Catecholamine receptors Dopamine D, receptors; Mutagenesis; Receptor binding (Mansour, Degranulation A. (227) 205) Neutrophil; Respiratory burst; Protein kinase C; Staurosporin; cgp 41251 (Krause, K.-H. (227) 221) Catecholamines Adrenoceptors; Inositol phosphates (Schwinn, D.A. (227) 433) Desensitization (agonist induced) Cation blockers Adenosine A, receptors; Adenosine A, receptors; Neuroprotection; Maitotoxin; Ca7* channels; Liposomes (Murata, M. (227) 43) Brain (rat) (Abbracchio, M.P. (227) 317) Cerebellar granule cells 3,4-Dichlorobenzamil GABA, receptors; GABA (y-aminobuteric acid); Adenylyl cyclase Amiloride; Quinacrine; Ca**; Ca**+ channel blockers; L-type Ca** (inhibition); cAMP; Baclofen (Holopainen, I. (227) 225) channels (Stokke, M. (227) 379) Cerebral cortex Diethylpyrocarbonate Substance P; Inositol phosphates; Spinal cord; Anesthesia; Pentobar- Benzodiazepine receptors (central); Modification of receptors; bital (Hasséssian, H. (227) 103) [7H]JRo 15-4513 binding; GABA, receptors (a@ subunits); 2,3- Butanedione (Maksay, G. (227) 57) C6 glioma cells Idazoxan; Antidepressants; B-Adrenoceptors; Adenylyl cyclase; Pro- Dihydropyridine receptors tein kinase C (Manji, H.K. (227) 275) Ca*+ channels; Monoclonal antibodies; Purification; Cardiac sar- colemma (Tokumaru, H. (227) 363) [7H]CFT (28-carbomethoxy-3f-(4-fluorophenyl)-tropane) binding Cocaine; BTCP (N[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine) 1,2-Dioctanoylglycerol GBR 12935; Dopamine uptake inhibitors; Striatum (rat) (Reith, Norepinephrine; Protein kinase C; Ca“* 2+ current; Whole-cell voltage M.E.A. (227) 417) clamp; Sympathetic ganglia (Abrahams, T.P. (227) 189) cgp 41251 Dipyridamole Neutrophil; Respiratory burst; Degranulation; Protein kinase C; Scavenging effects; Electron spin resonance; Hydroxyl radicals; Su- Staurosporin (Krause, K.-H. (227) 221) peroxide anions (Suzuki, S. (227) 395) Cholinomimetics Protein kinase C; Trachealis (bovine); Smooth muscle contraction; 2,5-Di-(tert-butyl)-1,4-benzohydroquinone Bronchodilators (Langlands, J.M. (227) 131) Cyclopiazonic acid; Ca** permeability; A7r5 aortic cells (Missiaen, L. (227) 391) Clonidine Norepinephrine; a,-Adrenoceptors; Morphine; w-Opioid receptors; Dopamine receptor antagonist ligands Adenylyl cyclase inhibition; Neuroblastoma SH-SYSY cells; Retinoic Dopamine D, receptors; Positron emission tomography (human acid (Lameh, J. (227) 19) brain) (Seeman, P. (227) 139) Cloning of receptors Dopamine D, receptors G-protein-coupled receptors; Neuropeptides; Neurokinin-type re- Dopamine receptor antagonist ligands; Positron emission tomogra- ceptors; Secretin-type receptors (Burbach, J.P.H. (227) 1) phy (human brain) (Seeman, P. (227) 139) Cocaine Mutagenesis; Receptor binding; Catecholamine receptors (Mansour, Dopamine transport; N-Ethylmaleimide alkylation; d-Amphetamine; A. (227) 205) [>H]Mazindol binding (Johnson, K.M. (227) 411) Dopamine D, receptors; Striatum (Murray, A.M. (227) 443) [7HICFT (2f-carbomethoxy-38-(4-fluorophenyl)-tropane) binding; BTCP (N[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine) GBR 12935; Dopamine uptake inhibitors; Striatum (rat) (Reith, M.E.A. (227) Dopamine D, receptors 417) Dopamine D, receptors; Striatum (Murray, A.M. (227) 443) Converting enzyme inhibitors Dopamine transport Angiotensin-converting enzyme; Captopril; Angiotensinogen; Solu- N-Ethylmaleimide alkylation; Cocaine; d-Amphetamine; [7HI]- tion hybridization /RNase protection (Ye, M.-Q. (227) 79) Mazindol binding (Johnson, K.M. (227) 411) 462 Dopamine uptake inhibitors Forskolin [SHICFT (2B-carbomethoxy-36-(4-fluorophenyl)-tropane) binding; Bradykinin; cGMP; Endothelin; EDRF (endothelium-derived relax- Cocaine; BTCP (N[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine) ing factor); 5-HT (serotonin) (Reiser, G. (227) 89) GBR 12935; Striatum (rat) (Reith, M.E.A. (227) 417) GABA (y-aminobuteric acid) DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine) GABA, receptors; Adenylyl cyclase (inhibition); cAMP; Baclofen; Transcription factors; Locus coeruleus (Bhat, R.V. (227) 447) Cerebellar granule cells (Holopainen, I. (227) 225) EDRF (endothelium-derived relaxing factor) GABA, receptor antagonism Bradykinin; cGMP; Endothelin; Forskolin; 5-HT (serotonin) (Reiser, RU 5135; GABA, receptor complex; 5a-Pregnane-3a-ol-20-one G. (227) 89) (3a,5a-P); 5S5a-Pregnane-3a-20a-diol (Sa-pregnanediol); Neuro- steroid site (Cadoni, C. (227) 147) Electron spin resonance Dipyridamole; Scavenging effects; Hydroxyl radicals; Superoxide an- GABA, receptor complex ions (Suzuki, S. (227) 395) RU 5135; Sa-Pregnane-3a-ol-20-one (3a,5a-P); Sa-Pregnane-3a- 20a-diol (Sa-pregnanediol); GABA, receptor antagonism; Neuro- EMD 53998 steroid site (Cadoni, C. (227) 147) Ca?* sensitization; Cardiac muscle (skinned); Muscle regulation; Inorganic phosphate (Strauss, J.D. (227) 437) GABA, receptors GABA (y-aminobuteric acid); Adenylyl cyclase (inhibition); cAMP; Endothelial cells (vascular) Baclofen; Cerebellar granule cells (Holopainen, I. (227) 225) Granulocyte-colony stimulating factor (G-CSF); Endothelin-1 (Namiki, A. (227) 339) GABA, receptors (@ subunits) Benzodiazepine receptors (central); Modification of receptors; Endothelin [7H]JRo 15-4513 binding; Diethylpyrocarbonate; 2,3-Butanedione Bradykinin; cGMP; EDRF (endothelium-derived relaxing factor); (Maksay, G. (227) 57) Forskolin; 5-HT (serotonin) (Reiser, G. (227) 89) Gene transcription Endothelin-1 Phorbol esters; Adenosine receptors; Adenylyl cyclase; T-lympho- Granulocyte-colony stimulating factor (G-CSF); Endothelial cells cytes (Kontny, E. (227) 333) (vascular) (Namiki, A. (227) 339) Glomeruli Endothelins Thromboxane A, receptors; Platelets (radioligand binding); Inositol Megakaryoblastic cells; Ca2*; Inositol phosphates (Diochot, S. (227) phosphates (Folger, W.H. (227) 71) 427) Glycine Epidermal cells (mouse) [SHICPP ((°H]3-((+ )-2-carboxypiperazin-4-yl)propyl-1-phosphonic Staurosporine; 12-O-Tetradecanoylphorbol 13-acetate; Protein ki- acid) binding; NMDA receptors; HA-966; Polyamines (Porter, R.H.P. nase C; Ornithine decarboxylase; Morphological changes (Yamamoto, (227) 83) S. (227) 113) cGMP Estrogen receptors Bradykinin; Endothelin; EDRF (endothelium-derived relaxing fac- Polymerase chain reaction; (Sprague-Dawley rat) (Spreafico, E. (227) tor); Forskolin; 5-HT (serotonin) (Reiser, G. (227) 89) 353) Formycin A triphosphate (FTP); Guanylate cyclase; ATP; Atrial N-Ethylmaleimide alkylation natriuretic factor (ANF) (Chang, C.-H. (227) 229) Dopamine transport; Cocaine; d-Amphetamine; [*H]Mazindol bind- ing (Johnson, K.M. (227) 411) ANP-R, receptors; Neutral metalloendopeptidase; Human neuro- blastoma cell line NB-OK1 (Delporte, C. (227) 247) Eudismic analysis Muscarinic receptors; Hexahydro-difenidol; Hexbutinol; Oxyphency- G-Protein climine; Pfeiffer’s rule; Stereoselectivity; Receptor interaction Leukotrienes; Smooth muscles; Pulmonary system; Inositol phos- (Waelbroeck, M. (227) 33) phates; Protein kinase C (Howard, S. (227) 123) Excitatory amino acid receptors G-protein-coupled receptors Spider toxins; NMDA (N-methyl-D-aspartic acid); Kainate; AMPA Cloning of receptors; Neuropeptides; Neurokinin-type receptors; Se- (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) (Davies, cretin-type receptors (Burbach, J.P.H. (227) 1) M.S. (227) 51) G-protein coupling Fluoxetine 5-HT, receptors (human); 5-HT,, receptors (human); Ketanserin; G proteins; Polymerase chain reaction; mRNA expression (Lesch, (+ )-8-Hydroxy-2-(di-n-propylamino)tetralin HBr (8-OH-DPAT) K.P. (227) 233) (Stam, N.J. (227) 153) Formycin A triphosphate (FTP) G-proteins Guanylate cyclase; ATP; Atrial natriuretic factor (ANF); cGMP Polymerase chain reaction; mRNA expression; Fluoxetine (Lesch, (Chang, C.-H. (227) 229) K.P. (227) 233) Opioid receptors; Affinity cross-linking; NG108-15 cells (Harada, J. 5-HT (serotonin) (227) 301) Bradykinin; cGMP; Endothelin; EDRF (endothelium-derived relax- ing factor); Forskolin (Reiser, G. (227) 89) Granulocyte-colony stimulating factor (G-CSF) Endothelin-1; Endothelial cells (vascular) (Namiki, A. (227) 339) Human neuroblastoma cell line NB-OK1 ANP-R, receptors; cGMP; Neutral metalloendopeptidase (Delporte, Guanylate cyclase C. (227) 247) Formycin A triphosphate (FTP); ATP; Atrial natriuretic factor (ANF); cGMP (Chang, C.-H. (227) 229) Hydroxyl radicals Dipyridamole; Scavenging effects; Electron spin resonance; Superox- H + ide anions (Suzuki, S. (227) 395) NMDA channels; Mg* (Von Euler, G. (227) 449) Hypertrophy HA-966 [SHICPP ((°H]3-((+ )-2-carboxypiperazin-4-yl)propyl-1-phosphonic Smooth muscle cells; Losartan; Phosphoinositide signalling system acid) binding; NMDA receptors; Glycine; Polyamines (Porter, R.H.P. (Ko, Y. (227) 215) (227) 83) Idazoxan Hepatocytes, Inositol phosphates Antidepressants; B-Adrenoceptors; Adenylyl cyclase; C6 glioma cells; Histamine H, receptors (Garcia-Sainz, J.A. (227) 325) Protein kinase C (Manji, H.K. (227) 275) Hepatoma cells Immediate-early genes PLC-PRF-5; Angiotensin II receptors; (Radioligand binding); (Re- Striatum; Phosphorothioate (Chiasson, B.J. (227) 451) ceptor subtypes) (Wintersgill, H.P. (227) 283) IMR-90 cells Hexahydro-difenidol Bradykinin; Bradykinin receptors; Bradykinin receptor antagonists Muscarinic receptors; Hexbutinol; Oxyphencyclimine; Eudismic anal- (Sawutz, D.G. (227) 309) ysis; Pfeiffer’s rule; Stereoselectivity; Receptor interaction (Wael- broeck, M. (227) 33) Inorganic phosphate Ca?* sensitization; Cardiac muscle (skinned); Muscle regulation; Hexbutinol EMD 53998 (Strauss, J.D. (227) 437) Muscarinic receptors; Hexahydro-difenidol; Oxyphencyclimine; Eu- dismic analysis; Pfeiffer’s rule; Stereoselectivity; Receptor interac- tion (Waelbroeck, M. (227) 33) Inositol phosphates Thromboxane A, receptors; Glomeruli; Platelets (radioligand bind- Hippocampus ing) (Folger, W.H. (227) 71) S-Adenosyl-L-methionine; Brain; Aging; Muscarinic receptors; Stria- tum (Muccioli, G. (227) 293) Substance P; Spinal cord; Cerebral cortex; Anesthesia; Pentobarbital (Hasséssian, H. (227) 103) ['251] His-NKA NK, receptors; Small intestine smooth muscle (rat); NK receptor Leukotrienes; Smooth muscles; Pulmonary system; Protein kinase C; subtypes; Radioligand binding (Brown, M.C.S. (227) 163) G-Protein (Howard, S. (227) 123) Histamine H, receptors Endothelins; Megakaryoblastic cells; Ca?* (Diochot, S. (227) 427) Hepatocytes, Inositol phosphates (Garcia-Sainz, J.A. (227) 325) 5-HT,, receptor binding sites Adrenoceptors; Catecholamines (Schwinn, D.A. (227) 433) Trigeminal ganglia (rat); 5-HT,, receptor messenger RNA (Bruin- vels, A.T. (227) 357) Kainate Spider toxins; Excitatory amino acid receptors; NMDA (N-methyl- 5-HT,, receptor messenger RNA D-aspartic acid); AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazo- Trigeminal ganglia (rat); 5-HT,, receptor binding sites (Bruinvels, lepropionic acid) (Davies, M.S. (227) 51) A.T. (227) 357) Ketanserin 5-HT receptors 5-HT, receptors (human); 5-HT,, receptors (human); G-protein cAMP; Sumatriptan; 5-HT,p, receptors (Miller, K.J. (227) 99) coupling; (+)-8-Hydroxy-2-(di-n-propylamino)tetralin HBr (8-OH- DPAT) (Stam, N.J. (227) 153) 5-HT jpg receptors 5-HT receptors; cAMP; Sumatriptan (Miller, K.J. (227) 99) Leukotrienes Smooth muscles; Pulmonary system; Inositol phosphates; Protein 5-HT,, receptors (human) kinase C; G-Protein (Howard, S. (227) 123) 5-HT, receptors (human); G-protein coupling; Ketanserin; (+ )-8- Hydroxy-2-(di-n-propylamino)tetralin HBr (8-OH-DPAT) (Stam, N.J. (227) 153) Liposomes Maitotoxin; Ca2* channels; Cation blockers (Murata, M. (227) 43) 5-HT, receptors (human) 5-HT,, receptors (human); G-protein coupling; Ketanserin; (+ )-8- Locus coeruleus Hydroxy-2-(di-n-propylamino)tetralin HBr (8-OH-DPAT) (Stam, N.J. Transcription factors; DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromo- (227) 153) benzylamine) (Bhat, R.V. (227) 447) - 464 Losartan Myenteric plexus (guinea-pig) Smooth muscle cells; Hypertrophy; Phosphoinositide signalling sys- Adenylate cyclase; p-Opioid receptors (pre- and postsynaptic) tem (Ko, Y. (227) 215) (Rengel, I. (227) 385) Maitotoxin Neuroblastoma SH-SYSY cells Ca?*+ channels; Cation blockers; Liposomes (Murata, M. (227) 43) Clonidine; Norepinephrine; a,-Adrenoceptors; Morphine; u-Opioid receptors; Adenylyl cyclase inhibition; Retinoic acid (Lameh, J. (227) [7H]M azindol binding 19) Dopamine transport; N-Ethylmaleimide alkylation; Cocaine; d- Amphetamine (Johnson, K.M. (227) 411) Neurokinin-type receptors Cloning of receptors; G-protein-coupled receptors; Neuropeptides; Megakaryoblastic cells Secretin-type receptors (Burbach, J.P.H. (227) 1) Endothelins; Ca?*; Inositol phosphates (Diochot, S. (227) 427) Neuropeptides Metabotropic glutamate receptors Cloning of receptors; G-protein-coupled receptors; Neurokinin-type L-2-Amino-4-phosphonobutyrate (L-AP4); cAMP (Thomsen, C. (227) receptors; Secretin-type receptors (Burbach, J.P.H. (227) 1) 361) Neuroprotection 3-Methylcholanthrene Adenosine A, receptors; Adenosine A, receptors; Brain (rat); De- Cytochrome P-450; a Receptors; Phenobarbital (Basile, A.S. (227) sensitization (agonist induced) (Abbracchio, M.P. (227) 317) 95) Neurosteroid site Mg * RU 5135; GABA, receptor complex; Sa-Pregnane-3a-ol-20-one NMDA channels; H* (Von Euler, G. (227) 449) (3a,5a-P); 5a-Pregnane-3a-20a-diol (Sa-pregnanediol); GABA , re- ceptor antagonism (Cadoni, C. (227) 147) Modification of receptors Benzodiazepine receptors (central); [>H]Ro 15-4513 binding; GABA, receptors (@ subunits); Diethylpyrocarbonate; 2,3-Butane- Neutral metalloendopeptidase dione (Maksay, G. (227) 57) ANP-R, receptors; cGMP; Human neuroblastoma cell line NB-OK1 (Delporte, C. (227) 247) Monoclonal antibodies Dihydropyridine receptors; Ca** channels; Purification; Cardiac sar- Neutrophil colemma (Tokumaru, H. (227) 363) Respiratory burst; Degranulation; Protein kinase C; Staurosporin; cgp 41251 (Krause, K.-H. (227) 221) Morphine Clonidine; Norepinephrine; a,-Adrenoceptors; u-Opioid receptors; NG108-15 cells Adenylyl cyclase inhibition; Neuroblastoma SH-SYSY cells; Retinoic Opioid receptors; G-proteins; Affinity cross-linking (Harada, J. (227) acid (Lameh, J. (227) 19) 301) Morphological changes NK, receptors Staurosporine; 12-O-Tetradecanoylphorbol 13-acetate; Protein ki- Small intestine smooth muscle (rat); NK receptor subtypes; Radioli- nase C; Ornithine decarboxylase; Epidermal cells (mouse) gand binding; ['*IJHis-NKA (Brown, M.C.S. (227) 163) (Yamamoto, S. (227) 113) NK receptor subtypes Muscarinic receptor agonists (selective) NK. receptors; Small intestine smooth muscle (rat); Radioligand SR 95639A; Muscarinic receptor subtypes; Phosphoinositides; cAMP; binding; [!*°IJHis-NKA (Brown, M.C.S. (227) 163) Acetylcholine release (Mohamed, A.S. (227) 181) NMDA channels Muscarinic receptors H*; Mg* (Von Euler, G. (227) 449) Hexahydro-difenidol; Hexbutinol; Oxyphencyclimine; Eudismic anal- ysis; Pfeiffer’s rule; Stereoselectivity; Receptor interaction (Wael- NMDA (N-methyl-D-aspartic acid) broeck, M. (227) 33) Spider toxins; Excitatory amino acid receptors; Kainate; AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) (Davies, S-Adenosyl-L-methionine; Brain; Aging; Striatum; Hippocampus M.S. (227) 51) (Muccioli, G. (227) 293) NMDA receptor antagonists Muscarinic receptor subtypes SR 95639A; Muscarinic receptor agonists (selective); Phosphoinosi- NMDA receptor mRNA; Polymerase chain reaction (Lesch, K.P. tides; cAMP; Acetylcholine release (Mohamed, A.S. (227) 181) (227) 109) Muscle regulation NMDA receptor mRNA Ca** sensitization; Cardiac muscle (skinned); Inorganic phosphate; NMDA receptor antagonists; Polymerase chain reaction (Lesch, K.P. EMD 53998 (Strauss, J.D. (227) 437) (227) 109) Mutagenesis NMDA receptors Dopamine D, receptors; Receptor binding; Catecholamine receptors [SHICPP ((°H]3-(( + )-2-carboxypiperazin-4-yl)propyl-1-phosphonic (Mansour, A. (227) 205) acid) binding; HA-966; Glycine; Polyamines (Porter, R.H.P. (227) 83)

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European Journal of Pharmacology. Molecular Pharmacology Section 1992: Vol 227 Index PDF

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Preview European Journal of Pharmacology. Molecular Pharmacology Section 1992: Vol 227 Index

European Journal of Pharmacology — Molecular Pharmacology Section, 227 (1992) 455-458 © 1992 Elsevier Science Publishers B.V. All rights reserved 0922-/4921 /0$056.0 0 Author index Aasen, A., see Waelbroeck, M. (227) 33 Bryson, S.E., see Wintersgill, H.P. (227) 283 Abbracchio, M.P., Fogliatto, G., Paoletti, A.M., Rovati, G.E. and Burbach, J.P.H. and Meijer, O.C. Cattabeni, F. The structure of neuropeptide receptors (227) 1 Prolonged in vitro exposure of rat brain slices to adenosine analogues: selective desensitization of adenosine A, but not A, Cadoni, C. and Gee, K.W. receptors (227) 317 Complex interactions between the steroid derivative RU 5135 Abe, T., see Tokumaru, H. (227) 363 and the GABA ,-receptor complex (227) 147 Abrahams, T.P. and Schofield, G.G. Campbell, A.K., see Bazan, E. (227) 343 Norepinephrine-induced Ca?* current inhibition in adult rat Camus, J., see Waelbroeck, M. (227) 33 sympathetic neurons does not require protein kinase C activation Caspar Ruegg, J., see Strauss, J.D. (227) 437 (227) 189 Casteels, R., see Missiaen, L. (227) 391 Aikawa, J., see Namiki, A. (227) 339 Cattabeni, F., see Abbracchio, M.P. (227) 317 Akil, H., see Mansour, A. (227) 205 Chan-Yeung, M., see Howard, S. (227) 123 Akiyoshi, J., see Lesch, K.P. (227) 233 Chang, C.-H., Yu, Z.-N. and Song, D.-L. Aly, M.H.M., see Mohamed, A.S. (227) 181 Formycin triphosphate as a probe for the ATP binding site Anzai, K., see Tokumaru, H. (227) 363 involved in the activation of guanylate cyclase (227) 229 Appenheimer, M., see Ko, Y. (227) 215 Chen, G., see Manji, H.K. (227) 275 Arakawa, M., see Suzuki, S. (227) 395 Chevillard, C., see Diochot, S. (227) 427 Aulakh, C.S., see Lesch, K.P. (227) 109 Chiasson, B.J., Hooper, M.L., Murphy, P.R. and Robertson, H.A. Aulakh, C.S., see Lesch, K.P. (227) 233 Antisense oligonucleotide eliminates in vivo expression of c-fos in mammalian brain (227) 451 Baganoff, M.P., see Davies, M.S. (227) 51 Chiavaroli, C., Vacher, P. and Schlegel, W. Ball, S.G., see Wintersgill, H.P. (227) 283 Modulation of Ca** influx by protein phosphorylation in single Ballesta, J.J. and Orts, A. intact clonal pituitary cells (227) 173 Interaction of opioid drugs with human platelet a,-adrenoceptors Chiu, A.T., see Leung, K.H. (227) 63 (227) 349 Christophe, J., see Delporte, C. (227) 247 Balmforth, A.J., see Wintersgill, H.P. (227) 283 Christophe, J., see Waelbroeck, M. (227) 33 Baraban, J.M., see Bhat, R.V. (227) 447 Chuang, D.-M., see Lesch, K.P. (227) 233 Basile, A.S., Paul, 1.A. and De Costa, B. Civelli, O., see Mansour, A. (227) 205 Differential effects of cytochrome P-450 induction on ligand Civelli, O., see Seeman, P. (227) 139 binding to o receptors (227) 95 Couture, R., see Hasséssian, H. (227) 103 Bast, A., see Voss, H.-P. (227) 403 Criscuoli, M., see Brown, M.C.S. (227) 163 Bazan, E., Campbell, A.K. and Rapoport, R.M. Protein kinase C activity in blood vessels from normotensive and spontaneously hypertensive rats (227) 343 Daly, J.W., see Murata, M. (227) 43 Bergmann, J.S., see Johnson, K.M. (227) 411 Davies, M.S., Baganoff, M.P., Grishin, E.V., Lanthorn, T.H., Volkova, Bertacco, S., see Muccioli, G. (227) 293 T.M., Watson, G.B. and Wiegand, R.C. Bettini, E., see Spreafico, E. (227) 353 Polyamine spider toxins are potent un-competitive antagonists of Bhat, R.V. and Baraban, J.M. rat cortex excitatory amino acid receptors (227) 51 High basal expression of zif268 in cortex is dependent on intact De Costa, B., see Basile, A.S. (227) 95 noradrenergic system (227) 447 De Costa, B., see Reith, M.E.A. (227) 417 Biagi, M., see Brown, M.C.S. (227) 163 DeHaven-Hudkins, D.L., Fleissner, L.C. and Ford-Rice, F.Y. Bidlack, J.M., Saripalli, L.D. and Lawrence, D.M.P. Characterization of the binding of [*H)(+)-pentazocine to o «k-Opioid binding sites on a murine lymphoma cell line (227) 257 recognition sites in guinea pig brain (227) 371 Bitran, J.A., see Manji, H.K. (227) 275 Delporte, C., Poloczek, P., Tastenoy, M., Winand, J. and Christophe, Brands, J., see Stam, N.J. (227) 153 J. Briggs, R.S.J., see Porter, R.H.P. (227) 83 Atrial natriuretic peptide binds to ANP-R, receptors in neuro- Brogrs, O., see Stokke, M. (227) 379 blastoma cells or is degraded extracellularly at the Ser-Phe bond Brown, M.C.S., Biagi, M., Renzetti, A.R., Rovero, P., Criscuoli, M. (227) 247 and Mizrahi, J. Demchyshyn, L., see Miller, K.J. (227) 99 ['*>]]His-neurokinin A binds selectively to NK, receptors of the De Smedt, H., see Missiaen, L. (227) 391 B-type in rat small intestine smooth muscle membranes (227) 163 Diamond, J., see Langlands, J.M. (227) 131 Bruinvels, A.T., Landwehrmeyer, B., Moskowitz, M.A. and Hoyer, Di Carlo, R., see Muccioli, G. (227) 293 D. Dijkema, R., see Stam, N.J. (227) 153 Evidence for the presence of 5-HT,, receptor messenger RNA in Diochot, S., Vittet, D., Mathieu, M.-N., Launay, J.-M. and Chevil- neurons of the rat trigeminal ganglia (227) 357 lard, C. 456 Effects of endothelins on the human megakaryoblastic cell line Ishikawa, M., see Namiki, A. (227) 339 MEG-01 (227) 427 Iso, Y., see Harada, J. (227) 301 Donnell, D., see Voss, H.-P. (227) 403 Droogmans, G., see Missiaen, L. (227) 391 Jacobson, A.E., see Reith, M.E.A. (227) 417 Diising, R., see Ko, Y. (227) 215 Jiang, H., see Yamamoto, S. (227) 113 Johnson, K.M., Bergmann, J.S. and Kozikowski, A.P. Eiger, S., see Lameh, J. (227) 19 Cocaine and dopamine differentially protect [*H]mazindol bind- El-Fakahany, E.E., see Mohamed, A.S. (227) 181 ing sites from alkylation by N-ethylmaleimide (227) 411 Joyce, J.N., see Murray, A.M. (227) 443 Faunce, D.M., see Sawutz, D.G. (227) 309 Fleissner, L.C., see DeHaven-Hudkins, D.L. (227) 371 Kase, H., see Miki, I. (227) 199 Fogliatto, G., see Abbracchio, M.P. (227) 317 Kato, R., see Yamamoto, S. (227) 113 Folger, W.H., Halushka, P.V., Wilcox, C.S. and Guzman, N.J. King, A., see Miller, K.J. (227) 99 Characterization of rat glomerular thromboxane A, receptors: Kirino, Y., see Tokumaru, H. (227) 363 comparison to rat platelets (227) 71 Ko, Y., Gorg, A., Appenheimer, M., Wieczorek, A.J., Dusing, R.., Ford-Rice, F.Y., see DeHaven-Hudkins, D.L. (227) 371 Vetter, H. and Sachinidis, A. Forray, C., see Mohamed, A.S. (227) 181 Losartan inhibits the angiotensin II-induced stimulation of the Fredholm, B.B., see Kontny, E. (227) 333 phosphoinositide signalling system in vascular smooth muscle Fukazawa, M., see Namiki, A. (227) 339 cells (227) 215 Kondo, Y., see Tada, S. (227) 25 Garcia-Sainz, J.A., Macias-Silva, M., Olivares-Reyes, A. and Kontny, E., Kvanta, A. and Fredholm, B.B. Romero-Avila, M.T. Activation of protein kinase C and elevation of cAMP interact Histamine activates phosphorylase and inositol phosphate pro- synergistically to raise c-Fos and AP-1 activity in Jurkat cells duction in guinea pig hepatocytes (227) 325 (227) 333 Garcia-Sainz, J.A., Romero-Avila, M.T., Olivares-Reyes, J.A. and Kozikowski, A.P., see Johnson, K.M. (227) 411 Macias-Silva, M. Krause, K.-H., Van Delden, C., Huggler, E., Monod, A. and Lew, Guinea pig hepatocyte a,,-adrenoceptors: characterization, sig- D.P. nal transduction and regulation (227) 239 Differential effects on neutrophil activation of staurosporin and Gee, K.W., see Cadoni, C. (227) 147 its protein kinase C-selective derivative cgp 41231 (227) 221 Gorg, A., see Ko, Y. (227) 215 Kristensen, P., see Thomsen, C. (227) 361 Grishin, E.V., see Davies, M.S. (227) 51 Kvanta, A., see Kontny, E. (227) 333 Guan, H.-c., see Seeman, P. (227) 139 Gusovsky, F., see Manji, H.K. (227) 275 Lambrecht, G., see Waelbroeck, M. (227) 33 Gusovsky, F., see Murata, M. (227) 43 Lameh, J., Eiger, S. and Sadée, W. Guzman, N.J., see Folger, W.H. (227) 71 Interaction among p-opioid receptors and a,-adrenoceptors on SH-SY5Y human neuroblastoma cells (227) 19 Hagelin, E.M., see Stokke, M. (227) 379 Haldeman, B., see Thomsen, C. (227) 361 Landwehrmeyer, B., see Bruinvels, A.T. (227) 357 Halushka, P.V., see Folger, W.H. (227) 71 Langlands, J.M. and Diamond, J. Harada, J., Ueda, H., Iso, Y. and Satoh, M. Translocation of protein kinase C in bovine tracheal smooth Affinity cross-linked 6-opioid receptor in NG108-15 cells is low muscle strips: the effect of methacholine and isoprenaline (227) molecular weight (25 kDa) and coupled to GTP-binding proteins 131 (227) 301 Lanthorn, T.H., see Davies, M.S. (227) 51 Hasséssian, H., Prat, A. and Couture, R. Launay, J.-M., see Diochot, S. (227) 427 Anaesthetic doses of pentobarbital antagonize phosphatidylinosi- Lawrence, D.M.P., see Bidlack, J.M. (227) 257 tol hydrolysis induced by substance P or carbachol in the spinal Lesch, K.P., Aulakh, C.S., Wolozin, B.L., Hill, J.L. and Murphy, D.L. cord and cerebral cortex of the rat (227) 103 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid decreases Haycock, D., see Sawutz, D.G. (227) 309 NMDA receptor mRNA (227) 109 Healy, D.P., see Ye, M.-Q. (227) 79 Lesch, K.P., Hough, C.J., Aulakh, C.S., Wolozin, B.L., Tolliver, T.J., Hill, J.L., see Lesch, K.P. (227) 109 Hill, J.L., Akiyoshi, J., Chuang, D.-M. and Murphy, D.L. Hill, J.L., see Lesch, K.P. (227) 233 Fluoxetine modulates G protein a,, a, and a, subunit MRNA Hirata, Y., see Namiki, A. (227) 339 expression in rat brain (227) 233 Holopainen, I., Rau, C. and Wojcik, W.J. Leung, K.H., Roscoe, W.A., Smith, R.D., Timmermans, P.B.M.W.M. Proposed antagonists at GABA, receptors that inhibit adenylyl and Chiu, A.T. cyclase in cerebellar granule cell cultures of rat (227) 225 Characterization of biochemical responses of angiotensin II (AT,) Hooper, M.L., see Chiasson, B.J. (227) 451 binding sites in the rat pheochromocytoma PC12W cells (227) 63 Houck, W.T., see Sawutz, D.G. (227) 309 Lew, D.P., see Krause, K.-H. (227) 221 Hough, C.J., see Lesch, K.P. (227) 233 Liu, Y., see Von Euler, G. (227) 449 Lomasney, J.W., see Schwinn, D.A. (227) 433 Howard, S., Chan-Yeung, M., Martin, L., Phaneuf, S. and Salari, H. Polyphosphoinositide hydrolysis and protein kinase C activation in guinea pig tracheal smooth muscle cells in culture by Machii, K., see Namiki, A. (227) 339 leukotriene D, involve a pertussis toxin sensitive G-protein (227) Macias-Silva, M., see Garcia-Sainz, J.A. (227) 239 123 Macias-Silva, M., see Garcia-Sainz, J.A. (227) 325 Hoyer, D., see Bruinvels, A.T. (227) 357 Maggi, A., see Spreafico, E. (227) 353 Huggler, E., see Krause, K.-H. (227) 221 Mais, D.E., True, T.A. and Martinelli, M.J. Characterization by photoaffinity labelling of the human platelet Ishihara, M., see Yamamoto, S. (227) 113 thromboxane A,/prostaglandin H, receptor: evidence for N- Ishii, A., see Miki, I. (227) 199 linked glycosylation (227) 267 Maksay, G. Pollio, G., see Spreafico, E. (227) 353 Modification of benzodiazepine receptors supports the distinctive Poloczek, P., see Delporte, C. (227) 247 role of histidine residues (227) 57 Porter, R.H.P., Briggs, R.S.J. and Roberts, P.J. Manji, H.K., Chen, G., Bitran, J.A., Gusovsky, F. and Potter, W.Z. Modulation of [*H]3-(( + )-2-carboxypiperazin-4-yl)propyl-1-phos- Idazoxan down-regulates B-adrenoceptors on C6 glioma cells in phonic acid ((7HJCPP) binding by ligands acting at the glycine vitro (227) 275 and the polyamine sites of the rat brain NMDA receptor complex Mansour, A., Meng, F., Meador-Woodruff, J.H., Taylor, L.P., Civelli, (227) 83 O. and Akil, H. Potter, W.Z., see Manji, H.K. (227) 275 Site-directed mutagenesis of the human dopamine D, receptor Poulsson, C., see Stokke, M. (227) 379 (227) 205 Prat, A., see Hasséssian, H. (227) 103 Martin, L., see Howard, S. (227) 123 Rapoport, R.M., see Bazan, E. (227) 343 Martinelli, M.J., see Mais, D.E. (227) 267 Rau, C., see Holopainen, I. (227) 225 Mathieu, M.-N., see Diochot, S. (227) 427 Reiser, G. Meador-Woodruff, J.H., see Mansour, A. (227) 205 Nitric oxide formation caused by Ca** release from internal Meijer, O.C., see Burbach, J.P.H. (227) 1 stores in neuronal cell line is enhanced by cyclic AMP (227) 89 Meng, F., see Mansour, A. (227) 205 Reith, M.E.A., De Costa, B., Rice, K.C. and Jacobson, A.E. Miki, I., Kase, H. and Ishii, A. Differences in activities of thromboxane A, receptor antagonists Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter (227) 417 in smooth muscle cells (227) 199 Rengel, I., Sinowatz, F. and Schulz, R. Miller, K.J., King, A., Demchyshyn, L., Niznik, H. and Teitler, M. Opioid-controlled adenylate cyclase in the guinea-pig myenteric Agonist activity of sumatriptan and metergoline at the human plexus is confined to nerve somata (227) 385 S-HT pg receptor: further evidence for a role of the 5-HT,p Renzetti, A.R., see Brown, M.C.S. (227) 163 receptor in the action of sumatriptan (227) 99 Rice, K.C., see Reith, M.E.A. (227) 417 Missiaen, L., De Smedt, H., Droogmans, G. and Casteels, R. Roberts, P.J., see Porter, R.H.P. (227) 83 2,5-Di-(tert-butyl)-1,4-benzohydroquinone and cyclopiazonic acid Robertson, H.A., see Chiasson, B.J. (227) 451 decrease the Ca”* permeability of endoplasmic reticulum (227) Romero-Avila, M.T., see Garcia-Sainz, J.A. (227) 239 391 Romero-Avila, M.T., see Garcia-Sainz, J.A. (227) 325 Mitsui, Y., see Tada, S. (227) 25 Roscoe, W.A., see Leung, K.H. (227) 63 Mizrahi, J., see Brown, M.C.S. (227) 163 Rovati, G.E., see Abbracchio, M.P. (227) 317 Mohamed, A.S., Forray, C., Aly, M.H.M. and El-Fakahany, E.E. Rovero, P., see Brown, M.C.S. (227) 163 Lack of intrinsic activity and significant subtype selectivity of SR Ryoo, H., see Murray, A.M. (227) 443 95639A at muscarinic receptors (227) 181 Monod, A., see Krause, K.-H. (227) 221 Sachinidis, A., see Ko, Y. (227) 215 Moroi, M., see Namiki, A. (227) 339 Sadée, W., see Lameh, J. (227) 19 Moskowitz, M.A., see Bruinvels, A.T. (227) 357 Sakatume, M., see Suzuki, S. (227) 395 Muccioli, G., Scordamaglia, A., Bertacco, S. and Di Carlo, R. Salari, H., see Howard, S. (227) 123 Effect of S-adenosyl-L-methionine on brain muscarinic receptors Saripalli, L.D., see Bidlack, J.M. (227) 257 of aged rats (227) 293 Sato, H., see Suzuki, S. (227) 395 Mulvihill, E., see Thomsen, C. (227) 361 Satoh, M., see Harada, J. (227) 301 Murata, M., Gusovsky, F., Yasumoto, T. and Daly, J.W. Sawutz, D.G., Faunce, D.M., Houck, W.T. and Haycock, D. Selective stimulation of Ca* flux in cells by maitotoxin (227) 43 Characterization of bradykinin B, receptors on human IMR-90 Murphy, D.L., see Lesch, K.P. (227) 109 lung fibroblasts: stimulation of *Ca** efflux by D-Phe’ substi- Murphy, D.L., see Lesch, K.P. (227) 233 tuted bradykinin analogues (227) 309 Murphy, P.R., see Chiasson, B.J. (227) 451 Schjelderup, L., see Waelbroeck, M. (227) 33 Murray, A.M., Ryoo, H. and Joyce, J.N. Schlegel, W., see Chiavaroli, C. (227) 173 Visualization of dopamine D,-like receptors in human brain with Schofield, G.G., see Abrahams, T.P. (227) 189 [!*>Tepidepride (227) 443 Schulz, R., see Rengel, I. (227) 385 Mutschler, E., see Waelbroeck, M. (227) 33 Schwinn, D.A. and Lomasney, J.W. Pharmacologic characterization of cloned a,-adrenoceptor sub- Namiki, A., Hirata, Y., Fukazawa, M., Ishikawa, M., Moroi, M., types: selective antagonists suggest the existence of a fourth Aikawa, J., Yamaguchi, T. and Machii, K. subtype (227) 433 Granulocyte-colony stimulating factor stimulates immunoreactive Scordamaglia, A., see Muccioli, G. (227) 293 endothelin-1 release from cultured bovine endothelial cells (227) Seeman, P., Guan, H.-c., Civelli, O., Wan Tol, H.H.M., Sunahara, 339 R.K. and Niznik, H.B. Nishikawa, K., see Yamamoto, S. (227) 113 The cloned dopamine D, receptor reveals different densities for Niznik, H., see Miller, K.J. (227) 99 dopamine receptor antagonist ligands. Implications for human Niznik, H.B., see Seeman, P. (227) 139 brain positron emission tomography (227) 139 Sinowatz, F., see Rengel, I. (227) 385 Okajima, F., see Tada, S. (227) 25 Smith, R.D., see Leung, K.H. (227) 63 Olijve, W., see Stam, N.J. (227) 153 Song, D.-L., see Chang, C.-H. (227) 229 Olivares-Reyes, A., see Garcia-Sainz, J.A. (227) 325 Spreafico, E., Bettini, E., Pollio, G. and Maggi, A. Olivares-Reyes, J.A., see Garcia-Sainz, J.A. (227) 239 Nucleotide sequence of estrogen receptor cDNA from Sprague- Orts, A., see Ballesta, J.J. (227) 349 Dawley rat (227) 353 Stam, N.J., Van Huizen, F., Van Alebeek, C., Brands, J., Dijkema, Paoletti, A.M., see Abbracchio, M.P. (227) 317 R., Tonnaer, J.A.D.M. and Olijve, W. Paul, I.A., see Basile, A.S. (227) 95 Genomic organization, coding sequence and functional expres- Phaneuf, S., see Howard, S. (227) 123 sion of human 5-HT, and 5-HT,, receptor genes (227) 153 458 Stokke, M., Hagelin, E.M., Poulsson, C. and Br@grs, O. Vetter, H., see Ko, Y. (227) 215 Ca** modulates the inhibition of (+)-[*H]isradipine binding by Vittet, D., see Diochot, S. (227) 427 amiloride and quinacrine (227) 379 Volkova, T.M., see Davies, M.S. (227) 51 Strauss, J.D., Zeugner, C. and Caspar Riegg, J. Von Euler, G. and Liu, Y. The positive inotropic calcium sensitizer EMD 53998 antagonizes The glutamate- and glycine-induced reduction of [7H]MK-801 phosphate action on cross-bridges in cardiac skinned fibers (227) binding in the presence of Mg** is reversed at low pH (227) 449 437 Voss, H.-P., Donnell, D. and Bast, A. Strohmann, C., see Waelbroeck, M. (227) 33 Atypical molecular pharmacology of a new long-acting B,-adre- Sugai, K., see Suzuki, S. (227) 395 noceptor agonist, TA 2005 (227) 403 Sunahara, R.K., see Seeman, P. (227) 139 Suzdak, P.D., see Thomsen, C. (227) 361 Waelbroeck, M., Camus, J., Tastenoy, M., Mutschler, E., Strohmann, Suzuki, S., Sugai, K., Sato, H., Sakatume, M. and Arakawa, M. C., Tacke, R., Schjelderup, L., Aasen, A., Lambrecht, G. and Inhibition of active oxygen generation by dipyridamole in human Christophe, J. polymorphonuclear leukocytes (227) 395 Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, Tacke, R., see Waelbroeck, M. (227) 33 with four muscarinic receptors (227) 33 Tada, S., Okajima, F., Mitsui, Y., Kondo, Y. and Ui, M. Wang, J.C., see Yamamoto, S. (227) 113 P, purinoceptor-mediated cyclic AMP accumulation in bovine Warburton, P., see Wintersgill, H.P. (227) 283 vascular smooth muscle cells (227) 25 Watson, G.B., see Davies, M.S. (227) 51 Tastenoy, M., see Delporte, C. (227) 247 Wieczorek, A.J., see Ko, Y. (227) 215 Tastenoy, M., see Waelbroeck, M. (227) 33 Wiegand, R.C., see Davies, M.S. (227) 51 Taylor, L.P., see Mansour, A. (227) 205 Wilcox, C.S., see Folger, W.H. (227) 71 Teitler, M., see Miller, K.J. (227) 99 Winand, J., see Delporte, C. (227) 247 Thomsen, C., Kristensen, P., Mulvihill, E., Haldeman, B. and Suz- Wintersgill, H.P., Warburton, P., Bryson, S.E., Ball, S.G. and Balm- dak, P.D. forth, A.J. L-2-Amino-4-phosphonobutyrate (L-AP4) is an agonist at the Characterization of the angiotensin II receptor expressed by the type IV metabotropic glutamate receptor which is negatively human hepatoma cell line, PLC-PRF-5 (227) 283 coupled to adenylate cyclase (227) 361 Wojcik, W.J., see Holopainen, I. (227) 225 Timmermans, P.B.M.W.M., see Leung, K.H. (227) 63 Wolozin, B.L., see Lesch, K.P. (227) 109 Tokumaru, H., Anzai, K., Abe, T. and Kirino, Y. Wolozin, B.L., see Lesch, K.P. (227) 233 Purification of the cardiac 1,4-dihydropyridine receptor using immunoaffinity chromatography with a monoclonal antibody Yamaguchi, T., see Namiki, A. (227) 339 against the a,6 subunit of the skeletal muscle dihydropyridine receptor (227) 363 Yamamoto, S., Jiang, H., Nishikawa, K., Ishihara, M., Wang, J.C. and Kato, R. Tolliver, T.J., see Lesch, K.P. (227) 233 Protein kinase C-dependent and -independent actions of a potent Tonnaer, J.A.D.M., see Stam, N.J. (227) 153 protein kinase C inhibitor, staurosporine (227) 113 True, T.A., see Mais, D.E. (227) 267 Yasumoto, T., see Murata, M. (227) 43 Ye, M.-Q., Yuan, L.-X. and Healy, D.P. Ueda, H., see Harada, J. (227) 301 Effects of intracerebroventricular captopril on angiotensin-con- Ui, M., see Tada, S. (227) 25 verting enzyme and angiotensinogen mRNA levels in rat brain (227) 79 Vacher, P., see Chiavaroli, C. (227) 173 Yu, Z.-N., see Chang, C.-H. (227) 229 Van Alebeek, C., see Stam, N.J. (227) 153 Yuan, L.-X., see Ye, M.-Q. (227) 79 Van Delden, C., see Krause, K.-H. (227) 221 Van Huizen, F., see Stam, N.J. (227) 153 Van Tol, H.H.M., see Seeman, P. (227) 139 Zeugner, C., see Strauss, J.D. (227) 437 European Journal of Pharmacology — Molecular Pharmacology Section, 227 (1992) 459-467 © 1992 Elsevier Science Publishers B.V. All rights reserved 0922-/4921 /0$056.0 0 Key word index Acetylcholine release a@ ,,-Adrenoceptors SR 95639A; Muscarinic receptor agonists (selective); Muscarinic Adrenoceptors; Phosphoinositide turnover; Phosphorylase (Garcia- receptor subtypes; Phosphoinositides; cAMP (Mohamed, A.S. (227) Sainz, J.A. (227) 239) 181) a,-Adrenoceptors Action potentials Clonidine; Norepinephrine; Morphine; u-Opioid receptors; Adenylyl Ca**; Pituitary; Protein kinase A; Protein kinase C; Okadaic acid cyclase inhibition; Neuroblastoma SH-SYSY cells; Retinoic acid (Chiavaroli, C. (227) 173) (Lameh, J. (227) 19) Adenosine receptors a ,-Adrenoceptors Phorbol esters; Adenylyl cyclase; Gene transcription; T-lymphocytes Platelets (human): Opioids (Ballesta, J.J. (227) 349) (Kontny, E. (227) 333) B-Adrenoceptors Adenosine A, receptors Idazoxan; Antidepressants; Adenylyl cyclase; C6 glioma cells; Protein Adenosine A, receptors; Neuroprotection; Brain (rat); Desensitiza- kinase C (Manji, H.K. (227) 275) tion (agonist induced) (Abbracchio, M.P. (227) 317) Affinity cross-linking Adenosine A, receptors Opioid receptors; G-proteins; NG108-15 cells (Harada, J. (227) 301) Adenosine A, receptors; Neuroprotection; Brain (rat); Desensitiza- tion (agonist induced) (Abbracchio, M.P. (227) 317) Aging S-Adenosyl-L-methionine; Brain; Muscarinic receptors; Striatum; S-Adenosyl-L-methionine Hippocampus (Muccioli, G. (227) 293) Brain; Aging; Muscarinic receptors; Striatum; Hippocampus (Muc- cioli, G. (227) 293) Amiloride 3,4-Dichlorobenzamil; Quinacrine; Ca?*; Ca** channel blockers; Adenylate cyclase L-type Ca?* channels (Stokke, M. (227) 379) Myenteric plexus (guinea-pig); -Opioid receptors (pre- and post- synaptic) (Rengel, I. (227) 385) L-2-Amino-4-phosphonobutyrate (L-AP4) Metabotropic glutamate receptors; cAMP (Thomsen, C. (227) 361) Adenylyl cyclase Idazoxan; Antidepressants; B-Adrenoceptors; C6 glioma cells; Pro- cAMP tein kinase C (Manji, H.K. (227) 275) P, Purinoceptors; Smooth muscle cells (vascular) (Tada, S. (227) 25) Phorbol esters; Adenosine receptors; Gene transcription; T-lympho- 5-HT receptors; Sumatriptan; 5-HT,pg receptors (Miller, K.J. (227) cytes (Kontny, E. (227) 333) 99) Adenylyl cyclase inhibition SR 95639A; Muscarinic receptor agonists (selective); Muscarinic Clonidine; Norepinephrine; a,-Adrenoceptors; Morphine; ,.-Opioid receptor subtypes; Phosphoinositides; Acetylcholine release (Mo- receptors; Neuroblastoma SH-SY5Y cells; Retinoic acid (Lameh, J. hamed, A.S. (227) 181) (227) 19) GABA , receptors; GABA (y-aminobuteric acid); Adenylyl cyclase Adenylyl cyclase (inhibition) (inhibition); Baclofen; Cerebellar granule cells (Holopainen, I. (227) GABA g receptors; GABA (y-aminobuteric acid); cAMP; Baclofen; 225) Cerebellar granule cells (Holopainen, I. (227) 225) Metabotropic glutamate receptors; L-2-Amino-4-phosphonobutyrate B,-Adrenoceptor agonists (long acting) (L-AP4) (Thomsen, C. (227) 361) Ternary complex; Tight agonist binding; Tracheal smooth muscle relaxation (Voss, H.-P. (227) 403) AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) Spider toxins; Excitatory amino acid receptors; NMDA (N-methyl- Adrenoceptors D-aspartic acid); Kainate (Davies, M.S. (227) 51) a,,-Adrenoceptors; Phosphoinositide turnover; Phosphorylase (Garcia-Sainz, J.A. (227) 239) d-Amphetamine Dopamine transport; N-Ethylmaleimide alkylation; Cocaine; [>H]- Catecholamines; Inositol phosphates (Schwinn, D.A. (227) 433) Mazindol binding (Johnson, K.M. (227) 411) 460 Anesthesia Brain (guinea pig) Substance P; Inositol phosphates; Spinal cord; Cerebral cortex; Pen- o Receptors; Radioreceptor assay; (+)-Pentazocine (DeHaven- tobarbital (Hasséssian, H. (227) 103) Hudkins, D.L. (227) 371) Angiotensin-converting enzyme Brain (rat) Converting enzyme inhibitors; Captopril; Angiotensinogen; Solution Adenosine A, receptors; Adenosine A, receptors; Neuroprotection; hybridization /RNase protection (Ye, M.-Q. (227) 79) Desensitization (agonist induced) (Abbracchio, M.P. (227) 317) Angiotensin II receptors Bronchodilators PLC-PRF-5; Hepatoma cells; (Radioligand binding); (Receptor sub- Protein kinase C; Trachealis (bovine); Smooth muscle contraction; types) (Wintersgill, H.P. (227) 283) Cholinomimetics (Langlands, J.M. (227) 131) Angiotensin II receptor subtypes BTCP (N[1-(2-benzo[b]thiophenyl)cyclpoihpeerxiydlin]e ) GBR PC12W; Signal transduction pathways (Leung, K.H. (227) 63) 12935 [SH]CFT (2B-carbomethoxy-38-(4-fluorophenyl)-tropane) binding; Angiotensinogen Cocaine; Dopamine uptake inhibitors; Striatum (rat) (Reith, M.E.A. Angiotensin-converting enzyme; Converting enzyme inhibitors; Cap- (227) 417) topril; Solution hybridization /RNase protection (Ye, M.-Q. (227) 79) 2,3-Butanedione ANP-R, receptors Benzodiazepine receptors (central); Modification of receptors; [*H]- cGMP; Neutral metalloendopeptidase; Human neuroblastoma cell Ro 15-4513 binding; GABA , receptors (a subunits); Diethylpyrocar- line NB-OK1 (Delporte, C. (227) 247) bonate (Maksay, G. (227) 57) Antidepressants Ca*+ Idazoxan; B-Adrenoceptors; Adenylyl cyclase; C6 glioma cells; Pro- Action potentials; Pituitary; Protein kinase A; Protein kinase C; tein kinase C (Manji, H.K. (227) 275). Okadaic acid (Chiavaroli, C. (227) 173) A7r5 aortic cells Smooth muscle (vascular); Protein kinase C activity (cytosolic, partic- 2,5-Di-(tert-butyl)-1,4-benzohydroquinone; Cyclopiazonic acid; Ca** ulate); Phorbol esters (Bazan, E. (227) 343) permeability (Missiaen, L. (227) 391) Amiloride; 3,4-Dichlorobenzamil; Quinacrine; Ca** channel block- ATP ers; L-type Ca**+ channels (Stokke, M. (227) 379) Formycin A triphosphate (FTP); Guanylate cyclase; Atrial natri- uretic factor (ANF); cGMP (Chang, C.-H. (227) 229) Endothelins; Megakaryoblastic cells; Inositol phosphates (Diochot, S. (227) 427) Atrial natriuretic factor (ANF) Formycin A triphosphate (FTP); Guanylate cyclase; ATP; cGMP Ca** channel blockers (Chang, C.-H. (227) 229) ‘ Amiloride; 3,4-Dichlorobenzamil; Quinacrine; Ca**; L-type Ca?* channels (Stokke, M. (227) 379) Baclofen GABA, receptors; GABA (y-aminobuteric acid); Adenylyl cyclase Ca?* channels (inhibition); cAMP; Cerebellar granule cells (Holopainen, I. (227) Maitotoxin; Cation blockers; Liposomes (Murata, M. (227) 43) 225) Dihydropyridine receptors; Monoclonal antibodies; Purification; Benzodiazepine receptors (central) Cardiac sarcolemma (Tokumaru, H. (227) 363) Modification of receptors; [*H]Ro 15-4513 binding; GABA, 4 recep- tors (a subunits); Diethylpyrocarbonate; 2,3-Butanedione (Maksay, L-type Ca7* channels G. (227) 57) Amiloride; 3,4-Dichlorobenzamil; Quinacrine; Ca**; Ca** channel blockers (Stokke, M. (227) 379) Bradykinin cGMP; Endothelin; EDRF (endothelium-derived relaxing factor); Ca?* concentrations (intracellular) Forskolin; 5-HT (serotonin) (Reiser, G. (227) 89) Thromboxane A.,/prostaglandin H, receptors (TXA,/PGH, re- ceptors); Smooth muscle cells (vascular); Thromboxane A, receptor Bradykinin receptors; Bradykinin receptor antagonists; IMR-90 cells antagonist (KW-3635 and BM-13505) (Miki, I. (227) 199) (Sawutz, D.G. (227) 309) Ca?* current Bradykinin receptor antagonists Norepinephrine; Protein kinase C; 1,2-Dioctanoylglycerol; Whole-cell Bradykinin; Bradykinin receptors; IMR-90 cells (Sawutz, D.G. (227) voltage clamp; Sympathetic ganglia (Abrahams, T.P. (227) 189) 309) Ca’** permeability Bradykinin receptors 2,5-Di-(tert-butyl)-1,4-benzohydroquinone; Cyclopiazonic acid; A7r5 Bradykinin; Bradykinin receptor antagonists; IMR-90 cells (Sawutz, aortic cells (Missiaen, L. (227) 391) D.G. (227) 309) Captopril Brain Angiotensin-converting enzyme; Converting enzyme inhibitors; An- S-Adenosyl-L-methionine; Aging; Muscarinic receptors; Striatum; giotensinogen; Solution hybridization /RNase protection (Ye, M.-Q. Hippocampus (Muccioli, G. (227) 293) (227) 79) 461 Cardiac muscle (skinned) [SHICPP ([°H]3-((+ )-2-carboxypiperazin-4-yl) propyl-1-phosphonic Ca** sensitization; Muscle regulation; Inorganic phosphate; EMD acid) binding 53998 (Strauss, J.D. (227) 437) NMDA receptors; HA-966; Glycine; Polyamines (Porter, R.H.P. (227) 83) Cardiac sarcolemma Dihydropyridine receptors; Ca** channels; Monoclonal antibodies; Cyclopiazonic acid Purification (Tokumaru, H. (227) 363) 2,5-Di-(tert-butyl)-1,4-benzohydroquinone; Ca** permeability; A7r5 aortic cells (Missiaen, L. (227) 391) Ca’* sensitization Cardiac muscle (skinned); Muscle regulation; Inorganic phosphate; Cytochrome P-450 EMD 53998 (Strauss, J.D. (227) 437) ao Receptors; Phenobarbital; 3-Methylcholanthrene (Basile, A.S. (227) 95) Catecholamine receptors Dopamine D, receptors; Mutagenesis; Receptor binding (Mansour, Degranulation A. (227) 205) Neutrophil; Respiratory burst; Protein kinase C; Staurosporin; cgp 41251 (Krause, K.-H. (227) 221) Catecholamines Adrenoceptors; Inositol phosphates (Schwinn, D.A. (227) 433) Desensitization (agonist induced) Cation blockers Adenosine A, receptors; Adenosine A, receptors; Neuroprotection; Maitotoxin; Ca7* channels; Liposomes (Murata, M. (227) 43) Brain (rat) (Abbracchio, M.P. (227) 317) Cerebellar granule cells 3,4-Dichlorobenzamil GABA, receptors; GABA (y-aminobuteric acid); Adenylyl cyclase Amiloride; Quinacrine; Ca**; Ca**+ channel blockers; L-type Ca** (inhibition); cAMP; Baclofen (Holopainen, I. (227) 225) channels (Stokke, M. (227) 379) Cerebral cortex Diethylpyrocarbonate Substance P; Inositol phosphates; Spinal cord; Anesthesia; Pentobar- Benzodiazepine receptors (central); Modification of receptors; bital (Hasséssian, H. (227) 103) [7H]JRo 15-4513 binding; GABA, receptors (a@ subunits); 2,3- Butanedione (Maksay, G. (227) 57) C6 glioma cells Idazoxan; Antidepressants; B-Adrenoceptors; Adenylyl cyclase; Pro- Dihydropyridine receptors tein kinase C (Manji, H.K. (227) 275) Ca*+ channels; Monoclonal antibodies; Purification; Cardiac sar- colemma (Tokumaru, H. (227) 363) [7H]CFT (28-carbomethoxy-3f-(4-fluorophenyl)-tropane) binding Cocaine; BTCP (N[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine) 1,2-Dioctanoylglycerol GBR 12935; Dopamine uptake inhibitors; Striatum (rat) (Reith, Norepinephrine; Protein kinase C; Ca“* 2+ current; Whole-cell voltage M.E.A. (227) 417) clamp; Sympathetic ganglia (Abrahams, T.P. (227) 189) cgp 41251 Dipyridamole Neutrophil; Respiratory burst; Degranulation; Protein kinase C; Scavenging effects; Electron spin resonance; Hydroxyl radicals; Su- Staurosporin (Krause, K.-H. (227) 221) peroxide anions (Suzuki, S. (227) 395) Cholinomimetics Protein kinase C; Trachealis (bovine); Smooth muscle contraction; 2,5-Di-(tert-butyl)-1,4-benzohydroquinone Bronchodilators (Langlands, J.M. (227) 131) Cyclopiazonic acid; Ca** permeability; A7r5 aortic cells (Missiaen, L. (227) 391) Clonidine Norepinephrine; a,-Adrenoceptors; Morphine; w-Opioid receptors; Dopamine receptor antagonist ligands Adenylyl cyclase inhibition; Neuroblastoma SH-SYSY cells; Retinoic Dopamine D, receptors; Positron emission tomography (human acid (Lameh, J. (227) 19) brain) (Seeman, P. (227) 139) Cloning of receptors Dopamine D, receptors G-protein-coupled receptors; Neuropeptides; Neurokinin-type re- Dopamine receptor antagonist ligands; Positron emission tomogra- ceptors; Secretin-type receptors (Burbach, J.P.H. (227) 1) phy (human brain) (Seeman, P. (227) 139) Cocaine Mutagenesis; Receptor binding; Catecholamine receptors (Mansour, Dopamine transport; N-Ethylmaleimide alkylation; d-Amphetamine; A. (227) 205) [>H]Mazindol binding (Johnson, K.M. (227) 411) Dopamine D, receptors; Striatum (Murray, A.M. (227) 443) [7HICFT (2f-carbomethoxy-38-(4-fluorophenyl)-tropane) binding; BTCP (N[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine) GBR 12935; Dopamine uptake inhibitors; Striatum (rat) (Reith, M.E.A. (227) Dopamine D, receptors 417) Dopamine D, receptors; Striatum (Murray, A.M. (227) 443) Converting enzyme inhibitors Dopamine transport Angiotensin-converting enzyme; Captopril; Angiotensinogen; Solu- N-Ethylmaleimide alkylation; Cocaine; d-Amphetamine; [7HI]- tion hybridization /RNase protection (Ye, M.-Q. (227) 79) Mazindol binding (Johnson, K.M. (227) 411) 462 Dopamine uptake inhibitors Forskolin [SHICFT (2B-carbomethoxy-36-(4-fluorophenyl)-tropane) binding; Bradykinin; cGMP; Endothelin; EDRF (endothelium-derived relax- Cocaine; BTCP (N[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine) ing factor); 5-HT (serotonin) (Reiser, G. (227) 89) GBR 12935; Striatum (rat) (Reith, M.E.A. (227) 417) GABA (y-aminobuteric acid) DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine) GABA, receptors; Adenylyl cyclase (inhibition); cAMP; Baclofen; Transcription factors; Locus coeruleus (Bhat, R.V. (227) 447) Cerebellar granule cells (Holopainen, I. (227) 225) EDRF (endothelium-derived relaxing factor) GABA, receptor antagonism Bradykinin; cGMP; Endothelin; Forskolin; 5-HT (serotonin) (Reiser, RU 5135; GABA, receptor complex; 5a-Pregnane-3a-ol-20-one G. (227) 89) (3a,5a-P); 5S5a-Pregnane-3a-20a-diol (Sa-pregnanediol); Neuro- steroid site (Cadoni, C. (227) 147) Electron spin resonance Dipyridamole; Scavenging effects; Hydroxyl radicals; Superoxide an- GABA, receptor complex ions (Suzuki, S. (227) 395) RU 5135; Sa-Pregnane-3a-ol-20-one (3a,5a-P); Sa-Pregnane-3a- 20a-diol (Sa-pregnanediol); GABA, receptor antagonism; Neuro- EMD 53998 steroid site (Cadoni, C. (227) 147) Ca?* sensitization; Cardiac muscle (skinned); Muscle regulation; Inorganic phosphate (Strauss, J.D. (227) 437) GABA, receptors GABA (y-aminobuteric acid); Adenylyl cyclase (inhibition); cAMP; Endothelial cells (vascular) Baclofen; Cerebellar granule cells (Holopainen, I. (227) 225) Granulocyte-colony stimulating factor (G-CSF); Endothelin-1 (Namiki, A. (227) 339) GABA, receptors (@ subunits) Benzodiazepine receptors (central); Modification of receptors; Endothelin [7H]JRo 15-4513 binding; Diethylpyrocarbonate; 2,3-Butanedione Bradykinin; cGMP; EDRF (endothelium-derived relaxing factor); (Maksay, G. (227) 57) Forskolin; 5-HT (serotonin) (Reiser, G. (227) 89) Gene transcription Endothelin-1 Phorbol esters; Adenosine receptors; Adenylyl cyclase; T-lympho- Granulocyte-colony stimulating factor (G-CSF); Endothelial cells cytes (Kontny, E. (227) 333) (vascular) (Namiki, A. (227) 339) Glomeruli Endothelins Thromboxane A, receptors; Platelets (radioligand binding); Inositol Megakaryoblastic cells; Ca2*; Inositol phosphates (Diochot, S. (227) phosphates (Folger, W.H. (227) 71) 427) Glycine Epidermal cells (mouse) [SHICPP ((°H]3-((+ )-2-carboxypiperazin-4-yl)propyl-1-phosphonic Staurosporine; 12-O-Tetradecanoylphorbol 13-acetate; Protein ki- acid) binding; NMDA receptors; HA-966; Polyamines (Porter, R.H.P. nase C; Ornithine decarboxylase; Morphological changes (Yamamoto, (227) 83) S. (227) 113) cGMP Estrogen receptors Bradykinin; Endothelin; EDRF (endothelium-derived relaxing fac- Polymerase chain reaction; (Sprague-Dawley rat) (Spreafico, E. (227) tor); Forskolin; 5-HT (serotonin) (Reiser, G. (227) 89) 353) Formycin A triphosphate (FTP); Guanylate cyclase; ATP; Atrial N-Ethylmaleimide alkylation natriuretic factor (ANF) (Chang, C.-H. (227) 229) Dopamine transport; Cocaine; d-Amphetamine; [*H]Mazindol bind- ing (Johnson, K.M. (227) 411) ANP-R, receptors; Neutral metalloendopeptidase; Human neuro- blastoma cell line NB-OK1 (Delporte, C. (227) 247) Eudismic analysis Muscarinic receptors; Hexahydro-difenidol; Hexbutinol; Oxyphency- G-Protein climine; Pfeiffer’s rule; Stereoselectivity; Receptor interaction Leukotrienes; Smooth muscles; Pulmonary system; Inositol phos- (Waelbroeck, M. (227) 33) phates; Protein kinase C (Howard, S. (227) 123) Excitatory amino acid receptors G-protein-coupled receptors Spider toxins; NMDA (N-methyl-D-aspartic acid); Kainate; AMPA Cloning of receptors; Neuropeptides; Neurokinin-type receptors; Se- (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) (Davies, cretin-type receptors (Burbach, J.P.H. (227) 1) M.S. (227) 51) G-protein coupling Fluoxetine 5-HT, receptors (human); 5-HT,, receptors (human); Ketanserin; G proteins; Polymerase chain reaction; mRNA expression (Lesch, (+ )-8-Hydroxy-2-(di-n-propylamino)tetralin HBr (8-OH-DPAT) K.P. (227) 233) (Stam, N.J. (227) 153) Formycin A triphosphate (FTP) G-proteins Guanylate cyclase; ATP; Atrial natriuretic factor (ANF); cGMP Polymerase chain reaction; mRNA expression; Fluoxetine (Lesch, (Chang, C.-H. (227) 229) K.P. (227) 233) Opioid receptors; Affinity cross-linking; NG108-15 cells (Harada, J. 5-HT (serotonin) (227) 301) Bradykinin; cGMP; Endothelin; EDRF (endothelium-derived relax- ing factor); Forskolin (Reiser, G. (227) 89) Granulocyte-colony stimulating factor (G-CSF) Endothelin-1; Endothelial cells (vascular) (Namiki, A. (227) 339) Human neuroblastoma cell line NB-OK1 ANP-R, receptors; cGMP; Neutral metalloendopeptidase (Delporte, Guanylate cyclase C. (227) 247) Formycin A triphosphate (FTP); ATP; Atrial natriuretic factor (ANF); cGMP (Chang, C.-H. (227) 229) Hydroxyl radicals Dipyridamole; Scavenging effects; Electron spin resonance; Superox- H + ide anions (Suzuki, S. (227) 395) NMDA channels; Mg* (Von Euler, G. (227) 449) Hypertrophy HA-966 [SHICPP ((°H]3-((+ )-2-carboxypiperazin-4-yl)propyl-1-phosphonic Smooth muscle cells; Losartan; Phosphoinositide signalling system acid) binding; NMDA receptors; Glycine; Polyamines (Porter, R.H.P. (Ko, Y. (227) 215) (227) 83) Idazoxan Hepatocytes, Inositol phosphates Antidepressants; B-Adrenoceptors; Adenylyl cyclase; C6 glioma cells; Histamine H, receptors (Garcia-Sainz, J.A. (227) 325) Protein kinase C (Manji, H.K. (227) 275) Hepatoma cells Immediate-early genes PLC-PRF-5; Angiotensin II receptors; (Radioligand binding); (Re- Striatum; Phosphorothioate (Chiasson, B.J. (227) 451) ceptor subtypes) (Wintersgill, H.P. (227) 283) IMR-90 cells Hexahydro-difenidol Bradykinin; Bradykinin receptors; Bradykinin receptor antagonists Muscarinic receptors; Hexbutinol; Oxyphencyclimine; Eudismic anal- (Sawutz, D.G. (227) 309) ysis; Pfeiffer’s rule; Stereoselectivity; Receptor interaction (Wael- broeck, M. (227) 33) Inorganic phosphate Ca?* sensitization; Cardiac muscle (skinned); Muscle regulation; Hexbutinol EMD 53998 (Strauss, J.D. (227) 437) Muscarinic receptors; Hexahydro-difenidol; Oxyphencyclimine; Eu- dismic analysis; Pfeiffer’s rule; Stereoselectivity; Receptor interac- tion (Waelbroeck, M. (227) 33) Inositol phosphates Thromboxane A, receptors; Glomeruli; Platelets (radioligand bind- Hippocampus ing) (Folger, W.H. (227) 71) S-Adenosyl-L-methionine; Brain; Aging; Muscarinic receptors; Stria- tum (Muccioli, G. (227) 293) Substance P; Spinal cord; Cerebral cortex; Anesthesia; Pentobarbital (Hasséssian, H. (227) 103) ['251] His-NKA NK, receptors; Small intestine smooth muscle (rat); NK receptor Leukotrienes; Smooth muscles; Pulmonary system; Protein kinase C; subtypes; Radioligand binding (Brown, M.C.S. (227) 163) G-Protein (Howard, S. (227) 123) Histamine H, receptors Endothelins; Megakaryoblastic cells; Ca?* (Diochot, S. (227) 427) Hepatocytes, Inositol phosphates (Garcia-Sainz, J.A. (227) 325) 5-HT,, receptor binding sites Adrenoceptors; Catecholamines (Schwinn, D.A. (227) 433) Trigeminal ganglia (rat); 5-HT,, receptor messenger RNA (Bruin- vels, A.T. (227) 357) Kainate Spider toxins; Excitatory amino acid receptors; NMDA (N-methyl- 5-HT,, receptor messenger RNA D-aspartic acid); AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazo- Trigeminal ganglia (rat); 5-HT,, receptor binding sites (Bruinvels, lepropionic acid) (Davies, M.S. (227) 51) A.T. (227) 357) Ketanserin 5-HT receptors 5-HT, receptors (human); 5-HT,, receptors (human); G-protein cAMP; Sumatriptan; 5-HT,p, receptors (Miller, K.J. (227) 99) coupling; (+)-8-Hydroxy-2-(di-n-propylamino)tetralin HBr (8-OH- DPAT) (Stam, N.J. (227) 153) 5-HT jpg receptors 5-HT receptors; cAMP; Sumatriptan (Miller, K.J. (227) 99) Leukotrienes Smooth muscles; Pulmonary system; Inositol phosphates; Protein 5-HT,, receptors (human) kinase C; G-Protein (Howard, S. (227) 123) 5-HT, receptors (human); G-protein coupling; Ketanserin; (+ )-8- Hydroxy-2-(di-n-propylamino)tetralin HBr (8-OH-DPAT) (Stam, N.J. (227) 153) Liposomes Maitotoxin; Ca2* channels; Cation blockers (Murata, M. (227) 43) 5-HT, receptors (human) 5-HT,, receptors (human); G-protein coupling; Ketanserin; (+ )-8- Locus coeruleus Hydroxy-2-(di-n-propylamino)tetralin HBr (8-OH-DPAT) (Stam, N.J. Transcription factors; DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromo- (227) 153) benzylamine) (Bhat, R.V. (227) 447) - 464 Losartan Myenteric plexus (guinea-pig) Smooth muscle cells; Hypertrophy; Phosphoinositide signalling sys- Adenylate cyclase; p-Opioid receptors (pre- and postsynaptic) tem (Ko, Y. (227) 215) (Rengel, I. (227) 385) Maitotoxin Neuroblastoma SH-SYSY cells Ca?*+ channels; Cation blockers; Liposomes (Murata, M. (227) 43) Clonidine; Norepinephrine; a,-Adrenoceptors; Morphine; u-Opioid receptors; Adenylyl cyclase inhibition; Retinoic acid (Lameh, J. (227) [7H]M azindol binding 19) Dopamine transport; N-Ethylmaleimide alkylation; Cocaine; d- Amphetamine (Johnson, K.M. (227) 411) Neurokinin-type receptors Cloning of receptors; G-protein-coupled receptors; Neuropeptides; Megakaryoblastic cells Secretin-type receptors (Burbach, J.P.H. (227) 1) Endothelins; Ca?*; Inositol phosphates (Diochot, S. (227) 427) Neuropeptides Metabotropic glutamate receptors Cloning of receptors; G-protein-coupled receptors; Neurokinin-type L-2-Amino-4-phosphonobutyrate (L-AP4); cAMP (Thomsen, C. (227) receptors; Secretin-type receptors (Burbach, J.P.H. (227) 1) 361) Neuroprotection 3-Methylcholanthrene Adenosine A, receptors; Adenosine A, receptors; Brain (rat); De- Cytochrome P-450; a Receptors; Phenobarbital (Basile, A.S. (227) sensitization (agonist induced) (Abbracchio, M.P. (227) 317) 95) Neurosteroid site Mg * RU 5135; GABA, receptor complex; Sa-Pregnane-3a-ol-20-one NMDA channels; H* (Von Euler, G. (227) 449) (3a,5a-P); 5a-Pregnane-3a-20a-diol (Sa-pregnanediol); GABA , re- ceptor antagonism (Cadoni, C. (227) 147) Modification of receptors Benzodiazepine receptors (central); [>H]Ro 15-4513 binding; GABA, receptors (@ subunits); Diethylpyrocarbonate; 2,3-Butane- Neutral metalloendopeptidase dione (Maksay, G. (227) 57) ANP-R, receptors; cGMP; Human neuroblastoma cell line NB-OK1 (Delporte, C. (227) 247) Monoclonal antibodies Dihydropyridine receptors; Ca** channels; Purification; Cardiac sar- Neutrophil colemma (Tokumaru, H. (227) 363) Respiratory burst; Degranulation; Protein kinase C; Staurosporin; cgp 41251 (Krause, K.-H. (227) 221) Morphine Clonidine; Norepinephrine; a,-Adrenoceptors; u-Opioid receptors; NG108-15 cells Adenylyl cyclase inhibition; Neuroblastoma SH-SYSY cells; Retinoic Opioid receptors; G-proteins; Affinity cross-linking (Harada, J. (227) acid (Lameh, J. (227) 19) 301) Morphological changes NK, receptors Staurosporine; 12-O-Tetradecanoylphorbol 13-acetate; Protein ki- Small intestine smooth muscle (rat); NK receptor subtypes; Radioli- nase C; Ornithine decarboxylase; Epidermal cells (mouse) gand binding; ['*IJHis-NKA (Brown, M.C.S. (227) 163) (Yamamoto, S. (227) 113) NK receptor subtypes Muscarinic receptor agonists (selective) NK. receptors; Small intestine smooth muscle (rat); Radioligand SR 95639A; Muscarinic receptor subtypes; Phosphoinositides; cAMP; binding; [!*°IJHis-NKA (Brown, M.C.S. (227) 163) Acetylcholine release (Mohamed, A.S. (227) 181) NMDA channels Muscarinic receptors H*; Mg* (Von Euler, G. (227) 449) Hexahydro-difenidol; Hexbutinol; Oxyphencyclimine; Eudismic anal- ysis; Pfeiffer’s rule; Stereoselectivity; Receptor interaction (Wael- NMDA (N-methyl-D-aspartic acid) broeck, M. (227) 33) Spider toxins; Excitatory amino acid receptors; Kainate; AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) (Davies, S-Adenosyl-L-methionine; Brain; Aging; Striatum; Hippocampus M.S. (227) 51) (Muccioli, G. (227) 293) NMDA receptor antagonists Muscarinic receptor subtypes SR 95639A; Muscarinic receptor agonists (selective); Phosphoinosi- NMDA receptor mRNA; Polymerase chain reaction (Lesch, K.P. tides; cAMP; Acetylcholine release (Mohamed, A.S. (227) 181) (227) 109) Muscle regulation NMDA receptor mRNA Ca** sensitization; Cardiac muscle (skinned); Inorganic phosphate; NMDA receptor antagonists; Polymerase chain reaction (Lesch, K.P. EMD 53998 (Strauss, J.D. (227) 437) (227) 109) Mutagenesis NMDA receptors Dopamine D, receptors; Receptor binding; Catecholamine receptors [SHICPP ((°H]3-(( + )-2-carboxypiperazin-4-yl)propyl-1-phosphonic (Mansour, A. (227) 205) acid) binding; HA-966; Glycine; Polyamines (Porter, R.H.P. (227) 83)

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