European Journal of Pharmacology, 223 (1992) 211-212 © 1992 Elsevier Science Publishers B.V. All rights reserved 0014-/2929 /9$059.0 0 Author index Abe, K., see Watanabe, Y. (223) 179 Garrick, T., Yang, H., Trauner, M., Livingston, E. and Taché, Y. Ansari, M.S., see Kessler, R.M. (223) 105 Thyrotropin-releasing hormone analog injected into the raphe pallidus and obscurus increases gastric contractility in rats (223) Bakich, V., see McIntosh, C.H.S. (223) 117 75 Bell, R.L., see Kessler, R.M. (223) 105 Gewecke, M., see Wedemeyer, S. (223) 173 Besse, D., Weil-Fugazza, J., Lombard, M.-C., Butler, S.H. and Gonzalez, A.M. and Pazos, A. Besson, J.-M. Modification of muscarinic acetylcholine receptors in the rat Monoarthritis induces complex changes in y-, 5- and «-opioid brain following chronic immobilization stress: an autoradio- binding sites in the superficial dorsal horn of the rat spinal cord graphic study (223) 25 (223) 123 Goodson, Jr., T., see Silbaugh, S.A. (223) 57 Besson, J.-M., see Besse, D. (223) 123 Booth, R.F.G., see Lad, N. (223) 163 Hanson, P.J., see Brown, J.F. (223) 103 Brown, J.F., Hanson, PJ. and Whittle, B.J.R. Harding, S.E., Jones, $.M., Vescovo, G., Del Monte, F. and Poole- Nitric oxide donors increase mucus gel thickness in rat stomach Wilson, P.A. (223) 103 Reduced contractile responses to forskolin and a cyclic AMP Buisson-Defferier, S. and Van den Buuse, M. analogue in myocytes from failing human ventricle (223) 39 Cardiovascular effects of the 5-HT,, receptor ligand, MDL Helgren, M.C., see Klabunde, R.E. (223) 1 7300S5EF, in conscious spontaneously hypertensive rats (223) 133 Herron, D.K., see Silbaugh, S.A. (223) 57 Butler, S.H., see Besse, D. (223) 123 Hiramatsu, M., see Nabeshima, T. (223) 109 Caporali, M.G., Scotti de Carolis, A. and Popoli, P. Ishihara, K., see Renming, X. (223) 185 N-Ethyl-carboxamide adenosine inhibits perioral dyskinesias in- duced by sulpiride + SKF 38393 in rabbits (223) 15 Chen, G. and Cheung, D.W. Jones, S.M., see Harding, S.E. (223) 39 Pharmacological distinction of the hyperpolarization response to Junien, J.L., see Yoneda, M. (223) 197 caffeine and acetylcholine in guinea-pig coronary endothelial cells (223) 33 Kameyama, T., see Nabeshima, T. (223) 109 Cheung, D.W., see Chen, G. (223) 33 Karaki, H., see Kim, B.K. (223) 157 Clanton, J.A., see Kessler, R.M. (223) 105 Kessler, R.M., Mason, N.S., Votaw, J.R., De Paulis, T., Clanton, Cockerham, S.L., see Silbaugh, S.A. (223) 57 J.A., Ansari, M.S., Schmidt, D.E., Manning, R.G. and Bell, R.L. Cordeiro, R.S.B., see Pasquale, C.P. (223) 9 Visualization of extrastriatal dopamine D, receptors in the hu- Coric, P., see Noble, F. (223) 91 man brain (223) 105 Kim, B.K., Mitsui, M. and Karaki, H. Del Monte, F., see Harding, S.E. (223) 39 The long-term inhibitory effect of a Ca?* channel blocker, nisol- De Paulis, T., see Kessler, R.M. (223) 105 dipine, on cytosolic Ca?* and contraction in vascular smooth Diaz, B.L., see Pasquale, C.P. (223) 9 muscle (223) 157 Kimber, N.D., see Klabunde, R.E. (223) 1 Endoh, M., Takanashi, M. and Norota, I. Klabunde, R.E., Kimber, N.D., Kuk, J.E., Helgren, M.C. and Effect of (+ )-niguldipine on myocardial a,-adrenoceptors in the Férstermann, U. rabbit (223) 143 N°-Methyl-L-arginine decreases contractility, CGMP and cAMP in isoproterenol-stimulated rat hearts in vitro (223) | Fadayel, G.M., see Schmidt, C.J. (223) 65 Kuk, J.E., see Klabunde, R.E. (223) 1 Fleisch, J.H., see Silbaugh, S.A. (223) 57 Férstermann, U., see Klabunde, R.E. (223) 1 Lad, N., Williams, T.J. and Booth, R.F.G. Fournié-Zaluski, M.-C., see Noble, F. (223) 83 Neutrophil infiltration into the ischaemic/ reperfused rabbit iso- Fournié-Zaluski, M.-C., see Noble, F. (223) 91 lated myocardium: effect of PF-5901 and cycloheximide (223) 163 Fuji, K., see Nabeshima, T. (223) 109 Laorden, M.L., see Garaulet, J.V. (223) 19 Fujita, Y., see Renming, X. (223) 185 Law, S., see McIntosh, C.H.S. (223) 117 Furspan, P.B. Lefebvre, R.A., see Smits, G.J.M. (223) 97 WAY 120,491 activates ATP-sensitive potassium channels in rat Lima, M.C.R., see Pasquale, C.P. (223) 9 tail artery (223) 201 Liu, YJ. Effect of extracellular calcium concentration on angiotensin AT, Garaulet, J.V., Laorden, M.L. and Milanés, M.V. receptor-mediated smooth muscle contraction and antagonism in Influence of temperature on the effects of u-, 5- and «-opioid rabbit aorta (223) 205 receptor agonists in the guinea-pig ileum myenteric plexus (223) Livingston, E., see Garrick, T. (223) 75 19 Lombard, M.-C., see Besse, D. (223) 123 Manning, R.G., see Kessler, R.M. (223) 105 Schmidt, C.J., Fadayel, G.M., Sullivan, C.K. and Taylor, V.L. Martins, M.A., see Pasquale, C.P. (223) 9 5-HT, receptors exert a state-dependent regulation of dopamin- Mason, N.S., see Kessler, R.M. (223) 105 ergic function: studies with MDL 100,907 and the amphetamine McIntosh, C.H.S., Law, S. and Bakich, V. analogue, 3,4-methylenedioxymethamphetamine (223) 65 Chronic naltrexone treatment of rats: effects on gastrointestinal Schmidt, D.E., see Kessler, R.M. (223) 105 opioid peptide content (223) 117 Scotti de Carolis, A., see Caporali, M.G. (223) 15 Milanés, M.V., see Garaulet, J.V. (223) 19 Serikawa, T., see Renming, X. (223) 185 Mitsui, M., see Kim, B.K. (223) 157 Silbaugh, S.A., Stengel, P.W., Cockerham, S.L.. Roman, C.R., Momiyama, T., see Renming, X. (223) 185 Saussy, Jr., D.L., Spaethe, $.M., Goodson, Jr., T., Herron, D.K. and Fleisch, J.H. Nabeshima, T., Hiramatsu, M., Niwa, K., Fuji, K. and Kameyama, T. Pulmonary actions of LY255283, a leukotriene B, receptor antag- Effect of naftidrofuryl oxalate on 5-HT, receptors in mouse onist (223) 57 brain: evaluation based on quantitative autoradiography and Silva, P.M.R., see Pasquale, C.P. (223) 9 head-twitch response (223) 109 Smart, T.G., see Xie, X. (223) 193 Nagata, M. and Osumi, Y. Smits, G.J.M. and Lefebvre, R.A. Central noradrenergic inhibition of gastric motility in rats (223) Influence of age on responsiveness of rat gastric fundus to 153 agonists and to stimulation of intrinsic nerves (223) 97 Niwa, K., see Nabeshima, T. (223) 109 Spaethe, S.M., see Silbaugh, S.A. (223) 57 Noble, F., Coric, P., Fournié-Zaluski, M.-C. and Roques, B.P. Stengel, P.W., see Silbaugh, S.A. (223) 57 Lack of physical dependence in mice after repeated systemic Sullivan, C.K., see Schmidt, C.J. (223) 65 administration of the mixed inhibitor prodrug of enkephalin-de- grading enzymes, RB1O1 (223) 91 Taché, Y., see Garrick, T. (223) 75 Noble, F., Turcaud, S., Fournié-Zaluski, M.-C. and Roques, B.P. Taché, Y., see Yoneda, M. (223) 197 Repeated systemic administration of the mixed inhibitor of Takanashi, M., see Endoh, M. (223) 143 enkephalin-degrading enzymes, RB1O1, does not induce either Takaori, S., see Renming, X. (223) 185 antinociceptive tolerance or cross-tolerance with morphine (223) Taylor, V.L., see Schmidt, C.J. (223) 65 83 Todo, N., see Renming, X. (223) 185 Norota, I., see Endoh, M. (223) 143 Trauner, M., see Garrick, T. (223) 75 Turcaud, S., see Noble, F. (223) 83 Osumi, Y., see Nagata, M. (223) 153 Ujihara, H., see Renming, X. (223) 185 Pasquale, C.P., Silva, P.M.R., Lima, M.C.R., Diaz, B.L., Rihoux, J.P., Vargaftig, B.B., Cordeiro, R.S.B. and Martins, M.A. Van den Buuse, M., see Buisson-Defferier, S$. (223) 133 Suppression by cetirizine of pleurisy triggered by antigen in Vargaftig, B.B., see Pasquale, C.P. (223) 9 actively sensitized rats (223) 9 Vescovo, G., see Harding, $.E. (223) 39 Pazos, A., see Gonzalez, A.M. (223) 25 Votaw, J.R., see Kessler, R.M. (223) 105 Poole-Wilson, P.A., see Harding, S.E. (223) 39 Popoli, P., see Caporali, M.G. (223) 15 Watanabe, Y., Saito, H. and Abe, K. Effects of glycine and structurally related amino acids on genera- Reid, A., see Sawynok, J. (223) 49 tion of long-term potentiation in rat hippocampal slices (223) 179 Renming, X., Ishihara, K., Sasa, M., Ujihara, H., Momiyama, T.., Wedemeyer, S., Roeder, T. and Gewecke, M. Fujita, Y., Todo, N., Serikawa, T., Yamada, J. and Takaori, S. Pharmacological characterization of a 5-HT receptor in locust Antiepileptic effects of CNK-602A, a novel thyrotropin-releasing nervous tissue (223) 173 hormone analog, on absence-like and tonic seizures of sponta- Weil-Fugazza, J., see Besse, D. (223) 123 neously epileptic rats (223) 185 Whittle, B.J.R., see Brown, J.F. (223) 103 Rihoux, J.P., see Pasquale, C.P. (223) 9 Williams, T.J., see Lad, N. (223) 163 Roeder, T., see Wedemeyer, S. (223) 173 Roman, C.R., see Silbaugh, S.A. (223) 57 Xie, X. and Smart, T.G. Roques, B.P., see Noble, F. (223) 83 y-Hydroxybutyrate depresses monosynaptic excitatory and in- Roques, B.P., see Noble, F. (223) 91 hibitory postsynaptic potentials in rat hippocampal slices (223) 193 Saito, H., see Watanabe, Y. (223) 179 Sasa, M., see Renming, X. (223) 185 Yamada, J., see Renming, X. (223) 185 Saussy, Jr., D.L., see Silbaugh, S.A. (223) 57 Yang, H., see Garrick, T. (223) 75 Sawynok, J. and Reid, A. Yoneda, M., Junien, J.L. and Taché, Y. Noradrenergic mediation of spinal antinociception by 5-hydroxy- Central action of a receptor ligand, JO 1784, to suppress CRF- tryptamine: characterization of receptor subtypes (223) 49 induced inhibition of gastric function in conscious rats (223) 197 European Journal of Pharmacology, 223 (1992) 213-217 © 1992 Elsevier Science Publishers B.V. All rights reserved 0014-/2929 /9$059.0 0 Key word index Adenosine receptors Aorta (rat) Dopamine D, receptors; Dopamine D, receptors; Perioral dyskine- Smooth muscle (vascular); Nisoldipine; Inhibitory effects (residual), sia; (Rabbit) (Caporali, M.G. (223) 15) Ca?* levels (cytosolic); Ca?* channels; (Relaxation) (Kim, B.K. (223) 157) a-Adrenoceptor antagonists 5-HT (5-hydroxytryptamine, serotonin); Noradrenaline; Desipra- ATP mine; 6-Hydroxydopamine (6-OHDA); Spinal antinociception K* channels; Smooth muscle (vascular); Patch clamp (Furspan, P.B. (Sawynok, J. (223) 49) (223) 201) a@ ,,-Adrenoceptors Atropine (+)-Niguldipine; Positive inotropic effect; [*H)Prazosin binding; Raphe nuclei (medullary); Vagus; RX 77368; Thyrotropin-releasing Ventricular myocardium (rabbit) (Endoh, M. (223) 143) hormone (Garrick, T. (223) 75) a -Adrenoceptors Noradrenergic mechanisms (central); Gastric motility; Brainstem Autoradiography (Nagata, M. (223) 153) Chronic stress; Muscarinic receptors; Supersensitivity; Hippocampus; Striatum (Gonzalez, A.M. (223) 25) Aging Stomach (rat); Non-adrenergic, non-cholinergic (NANC); VIP Autoradiography (quantitative) (vasoactive intestinal polypeptide); Nitric oxide (NO); Cholinergic Joint inflammation; Pain (chronic); Polyarthritic rat; Opioid receptor neurons (Smits, G.J.M. (223) 97) regulation (Besse, D. (223) 123) Airway obstruction Benzamide (substituted) Leukotriene B,; Receptor binding; Parenchymal contraction; Dopamine D, receptors; SPECT imaging (Kessler, R.M. (223) 105) Leukotriene B, receptor antagonists; (Guinea-pig) (Silbaugh, S.A. (223) 57) Blood pressure 5-HT,, receptors; 5-HT,, receptor agonists; 5-HT,, receptor antag- Alanine onists; Heart rate; MDL 73005SEF; Spontaneously hypertensive rat Glycine; Serine; Valine; Glycine modulatory site; NMDA receptors; (SHR) (Buisson-Defferier, S. (223) 133) Long-term potentiation; Hippocampal slices (rat) (Watanabe, Y. (223) 179) Brainstem Noradrenergic mechanisms (central); a@-Adrenoceptors; Gastric Allergen motility (Nagata, M. (223) 153) Cetirizine; Leucocyte recruitment; Pleurisy (rat) (Pasquale, C.P. (223) 9) Ca** dbcAMP Endothelial cells; Caffeine (Chen, G. (223) 33) Forskolin; Desensitisation; Myocytes; Heart failure; (Human) (Hard- ing, S.E. (223) 39) Angiotensin; Angiotensin AT, receptors; Efficacy (Liu, YJ. (223) 205) Amphetamine Dopamine synthesis; Microdialysis;s MDMA (3,4-methylenedioxy- Ca** channels methamphetamine), 5-HT, receptors (Schmidt, C.J. (223) 65) Smooth muscle (vascular); Nisoldipine; Inhibitory effects (residual); Ca?* levels (cytosolic); Aorta (rat); (Relaxation) (Kim, B.K. (223) Angiotensin 157) Angiotensin AT, receptors; Ca?*; Efficacy (Liu, YJ. (223) 205) Caffeine Angiotensin AT, receptors Endothelial cells; Ca** (Chen, G. (223) 33) Angiotensin; Ca?*; Efficacy (Liu, YJ. (223) 205) Ca?* levels (cytosolic) Antiepileptic effect Spontaneously epileptic rat (SER); Thyrotropin-releasing hormone Smooth muscle (vascular); Nisoldipine; Inhibitory effects (residual), analogs; CNK-602A; Dopamine (Renming, X. (223) 185) Ca?* channels; Aorta (rat); (Relaxation) (Kim, B.K. (223) 157) Antinociceptive tolerance Cetirizine RB101 (mixed inhibitor of enkephalin-degrading enzymes); Mor- Allergen; Leucocyte recruitment; Pleurisy (rat) (Pasquale, C.P. (223) phine; Cross-tolerance (Noble, F. (223) 83) 9) 214 CGP 36742 B-Endorphin y-Hydroxybutyrate; GABA, receptors; EPSP (excitatory postsynap- Naltrexone; [Met*Jenkephalin; [Leu*]enkephalin; Gastrointestinal tic potential); IPSP (inhibitory postsynaptic potential); Hippocampus content (McIntosh, C.H.S. (223) 117) (Xie, X. (223) 193) Endothelial cells Cholinergic neurons Caffeine; Ca** (Chen, G. (223) 33) Aging; Stomach (rat); Non-adrenergic, non-cholinergic (NANC); VIP (vasoactive intestinal polypeptide); Nitric oxide (NO) (Smits, G.J.M. EPSP (excitatory postsynaptic potential) (223) 97) y-Hydroxybutyrate; GABA , receptors; CGP 36742; IPSP (inhibitory postsynaptic potential); Hippocampus (Xie, X. (223) 193) Chronic stress Muscarinic receptors; Autoradiography; Supersensitivity; Hippocam- Forskolin pus; Striatum (Gonzalez, A.M. (223) 25) dbcAMP; Desensitisation; Myocytes; Heart failure; (Human) (Hard- ing, S.E. (223) 39) CNK-602A Spontaneously epileptic rat (SER); Thyrotropin-releasing hormone GABA, receptors analogs; Antiepileptic effect; Dopamine (Renming, X. (223) 185) y-Hydroxybutyrate; CGP 36742; EPSP (excitatory postsynaptic po- tential); IPSP (inhibitory postsynaptic potential); Hippocampus (Xie, CRF (corticotropin-releasing factor) X. (223) 193) @ Receptor ligands; Gastric acid secretion; Gastric emptying (Yoneda, M. (223) 197) Gastric acid secretion o Receptor ligands; CRF (corticotropin-releasing factor); Gastric Cross-tolerance emptying (Yoneda, M. (223) 197) RB101 (mixed inhibitor of enkephalin-degrading enzymes); Mor- Gastric emptying phine; Antinociceptive tolerance (Noble, F. (223) 83) o Receptor ligands; CRF (corticotropin-releasing factor); Gastric DAGO ([D-Ala?,N-MePhe*,Gly 5-ol]enkephalin) acid secretion (Yoneda, M. (223) 197) Temperature; Opioid receptors; Myenteric plexus; DPDPE ([D- Gastric motility Pen?,D-Pen® Jenkephalin); U-50,488H (Garaulet, J.V. (223) 19) Noradrenergic mechanisms (central); a-Adrenoceptors; Brainstem (Nagata, M. (223) 153) Desensitisation Forskolin,; dbcAMP; Myocytes; Heart failure; (Human) (Harding, Gastric mucosa S.E. (223) 39) Nitric oxide (NO); Mucus (Brown, J.F. (223) 103) Desipramine Gastrointestinal content 5-HT (5-hydroxytryptamine, serotonin); Noradrenaline; a-Adreno- Naltrexone; [Met*Jenkephalin; [Leu* Jenkephalin; B-Endorphin (Mc- ceptor antagonists; 6-Hydroxydopamine (6-OHDA), Spinal antinoci- Intosh, C.H.S. (223) 117) ception (Sawynok, J. (223) 49) Glycine Dopamine Serine; Alanine; Valine; Glycine modulatory site; NMDA receptors; Spontaneously epileptic rat (SER); Thyrotropin-releasing hormone Long-term potentiation; Hippocampal slices (rat) (Watanabe, Y. analogs; CNK-602A; Antiepileptic effect (Renming, X. (223) 185) (223) 179) Dopamine D, receptors Glycine modulatory site Dopamine D, receptors; Adenosine receptors; Perioral dyskinesia; Glycine; Serine; Alanine; Valine; NMDA receptors; Long-term po- (Rabbit) (Caporali, M.G. (223) 15) tentiation; Hippocampal slices (rat) (Watanabe, Y. (223) 179) Dopamine D, receptors Head-twitch response Dopamine D, receptors; Adenosine receptors; Perioral dyskinesia; Naftidrofuryl oxalate (LS-121); Quantitative autoradiography; 5-HT, (Rabbit) (Caporali, M.G. (223) 15) receptors; 5-Hydroxytryptophan (5-HTP); (Mouse) (Nabeshima, T. (223) 109) Benzamide (substituted); SPECT imaging (Kessler, R.M. (223) 105) Heart failure Dopamine synthesis Forskolin; dbcAMP; Desensitisation; Myocytes; (Human) (Harding, Amphetamine; Microdialysis, MDMA (3,4-methylenedioxymetham- S.E. (223) 39) phetamine), 5-HT, receptors (Schmidt, C.J. (223) 65) Heart rate DPDPE ((D-Pen?,D-Pen*]enkephalin) 5-HT,, receptors; 5-HT,, receptor agonists; 5-HT,, receptor antag- Temperature; Opioid receptors; Myenteric plexus; DAGO ((D- onists; Blood pressure; MDL 73005EF; Spontaneously hypertensive Ala?,N-MePhe*,Gly°-ollenkephalin); U-50,488H (Garaulet, J.V. rat (SHR) (Buisson-Defferier, S. (223) 133) (223) 19) Hippocampal slices (rat) EDRF (endothelium-derived relaxing factor) Glycine; Serine; Alanine; Valine; Glycine modulatory site; NMDA Nitric oxide (NO); Nitric oxide synthase inhibition; Vasoconstriction receptors; Long-term potentiation (Watanabe, Y. (223) 179) (Klabunde, R.E. (223) 1) Hippocampus Efficacy Chronic stress; Muscarinic receptors; Autoradiography; Supersensi- Angiotensin; Angiotensin AT, receptors; Ca?* (Liu, Y.J. (223) 205) tivity; Striatum (Gonzalez, A.M. (223) 25) y-Hydroxybutyrate; GABA, receptors; CGP 36742; EPSP (excita- Learning tory postsynaptic potential); IPSP (inhibitory postsynaptic potential) 5-HT receptors; LSD (lysergic acid diethylamide); (Locust) (Xie, X. (223) 193) (Wedemeyer, S. (223) 173) 5-HT (5-hydroxytryptamine, serotonin) Leucocyte recruitment Noradrenaline; a-Adrenoceptor antagonists; Desipramine; 6-Hy- Cetirizine; Allergen; Pleurisy (rat) (Pasquale, C.P. (223) 9) droxydopamine (6-OHDA); Spinal antinociception (Sawynok, J. (223) 49) [Leu‘ Jenkephalin Naltrexone; [Met*]enkephalin; 8-Endorphin; Gastrointestinal con- 5-HT,, receptor agonists tent (McIntosh, C.H.S. (223) 117) 5-HT,, receptors; 5-HT,, receptor antagonists; Blood pressure; Heart rate; MDL 73005EF; Spontaneously hypertensive rat (SHR) Leukotriene B, (Buisson-Defferier, S. (223) 133) Receptor binding; Parenchymal contraction; Airway obstruction; Leukotriene B, receptor antagonists; (Guinea-pig) (Silbaugh, S.A. 5-HT,, receptor antagonists (223) 57) 5-HT,, receptors; 5-HT,, receptor agonists; Blood pressure; Heart Leukotriene B, receptor antagonists rate; MDL 73005EF; Spontaneously hypertensive rat (SHR) (Buis- son-Defferier, S. (223) 133) Leukotriene B,; Receptor binding; Parenchymal contraction; Airway obstruction; (Guinea-pig) (Silbaugh, S.A. (223) 57) 5-HT receptors Long-term potentiation LSD (lysergic acid diethylamide); Learning; (Locust) (Wedemeyer, S. Glycine; Serine; Alanine; Valine; Glycine modulatory site; NMDA (223) 173) receptors; Hippocampal slices (rat) (Watanabe, Y. (223) 179) 5-HT,, receptors LSD (lysergic acid diethylamide) 5-HT,, receptor agonists; 5-HT,, receptor antagonists; Blood pres- 5-HT receptors; Learning; (Locust) (Wedemeyer, S. (223) 173) sure; Heart rate; MDL 7300SEF; Spontaneously hypertensive rat (SHR) (Buisson-Defferier, S. (223) 133) MDL 7300SEF 5-HT,, receptors; 5-HT,, receptor agonists; 5-HT,, receptor antag- 5-HT, receptors onists; Blood pressure; Heart rate; Spontaneously hypertensive rat Amphetamine; Dopamine synthesis; Microdialysis;s MDMA (3,4- (SHR) (Buisson-Defferier, S$. (223) 133) methylenedioxymethamphetamine ) (Schmidt, C.J. (223) 65) MDMA (3,4-methylenedioxymethamphetamine ) Naftidrofuryl oxalate (LS-121); Quantitative autoradiography; 5-Hy- Amphetamine; Dopamine synthesis; Microdialysis; 5-HT, receptors droxytryptophan (5-HTP); Head-twitch response; (Mouse) (Nabeshi- (Schmidt, C.J. (223) 65) ma, T. (223) 109) [Met* enkephalin y -Hydroxybutyrate Naltrexone; [Leu*Jenkephalin; B-Endorphin; Gastrointestinal con- GABA, receptors; CGP 36742; EPSP (excitatory postsynaptic po- tent (McIntosh, C.H.S. (223) 117) tential); IPSP (inhibitory postsynaptic potential); Hippocampus (Xie, X. (223) 193) Microdialysis Amphetamine; Dopamine synthesis;s MDMA (3,4-methylenedioxy- 6-Hydroxydopamine (6-OHDA) methamphetamine); 5-HT, receptors (Schmidt, C.J. (223) 65) 5-HT (5-hydroxytryptamine, serotonin); Noradrenaline; a-Adreno- ceptor antagonists; Desipramine; Spinal antinociception (Sawynok, J. Morphine (223) 49) RB101 (mixed inhibitor of enkephalin-degrading enzymes); Antinoci- ceptive tolerance; Cross-tolerance (Noble, F. (223) 83) §-Hydroxytryptophan (5-HTP) RB101 (mixed inhibitor of enkephalin-degrading enzymes), Nalox- Naftidrofuryl oxalate (LS-121); Quantitative autoradiography; 5-HT, one; Physical dependence; (Systemic administration) (Noble, F. (223) receptors; Head-twitch response; (Mouse) (Nabeshima, T. (223) 109) 91) Inhibitory effects (residual) Mucus Smooth muscle (vascular); Nisoldipine; Ca?* levels (cytosolic); Ca?* Nitric oxide (NO); Gastric mucosa (Brown, J.F. (223) 103) channels; Aorta (rat); (Relaxation) (Kim, B.K. (223) 157) Muscarinic receptors IPSP (inhibitory postsynaptic potential) Chronic stress; Autoradiography; Supersensitivity; Hippocampus; y-Hydroxybutyrate; GABA, receptors; CGP 36742; EPSP (excita- Striatum (Gonzalez, A.M. (223) 25) tory postsynaptic potential); Hippocampus (Xie, X. (223) 193) M Joint inflammation Neutrophil-endothelial cell interaction; Myocardium (rabbit); Reper- Pain (chronic); Polyarthritic rat; Autoradiography (quantitative), fusion injury (Lad, N. (223) 163) Opioid receptor regulation (Besse, D. (223) 123) Myenteric plexus K* channels Temperature; Opioid receptors; DAGO ({(D-Ala?,N-MePhe*,Gly*- ATP; Smooth muscle (vascular); Patch clamp (Furspan, P.B. (223) oljenkephalin); DPDPE ({D-Pen?,D-Pen*]Jenkephalin); U-50,488H 201) (Garaulet, J.V. (223) 19) 216 Myocardium (rabbit) Opioid receptors Neutrophil-endothelial cell interaction; Reperfusion injury; Myelo- Temperature; Myenteric plexus; DAGO ((D-Ala?,N-MePhe*,Gly°- peroxidase (Lad, N. (223) 163) oljenkephalin); DPDPE ({D-Pen?,D-Pen* enkephalin); U-50,488H (Garaulet, J.V. (223) 19) Myocytes Forskolin; dbcAMP; Desensitisation; Heart failure: (Human) (Hard- Pain (chronic) ing, S.E. (223) 39) Joint inflammation; Polyarthritic rat; Autoradiography (quantitative); Opioid receptor regulation (Besse, D. (223) 123) Naftidrofuryl oxalate (LS-121) Quantitative autoradiography; 5-HT, receptors; 5-Hydroxytrypto- Parenchymal contraction phan (5-HTP); Head-twitch response; (Mouse) (Nabeshima, T. (223) Leukotriene B,; Receptor binding; Airway obstruction; Leukotriene 109) B, receptor antagonists; (Guinea-pig) (Silbaugh, S.A. (223) 57) Naloxone Patch clamp RBIO1 (mixed inhibitor of enkephalin-degrading enzymes); Mor- K* channels; ATP: Smooth muscle (vascular) (Furspan, P.B. (223) phine; Physical dependence; (Systemic administration) (Noble, F. 201) (223) 91) Perioral dyskinesia Naltrexone ; Dopamine D, receptors; Dopamine D, receptors; Adenosine recep- {Met *]enkephalin; [Leu*]enkephalin; B-Endorphin; Gastrointestinal tors; (Rabbit) (Caporali, M.G. (223) 15) content (McIntosh, C.H.S. (223) 117) Physical dependence Neutrophil-endothelial cell interaction RBIOL (mixed inhibitor of enkephalin-degrading enzymes); Mor- Myocardium (rabbit); Reperfusion injury; Myeloperoxidase (Lad, N. phine; Naloxone; (Systemic administration) (Noble, F. (223) 91) (223) 163) Pleurisy (rat) ( + )-Niguldipine Cetirizine; Allergen; Leucocyte recruitment (Pasquale, C.P. (223) 9) a@,,-Adrenoceptors; Positive inotropic effect; [*H]Prazosin binding; Ventricular myocardium (rabbit) (Endoh, M. (223) 143) Polyarthritic rat Joint inflammation; Pain (chronic); Autoradiography (quantitative), Nisoldipine Opioid receptor regulation (Besse, D. (223) 123) Smooth muscle (vascular); Inhibitory effects (residual); Ca?* levels (cytosolic); Ca?* channels; Aorta (rat); (Relaxation) (Kim, B.K. (223) Positive inotropic effect 157) (+ )-Niguldipine; a, ,-Adrenoceptors; [*H]Prazosin binding; Ventric- ular myocardium (rabbit) (Endoh, M. (223) 143) Nitric oxide (NO) EDRF (endothelium-derived relaxing factor); Nitric oxide synthase (7H) Prazosin binding inhibition; Vasoconstriction (Klabunde, R.E. (223) 1) (+ )-Niguldipine; a,,-Adrenoceptors; Positive inotropic effect; Ven- tricular myocardium (rabbit) (Endoh, M. (223) 143) Aging; Stomach (rat); Non-adrenergic, non-cholinergic (NANC); VIP (vasoactive intestinal polypeptide); Cholinergic neurons (Smits, Quantitative autoradiography G.J.M. (223) 97) Naftidrofuryl oxalate (LS-121); 5-HT, receptors; 5-Hydroxytryp- tophan (5-HTP); Head-twitch response; (Mouse) (Nabeshima, T. Mucus; Gastric mucosa (Brown, J.F. (223) 103) (223) 109) Nitric oxide synthase inhibition Raphe nuclei (medullary) EDRF (endothelium-derived relaxing factor); Nitric oxide (NO); Vagus; Atropine; RX 77368; Thyrotropin-releasing hormone (Gar- Vasoconstriction (Klabunde, R.E. (223) 1) rick, T. (223) 75) NMDA receptors RB101 (mixed inhibitor of enkephalin-degrading enzymes) Glycine; Serine; Alanine; Valine; Glycine modulatory site; Long-term Morphine; Antinociceptive tolerance; Cross-tolerance (Noble, F. potentiation; Hippocampal slices (rat) (Watanabe, Y. (223) 179) (223) 83) Non-adrenergic, non-cholinergic (NANC) Morphine; Naloxone; Physical dependence; (Systemic administra- Aging; Stomach (rat); VIP (vasoactive intestinal polypeptide); Nitric tion) (Noble, F. (223) 91) oxide (NO); Cholinergic neurons (Smits, G.J.M. (223) 97) Receptor binding Noradrenaline Leukotriene B,; Parenchymal contraction; Airway obstruction; 5-HT (5-hydroxytryptamine, serotonin); a-Adrenoceptor antagonists; Leukotriene B, receptor antagonists; (Guinea-pig) (Silbaugh, S.A. Desipramine; 6-Hydroxydopamine (6-OHDA); Spinal antinocicep- (223) 57) tion (Sawynok, J. (223) 49) ao Receptor ligands Noradrenergic mechanisms (central) CRF (corticotropin-releasing factor), Gastric acid secretion; Gastric a-Adrenoceptors; Gastric motility; Brainstem (Nagata, M. (223) 153) emptying (Yoneda, M. (223) 197) Opioid receptor regulation Reperfusion injury Joint inflammation; Pain (chronic), Polyarthritic rat; Autoradiogra- Neutrophil-endothelial cell interaction; Myocardium (rabbit); Myelo- phy (quantitative) (Besse, D. (223) 123) peroxidase (Lad, N. (223) 163) RX 77368 Supersensitivity Raphe nuclei (medullary); Vagus; Atropine; Thyrotropin-releasing Chronic stress; Muscarinic receptors; Autoradiography; Hippocam- hormone (Garrick, T. (223) 75) pus; Striatum (Gonzalez, A.M. (223) 25) Serine Temperature Glycine; Alanine; Valine; Glycine modulatory site; NMDA recep- Opioid receptors; Myenteric plexus; DAGO ([D-Ala*,N-MePhe’*, Gly*-oljenkephalin),; DPDPE ({D-Pen?,D-Pen*Jenkephalin); U-S0, tors; Long-term potentiation; Hippocampal slices (rat) (Watanabe, Y. (223) 179) 488H (Garaulet, J.V. (223) 19) Smooth muscle (vascular) Thyrotropin-releasing hormone Nisoldipine; Inhibitory effects (residual); Ca** levels (cytosolic); Raphe nuclei (medullary); Vagus; Atropine; RX 77368 (Garrick, T. Ca?* channels; Aorta (rat); (Relaxation) (Kim, B.K. (223) 157) (223) 75) Thyrotropin-releasing hormone analogs K* channels; ATP; Patch clamp (Furspan, P.B. (223) 201) Spontaneously epileptic rat (SER); CNK-602A; Antiepileptic effect: Dopamine (Renming, X. (223) 185) SPECT imaging Dopamine D, receptors; Benzamide (substituted) (Kessler, R.M. U-50,488H (223) 105) Temperature; Opioid receptors; Myenteric plexus; DAGO ({D- Ala*,N-GlMy *e-olPjenhkepehal*in) ; DPDPE ((D-Pen?,D-PenJ®e*n - Spinal antinociception kephalin) (Garaulet, J.V. (223) 19) 5-HT (5-hydroxytryptamine, serotonin); Noradrenaline; a-Adreno- ceptor antagonists; Desipramine; 6-Hydroxydopamine (6-OHDA) Vagus (Sawynok, J. (223) 49) Raphe nuclei (medullary); Atropine; RX 77368; Thyrotropin-releas- ing hormone (Garrick, T. (223) 75) Spontaneously epileptic rat (SER) Thyrotropin-releasing hormone analogs; CNK-602A; Antiepileptic Valine effect; Dopamine (Renming, X. (223) 185) Glycine; Serine; Alanine; Glycine modulatory site; NMDA receptors; Long-term potentiation; Hippocampal slices (rat) (Watanabe, Y. Spontaneously hypertensive rat (SHR) (223) 179) 5-HT,, receptors; 5-HT,, receptor agonists; 5-HT,, receptor antag- Vasoconstriction onists; Blood pressure; Heart rate; MDL 7300S5EF (Buisson- Defferier, S. (223) 133) EDRF (endothelium-derived relaxing factor); Nitric oxide (NO); Nitric oxide synthase inhibition (Klabunde, R.E. (223) 1) Stomach (rat) Ventricular myocardium (rabbit) Aging; Non-adrenergic, non-cholinergic (NANC), VIP (vasoactive (+)-Niguldipine; a,,-Adrenoceptors; Positive inotropic effect; intestinal polypeptide); Nitric oxide (NO); Cholinergic neurons [*H]Prazosin binding (Endoh, M. (223) 143) (Smits, G.J.M. (223) 97) VIP (vasoactive intestinal polypeptide) Striatum Aging; Stomach (rat); Non-adrenergic, non-cholinergic (NANC), Ni- Chronic stress; Muscarinic receptors; Autoradiography; Supersensi- tric oxide (NO); Cholinergic neurons (Smits, G.J.M. (223) 97) tivity; Hippocampus (Gonzalez, A.M. (223) 25)