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European Journal of Cancer Abstract Book European Cancer Congress, Amsterdam 27 September PDF

1055 Pages·2013·23.54 MB·English
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Vol. 49 Supplement 2 September 2013 ISSN 0959-8049 European Journal of Cancer Abstract Book European Cancer Congress, Amsterdam 27 September – 1 October 2013 Disclaimer All advertising material in this publication is expected to conform to ethical (medical) standards, and does not constitute a guarantee or endorsementofthequalityorvalueofsuchproductortheclaimsmadeofitbyitsmanufacturer,andisintendedforprescribinghealthcare professionalsonly. NoresponsibilityisassumedbythePublisherforanyinjuryand/ordamagetopersonsorpropertyasamatterofproductsliability,negligence orotherwise,orfromanyuseoroperationofanymethods,products,instructionsorideascontainedinthematerialherein.Becauseofrapid advancesinthemedicalsciences,inparticular,independentverificationofdiagnosesanddrugdosagesshouldbemade. Amsterdam • Boston • London • New York • Oxford • Paris • Philadelphia • San Diego • St Louis EQUIPPED WITH NEXT-GENERATION SEQUENCING Decode each patient’s tumour — individualise cancer treatment. (cid:116) Provides a rationale for making your next treatment decision (cid:116) Helps determine which drugs to avoid (cid:116) Identifies therapies which may not have been considered For example when: (cid:102) Choosing amongst standards treatments (cid:102) Standard treatments are not enough (cid:102)(cid:3)Faced with rare or aggressive tumours EXHIBITOR SPOTLIGHT THEATRE SEPTEMBER 29TH AT 12:30 (ROOM 2) | CarisLifeSciences.eu VISIT CARIS LIFE SCIENCES AT BOOTH NUMBER 2400 TO FIND OUT MORE European Journal of Cancer Editor-in-Chief: AlexanderM.M.Eggermont InstitutGustaveRoussy Villejuif,France Editors: BasicandPreclinicalResearch: RichardMarais,Manchester,UK GiorgioParmiani,Milan,Italy DrugDevelopment: Jean-CharlesSoria,Villejuif,France EarlyBreastCancer: KathleenI.Pritchard,Toronto,Canada AdvancedBreastCancer: DavidCameron,Edinburgh,UK GastrointestinalCancers: EricVanCutsem,Leuven,Belgium MichelDucreux,Villejuif,France GenitourinaryCancers: CoraSternberg,Rome,Italy LungCancer: MaryO’Brien,London,UK GynaecologicalCancers: IgnaceVergote,Leuven,Belgium HeadandNeckCancer: KevinHarrington,London,UK Sarcomas: Jean-YvesBlay,Lyon,France Melanoma: DirkSchadendorf,Essen,Germany Neuro-oncology: RogerStupp,Zurich,Switzerland EpidemiologyandPrevention: JanWillemCoebergh,Rotterdam,TheNetherlands PaediatricOncology: RobPieters,Rotterdam,TheNetherlands FoundingEditor: HenriTagnon PastEditors: MichaelPeckham,London,UK;Hans-Jo¨rgSenn,StGallen,Switzerland;JohnSmyth,Edinburgh,UK EditorialOffice: Elsevier,TheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UK Tel:+44(0)1865843590,Email:[email protected] EDITORIALBOARD CLINICALONCOLOGY J.-P.Armand(France) G.Ferrandina(Italy) P.O’Dwyer(USA) A.Ayhan(Japan) H.Gabra(UK) J.Overgaard(Denmark) R.Blamey(UK) H.Gelderblom(TheNetherlands) N.Pavlidis(Greece) M.Bolla(France) B.Hasan(Belgium) J.Perry(Canada) J.Boyages(Australia) J.C.Horiot(Switzerland) P.Price(UK) N.Bru¨nner(Denmark) C.Huber(Germany) D.Raghavan(USA) F.Cardoso(Portugal) R.Jakesz(Austria) J.Ringash(Canada) J.Cassidy(UK) J.Jassem(Poland) J.Robert(France) M.Castiglione(Switzerland) D.Jodrell(UK) A.Rody(Germany) L.Cataliotti(Italy) V.C.Jordan(USA) D.Sargent(USA) L.Cheng(USA) A.Katz(Brazil) M.Schmidinger(Austria) H.Cody(USA) M.Kaufmann(Germany) S.Sleijfer(TheNetherlands) R.Coleman(UK) I.Kunkler(UK) P.Sonneveld(TheNetherlands) A.Costa(Italy) L.Lindner(Germany) A.Sparreboom(USA) J.DeBono(UK) P.E.Lønning(Norway) M.vandenBent(TheNetherlands) M.J.A.DeJong(TheNetherlands) P.Lorigan(UK) M.VanGlabbeke(Belgium) E.deVries(TheNetherlands) K.McDonald(Australia) G.Velikova(UK) A.Dicker(USA) R.Mertelsmann(UK) U.Veronesi(Italy) R.Dummer(Switzerland) F.Meunier(Belgium) A.Vincent-Salomon(France) F.Eisinger(France) T.Mok(HongKong) A.Voogd(TheNetherlands) S.Erridge(UK) D.Nam(Korea) E.Winquist(Canada) BASIC,PRECLINICALANDTRANSLATIONALRESEARCH A.Albini(Italy) A.Gescher(UK) A.Puisieux(France) P.Allavena(Italy) R.Giavazzi(Italy) V.Rotter(Israel) F.Balkwill(UK) I.Hart(UK) M.Schmitt(Germany) M.Barbacid(Spain) W.Keith(UK) C.G.J.Sweep(TheNetherlands) M.Broggini(Italy) L.A.Kiemeney(TheNetherlands) G.Taraboletti(Italy) C.Catapano(Switzerland) J.Lunec(UK) P.Vineis(UK) J.Collard(TheNetherlands) D.R.Newell(UK) N.Zaffaroni(Italy) E.Garattini(Italy) G.J.Peters(TheNetherlands) EPIDEMIOLOGYANDPREVENTION B.Armstrong(Australia) A.Green(Australia) S.Sanjose(Spain) P.Autier(France) K.Hemminki(Germany) M.K.Schmidt(TheNetherlands) J.M.Borras(Spain) C.Johansen(Denmark) H.Storm(Denmark) C.Bosetti(Italy) L.A.Kiemeney(TheNetherlands) L.V.vandePoll-Franse(TheNetherlands) J.Faivre(France) M.Maynadie´ (France) H.M.Verkooijen(TheNetherlands) S.Franceschi(France) H.Møller(UK) R.Zanetti(Italy) D.Forman(France) P.Peeters(TheNetherlands) PAEDIATRICONCOLOGY C.Bergeron(France) G.Chantada(Argentina) L.Sung(Canada) A.Biondi(Italy) F.Doz(France) M.vandenHeuvel-Eibrink(TheNetherlands) E.Bouffet(Canada) A.Ferrari(Italy) M.vanNoesel(TheNetherlands) M.Cairo(USA) M.A.Grootenhuis(TheNetherlands) H.Caron(TheNetherlands) K.Pritchard-Jones(UK) Integrate Streamline Optimize Be Integrated Varian Medical Systems International AG www.varian.com/aria Zug, Switzerland [email protected] Phone +41(cid:2)-(cid:2)41(cid:2)-749 88 44 European Journal of Cancer including EJC Supplements AimsandScope TheEuropeanJournalofCancer(includingEJCSupplements)isaninternationalmultidisciplinaryoncologyjournalthatpublishesoriginal research, editorial comments, review articles and news on basic and preclinical research, clinical oncology (medical, paediatric, radiation,surgical),translationaloncologyandoncancerepidemiologyandprevention. ForafullandcompleteGuideforAuthors,pleasegotohttp://www.ejcancer.com Publishing&AdvertisingOffices:ElsevierLtd,TheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UK.(01865843000). Advertisinginformation.Advertisingordersandinquiriescanbesentto:USA,CanadaandSouthAmerica:PatHamptonAdvertising Department,ElsevierInc.,360ParkAvenueSouth,NewYork,NY10010-1710,USA;phone:(+1)(212)6333181;fax:(+1)(212)6333820; e-mail:[email protected]:AdvertisingSales:ElsevierPharmaSolutions;32JamestownRoad,LondonNW1 7BY,UK;Tel.:+44(0)2074244259;fax:+44(0)2074244433;e-mail:[email protected]. Publication information: European Journal of Cancer (ISSN 0959-8049). For2013, volume 49 (18 issues) is scheduled for publication. 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Join prIME Oncology at the Official European Cancer Congress 2013 Sponsored Satellite Symposia HEMATOLOGIC MALIGNANCIES * 11.00 - 13.00 * Hall G106 2 7 (cid:116) Refining Therapeutic Strategies in CD30-Positive Lymphomas Chair: Timothy Illidge, MD, PhD BREAST CANCER * 14.00 - 15.30 * Hall G102 S E P T E M B E R (cid:116) Strategic Options in Hard-to-Treat Advanced Breast Cancer: Triple-Negative and Other HER2-Negative Cases Co-Chairs: Angelo Di Leo, MD, PhD, and Vivianne Tjan-Heijnen, MD, PhD FRIDAY GASTROINTESTINAL MALIGNANCIES * 17.00 - 18.30 * Hall 3-1 (cid:116) Sharpening the Focus on Pancreatic Adenocarcinoma Co-Chairs: Volker Heinemann, MD, and Dirk Richel, MD GASTROINTESTINAL MALIGNANCIES * 17.00 - 19.00 * Hall G104 (cid:116) How I Treat Metastatic Colorectal Cancer in 2013 2 8 Chair: Aimery de Gramont, MD, PhD SEPTEMBER BREAST CANCER * 18.30 - 20.00 * Hall G104 (cid:116) Contemporary Management of Breast Cancer: SATURDAY A Focus on Innovator and Biosimilar Therapeutic Antibodies Chair: Javier Cortés, MD, PhD 29 SEPTEMBER GENITOURINARY MALIGNANCIES * 18.30 - 20.00 * Hall G104 (cid:116) Treating Castration-Resistant Prostate Cancer: SUNDAY A Work in Progress Chair: Bertrand Tombal, MD, PhD 30 SEPTEMBER GLIOBLASTOMA * 18.30 - 20.00 * Elicium 1 MONDAY (cid:116) Therapeutic Trends in Newly Diagnosed Glioblastoma: In Pursuit of Improved Patient Outcomes Chair: Michael Weller, MD www.prIMEoncology.org Peer Review Policy for the European Journal of Cancer (EJC) Thepracticeofpeerreviewistoensurethatonlygoodscience process.Reviewersarerequestedtorefrainfromgivingtheir is published. It is an objective process at the heart of good personalopinioninthe‘‘ReviewerblindcommentstoAuthor’’ scholarly publishing and is carried out by all reputable sectionoftheirreviewonwhetherornotthepapershouldbe scientific journals. Our reviewers therefore play a vital role published. Personal opinions can be expressed in the in maintaining the high standards of the European Journal of ‘‘ReviewerconfidentialcommentstoEditor’’section. Cancer(EJC)andallmanuscriptsarepeerreviewedfollowing Howlongdoesthepeerreviewprocesstake? theprocedureoutlinedbelow. Typicallythe manuscript will be reviewedwithin 2-8 weeks. Initialmanuscriptevaluation Should the reviewers’ reports contradict one another or a The Editors first evaluate all manuscripts. In some circum- reportisunnecessarilydelayedafurtherexpertopinionwill stancesitisentirelyfeasibleforanexceptionalmanuscriptto be sought. Revised manuscripts are usually returned to the be accepted at this stage. Those rejected at this stage are Editors within 3 weeks and the Editors may request further insufficientlyoriginal,haveseriousscientificflaws,havepoor advice from the reviewers at this time. The Editors may grammar or English language, or are outside the aims and requestmorethanonerevisionofamanuscript. scopeofthejournal.Thosethatmeettheminimumcriteria Finalreport arepassedontoexpertsforreview. Afinaldecisiontoacceptorrejectthemanuscriptwillbesent Authorsofmanuscriptsrejectedatthisstagewillbeinformed totheauthoralongwithanyrecommendationsmadebythe within2weeksofreceipt. reviewers, and may include verbatim comments by the TypeofPeerReview reviewers. The EJC employs single blind review, where the reviewer Editor’sDecisionisfinal remainsanonymoustotheauthorsthroughouttheprocess. ReviewersadvisetheEditors,whoareresponsibleforthefinal Howthereviewerisselected decisiontoacceptorrejectthearticle. Reviewers are matched to the paper according to their SpecialIssues/ConferenceProceedings expertise. Our reviewer database contains reviewer contact detailstogetherwiththeirsubjectareasofinterest,andthisis Special issues and/or conference proceedings may have constantlybeingupdated. different peer review procedures involving, for example, GuestEditors,conferenceorganisersorscientificcommittees. Reviewerreports Authorscontributingtotheseprojectsmayreceivefulldetails Reviewersareaskedtoevaluatewhetherthemanuscript: ofthepeerreviewprocessonrequestfromtheeditorialoffice. – Isoriginal BecomingaReviewerfortheEJC – Ismethodologicallysound IfyouarenotcurrentlyareviewerfortheEJCbutwouldliketo – Followsappropriateethicalguidelines be considered as a reviewer for this Journal, please contact – Has results which are clearly presented and support the the editorial office by e-mail at [email protected], and conclusions provideyourcontactdetails.Ifyourrequestisapprovedand – Correctlyreferencespreviousrelevantwork youareaddedtotheonlinereviewerdatabaseyouwillreceive Reviewers are not expected to correct or copyedit manu- aconfirmatoryemail,askingyoutoadddetailsonyourfield scripts. Language correction is not part of the peer review ofexpertise,intheformatofsubjectclassifications. The European Cancer Congress 2013 C. van de Velde ECCO President and Congress Chair M. Piccart ESMO President C. Sternberg Co-Scientific Chair J. Yarnold Co-Scientific Chair M. Verheij National Organising Committee Chair

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The European Journal of Cancer (including EJC Supplements) is an . of contents or prepare lists of articles including abstracts for internal circulation . Typically the manuscript will be reviewed within 2-8 weeks. Final report . New Challenges in Metastatic Renal Cancer Cells: Identifying What is
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Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.