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European Journal of Cancer 1993: Vol 29 Index & Table of Contents PDF

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European Journal of Cancer Volume 29, 1993 List of Contents and Author Index Published by PERGAMON PRESS Oxford - New York - Seoul - Tokyo European Journal of Cancer Editor in Chief: Editors: MICHAEL PECKHAM MATTI AAPRO IAN HART UMBERTO VERONESI Director of Research Centre Anticancéreux, Imperial Cancer Research Istituto Nazionale Tumori, and Development Clinique de Genolier, Fund Laboratories, Via Venezian I, Department of Health 1261 Genolier, Lincoln’s Inn Fields, 20133 Milan, Italy Switzerland London WC2A 3PX, UK European Journal of Cancer Part B: Oral Oncology Editorial Office: PETER BOYLE EMMANUEL Division of Epidemiology and VAN DER SCHUEREN CRISPIAN SCULLY European Journal of Cancer, Biostatistics, Universitair Ziekenhuis Eastman Dental Institute British Postgraduate Istituto Europeo di Oncologia, St Rafaél, for Oral and Dental Medical Federation, Milan, Leuven, Healthcare Sciences, 33 Millman Street, Italy Belgium 256 Grays Inn Road, London, WCIN 3EJ, UK London WCI1X 8LD, Telephone 44-71-430-0100 UK Fax 44-71-430-0072 Editor, Education and Training in Oncology Section Alberto Costa Senior Advisors Kari Alitalo, Harry Bartelink, Henri Bismuth, Walter Bodmer, Gianni Bonadonna, Piet Borst, Frans Cleton, Derek Crowther, Louis Denis, Jean-Pierre Gerard, Jack Hardcastle, Jean-Claude Horiot, Gordon McVie, Jacques Ninane, Jens Overgaard, Thierry Philip, Herbert Pinedo, Manfred Rajewsky, Bruno Salvadori, Harald Stein Consulting Editors Molecular Biology Radiotherapy Medical Oncology Surgery A Balmain D Ash F Cavalli G Chisholm M Beato F Eschwege H H Hansen F Demard T Boon R Greiner A Harris J van Dongen C-H Heldin A Horwich R Mertelsmann IS Fentiman M Yaniv D Kogelnik S Monfardini U Metzger P Scalliet H T Mouridsen A Peracchia Cell Biology I Turesson A van Oosterom P Schlag G Gabbiani A Vritsios JF Smyth B Geiger O Dahl D Louvard Pharmacology and New Epidemiology and Cancer E Rozengurt Tumour Virology Drug Development Prevention J M Vasiliev L Crawford J P Armand F Alexander H Diggelman M D'Incalci J Cuzick Genetics H zur Hausen S B Kaye N E Day F Cuzin P Tiollais P Workman S Franceschi G P Georgiev G Schwartsmann P Ghadirian A Hagemeijer Radiobiology M Hakama G Klein G Adams Paediatric Oncology C Hsieh H Lehrach A van der Kogel H Jurgens K Katsouyanni G Steel J Pritchard Levi Biochemistry D Sommelet-Olive J Martin-Moreno M M Burger Pathology P A Voite CS Muir P A Cerutti P Bannasch E Negri C G Gahmberg J Costa Endocrinology R Saracci F Oesch B Gusterson K Griffiths D Trichopoulos F Rilke S Lamberts LJ Vatten Molecular Diagnostics C Mahler C La Vecchia B Groner Imaging, Interventional D Zaridze J P Mach Radiology, Medical Physics Haematology W Zatonski C Marshall A Breit M Boiron G Riethmuller R S Dondelinger M H Bronchud D Gadian TM Dexter Clinical Trial Methodology, Molecular Therapeutics H Svensson G Gahrton Biostatistics T Hercend R Flamant C Huber Psychosocial Issues Palliative Oncology E Marubini S Meuer A Cull J Maher R Sylvester P Maguire HJ Senn Biotechnology and Industry R Zittoun M Slevin S Foden V Ventafridda Ethics M Baum Corresponding Editors North America India Australia C Balch, Z Fuks, C Henderson, I Mittra A Langlands, V Marshall, V C Jordan, A Knudson, H Koprowski, D Metcalf, R Stuart-Harris, J Minna, L Peters, D Raghavan, R Sutherland, M Tattersall E J Stanbridge, H R Withers Society and News F Meunier ESTRO J WH Leer Correspondents V Majstorovic EACR MR Price H Cortes-Funes ECL O Bang W Mattheiem SIOP (European PA Voite J Smyth Branch) Editor in Chief’s Office Scientific Editor Delphine Purves Production Editor (Pergamon) Shirley Parker Editorial Assistant Sarah Hole List of Contents E. Jahde, S. Roszinski, T. Volk, K.-H. Gliisenkamp, Metabolic response of AH13r rat tumours to cyclophosphamide as monitored by G. Wiedemann and M. F. Rajewsky pO, and pH semi-microelectrodes R. Sankila and M. Hakama Survival trends for neuroblastoma patients in Finland: negative reflections on screening C. Helige, J. Smolle, G. Zellnig, R. Fink-Puches, Effect of dequalinium on K1735-M2 melanoma cell growth, directional migration H. Kerl and H. A. Tritthart and invasion in vitro G. Milano, M.-C. Etienne, E. Cassuto-Viguier, Long-term stability of 5-fluorouracil and folinic acid admixtures N. Renée, M. Bousselet, T. Guillot and D. Lecompte B. Horvat, S. Taheri and A. Salihagi¢ Tumour cell proliferation is abolished by inhibitors of Na*/H* and HCO; /CI~ exchange Z. Trizna, T. C. Hsu, S. P. Schantz, J. J. Lee Anticlastogenic effects of 13-cis-retinoic acid in vitro and W. K. Hong A. T. Williams, M. J. Shearer, J. Oyeyi, Serum osteocalcin in the management of myeloma R. G. Aitchison, A. C. Newland and S. A. Schey P. Kerbrat, R. Somers, J. Verweij et al. On behalfo f Phase II study of fotemustine in advanced soft tissue sarcomas the EORTC Soft Tissue and Bone Sarcoma Group E. Bombardieri, M. Pizzichetta, P. Veronesi, CA 15.3 determination in patients with breast cancer: clinical utility for the E. Seregni, A. Bogni, L. Maffioli, G. S. Jotti, detection of distant metastases M. A. Bassetto, S. Zurrida and A. Costa M. E. L. van der Burg, S. Monfardini, J. P. Guastalla, Phase II study of weekly 4’-epidoxorubicin in patients with metastatic squamous C. de Oliveira, J. Renard and J. B. Vermorken cell cancer of the cervix: an EORTC Gynaecological Cancer Cooperative Group Study Feature Articles M. Marselos and L. Tomatis Diethylstilboestrol: II, pharmacology, toxicology and carcinogenicity in experimental animals L. G. Baggetto Role of mitochondria in carcinogenesis Book Review M. Parker Growth Regulation by Nuclear Hormone Receptors Edited by L. M. Franks News Letters C. Hsieh, A. Ekbom and D. Trichopoulos Left handedness and breast cancer risk D. G. Altman Left handedness and breast cancer H. Olsson and C. Ingvar Left handedness and breast cancer V. Torri and N. Scorpiglione Cell kinetics in management of ovarian cancer A reply by R. Silvestrini et al. Potentials of cell kinetics in the management of patients with ovarian cancer S. Kapitanovi¢, R. Spaventi, B. KuSi¢ and K. Paveli¢ c-erbB-2/neu in colorectal carcinoma: a potential prognostic value? NUMBER 2 Comments and Critique E. S. Casper Pancreatic cancer: how can we progress? E. van der Schueren, J. Cl. Horiot, G. Leunens, Quality assurance in cancer treatment R. Rubens, W. Steward, J.A. van Dongen, A.T. van Oosterom and K. Vantongelen Report of aW orking Party from the European School of Oncology List of Contents Papers L. Repetto, M. Pace, S. Mammoliti, M. Bruzzone, 181 The impact of received dose intensity on the outcome of advanced ovarian cancer S. Chiara, C. Oliva, T. Guido, P. F. Conte, E. Campora, A. Rubagotti, P. Bruzzi and R. Rosso P. Lissoni, S. Barni, F. Rovelli, F. Brivio, Neuroimmunotherapy of advanced solid neoplasms with single evening A. Ardizzoia, G. Tancini, A. Conti subcutaneous injection of low-dose interleukin-2 and melatonin: preliminary and G. J. M. Maestroni results J. W. Sweetenham, J. J. McKendrick, G. M. Mead Prednisolone, cytosine arabinoside, lomustine (CCNU), etoposide and thioguanine and J. M. A. Whitehouse (PACET) combination chemotherapy for relapsed or refractory non-Hodgkin lymphoma N. A. A. Beelen, A. Twijnstra, M. van de Pol Neuron-specific enolase in cerebrospinal fluid of patients with metastatic and non- and P. P. C. A. Menheere metastatic neurological disease L. Pace, G. D’Aiuto, C. Acampora, P. Oliviero, Tumour uptake of 57-cobalt-bleomycin in patients with breast cancer G. Botti, F. Tatangelo, M. Cerra and M. Salvatore B. Bergman, F.-T. Brezicka, C.-P. Engstrém Clinical usefulness of serum assays of neuron-specific enolase, carcinoembryonic and S. Larsson antigen and CA-SO antigen in the diagnosis of lung cancer J. A. Wils, T. Kok, D. J. Th. Wagener, J. Selleslags Activity of cisplatin in adenocarcinoma of the pancreas and N. Duez P. E. Postmus, E. F. Smit, A. Kirkpatrick Testing the possible non-cross resistance of two equipotent combination and T. A. W. Splinter chemotherapy regimens against small-cell lung cancer: a phase II study of the EORTC lung cancer cooperative group J. Verweij, K. Krzemieniecki, T. Kok, A. Poveda, Phase II study of miltefosine (hexadecylphosphocholine) in advanced soft tissue C. van Pottelsberghe, M. van Glabbeke sarcomas of the adult—an EORTC soft tissue and bone sarcoma group study and H. Mouridsen E. Anderson, J. E. Ferguson, H. Morten, S. M. Shalet, Serum immunoreactive and bioactive lactogenic hormones in advanced breast E. L. Robinson and A. Howell cancer patients treated with bromocriptine and octreotide U. Schmid, V. Schirrmacher, F. Momburg Preferential antibody targeting to small lymphoma metastases in the absence of the and S. Matzku primary tumour F. Ravera, L. Miglietta, P. Pirani, S. Ferrini Suramin-induced growth inhibition and insulin-like growth factor-I binding and R. E. Favoni blockade in human breast carcinoma cell lines: potentially related events S. Briggs, M. R. Price and S. J. B. Tendler Fine specificity of antibody recognition of carcinoma-associated epithelial mucins: antibody binding to synthetic peptide epitopes I. Algarra, S. Silva and H.-G. Ljunggren MHC class I expression on prelymphomatous and lymphomatous B-cells is not inhibited by an Eu-myc transgene S. Hofbauer, G. Hamilton, G. Theyer, K. Wollmann Insulin-like growth factor-I-dependent growth and in vitro chemosensitivity of and F. Gabor Ewing’s sarcoma and peripheral primitive neuroectodermal tumour cell lines I. A. Mérocz, B. Lauber, D. Schmitter 245 _— Invitro effect of suramin on lung tumour cells and R. A. Stahel P. Mullen, T. Bramley, G. Menzies and B. Miller Failure to detect gonadotrophin-releasing hormone receptors in human benign and malignant breast tissue and in MCF-7 and MDA-MB-231 cancer cells H. C. Kitchener, L. Neilson and J. C. M. Macnab 252 Oestrogen receptor message in premalignant and normal cervical cells: a methodological study S. M. Moss, D. A. Coleman, R. Ellman, Interval cancers and sensitivity in the screening centres of the UK trial of early J. Chamberlain, A. P. M. Forrest, A. E. Kirkpatrick, detection of breast cancer B. A. Thomas and J. L. Price M. Eriksson 259 Rheumatoid arthritis as a risk factor for multiple myeloma: a case-control study G. Launoy, M. Gignoux, D. Pottier, F. Lefort, Prognosis of rectal cancer in France A. Soumrany, J. Maurel and A. Beck R. Punnonen, R. Kudo, K. Punnonen, E. Hietanen, Activities of antioxidant enzymes and lipid peroxidation in endometrial cancer T. Kuoppala, H. Kainulainen, K. Sato and M. Ahotupa A. E. Kunst and J. P. Mackenbach 270 __ Regional lung cancer death rates unrelated to smoking? The case of The Netherlands List of Contents Feature Articles H. Sancho-Garnier and S. Theobald Black (air-cured) and blond (flue-cured) tobacco and cancer risk II: pharynx and larynx cancer P. Hopwood The assessment of body image in cancer patients Book Review N. M. Breach Limb Salvage—Major Reconstructions in Oncologic and Nontumoral Conditions Edited by F. Langlais and B. Tomeno Letters M. Mahjoubi, J. Kattan, J.-P. Droz, I. Philippot, Feasibility trial of a combination of vinorelbine, ifosfamide, fluorouracil and folinic P. Pautier, A. Boutan-Laroze, M. Azab and acid (VIF regimen) in advanced urothelial cancer C. Theodore V. Oliver, A. Aliaga, J. J. Lopez Lopez, E. Perez, Long-term complete remissions in patients with disseminated melanoma treated by A. Ponchon, J. P. Bizzari and V. Cour fotemustine and dacarbazine X. Garcia-del-Muro, F. Cardenal and P. Ferrer Extrapyramidal reaction associated with ondansetron P. RougierG,. G. Chabot, J. Bonneterre, Phase II and pharmacokinetic study of fotemustine in inoperable colorectal cancer J.-M. Tigaud,C . Lucas, M. Baud, J. Bérille and A. Gouyette J. A. Wils, T. Kok, D. J.T h. Wagener,E . Francois, Phase II trial with ifosfamide in pancreatic cancer J. Selleslags and N. Duez J.-P. Stalens and J. Ninane Hemihypertrophy, bilateral Wilms’ tumours and clear-cell adenocarcinoma of the uterine cervix in a young girl N. Imamura and A. Kuramoto Triple malignant neoplasms in a patient with adult T-cell leukaemia A.D.J. Pearson,M . M. Reid and A. W. Craft Treatment of advanced neuroblastoma R. Corbett and R. Pinkerton Treatment of advanced neuroblastoma NUMBER3 Comments and Critique M. Baum and J. Houghton Confirmed dissent and informed consent M. Goddard The real costs of emesis R. E.N. van Rijswijk, E. CvitkoJv. Wiagcst,af f Workshop on suramin with emphasis on prostate cancer: re-evaluation of response andC . E. Myers criteria I. Mittra Axillary lymph node metastasis in breast cancer: prognostic indicator or lead-time bias? Papers D. Cunningham, M. Gore, N. Davidson, The real costs of emesis—an economic analysis of ondansetron vs. metoclopramide M. Miocevich, M. Manchanda and N. Wells in controlling emesis in patients receiving chemotherapy for cancer T. A. Wiklund, T. A. Alvegard, H. T. Mouridsen, Marginal surgery and postoperative radiotherapy in soft tissue sarcomas A. Rydholm and C. P. Blomqvist M. Findlay, R. J. Simes, K. Cox, K. Carmichael, A randomised cross-over trial of antiemetic therapy for platinum-based T. Chey, E. McNeil and D. Raghavan chemotherapy. Improved control with an intensive multiagent regimen ‘i weA Evans, R. C. Stein, J. R. Pepper, J.-C. Gazet, A randomised prospective trial of surgical against medical tetracycline pleurodesis H. T. Ford and R. C. Coombes in the management of malignant pleural effusions secondary to breast cancer V. Trillet-Lenoir, J. Green, C. Manegold, Recombinant granulocyte colony stimulating factor reduces the infectious J. Von Pawel, U. Gatzemeier, B. Lebeau, complications of cytotoxic chemotherapy A. Depierre, P. Johnson, G. Decoster, D. Tomita and C. Ewen B. B. R. Kroon, J. M. Klaase, B. N. van Geel, Results of a double perfusion schedule with melphalan in patients with melanoma A. M. M. Eggermont, H. R. Franklin of the lower limb and J. A. van Dongen List of Contents G. Sica, F. Iacopino, G. Lama, D. Amadori, Steroid receptor enhancement by natural interferon-B in advanced breast cancer M. Baroni, F. Lo Sardo, P. Malacarne, P. Marchetti, A. Pellegrini, A. Zaniboni and G. Robustelli della Cuna J. M. Dixon, V. Dobie and U. Chetty The importance of interpectoral nodes in breast cancer P. Bichel, A. Jakobsen, K. Nielsen, B. Hdlund Prediction of lymph node metastases in patients with early squamous cell and J. Visfeldt carcinoma of the cervix uteri by histopathological grading and flow cytometry J. J. Grau, J. Estapé, F. Alcobendas, C. Pera, Positive results of adjuvant mitomycin-C in resected gastric cancer: a randomised M. Daniels and J. Terés trial on 134 patients E. A. M. Hassink, T. S. Souren, L.J. Boersma, Pulmonary morbidity 10-18 years after irradiation for Hodgkin’s disease P. F. Peerboom, R. Melkert, N. van Zandwijk, J. V. Lebesque and P. F. Bruning P. F. Geertsen, L. Sengelgv, S. K. Larsen A phase II study of cisplatin plus methotrexate with folinic acid rescue in metastatic and H. von der Maase or locally recurrent transitional cell carcinoma oft he urothelium J. Chauvergne, P. Fumoleau, P. Cappelaere, R. Metz, Phase II study of pirarubicin (THP) in patients with cervical, endometrial and J. P. Armand, B. Chevallier, P. Kerbrat, M. de Forni, ovarian cancer: study of the clinical screening group of the European Organization C. Lhommé, H. Roche, Ph. Chollet, A. Goupil, for Research and Treatment of Cancer (EORTC) N. Guiochet, P. Herait and M. A. Lentz J.C. Yang, E. Shlasko, J. L. Ritchey, J. G. Landry, Combination chemoimmunotherapy for metastatic colorectal cancer using D. E. White and S. A. Rosenberg 5-fluorouracil, leucovorin and interleukin-2 P. H. B. Willemse, J. A. Gietema, N. H. Mulder, Zeniplatin in patients with advanced ovarian cancer, a phase II study with a third E. G3 . E. de Vries, S. Meijer, J. Bouma, M. Birkhofer, generation platinum complex R. B. Rastogi and D. Th. Sleijfer G. Vv Scagliotti, M. Micela, L. Gubetta, E. Leonardo, Prognostic significance of Ki67 labelling in resected non small cell lung cancer Cappia, P. Borasio and E. Pozzi S. Thoresen, L. A. Akslen, E. Glattre Thyroid cancer in children in Norway 1953-1987 and T. Haldorsen M. Ponz de Leon, R. Sassatelli, A. Scalmati, Descriptive epidemiology of colorectal cancer in Italy: the 6-year experience of a C. Di Gregorio, R. Fante, G. Zanghieri, L. Roncucci, specialised registry M. Sant and A. Micheli D. Vitolo, A. Kanbour, J. T. Johnson, In situ hybridisation for cytokine gene transcripts in the solid tumour R. B. Herberman and T. L. Whiteside microenvironment T. Lai, C. M. P. Collins, P. Hall, A. P. Morgan, Verapamil enhances doxorubicin activity in cultured human renal carcinoma cells P. J. B. Smith, B. R. Stonebridge and M. O. Symes P. Volling, M. Jungehiilsing, M. Jiicker, H. Stiitzer, Coamplification of the Ast and bcl-1 oncogenes in advanced squamous cell V. Diehl and H. Tesch carcinomas of the head and neck K. A. Wright and P. R. Twentyman Derivation and characterisation of a mouse tumour cell line with acquired resistance to cyclosporin A R. P. Perez. A. K. Godwin, L. M. Handel A comparison of clonogenic, microtetrazolium and sulforhodamine B assays for and T. C. Hamilton determination of cisplatin cytotoxicity in human ovarian carcinoma cell lines H. Bleiberg, M. Morret and P. Galand Correlation between [H]thymidine and proliferating cell nuclear antigen (PCNA)/cyclin indices in archival, formaldehyde-fixed human colorectal tissues E. Veszelovszky, L. L. Thomsen, L. Zhuang Flavone acetic acid and 5,6-dimethylxanthenone-4-acetic acid: relationship and B. C. Baguley between plasma nitrate elevation and the induction of tumour necrosis M. A. Barrand, T. Rhodes, M. S. Center Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and and P. R. Twentyman verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein M. Dietel, U. Bals, B. Schaefer, I. Herzig, H. Arps In vitro prediction of cytostatic drug resistance in primary cell cultures of solid and M. Zabel malignant tumours S. Kondo, S. Nakatsu, H. Sakahara, H. Kobayashi, Antitumour activity of an immunoconjugate composed of anti-human astrocytoma J. Konishi and Y. Namba monoclonal antibody and neocarzinostatin A.-R. Hanauske, M. Ross, D. Degen, In vitro activity of the benzotriazene dioxide SR 4233 against human tumour S. G. Hilsenbeck and D. D. Von Hoff colony-forming units List of Contents N. P. M. Sacks, K. Smith, A. P. Norman, M. Greenall, Cathepsin D levels in primary breast cancers: relationship with epidermal growth S. LeJeune and A. L. Harris factor receptor, oestrogen receptor and axillary nodal status Feature Articles H. Thornton U.K. DCIS trial—time for review? I. S. Fentiman and C. A. F. Joslin The defence for the U.K. DCIS trial C. La Vecchia, F. Lucchini, E. Negri, P. Boyle Trends in cancer mortality in the Americas, 1955-1989 and F. Levi Book Review O.N. Witte Oncogenes in the Development of Leukaemia Series Editor L. M. Franks, Guest Editor O. W. Witte. News Letters C. Fortis, E. Ferrero, S. Heltai, C. Besana, C. Corti, Role of interleukin-2 in regulating lymphocyte activation and recirculation G. Di Lucca, M. Foppoli, G. Consogno and C. Rugarli Ch. Blairvacq, H. Bleiberg, J. M. Panzer The contribution of the aminopyrine-breath-test in metastatic liver disease and J. Frihling L. Tixi, E. Bolli, A. Guglielmi,.A. Mori, C. Aschele, Dacarbazine and fotemustine in advanced colorectal cancer M. T. Nobile, R. Rosso and A. Sobrero P. Thomas, J.-P. Kleisbauer, M. Perol, A. Taytard, Cisplatin-mitomycin and vindesine in the treatment of inoperable non-small cell R. Poirier, H. Le Caer, J.-C. Guerin, F. Bonnaud, lung cancer Groupe Frangais de Pneumo-Cancérologie (GFPC) P. Balmes, P. Carles, J. Vergeret, J.-M. Chavaillon and H. de Muizon J. Janinis, G. Panagos, A. Panousaki, D. Skarlos, Stevens—Johnson syndrome and epidermal necrolysis after administration of E. Athanasiou, N. Karpasitis and M. Pirounaki sodium phenytoin with cranial irradiation H. Swoboda Shifts in respiratory and upper digestive tract cancer in Eastern Austria C. Maulard, J.-P. Marie, S. Delanian and M. Housset Clinical effects on CA 15-3 level of cyclosporin A as a chemosensitiser in chemoresistant metastatic breast cancer J. Schneider, M. Avila, G. Barrenetxea, F. Montoya Elevated serum CA-125 levels in patients with ovarian fibrothecomas and F. J. Rodriguez-Escudero O. Merimsky and S. Chaitchik Fotemustine—dacarbazine combinations in the treatment of metastatic melanoma Correction NUMBER 4 Comments and Critique M. Aapro Third European Winter Oncology Conference (EWOC-3) M. Hansen Serum tumour markers in lung cancer I.S. Fentiman and I. Fogelman Breast cancer and osteoporosis—a bridge at last Papers A. Garaventa, R. Ladenstein, F. Chauvin, E. Lanino, High-dose chemotherapy with autologous bone marrow rescue in advanced stage I. Philip, P. Corciulo, M. Brisigotti, M. Favrot, G. Dini IV neuroblastoma and T. Philip J.P. Peyrat, J. Bonneterre, B. Hecquet, P. Vennin, Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancer M.M. Louchez, C. Fournier, J. Lefebvre and A. Demaille T. Fornander, L.E. Rutqvist, N. Wilking, K. Carlstrém Oestrogenic effects of adjuvant tamoxifen in postmenopausal breast cancer and B. von Schoultz A.G. Robertson, C. Robertson, P. Boyle, The effect of differing radiotherapeutic schedules on the response of glottic R.P. Symonds and T.E. Wheldon carcinoma of the larynx Vili List of Contents A.B. Weitberg, J. Yashar, A.S. Glicksman, Combined modality therapy for stage IIIA non-small cell carcinoma of the lung M. Posner, F. Cummings, M. Browne, J. Clark, P. Calabresi, J. Beitz and C. Murray J.B. Braken, J.M.M. Raemaekers, P.P. Koopmans Control of nausea and vomiting with ondansetron in patients treated with intensive and B.E. de Pauw non-cisplatin chemotherapy for acute myeloid leukaemia A.S.T. Planting, G. Stoter and J. Verweij Phase II study of daily oral miltefosine (hexadecylphosphocholine) in advanced colorectal cancer M.T. Glover, J. Bodmer, W. Bodmer, L.J. Kennedy, HLA antigen frequencies in renal transplant recipients and non-immunosuppressed J. Brown, C. Navarrete, J.T.C. Kwan and I.M. Leigh patients with non-melanoma skin cancer K.L. Pinder, A.J. Ramirez, M.E. Black, Psychiatric disorder in patients with advanced breast cancer: prevalence and M.A. Richards, W.M. Gregory and R.D. Rubens associated factors B. Ejlertsen, P. Pfeiffer, D. Pedersen, Decreased efficacy of cyclophosphamide, epirubicin and 5-fluorouracil in H.T. Mouridsen, C. Rose, M. Overgaard, E. Sandberg metastatic breast cancer when reducing treatment duration from 18 to 6 months and B. Kristensen L.J. Vatten, K.S. Bjerve, A. Andersen and E. Jellum Polyunsaturated fatty acids in serum phospholipids and risk of breast cancer: a case-control study from the Janus Serum Bank in Norway S. Friis and H.H. Storm Urban-rural variation in cancer incidence in Denmark 1943-1987 G. Pande and C. Sudhakar Differential expression of thymidine kinase gene in two subpopulations of a rat tumour correlates with their tumorigenic and cell division potential J. Wondergem, Z.H. Siddik, F.R. Strebel Effect of whole body hyperthermia on cis-diamminechloroplatinum (II)-induced and J.M.C. Bull antitumour activity and tissue Pt-distribution: do anaesthetics influence the therapeutic ratio? J. Schneider, T. Efferth, M.M. Centeno, J. Mattern, High rate of expression of multidrug resistance-associated P-glycoprotein in human F.J. Rodriguez-Escudero and M. Volm endometrial carcinoma and normal endometrial tissue B.G. Woodcock, M.S. Abdel-Rahman, F. Wosch Effect of D,L-verapamil, verapamil enantiomers and verapamil metabolites on the and S. Harder binding of vincristine to a,-acid glycoprotein N. Briinner, D. Yee, F.G. Kern, M. Spang-Thomsen, Effect of endocrine therapy on growth of T61 human breast cancer xenografts is M.E. Lippman and K.J. Cullen directly correlated to a specific down-regulation of insulin-like growth factor II (IGF-II) J. Marrink, R. Oosterom, H.M.G. Bonfrer, Tissue polypeptide-specific antigen: a discriminative parameter between prostate F.H. Schréder and H.J.A. Mensink cancer and benign prostatic hypertrophy T.J. Iveson, J. Ahern and I.E. Smith Response to third-line endocrine treatment for advanced breast cancer EWOC-3 Conference Papers O. Kronborg Staging and surgery for colorectal cancer R. Herrmann Systemic treatment of colorectal cancer M. Tubiana Organisation of screening A. Costa Breast cancer chemoprevention I.E. Smith, A.L. Jones, M.E.R. O’Brien, Primary medical (neo-adjuvant) chemotherapy for operable breast cancer J.A. McKinna, N. Sacks and M. Baum H.T. Mouridsen Adjuvant systemic therapy in breast cancer M. Clavel and G. Catimel Breast cancer: chemotherapy in the treatment of advanced disease R.D. Rubens Cost effectiveness in the treatment of advanced solid tumours F.J. Lejeune, D. Liénard, S. Layvraz Regional therapy of melanoma and R.O. Mirimanoff M.S. Aapro Advances in systemic treatment of malignant melanoma A. Azzarelli Surgery in soft tissue sarcomas J.G. Aalders and J.P. Neijt Aspects of surgery in ovarian and endometrial carcinoma J.P. Neijt Systemic treatment in disseminated endometrial cancer ix List of Contents S.B. Kaye Chemotherapy for ovarian cancer Feature Articles M. Lehnert Reversal of P-glycoprotein-associated multidrug resistance: the challenge continues D.J. Fowlis and A. Balmain Oncogenes and tumour suppressor genes in transgenic mouse models of neoplasia Book Reviews D.E. Sturdy Review of Urological Oncology Edited by J. Waxman and G. Williams D. Prakash Malignant Mesothelioma By D.W. Henderson, et al. News Letters F. Descotes, J.-J. Pavy and G.-L. Adessi HER-2/neu amplification in human breast cancer: Southern or slot blotting for amplification analysis? C. Gridelli, P. Incoronato, G. Airoma, R. Pepe, Ondansetron in the prophylaxis of nausea and vomiting induced by carboplatin F. Arpinelli and A.R. Bianco combination chemotherapy S. Chiara, E. Campora, L. Merlini, C. Simoni, L. Recurrent ovarian carcinoma: salvage treatment with platinum in patients Iskra, F. Odicino, N. Ragni, P.F. Conte and R. Rosso responding to first-line platinum-based regimens L.A. Akslen P53 immunostaining in melanocytic lesions J. Klijanienko, A.B. Bianchi, E. Cvitkovic, F. Janot, Unexpected Prad-1 amplification in multiple simultaneous localisations of B. Luboinski and C.J. Conti squamous cell carcinoma of the head and neck NUMBER 5 Comments and Critique P. Boyle Ole Moller Jensen Memorial EJC Travel Award F.H. Schréder and P. Boyle Screening for prostate cancer—necessity or nonsense? N. Becker Cancer epidemiology and privacy laws: recent trends in Germany M. Peckham Education and training in oncology Papers G.K. Jacobsen, A. Mellemgaard, S.A. Engelholm and Increased incidence of sarcoma in patients treated for testicular seminoma H. Moiler N.H. Mulder, P.O.M. Mulder, D.Th. Sleijfer, Induction chemotherapy and intensification with autologous bone marrow P.H.B. Willemse, E. van der Ploeg, W.V. Dolsma and reinfusion in patients with locally advanced and disseminated breast cancer E.G.E. de Vries H. M@ller, A. Mellemgaard, G.K. Jacobsen, Incidence of second primary cancer following testicular cancer D. Pedersen and H.H. Storm K. Mori, Y. Saitoh and K. Tominaga Recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for non-small cell lung cancer M.J. Tilby, D.R. Newell, C. Viner, P.J. Selby and Application of a sensitive immunoassay to the study of DNA adducts formed in C.J. Dean peripheral blood mononuclear cells of patients undergoing high-dose melphalan therapy A. Ardizzoni, M. Venturini, L. Crind, M.R. Sertoli, High dose-intensity chemotherapy, with accelerated cyclophosphamide- P. Bruzzi, M.C. Pennucci, G.L. Mariani, O. Garrone, doxorubicin-etoposide and granulocyte-macrophage colony stimulating factor, in S. Bracarda, R. Rosso and N. Van Zandwijk the treatment of small cell lung cancer M. Gasparini, L. Rottoli, M. Massimino, M.C. Gianni, Curability of advanced Burkitt’s lymphoma in children by intensive short-term E. Ballerini, F. Ravagnani, S. Pupa and F. Fossati- chemotherapy Bellani K.E. Bakkevold, B. Arnesj¢, O. Dahl and Adjuvant combination chemotherapy (AMF) following radical resection of B. Kambestad carcinoma of the pancreas and papilla of Vater—results of a controlled, prospective, randomised multicentre study

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