Essential and Non-essential Metals: Carcinogenesis, Prevention and Cancer Therapeutics PDF
Preview Essential and Non-essential Metals: Carcinogenesis, Prevention and Cancer Therapeutics
Molecular and Integrative Toxicology Anuradha Mudipalli Judith T. Zelikoff Editors Essential and Non-essential Metals Carcinogenesis, Prevention and Cancer Therapeutics Molecular and Integrative Toxicology Series editors Jamie DeWitt East Carolina University Greenville, North Carolina USA Sarah Blossom Research Institute Arkansas Children's Hospital Little Rock, Arkansas USA Molecular and Integrative Toxicology presents state-of-the-art toxicology in a useful context. Volumes emphasize the presentation of cellular and molecular information aimed toward the protection of human or animal health or the sustainability of environmental systems. More information about this series at http://www.springer.com/series/8792 Anuradha Mudipalli • Judith T. Zelikoff Editors Essential and Non-essential Metals Carcinogenesis, Prevention and Cancer Therapeutics Editors Anuradha Mudipalli Judith T. Zelikoff Natl Ctr Envtl Assessment Professor of Environmental Medicine Office of Res and Devt New York University Research Triangle Park Tuxedo, New York North Carolina USA USA ISSN 2168-4219 ISSN 2168-4235 (electronic) Molecular and Integrative Toxicology ISBN 978-3-319-55446-4 ISBN 978-3-319-55448-8 (eBook) DOI 10.1007/978-3-319-55448-8 Library of Congress Control Number: 2017944430 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Preface Metals are constituents of vital proteins that drive numerous critical biochemical activi- ties essential for life. In addition, metallic elements have become integral parts of human civilization by virtue of their diverse applications and utility throughout society. For the purposes of human health, metals are classified as ‘essential’ (e.g. cal- cium, magnesium, manganese, selenium, zinc, iron, and copper) or non-essential. Non-essential metals include nickel, hexavalent chromium, cadmium, and arsenic (the latter, in the strict sense, a metalloid, but referred here as a metal for practical purposes). Both essential and non-essential metals can occur naturally in the envi- ronment or via diverse routes of exposure such as from personal products from agricultural, commercial, and industrial applications. Advances in metal research have also revealed that several essential metals can pose health threats at certain dietary concentrations. Recent research also shed light on the therapeutic role that metal-based drugs can play in a variety of disease conditions including cancer. Metals can also prove helpful for prevention of disease under different levels of dietary intake and/or through interactions with the internal environment of the host. Each chapter in this book describes underlying molecular mechanisms and gene pathways associated with one or more of these effects. In addition, consideration is given to the cross talk among these pathways as elucidating the multifarious bio- logical role(s) of these metals is an active area of research. Though there are a number of excellent books on metal biology and health, this book provides a multi-disciplinary and integrative look at the diverse molecular pathways of metals focusing on ‘essential and non-essential metals, carcinogenesis, prevention and chemotherapy’. The nine chapters, contributed by renowned experts across the globe, detail the mechanistic pathways involved in metal carcinogenesis from an inter-disciplinary perspective including cancer prevention and applications in chemotherapy. We believe this book caters to the intellectual appetite of metal biologists relent- lessly pursuing the myriad of research and risk assessment questions which remain. North Carolina, USA Anuradha Mudipalli Tuxedo, USA Judith T. Zelikoff v Acknowledgements The Editors Drs. Mudipalli and Zelikoff would like to acknowledge the time and support provided by United States Environmental Protection Agency and the NYU NIEHS Environmental Health Sciences Core Center (5 P30 ES000260-52) in our efforts to bring this book forward. vii Contents 1 Calcium Channels and Pumps: Importance During Lactation as Potential Targets for Breast Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Gregory R. Monteith and Teneale A. Stewart 2 Tumor Development Through the Mg2+nifying Glass . . . . . . . . . . . . . . 19 Valentina Trapani and Federica I. Wolf 3 Selenium: Roles in Cancer Prevention and Therapies . . . . . . . . . . . . . 39 Xiangrong Geng, Liu Liu, Kan-Jen Tsai, and Zijuan Liu 4 Zinc and Zinc-Dependent Proteins in Cancer and Chemotherapeutics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 Jenna Guynn and Elizabeth A.W. Chan 5 Arsenic Carcinogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95 J. Christopher States 6 Cadmium Carcinogenesis and Mechanistic Insights . . . . . . . . . . . . . . 113 Anuradha Mudipalli 7 Molecular Mechanisms of Chromium-Induced Carcinogenesis . . . . 143 Cynthia L. Browning, Rachel M. Speer, and John Pierce Wise Sr. 8 Mechanisms of Nickel Carcinogenesis . . . . . . . . . . . . . . . . . . . . . . . . . 181 Qiao Yi Chen, Jason Brocato, Freda Laulicht, and Max Costa 9 Application of Metallomics and Metalloproteomics for Understanding the Molecular Mechanisms of Action of Metal- Based Drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 199 Yuchuan Wang, Haibo Wang, Hongyan Li, and Hongzhe Sun Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223 ix Contributors Jason Brocato Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY, USA Cynthia L. Browning Department of Pharmacology and Toxicology, School of Medicine, Wise Laboratory of Environmental and Genetic Toxicology, University of Louisville, Louisville, KY, USA Elizabeth A.W. Chan Oak Ridge Institute for Science and Education (ORISE) Fellow at the National Center for Environmental Assessment, U.S. Environmental Protection Agency (EPA), Research Triangle Park, NC, USA Qiao Yi Chen Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY, USA J. Christopher States University of Louisville, Louisville, KY, USA Max Costa Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY, USA Xiangrong Geng Department of Biological Sciences, Oakland University, Rochester, MI, USA Jenna Guynn Oak Ridge Institute for Science and Education (ORISE) Fellow at the National Health and Environmental Effects Research Laboratory, U.S. EPA, Research Triangle Park, NC, USA Freda Laulicht Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY, USA Hongyan Li Department of Chemistry, The University of Hong Kong, Hong Kong SAR, China Liu Liu Department of Biological Sciences, Oakland University, Rochester, MI, USA xi xii Contributors Zijuan Liu Department of Biological Sciences, Oakland University, Rochester, MI, USA Gregory R. Monteith School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia Mater Research, Translational Research Institute, The University of Queensland, Brisbane, QLD, Australia Anuradha Mudipalli Hazardous Pollutants Assessment Group, National Center for Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, NC, USA Rachel M. Speer Department of Pharmacology and Toxicology, School of Medicine, Wise Laboratory of Environmental and Genetic Toxicology, University of Louisville, Louisville, KY, USA Teneale A. Stewart School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia Hongzhe Sun MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, China Department of Chemistry, The University of Hong Kong, Hong Kong SAR, China Valentina Trapani Istituto di Patologia Generale, Facoltà di Medicina e Chirurgia “A. Gemelli”, Università Cattolica del Sacro Cuore, Milano Medical Center, Rome, Italy Kan-Jen Tsai School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan Yuchuan Wang MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, China Haibo Wang Department of Chemistry, The University of Hong Kong, Hong Kong SAR, China John Pierce Wise Sr. Department of Pharmacology and Toxicology, School of Medicine, Wise Laboratory of Environmental and Genetic Toxicology, University of Louisville, Louisville, KY, USA Federica I. Wolf Istituto di Patologia Generale, Facoltà di Medicina e Chirurgia “A. Gemelli”, Università Cattolica del Sacro Cuore, Milano Medical Center, Rome, Italy
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