Annals of Oncology Abstract Book of the 42nd ESMO Congress (ESMO 2017) Madrid, Spain 8–12 September 2017 GuestEditors: ESMO2017CongressScientificCommittee Annals of Oncology Official Journal of the European Society for Medical Oncology and the Japanese Society of Medical Oncology Editor-in-chief S.Pignata,Naples,Italy BioTechnologies E.Mardis,St.Louis,Missouri,USA J.-C.Soria,Villejuif,France Melanoma G.Long,Sydney,Australia Onco-Immunology Associateeditors Hematologicalmalignancies G.Coukos,Lausanne,Switzerland Urogenitaltumors K.Tsukasaki,Saitama,Japan A.Snyder,NewYork,NewYork,USA G.Attard,Sutton,UK P.L.Zinzani,Bologna,Italy Neuro-oncology M.DeSantis,Birmingham,UK Supportivecare A.Ibdaih,Paris,France Gastrointestinaltumors K.Jordan,Heidelberg,Germany Statistics D.Arnold,Lisbon,Portugal Epidemiology M.Buyse,Brussels,Belgium A.Cervantes,Valencia,Spain P.Boffetta,NewYork,NewYork,USA J.Tabernero,Barcelona,Spain P.Lagiou,Athens,Greece Molecularandsurgicalpathology Breasttumors Sarcomaandclinicalpharmacology I.I.Wistuba,Houston,Texas,USA F.Andre´,Villejuif,France O.Mir,Villejuif,France C.Sotiriou,Brussels,Belgium AnnalsofOncologyonline Earlydrugdevelopment C.Ferte´,Villejuif,France Thoracictumors J.-C.Soria,Villejuif,France T.Mitsudomi,Osaka,Japan Industrycorner:perspectivesandcontroversies J.F.Vansteenkiste,Leuven,Belgium Preclinicalandexperimentalscience K.Dhingra,NewYork,NewYork,USA T.U.E.Helleday,Stockholm,Sweden Headandnecktumors A.T.C.Chan,Shatin,HongKong Precisionmedicine Editorsemeriti E.Cohen,SanDiego,California,USA C.Swanton,London,UK F.Cavalli,Bellinzona,Switzerland Gynecologicaltumors Bioinformatics D.J.Kerr,Oxford,UK B.Monk,Phoenix,Arizona,USA N.McGranahan,London,UK J.B.Vermorken,Edegem,Belgium Editorialboard M.S.Aapro,Genolier,Switzerland A.Grothey,Rochester,Minnesota,USA S.I.Ou,Orange,California,USA M.Alsina,Barcelona,Spain S.Halabi,Durham,NorthCarolina,USA X.Paoletti,Paris,France Y.Ando,Nagoya,Japan D.G.Haller,Philadelphia,Pennsylvania,USA C.Pezaro,Melbourne,Australia P.Autier,Lyon,France K.Hotta,Okayama,Japan P.Pfeiffer,Odense,Denmark H.A.AzimJr,Brussels,Belgium I.Hyodo,Tsukuba,Japan S.Postel-Vinay,Villejuif,France I.Barnes,Oxford,UK M.Ignatiadis,Brussels,Belgium A.Psyrri,NewHaven,Connecticut,USA J.Baselga,NewYork,USA D.H.Ilson,NewYork,NewYork,USA D.Quinn,LosAngeles,California,USA J.Bellmunt,Boston,Massachusetts,USA H.Iwata,Aichi,Japan S.S.Ramalingam,Atlanta,Georgia,USA B.Besse,Villejuif,France F.Janku,Houston,Texas,USA M.Reck,Grosshansdorf,Germany J.Beyer,Zurich,Switzerland N.Katsumata,Kawasaki,Japan B.Rini,Cleveland,Ohio,USA P.Bierman,Omaha,Nebraska,USA N.Kiyota,Kobe,Japan R.Rosell,Badalona,Spain C.Bokemeyer,Hamburg,Germany C.LaVecchia,Milan,Italy A.D.Roth,Geneva,Switzerland N.Boku,Tokyo,Japan P.N.JrLara,Sacramento,California,USA R.Salazar,Barcelona,Spain E.Bria,Verona,Italy J.M.Larkin,London,UK M.Scartozzi,Ancona,Italy E.F.Burgess,Charlotte,USA S.Loi,Melbourne,Australia N.Schmitz,Hamburg,Germany P.G.Casali,Milan,Italy S.Loibl,Neu-Isenburg,Germany H.-J.Schmoll,Halle,Germany F.Ciardiello,Naples,Italy F.Lordick,Leipzig,Germany I.Sekine,Tsukuba,Japan A.Comandone,Turin,Italy Y.Loriot,Villejuif,France Q.Shi,Rochester,Minnesota,USA P.G.Corrie,Cambridge,UK D.Lorusso,Milan,Italy A.F.Sobrero,Genoa,Italy G.Curigliano,Milan,Italy S.Lutzker,SanFrancisco,California,USA G.Sonpavde,Birmingham,Alabama,USA A.DiLeo,Prato,Italy T.Macarulla,Barcelona,Spain S.Takahashi,Tokyo,Japan R.Dienstmann,Barcelona,Spain M.Martin,Madrid,Spain M.Toi,Kyoto,Japan T.Dorff,LosAngeles,California,USA S.Matsui,Tokyo,Japan R.Turck,Montclair,NewJersey,USA H.Dosaka-Akita,Sapporo,Japan J.Maurel,Barcelona,Spain B.A.VanTine,St.Louis,Missouri,USA A.Eniu,Cluj-Napoca,Romania G.McArthur,Melbourne,Australia E.Vilar,Houston,Texas,USA T.Fenske,Milwaukee,Wisconsin,USA S.Michiels,Villejuif,France Y.-L.Wu,Guangzhou,China S.Galbraith,Cambridge,UK H.Minami,Kobe,Japan J.C.-H.Yang,Taipei,Taiwan G.Giamas,Brighton,UK Y.Nishimura,Osaka-Sayama,Japan S.Yano,Kanazawa,Japan R.Glynne-Jones,Northwood,UK K.Nishio,Osaka-Sayama,Japan T.Yoshino,Chiba,Japan B.-C.Goh,Singapore M.Ogura,Gifu,Japan A.X.Zhu,Boston,Massachusetts,USA A.Goldhirsch,Milan,Italy A.Ohtsu,Kashiwa,Japan P.Grimison,Sydney,Australia I.Okamoto,Fukuoka,Japan Executiveeditor:LewisRowett Editorial office: Vanessa Marchesi, Paola Minotti Bernasconi, Giovannella Porcu, Annals of Oncology, Via Luigi Taddei 4, CH-6962 Viganello-Lugano,Switzerland AnnalsofOncologyiscoveredinC.A.B.International,CurrentClinicalCancer,CurrentContents/ClinicalMedicineVR,CurrentContents/Life Sciences,ElsevierBIOBASE/CurrentAwarenessinBiologicalSciences,EMBASE/ExcerptaMedica,IBIDS,IndexMedicus/MEDLINE,The InternationalMonitorinOncology,MedicalDocumentationService,ScienceCitationIndexVRandScienceCitationIndexExpanded. 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Annals of Oncology Official Journal of the European Society for Medical Oncology Volume 28, 2017 Supplement 5 AbstractBookofthe 42ndESMOCongress(ESMO2017) Madrid,Spain 8–12September2017 GuestEditors: ESMO2017CongressScientificCommittee Annals of Oncology Official Journal of the European Society for Medical Oncology Volume 28, 2017 Supplement 5 Abstract Bookofthe 42ndESMO Congress(ESMO2017) 8–12 September 2017, Madrid,Spain AboutESMO AboutEACR ESMOExecutiveBoard EACRExecutiveBoard ESMO2017CongressOfficers Acknowledgements Submittedabstracts Basicscience v1-v21 Biomarkers v22-v42 Breastcancer,earlystage v43-v67 Breastcancer,locallyadvanced v68-v73 Breastcancer,metastatic v74-v108 CNStumours v109-v121 Developmentaltherapeutics v122-v141 Endocrineandneuroendocrinetumours v142-v157 Gastrointestinaltumours,colorectal v158-v208 Gastrointestinaltumours,non-colorectal v209-v268 Genitourinarytumours,prostate v269-v294 Genitourinarytumours,non-prostate v295-v329 Gynaecologicalcancers v330-v354 Haematologicalmalignancies v355-v371 Headandneckcancer,excludingthyroid v372-v394 Healtheconomics v395-v402 Immunotherapyofcancer v403-v427 Melanomaandotherskintumours v428-v448 Newdiagnostictools v449-v452 NSCLC,earlystage v453-v456 NSCLC,locallyadvanced v457-v459 NSCLC,metastatic v460-v496 Palliativecare v497-v501 Preventionandscreening v502-v506 Psycho-oncology v507-v510 Publichealth v511-v520 Sarcoma v521-v538 SCLC v539-v542 Supportivecare v543-v567 Thoracicmalignancies,other v568-v572 Translationalresearch v573-v594 Tumourbiologyandpathology v595-v604 Note:Abstractsuffixes “O”indicatesasubmittedabstractacceptedforProfferedPaper(oral)presentation “PD”indicatesasubmittedabstractacceptedforPosterDiscussionpresentation “P”indicatesasubmittedabstractacceptedforPosterPresentation “TiP”indicatesasubmittedabstractacceptedforPosterPresentation,TrialinProgress _PRindicatesasubmittedabstractselectedforinclusionintheESMOPressProgramme Volume28|Supplement5|September2017 The European Society for Medical Oncology (ESMO) ESMO is the leading professional organisation for medical oncology, with the overarching goal of improving outcomes for cancer patientseverywhere.Wearethesocietyofreferenceforoncologyeducationandinformation,andarecommittedtosupportingour memberstodevelopandadvanceinafast-evolvingprofessionalenvironment. Foundedin1975,ESMOhasEuropeanrootswithaglobalreach:wewelcomeoncologyprofessionalsfromaroundtheworld.Wearea homeforalloncologystakeholders,connectingprofessionalswithdiverseexpertiseandexperience,andspeakingwithonevoicefor our discipline. Our educationandinformationresourcessupportan integrated multi-professional approachtocancer care, froma medicaloncologyperspective.Weseektoeraseboundariesincancercare,whetherbetweencountriesorspecialities,andpursueour missionacrossoncology,worldwide. TheESMOcommunitybringstogethermorethan16,000oncologyprofessionalsfromover130countries.Drawingon40yearsof experienceandaround500expertcommitteemembers,ESMOservesitsmembersandtheoncologycommunitythrough: • Post-graduateoncologyeducationandtraining • Careerdevelopmentandleadershiptrainingforthenextgenerationsofoncologists • Internationalcongressesandworkshopstoshareexpertiseandbestpractice,learnaboutthemostup-to-datescientificadvances, andconnectwithcolleaguesinrelateddisciplines. • Continuouslyreviewed,evidence-basedstandardsforcancercareinEurope • Advocacyandconsultationtofosterafavourableenvironmentforscientificresearch Cancercareisrapidlybecomingmoreintegratedandmorespecialised;whethertheirfieldisresearch,diagnosis,treatment,care,or advocacy,oncologyprofessionalsneedtobothbuildtheirspecialistknowledgeandconnectwiththebestpractitionersinotherdisci- plinesworldwide.ESMOmembershipmakesthispossible. Pleasevisitesmo.orgtolearnmore.AcrossOncology.Worldwide. The European Association for Cancer Research (EACR) TheEuropeanAssociationforCancerResearchisaprofessionalmembershipsocietyforcancerresearcherswithmorethan10,000 membersworldwide.TheEACRwasfoundedin1968andhasoneguidingaim:‘Theadvancementofcancerresearchforthepublic benefit’.Membershipisopentoanyoneactivelyworkingorstudyingincancerresearch.Ourmembersworkacrossthefullspectrumof thefield,frombasicthroughtotranslationalandclinicalresearch,andrangefrompostgraduatestudentstowinnersoftheNobelPrize. Researcherswhoaremembersofoneofthe14EACRaffiliated‘NationalSocieties’automaticallybecomemembersoftheEACRas partofthewiderbenefitsofbelongingtotheirnationalsociety.Themembershipfeeforactivemembersisjust40Eurosperannumor 120Eurosfor4years,andspecialreducedmembershipfeesareavailabletopostgraduatestudentsandthosewithlessthan4years’post- doctoralexperience. Wefacilitatecommunicationandcollaborationwithinthecancerresearchcommunity.Wealsosetouttoraisetheprofileofcancer researchinEuropeandtomakethecaseforsustainedpoliticalandeconomicsupport.Weorganisescientificconferencesofthehighest quality,opentomembersandnon-members.OurConferenceSeriesofsmall,focusedmeetingsishighlyregardedforitsfocusonthe latestresearchtopicsandfortheprovisionofopportunitiesforinteractionbetweenspeakersandparticipants.In2018wewillcelebrate our50thanniversaryandinviteyoutojoinusatEACR25,ourbiennialCongresstobeheldinAmsterdam,Netherlands,30June-03 July2018. FindoutmoreabouttheEACRatwww.eacr.org ESMO Executive Board President FortunatoCiardiello,Naples,Italy President-Elect JosepTabernero,Barcelona,Spain PastPresidentandMembershipCommitteeChair RolfA.Stahel,Zurich,Switzerland Treasurer EmileVoest,Amsterdam,Netherlands EducationalCommitteeChair Andre´sCervantes,Valencia,Spain NationalRepresentativesandMembershipCommitteeChair FatimaCardoso,Lisbon,Portugal EUPolicyCommitteeChair PaoloG.Casali,Milan,Italy GlobalPolicyCommitteeChair AlexandruEniu,Cluj-Napoca,Romania GuidelinesWorkingGroupChair GeorgePentheroudakis,Ioannina,Greece PressandMediaAffairsCommitteeChair SolangePeters,Lausanne,Switzerland BoardMember DirkArnold,Lisbon,Portugal BoardMember SusanaBanerjee,London,UnitedKingdom BoardMember AlexanderM.M.Eggermont,Villejuif,France BoardMember SumitraThongprasert,Bangkok,Thailand BoardMember ChristophZielinski,Vienna,Austria EACR Executive Board President AntonBerns,Amsterdam,Netherlands PresidentElect AlbertoBardelli,Turin,Italy PastPresident RichardMarais,Manchester,UK SecretaryGeneral JoanSeoane,Barcelona,Spain Treasurer ChristofvonKalle,Heidelberg,Germany Member CarlosCaldas,Cambridge,UK Member LeonorDavid,Porto,Portugal Member CarolineDive,Manchester,UK Member DanielPeeper,Amsterdam,Netherlands Member YardenaSamuels,Rehovot,Israel Member EmmyVerschuren,Helsinki,Finland RepresentativeforEarlyCareerResearchers EliPikarsky,Jerusalem,Israel RepresentativeforEarlyCareerResearchers ThereseSørlie,Oslo,Norway ESMO 2017 Congress Officers ESMOandCongressPresident FortunatoCiardiello,Naples,Italy ScientificCommitteeCo-Chairs AlbertoSobrero,Genoa,Italy(ESMO) RichardMarais,Manchester,UK(EACR) EducationalChair Andre´sCervantes,Valencia,Spain PressOfficer SolangePeters,Lausanne,Switzerland LocalOfficer MiguelMartin,Madrid,Spain ScientificCommittee Basicscience Breastcancer,earlystage Chairs:AntonBerns,Amsterdam,Netherlandsand Chair:NadiaHarbeck,Munich,Germany ChristofvonKalle,Heidelberg,Germany HerveBonnefoi,Bordeaux,France AlbertoBardelli,Candiolo,Italy FatimaCardoso,Lisbon,Portugal RaffaeleCalifano,Manchester,UK MarcoColleoni,Milan,Italy KarindeVisser,Amsterdam,Netherlands JavierCortes,Madrid,Spain KristianHelin,Copenhagen,Denmark CarlosCaldas,Cambridge,UK DavidHuntsman,Vancouver,BC,Canada CarstenDenkert,Berlin,Germany ClareIsacke,Cambridge,UK AngelodiLeo,Prato,Italy RichardMarais,Manchester,UK DougEaston,Cambridge,UK UltanMcDermott,Cambridge,UK MichaelGnant,Vienna,Austria PierGuiseppePelicci,Milan,Italy JosJonkers,Amsterdam,Netherlands DavidTuveson,ColdSpringHarbor,NY,USA OliviaPagani,Bellinzona,Switzerland ElzbietaSenkus,Gdan(cid:2)sk,Poland AndrewTutt,London,UK Breastcancer,metastatic CNStumours Chair:FabriceAndre´,Villejuif,France Chair:MichaelWeller,Zurich,Switzerland JoanAlbanell,Barcelona,Spain CarmenBalan~a,Barcelona,Spain ThomasBachelot,Lyon,France AlbaBrandes,Bologna,Italy FatimaCardoso,Lisbon,Portugal LouisChesler,London,UK RobClarke,Philadelphia,PA,USA PimFrench,Rotterdam,Netherlands ShereneLoi,Melbourne,Australia EmilieLeRhun,Lille,France SibylleLoibl,Neu-Isenburg,Germany RogerHenriksson,Stockholm,Sweden FrederiquePenault-Llorca,Clermont-Ferrand,France StefanPfister,Hedielberg,Germany AleixPrat,Barcelona,Spain MatthiasPreusser,Vienna,Austria RomanRouzier,Paris,France Jo¨rg-ChristianTonn,Munich,Germany PeterSchmid,London,UK MartinvandenBent,Rotterdam,Netherlands BrittaWeigelt,NewYork,NY,USA PatrickWen,Boston,MA,USA LucyYates,Cambridge,UK WolfgangWick,Heidelberg,Germany Developmentaltherapeutics Gastrointestinaltumours,colorectal Chair:JanSchellens,Amsterdam,Netherlands Chair:VolkerHeinemann,Munich,Germany AlexA.Adjei,Rochester,MN,USA RichardAdams,Cardiff,UK UdaiBanerji,London,UK DirkArnold,Lisbon,Portugal ChristianBlank,Amsterdam,Netherlands Andre´sCervantes,Valencia,Spain AnthonyChalmers,Glasgow,UK AlfredoFalcone,Pisa,Italy MariaGraziaDaidone,Milan,Italy GunnarFolprecht,Dresden,Germany AntoineItaliano,Bordeaux,France RobGlynne-Jones,Northwood,UK UlrikLassen,Copenhagen,Denmark ThomasGruenberger,Vienna,Austria IgnacioMelero,Pamplona,Spain RienkOffringa,Heidelberg,Germany RuthPlummer,NewcastleuponTyne,UK PerPfeiffer,Odense,Denmark JordiRodo(cid:2)n,Houston,TX,USA OwenSansom,Glasgow,UK TeresaTroiani,Naples,Italy JulienTaieb,Paris,France IanWaddell,Manchester,UK VincenzoValentini,Rome,Italy Gastrointestinaltumours,non-colorectal Genitourinarytumours,prostate Chair:EricVanCutsem,Leuven,Belgium Chair:JohanndeBono,Sutton,UK FatimaCarneiro,Porto,Portugal AndreaAlimonti,Bellinzona,Switzerland StefanoCascinu,Modena,Italy EstherBaena,Manchester,UK DavidCunningham,Sutton,UK HimishaBeltran,NewYork,NY,USA ManuelHidalgo,Madrid,Spain WinaldGerritsen,Nijmegen,Netherlands ClausJorgensen,Manchester,UK SilkeGillessen,St.Gallen,Switzerland Yoon-KooKang,Seoul,RepublicofKorea NicholasJames,Birmingham,UK FlorianLordick,Leipzig,Germany VesaKataja,Jyv€askyl€a,Finland ChristopheMariette†,Lille,France DavidLorente,Valencia,Spain ArnaudRoth,Geneva,Switzerland DavidOlmos,Madrid,Spain DieterSaur,Munich,Germany StephaneOudard,Paris,France ThomasSeufferlein,Ulm,Germany ScottTomlins,AnnArbor,MI,USA MarcelVerhej,Amsterdam,Netherlands DavidWaugh,Belfast,UK MarcYchou,Montpellier,France Genitourinarytumours,non-prostate Gynaecologicalcancers Chair:BernardEscudier,Villejuif,France Chair:DomenicaLorusso,Milan,Italy CoryAbate-Shen,NewYork,NY,USA FredericAmant,Leuven,Belgium LaurenceAlbiges,Villejuif,France SusanaBanerjee,London,UK ArisBamias,Athens,Greece AntonioGonz(cid:2)alez-Mart(cid:2)ın,Madrid,Spain AxelBex,Amsterdam,Netherlands PhilippHarter,Essen,Germany PetriBono,Helsinki,Finland MansoorMirza,Copenhagen,Denmark FernandoCalaisdaSilva,Lisbon,Portugal RemiANout,Leiden,Netherlands MariaDeSantis,Coventry,UK SandroPignata,Naples,Italy KarimFizazi,Villejuif,France JamiePrat,Barcelona,Spain VincentKhoo,London,UK IsabelleRay-Coquard,Lyon,France AntonioLo(cid:2)pez-Beltran,Lisbon,Portugal IgnaceVergote,Leuven,Belgium AndreaNecchi,Milan,Italy CamilloPorta,Pavia,Italy MichaelStaehler,Munich,Germany Haematologicalmalignancies Headandneckcancer Chair:MarianoProvencio,Madrid,Spain Chair:Jean-PascalMachiels,Brussels,Belgium ChristianBuske,Ulm,Germany AmparoCano,Madrid,Spain MariadelMarCo(cid:2)rdoba,Madrid,Spain IsabelFonseca,Lisbon,Portugal Andre´sFerreri,Milan,Italy VincentGre´goire,Brussels,Belgium JuanFernandoGarcia,Madrid,Spain JoelGuigay,Nice,France PaoloGhia,Milan,Italy ChristopheLeTourneau,Paris,France MicheleGhielmini,Bellinzona,Switzerland LisaLicitra,Milan,Italy Jose´GomezCodina,Valencia,Spain MarcoMerlano,Cuneo,Italy MarcoLadetto,Alessandria,Italy RicardoMesia,Barcelona,Spain StevenLeGouill,Nantes,France SjoukjeOosting,Groningen,Netherlands FredericPeyrade,Nice,France AmandaPsyrri,Athens,Greece TimSomervaille,Manchester,UK Hans-PeterRodemann,Tu¨bingen,Germany EvangelosTerpos,Athens,Greece ChristianSimon,Lausanne,Switzerland AndreasTrumpp,Heidelberg,Germany Immunotherapyofcancer Melanomaandotherskintumours Chair:IngeMarieSvane,Herlev,Denmark Chair:ReinhardDummer,Zurich,Switzerland MarioColombo,Milan,Italy PaoloAscierto,Naples,Italy GeorgeCoukos,Lausanne,Switzerland BorisBastian,SanFrancisco,CA,USA Je´roˆmeGalon,Paris,France MatthiasGuckenberger,Zurich,Switzerland HelenGogas,Athens,Greece PaulLorigan,Manchester,UK JohnHaanen,Amsterdam,Netherlands SalvadorMartin-Algarra,Pamplona,Spain GuidoKroemer,Paris,France OlivierMichielin,Lausanne,Switzerland PaulNathan,Northwood,UK DanielPeeper,Amsterdam,Netherlands EliPikarsky,Jerusalem,Israel AntoniRibas,LosAngeles,CA,USA ThomasPowles,London,UK CarolineRobert,Villejuif,France DanielSpeiser,Lausanne,Switzerland YardenaSamuels,Rehovot,Istrael FionaThistlethwaite,Manchester,UK DirkSchadendorf,Essen,Germany AlessandroTestori,Milan,Italy NETsandendocrinetumours Non-metastaticNSCLCandotherthoracic Chair:MichelDucreux,Villejuif,France malignancies EricBaudin,Villejuif,France Chair:PilarGarrido,Madrid,Spain JeromeBertherat,Paris,France PaulBaas,Amsterdam,Netherlands FelixBeuschlein,Munich,Germany MarianoBarbacid,Madrid,Spain JaumeCapdevila,Barcelona,Spain Anne-MarieDingemans,Maastricht,Netherlands IanChau,Sutton,UK MarinaGarassino,Milan,Italy RocioGarcia-Carbonero,Madrid,Spain Ce´cileLePe´choux,Villejuif,France DikKwekkeboom†,Rotterdam,Netherlands KeunchilPark,Seoul,RepublicofKorea MariannePavel,Erlangen,Germany LuisPaz-Ares,Madrid,Spain GuidoRindi,Rome,Italy SanjayPopat,London,UK EnricoRuffini,Turin,Italy EgbertSmit,Amsterdam,Netherlands JonathanStrosberg,Tampa,FL,USA PaulVanSchil,Edegem,Belgium JohanVansteenkiste,Leuven,Belgium EmmyVerschuren,Helsinki,Finland
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