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EPILEPSY – HISTOLOGICAL, ELECTROENCEPHALOGRAPHIC AND PSYCHOLOGICAL ASPECTS Edited by Dejan Stevanovic Epilepsy – Histological, Electroencephalographic and Psychological Aspects Edited by Dejan Stevanovic Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Bojan Rafaj Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published February, 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from [email protected] Epilepsy – Histological, Electroencephalographic and Psychological Aspects, Edited by Dejan Stevanovic p. cm. ISBN 978-953-51-0082-9 Contents Preface IX Part 1 Histological Aspects 1 Chapter 1 Cellular and Molecular Mechanisms Underlying Epilepsy: An Overview with Our Findings 3 Melda Yardimoglu, Gul Ilbay, Cannur Dalcik, Hakki Dalcik and Sibel Kokturk Chapter 2 The Blood-Brain Barrier and Epilepsy 31 Gul Ilbay, Cannur Dalcik, Melda Yardimoglu, Hakki Dalcik and Elif Derya Ubeyli Part 2 Electroencephalographic Aspects 47 Chapter 3 EEG Signal Processing for Epilepsy 49 Carlos Guerrero-Mosquera, Armando Malanda Trigueros and Angel Navia-Vazquez Chapter 4 Automated Epileptic Seizure Detection Methods: A Review Study 75 Alexandros T. Tzallas, Markos G. Tsipouras, Dimitrios G. Tsalikakis, Evaggelos C. Karvounis, Loukas Astrakas, Spiros Konitsiotis and Margaret Tzaphlidou Chapter 5 Automated Non-Invasive Identification and Localization of Focal Epileptic Activity by Exploiting Information Derived from Surface EEG Recordings 99 Amir Geva, Merav Ben-Asher, Dan Kerem, Mayer Aladjem and Alon Friedman Chapter 6 Hyper-Synchronization, De-Synchronization, Synchronization and Seizures 117 Jesús Pastor, Rafael García de Sola and Guillermo J. Ortega Chapter 7 Long-Term Monitoring: An Overview 145 B. Mesraoua, D. Deleu and H. G. Wieser VI Contents Part 3 Psychological Aspects 173 Chapter 8 Neuropsychological Evaluation in Epilepsy Surgery – A Cross-Cultural Perspective 175 Ahmed M. Hassan Chapter 9 Psychic Seizures and Their Relevance to Psychosis in Temporal Lobe Epilepsy 199 Kenjiro Fukao Chapter 10 Personality Profiles of Patients with Psychogenic Nonepileptic Seizures 215 Krzysztof Owczarek and Joanna Jędrzejczak Chapter 11 Psychogenic Pseudoepileptic Seizures – From Ancient Time to the Present 233 Joanna Jędrzejczak and Krzysztof Owczarek Chapter 12 Children with Cerebral Palsy and Epilepsy 251 Emira Švraka Preface As the very complex neurological condition primarily characterized by unexpected, episodic, and chronic nature of variety of seizures and neurophysiologic changes in the brain, epilepsy is also characterized by different neurodevelopmental, psychological, behavioral, educational, social, and many other difficulties. Therefore, many researchers all over the world investigating various aspects of epilepsy leave us with nearly 5000 new scientific documents every year. Reading all these documents is practically impossible, but unnecessary as well. Thus, periodically edited books about particular aspects of epilepsy are more than welcome. With the InTech vision of including authors from different parts of the world, different educational backgrounds, and offering open-access to their published work, I my proud to present the latest edited book in epilepsy research, Epilepsy: Histological, electroencephalographic, and psychological aspects. Here are selected twelve interesting and inspiring chapters dealing with basic molecular and cellular mechanisms underlying epileptic seizures, electroencephalographic findings, and neuropsychological, psychological, and psychiatric aspects of epileptic seizures, but non-epileptic as well. Each chapter is organized in two parts. In the first, authors summarized the most relevant past research on the topic they had selected, while in the second, they gave their recent findings on the topic. All authors took responsibility to present only the most relevant information. I am deeply convinced that the chapters will save our time reading many articles, but also contribute significantly to the growing nature of epilepsy research. Dejan Stevanovic, MD Department of Child Psychiatry General Hospital Sombor Serbia