Epigenetics of Cancer Prevention (Volume 8) (Translational Epigenetics (Volume 8))

429 Pages·2018·6.109 MB·English

by  Anupam Bishayee (editor), Deepak Bhatia (editor)

Translational Epigenetics Series
Trygve O. Tollefsbol, PhD, Series Editor
TransgenerationalEpigenetics ChromatinRegulationandDynamics
EditedbyTrygveO.Tollefsbol,2014 EditedbyAnitaGo€ndo€r,2016
PersonalizedEpigenetics NeuropsychiatricDisordersandEpigenetics
EditedbyTrygveO.Tollefsbol,2015 EditedbyDagH.Yasui,JacobPeedicayiland
DennisR.Grayson,2016
EpigeneticTechnologicalApplications
EditedbyY.GeorgeZheng,2015 PolycombGroupProteins
EditedbyVincenzoPirrotta,2016
EpigeneticCancerTherapy
EditedbyStevenG.Gray,2015 EpigeneticsandSystemsBiology
EditedbyLeonieRingrose,2017
DNAMethylationandComplexHumanDisease
ByMichelNeidhart,2015 CancerandNoncodingRNAs
EditedbyJayprokasChakrabartiand
EpigenomicsinHealthandDisease
SangaMitra,2017
EditedbyMarioF.Fragaand
AgustinF.FFern(cid:1)andez,2015 NuclearArchitectureandDynamics
EditedbyChristopheLavelleand
EpigeneticGeneExpressionandRegulation
Jean-MarcVictor,2017
EditedbySumingHuang,MichaelLittand
C.AnnBlakey,2015 EpigeneticMechanismsinCancer
EditedbySabitaSaldanha,2017
EpigeneticBiomarkersandDiagnostics
EditedbyJoseLuisGarcía-Giménez,2015 EpigeneticsofAgingandLongevity
EditedbyAlexeyMoskalevand
DrugDiscoveryinCancerEpigenetics
AlexanderM.Vaiserman,2017
EditedbyGerdaEggerand
PaolaBarbaraArimondo,2015 TheEpigeneticsofAutoimmunity
EditedbyRongxinZhang,2018
MedicalEpigenetics
EditedbyTrygveO.Tollefsbol,2016 EpigeneticsinHumanDisease,SecondEdition
EditedbyTrygveO.Tollefsbol,2018
ChromatinSignalingandDiseases
EditedbyOlivierBindaand
MartinFernandez-Zapico,2016
GenomeStability
EditedbyIgorKovalchukand
OlgaKovalchuk,2016
TRANSLATIONAL EPIGENETICS
VOLUME 8
EPIGENETICS OF
CANCER PREVENTION
Edited by
Anupam Bishayee, p d
h
LakeErieCollegeofOsteopathicMedicine,Bradenton,FL,UnitedStates
Deepak Bhatia, p d
h
DepartmentofPharmacogenomics,BernardJDunnSchoolofPharmacy
ShenandoahUniversity,Fairfax,VA,UnitedStates
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Contributors
DinaMoustafaAboEl-Ella DepartmentofPharma- Moonmoon Deb Epigenetics and Cancer Research
cology and Toxicology, Faculty of Pharmacy, Laboratory, Biochemistry and Molecular Biology
October6University,6thOctoberCity,Egypt Group, DepartmentofLife Science, National Insti-
Aamir Ahmad Department of Oncologic Sciences, tuteofTechnology,Rourkela,India
Mitchell Cancer Institute, University of South Kasi Pandima Devi Department of Biotechnology,
Alabama,Mobile,AL,UnitedStates AlagappaUniversity(ScienceCampus),Karaikudi,
Kristina Andrijauskaite Department of Molecular India
Medicine, UT Health San Antonio, San Antonio, Micah G. Donovan Department of Nutritional
TX,UnitedStates Sciences, The University of Arizona, Tucson, AZ,
FrankArfuso StemCellandCancerBiologyLabora- UnitedStates; TheUniversityofArizonaCancer
Center, The University of Arizona, Tucson, AZ,
tory, School of Biomedical Sciences, Curtin Health
UnitedStates
Innovation Research Institute, Curtin University,
Perth,WA,Australia Manuel Freire-Garabal SNL Laboratory, School of
Ritikraj Arya Loveless Academic Magnet Program Medicine and Dentistry, University of Santiago de
Compostela,SantiagodeCompostela,Spain
HighSchool,Montgomery,AL,UnitedStates
Shafquat Azim Department of Oncologic Sciences, Irontianta Gkorezi-Ntavela Department of Obstet-
rics and Gynecology, University Hospital of Lar-
Mitchell Cancer Institute, University of South
issa,Larissa,Greece
Alabama,Mobile,AL,UnitedStates
Barbara Banelli Laboratory of Tumor Epigenetics, Nikolaos Goutsias Department of Obstetrics and
IRCCS Ospedale Policlinico San Martino, Genova, Gynecology, University Hospital of Larissa, Lar-
issa,Greece
Italy; DepartmentofHealthSciences,University
ofGenova,Genova,Italy KarishmaGupta DepartmentofUrology,TheJames
Divya Bhagirath Department of Urology, Veterans andEilleenDickeResearchLaboratory,CaseWest-
Affairs MedicalCenter, SanFrancisco and Univer- ern Reserve University, Cleveland, OH, United
States; Department of Urology, The Urology
sityofCalifornia,SanFrancisco,CA,UnitedStates
Institute, University Hospitals Cleveland Medical
Deepak Bhatia Department of Pharmacogenomics,
Center,Cleveland,OH,UnitedStates
Bernard J Dunn School of Pharmacy, Shenandoah
University,Fairfax,VA,UnitedStates Sanjay Gupta Department of Urology, The James
andEilleenDickeResearchLaboratory,CaseWest-
AnupamBishayee LakeErieCollegeofOsteopathic
ern Reserve University, Cleveland, OH, United
Medicine,Bradenton,FL,UnitedStates
States; Department of Urology, The Urology
Rajvir Dahiya Department of Urology, Veterans Institute, University Hospitals Cleveland Medical
Affairs MedicalCenter, SanFrancisco and Univer- Center, Cleveland, OH, United States;
sityofCalifornia,SanFrancisco,CA,UnitedStates Department of Nutrition, Case Western Reserve
Laxmidhar Das Epigenetics and Cancer Research University, Cleveland, OH, United States;
Laboratory, Biochemistry and Molecular Biology Division of General Medical Sciences, Case
Group,Department ofLifeScience, National Insti- Comprehensive Cancer Center, Cleveland, OH,
tuteofTechnology,Rourkela,India United States; Department of Urology, Louis
ix
x
CONTRIBUTORS
StokesClevelandVeteransAffairsMedicalCenter, Fernando Salvador Moreno Department of Food
Cleveland,OH,UnitedStates andExperimentalNutrition,FacultyofPharmaceu-
JiannisHajiioannou DepartmentofENT,Headand ticalSciencesofUniversityofS~aoPaulo,S~aoPaulo,
Neck Surgery, University Hospital of Larissa, Brazil
Larissa,Greece Jay Morris Department of Molecular Medicine, UT
Renato Heidor Department of Food and Experi- HealthSanAntonio,SanAntonio,TX,UnitedStates
mental Nutrition, Faculty of Pharmaceutical Shahrzad Movafagh Department of Pharmacoge-
Sciences of University of S~ao Paulo, S~ao Paulo, nomics, Bernard J Dunn School of Pharmacy,
Brazil ShenandoahUniversity,Fairfax,VA,UnitedStates
Swayamsiddha Kar Epigenetics and Cancer Amanda Munson Department of Pharmacogenom-
Research Laboratory, Biochemistry and Molecular ics, Bernard J Dunn School of Pharmacy, Shenan-
Biology Group, Department of Life Science, doahUniversity,Fairfax,VA,UnitedStates
NationalInstituteofTechnology,Rourkela,India Silvia Novío SNL Laboratory, School of Medicine
MohammadAslamKhan DepartmentofOncologic and Dentistry, University of Santiago de Compos-
Sciences, Mitchell Cancer Institute, University of tela,SantiagodeCompostela,Spain
SouthAlabama,Mobile,AL,UnitedStates María Jesu(cid:2)s Nu(cid:2)n~ez-Iglesias SNL Laboratory,
Ourania Koukoura Department of Obstetrics and School of Medicine and Dentistry, University of
Gynecology, University Hospital of Larissa, Santiago de Compostela, Santiago de Compostela,
Larissa,Greece Spain
Avinash Kumar Arnold and Marie Schwartz SachinPai DepartmentofInterdisciplinaryClinical
College of Pharmacy and Health Sciences, Long Oncology, Mitchell Cancer Institute, University of
IslandUniversity,Brooklyn,NY,UnitedStates SouthAlabama,Mobile,AL,UnitedStates
Alan Prem Kumar Department of Pharmacology, Sabnam Parbin Epigenetics and Cancer Research
YongLooLinSchoolofMedicine,NationalUniver- Laboratory, Biochemistry and Molecular Biology
sity of Singapore, Singapore, Singapore; Cancer Group, DepartmentofLife Science, National Insti-
ScienceInstitute ofSingapore, NationalUniversity tuteofTechnology,Rourkela,India
of Singapore, Singapore, Singapore; Curtin Girijesh Kumar Patel Department of Oncologic
MedicalSchool, Faculty of Health Sciences, Curtin Sciences, Mitchell Cancer Institute, University of
University, Perth, WA, Australia; National Uni- SouthAlabama,Mobile,AL,UnitedStates
versityCancerInstitute,NationalUniversityHealth
Samir Kumar Patra Epigenetics and Cancer
System, Singapore, Singapore; Department of
Research Laboratory, Biochemistry and Molecular
Biological Sciences, University of North Texas,
Biology Group, Department of Life Science,
Denton,TX,UnitedStates
NationalInstituteofTechnology,Rourkela,India
AnaitS.Levenson ArnoldandMarieSchwartzCol-
NibeditaPradhan EpigeneticsandCancerResearch
legeofPharmacyandHealthSciences,LongIsland
Laboratory, Biochemistry and Molecular Biology
University,Brooklyn,NY,UnitedStates; College
Group, DepartmentofLife Science, National Insti-
of Veterinary Medicine, Long Island University,
tuteofTechnology,Rourkela,India
Brookville,NY,UnitedStates
Tamilselvam Rajavel Department of Biotech-
Thao L Yang Department of Urology, Veterans
nology, Alagappa University (Science Campus),
Affairs Medical Center, San Francisco and
Karaikudi,India
University of California, San Francisco, CA,
UnitedStates Donato F. Romagnolo Department of Nutritional
Sciences, The University of Arizona, Tucson, AZ,
Shahana Majid Department of Urology, Veterans
UnitedStates; TheUniversityofArizonaCancer
Affairs MedicalCenter, SanFrancisco and Univer-
Center, The University of Arizona, Tucson, AZ,
sityofCalifornia,SanFrancisco,CA,UnitedStates
UnitedStates
xi
CONTRIBUTORS
MassimoRomani LaboratoryofTumorEpigenetics, Qiwen Shi Collaborative Innovation Center of
IRCCS Ospedale Policlinico San Martino, Genova, YangtzeRiverDeltaRegionGreenPharmaceuticals,
Italy Hangzhou, China; Zhejiang University of
GianLuigiRusso NationalResearchCouncil,Insti- Technology,Hangzhou,China
tuteofFoodSciences,Avellino,Italy Stavros Sifakis Department of Obstetrics and
Sharanjot Saini Department of Urology, Veterans Gynecology, “Mitera” Hospital, Herakleion,
Greece
Affairs MedicalCenter, SanFrancisco and Univer-
sityofCalifornia,SanFrancisco,CA,UnitedStates Seema Singh Department of Oncologic Sciences,
Sabita N. Saldanha Department of Biological Mitchell Cancer Institute, University of South
Alabama,Mobile,AL,UnitedStates; Department
Sciences, Alabama State University, Montgomery,
ofBiochemistryandMolecularBiology,Collegeof
AL,UnitedStates
Medicine, University of South Alabama, Mobile,
Ornella I. Selmin Department of Nutritional
AL,UnitedStates
Sciences, The University of Arizona, Tucson, AZ,
Ajay P. Singh Department of Oncologic Sciences,
UnitedStates; TheUniversityofArizonaCancer
Mitchell Cancer Institute, University of South
Center, The University of Arizona, Tucson, AZ,
UnitedStates Alabama,Mobile,AL,UnitedStates; Department
ofBiochemistryandMolecularBiology,Collegeof
Dipta Sengupta Epigenetics and Cancer Research
Medicine, University of South Alabama, Mobile,
Laboratory, Biochemistry and Molecular Biology
AL,UnitedStates
Group,Department ofLifeScience, National Insti-
Judy C. Sng Department of Pharmacology, Yong
tuteofTechnology,Rourkela,India
Loo Lin School of Medicine, National University
Gautam Sethi Department of Pharmacology, Yong
ofSingapore,Singapore,Singapore
Loo Lin School of Medicine, National University
Paola Ungaro National Research Council, Institute
of Singapore, Singapore, Singapore; School of
of Experimental Endocrinology and Oncology ‘G.
Pharmacy and Biomedical Sciences, Curtin Health
Innovation Research Institute, Curtin University, Salvatore’,Naples,Italy
Perth,WA,Australia Ernesto Vargas-Mendez Department of Food and
Eswar Shankar Department of Urology, The James Experimental Nutrition, Faculty of Pharmaceutical
Sciences of University of S~ao Paulo, S~ao Paulo,
andEilleenDickeResearchLaboratory,CaseWest-
ern Reserve University, Cleveland, OH, United Brazil
States; Department of Urology, The Urology Michael J. Wargovich Department of Molecular
Institute, University Hospitals Cleveland Medical Medicine, UT Health San Antonio, San Antonio,
Center,Cleveland,OH,UnitedStates TX,UnitedStates
Muthu K. Shanmugam Department of Pharma- Haseeb Zubair Department of Oncologic Sciences,
cology,YongLooLinSchoolofMedicine,National Mitchell Cancer Institute, University of South
UniversityofSingapore,Singapore,Singapore Alabama,Mobile,AL,UnitedStates
Foreword
Environmentalfactorssuchasdietfrequently phytochemicals have been the topic of intense
influence gene expression and contribute to investigation for only about the last 15years.
epigenetic processes that consist of changes in As a result of these concerted efforts, we have
gene expression that are heritable but are not learnedthat manyof these compoundscanpre-
encodedintheDNAitself.Theimpactofdietary vent the initiation (i.e., primary prevention) or
components such as bioactive phytochemicals slowtheprogression(i.e.,secondaryprevention)
on gene expression has garnered a tremendous ofcancerdevelopment.Anothernotablefinding
amount of interest largely because the expres- has been that unlike what we too often observe
sion of genes encoding for tumor suppressors with standard cancer treatment using drugs,
and oncogenes is often altered in cancers. One many phytochemicals are able to confer cancer
of the most notable and encouraging aspects of chemopreventionwithnegligibleadverseeffects
chemoprevention is that epigenetic aberrations onnormalcellsandtissues.Therefore,inlightof
are readily reversible and can be corrected by a the high incidence of epigenetic aberrations in
myriad of mechanismsthrough which bioactive cancer combined with the reversibility of these
phytochemicalsinfluencetheepigeneticmachin- defectsandtherelativelackoftoxicityassociated
ery in cancer cells. These basic tenets of the epi- withtheuseofbioactivephytochemicals,thepo-
genetics of chemoprevention have opened a tentialforthesecompoundstohaveasignificant
rapidly expanding field of investigation not impact on cancer prevention seems particularly
only of the underlying mechanisms through high.
which these epigenetic-modifying compounds Despitetheseadvances,however,manychal-
confer their efficacy in preventing and treating lengesremain.Forinstance,althoughawealthof
cancerandotherdiseases,butalsoofthetransla- information about the use of phytochemicals in
tional potential of this approach in controlling preventing the epigenetic defects of cancer has
the incidence of disease. This book provides beenforthcoming, our understanding ofthe po-
numerous reviews on a number of different tential for combinatorial approaches that use
bioactive compounds that act through the multiple compounds to prevent cancer is rela-
correction of epigenetic defects such as alter- tively limited when compared with the field of
ations in DNA methylation, histone modifica- cancer therapy, where combinations of anti-
tions, and noncoding RNAs that are cancer drugs are frequently employed. Recent
characteristic of a variety of differentcancers. studies have found that certain combinations of
The epigenetic machinery is often a driving epigenetic-aberration-neutralizing phytochemi-
force in many diseases, although efforts to cals can act synergistically without added
neutralize epigenetic defects that contribute toxicity, which opens numerous possibilities for
to disease through the use of bioactive the increased efficacy of epigenetic-based
xiii
xiv
FOREWORD
cancer chemoprevention while maintaining the toefficaciouslyandsafelypreventdiseasessuch
relativelyhighsafetyofthesecompounds.There ascancer.Themosteffectiveapproachtohealth
are also challenges ahead in understanding the management is obviously to prevent these
temporalaspectsofcancerchemopreventionus- diseases before they take their toll in human
ing epigenetic-modulating phytochemicals, in suffering and rising medical costs, and
that many epigenetic processes change during epigenetic-intervention approaches to chemo-
key stages of the life span. Efforts to determine preventionascoveredinthisvolumeareprimed
when during the life span these compounds are tocontributegreatlytothisgoal.
the most efficacious will therefore be especially
useful, and clinical trials will likely address ProfessorTrygve Tollefsbol,PhD
many of these challengesin the near future. Departmentof Biology
The chapters contained within this volume College ofArts and Sciences
will lead us to further overcoming many of the University ofAlabama atBirmingham
challenges that we are facing in the epigenetics Birmingham, AL 35233
ofchemopreventionandopennewopportunities USA
PAR T I
MOLECULARE PIGENETIC
TARGETSO F NATURAL
PRODUCTS