Epigenetics in Allergy and Autoimmunity

408 Pages·2020·6.716 MB·English

by  Christopher Chang, Qianjin Lu

Advances in Experimental Medicine and Biology 1253
Christopher Chang
Qianjin Lu   Editors
Epigenetics
in Allergy and
Autoimmunity
Advances in Experimental Medicine and Biology
Volume 1253
Series Editors
Wim E. Crusio, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine,
CNRS and University of Bordeaux UMR 5287, Pessac Cedex, France
John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA
Heinfried H. Radeke, Institute of Pharmacology & Toxicology, Clinic of the
Goethe University Frankfurt Main, Frankfurt am Main, Hessen, Germany
NimaRezaei,ResearchCenterforImmunodeficiencies,Children’sMedicalCenter,
Tehran University of Medical Sciences, Tehran, Iran
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Christopher Chang Qianjin Lu
(cid:129)
Editors
Epigenetics in Allergy
and Autoimmunity
123
Editors
Christopher Chang Qianjin Lu
Division of Pediatric Immunology Department ofDermatology, HunanKey
andAllergy Laboratory of Medical Epigenomics
Joe DiMaggioChildren’s Hospital Second XiangyaHospital, Central South
Hollywood, FL,USA University
Changsha,Hunan,China
Division of Rheumatology, Allergy
andClinical Immunology
University of California Davis
Davis, CA,USA
ISSN 0065-2598 ISSN 2214-8019 (electronic)
Advances in Experimental Medicine andBiology
ISBN978-981-15-3448-5 ISBN978-981-15-3449-2 (eBook)
https://doi.org/10.1007/978-981-15-3449-2
©SpringerNatureSingaporePteLtd.2020
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This book is dedicated to all patients with
allergic and autoimmune diseases, in the
hope that one day there will not just be
treatments but cures.
Preface
As personalized medicine becomes more and more of a mainstream term, there is
no consensus on how to achieve this lofty goal. The dream of being able to
precisely identify patients who will respondoptimally toa given treatmenthasnot
yetbeenrealized, butepigenetics,thestudy ofhowgenes areturnedonandoffby
changes not in DNA sequence but in alterations of various elements of chromatin,
including nucleotides within the DNA and proteins which regulate expression that
areinclosephysicalcontactwithDNA,offersgreatpromiseinultimatelyachieving
this goal. The study of the impact of epigenetics in health and disease originated
only about 40 or so years ago and began in the oncology arena, but then quickly
progressed to include autoimmune diseases. Our understanding of the role of epi-
genetics has been facilitated by large populations studies and by the existence of
discordant twins, in other words, monozygotic twins who generally have identical
DNA but still manage to manifest changes in disease presentation. This work is
intended to cover the topics relating to epigenetics in allergic diseases and
autoimmunediseases.Theaimistoprovideacomprehensivesourceofinformation
for scientists, clinicians, fellows, residents and students who are interested in
cutting-edgedevelopmentsinepigeneticresearchdesignedtoelucidatemechanisms
of disease and the fulfilment of that promise of personalized medicine.
Mycolleagueandco-editor,ProfessorQianjinLu,istheHeadoftheHunanKey
LaboratoryforEpigeneticsResearchandhaspublishednumerouspapersontherole
of epigenetics in dermatology and rheumatology. I have been privileged to have
sharedinthepublicationofsomeofthesearticles.ProfessorLuandIhaveselected
theworld’s foremostexperts inepigeneticsin their research field tocover diseases
ranging from allergic rhinitis and asthma to primary biliary cirrhosis and multiple
sclerosis.Wehopethatthisbookwillhelpthereaderunderstandtheimportanceof
thisresearchtothefutureofmankind,notonlyinpreventingandtreatingdiseases,
but also in the appreciation of how good health can be maintained.
This project was first conceived three years ago, at the 2017 International
Symposium of Autoimmunity in Beijing, China. Professor Lu and I would like to
thankPengZhang,ourtirelesspublicationsliaisonatSpringerwhofirstapproached
us with the proposal, and Professor Haijing Wu, who co-authored the chapters on
vii
viii Preface
foodallergiesandsystemiclupuserythematosusandalsohelpedwithproofingand
many of the administrative tasks one faces when editing a scientific work. We
wouldliketoextendourthankstotheauthorsofeachoftheindividualchapters,for
their willingness to devote large amounts of time to share their expertise with us.
Wewouldalsoliketothankourfamilies,whoenduredmanysolitaryhourswithout
us as we retreated to our workspaces to continue our own work in bringing this
book into production. It has been a challenging but rewarding task.
Finally, we hope that an appreciation of the importance of epigenetics in health
and disease will spawn further research in this area and the book will provide a
launching pad for young investigators interested in developing a career in
epigenetics.
Hollywood, FL, USA Christopher Chang
May 2020
Contents
Part I Introduction
1 Epigenetics in Health and Disease. . . . . . . . . . . . . . . . . . . . . . . . . . 3
Lian Zhang, Qianjin Lu, and Christopher Chang
2 The Development of Epigenetics in the Study of Disease
Pathogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
Matlock A. Jeffries
3 Epigenetic Methods and Twin Studies . . . . . . . . . . . . . . . . . . . . . . 95
Angela Ceribelli and Carlo Selmi
Part II Allergic Diseases
4 The Role of Genetics, the Environment, and Epigenetics
in Atopic Dermatitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
Zhanglei Mu and Jianzhong Zhang
5 The Epigenetics of Food Allergy. . . . . . . . . . . . . . . . . . . . . . . . . . . 141
Christopher Chang, Haijing Wu, and Qianjin Lu
6 Epigenetics and the Environment in Airway Disease:
Asthma and Allergic Rhinitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153
Andrew Long, Bryan Bunning, Vanitha Sampath,
Rosemarie H. DeKruyff, and Kari C. Nadeau
Part III Autoimmune Diseases
7 The Epigenetics of Lupus Erythematosus . . . . . . . . . . . . . . . . . . . . 185
Haijing Wu, Christopher Chang, and Qianjin Lu
8 Epigenetics of Psoriasis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209
Shuai Shao and Johann E. Gudjonsson
ix
x Contents
9 The Role of Epigenetics in Type 1 Diabetes . . . . . . . . . . . . . . . . . . 223
Zhiguo Xie, Christopher Chang, Gan Huang, and Zhiguang Zhou
10 Epigenetics of Primary Biliary Cholangitis . . . . . . . . . . . . . . . . . . . 259
Yikang Li, Ruqi Tang, and Xiong Ma
11 Epigenetics in Primary Sjögren’s Syndrome. . . . . . . . . . . . . . . . . . 285
Anne Bordron, Valérie Devauchelle-Pensec, Christelle Le Dantec,
Arthur Capdeville, Wesley H. Brooks, and Yves Renaudineau
12 Epigenetics in Multiple Sclerosis. . . . . . . . . . . . . . . . . . . . . . . . . . . 309
Vera Sau-Fong Chan
13 The Epigenetic Regulation of Scleroderma and Its Clinical
Application . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 375
Yangyang Luo and Rong Xiao