Table Of Content

CONTENTS The Chromium Problem: Research Needs and Risk Assessment Analytical and Mechanistic Research M. Gochfeld. Setting the research agenda for chromium risk assessment S. I. Shupack. The chemistry of chromium and some resulting analytical problems .............c:ccsscssessesseeeeeeeeeeeees S. A. Katz. The analytical biochemistry of chromium R. J. Bartlett. Chromium cycling in soils and water: links, gaps, and Methods ............ccsceseeseeceeseeeeeeseeseeseeceeeeees C. D. Palmer and P. R. Wittbrodt. Processes affecting the remediation of chromium-contaminated sites ... M. Gochfeld. Panel discussion: Analysis of chromium: methodologies and detection levels and behavior of chromium in environmental media M. Costa. DNA-protein complexes induced by chromate and other carcinOgens ..........:sscssessesceseeseeseeceeceneeseeeeeee J. Aiyar, H. J. Berkovits, R.A. Floyd, and K. E. Wetterhahn. Reaction of chromium(VI) with glutathione or with hydrogen peroxide: identification of reactive intermediates and their role in chromium(V1I)-induced DNA damage M. Sugiyama. Effects of vitamins on chromium(VI)-induced damage R. P. Wedeen and L. Qian. Chromium-induced kidney disease ...........:cceseesseeesescessssesesceseescesseceeessecsececeaeeneeeeee E. T. Snow. A possible role for chromium(III) in genotoxicity C. A. Snyder and C. D. Valle. Immune function assays as indicators of chromate EXPOSUYE ..........scsceseeeeeeeee C. Witmer. Panel discussion. Mechanisms and health effects of chromium Applications of Chromium Chemistry and Toxicity to Risk Assessment and Remediation R. E. Albert. Commentary. Issues in the risk assessment of chromium P. S. J. Lees. Chromium and disease: review of epidemiologic studies with particular reference to etiologic information provided by measures of exposure C. M. Witmer, R. Harris, and S. I. Shupack. Oral bioavailability of chromium from a specific site ............. 105 R. E. Bagdon and R. E. Hazen. Skin permeation and cutaneous hypersensitivity as a basis for making risk assessments of chromium as a soil contaminant M. Gochfeld. Panel discussion. Epidemiologic and toxicologic studies of chromium J. M. LaVelle. Mechanisms of toxicity/carcinogenicity and Superfund decisions ............:ccsseseeseseseeseseeeesceseeeeeeeee 127 T. Burke, J. Fagliano, M. Goldoft, R. E. Hazen, R. igiewicz, and T McKee. Chromite ore processing residue in Hudson County, New Jersey é C. Witmer. Panel discussion. Exposure, remediation, and related research needs ........scsesesesessesessesesseseseeseeeeees 139 M. Gochfeld and C. Witmer. A research agenda for environmental health aspects of chromium Contributed Articles A. van Faassen and P. J. A. Borm. Composition and health hazards of water-based construction paints: IE OIE ROY T9h TIN PRCT os sccniesesiesicciesssrsnennivianwlssticilonnsathitecikeeitstelleb ddelaeacitmdasneien leeeealnsasae 14 R. L. Kodell and R. P. Felton. Two-stage and Weibull models for carcinogenesis applied to the ED, discontinued dosing data A. M. Soto, H. Justicia, J. W. Wray, and C. Sonnenschein. p-Nonyl-phenol: an estrogenic xenobiotic released from “modified” polystyrene J. M. Macher and S. B. Hayward. Public inquiries about indoor air quality in California