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Environmental Epidemiology, Volume 1: Public Health and Hazardous Wastes (Environmental Epidemiology) PDF

297 Pages·1991·2.56 MB·English
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http://www.nap.edu/catalog/1802.html We ship printed books within 1 business day; personal PDFs are available immediately. Environmental Epidemiology, Volume 1: Public Health and Hazardous Wastes Committee on Environmental Epidemiology, Board on Environmental Studies and Toxicology, National Research Council ISBN: 0-309-53758-4, 296 pages, 6 x 9, (1991) This PDF is available from the National Academies Press at: http://www.nap.edu/catalog/1802.html Visit the National Academies Press online, the authoritative source for all books from the National Academy of Sciences, the National Academy of Engineering, the Institute of Medicine, and the National Research Council: • Download hundreds of free books in PDF • Read thousands of books online for free • Explore our innovative research tools – try the “Research Dashboard” now! • Sign up to be notified when new books are published • Purchase printed books and selected PDF files Thank you for downloading this PDF. If you have comments, questions or just want more information about the books published by the National Academies Press, you may contact our customer service department toll- free at 888-624-8373, visit us online, or send an email to [email protected]. This book plus thousands more are available at http://www.nap.edu. Copyright © National Academy of Sciences. All rights reserved. Unless otherwise indicated, all materials in this PDF File are copyrighted by the National Academy of Sciences. Distribution, posting, or copying is strictly prohibited without written permission of the National Academies Press. Request reprint permission for this book. Environmental Epidemiology, Volume 1: Public Health and Hazardous Wastes http://www.nap.edu/catalog/1802.html i ee er book, not from thg, however, cannot bersion for attribution. EEnpviidreomnmioelongtayl pnv al pamattiative e origincific forauthorit Volume 1 osed from XML files created from thding styles, and other typesetting-speprint version of this publication as the BoCaorPdmN uomAbnlTi CitEctIeoOn HemvN ieomrAanoil nLstEhms nRi oeavEnnnirS tdooaE nlnH AmS LatReuizfnCdaetir HaeSdls coCE iauepOnnsidUd cW eeTNmsoaCxisoItiLcleoosgloygy been recompd breaks, heaease use the s orPl ginal work hane lengths, wally inserted. the original; liccident n of e orien a ohe w digital representatie breaks are true to thic errors may have b egp naa file: This ng files. Pme typogr PDF esettind so ut this nal typned, a NATIONAL ACADEMY PRESS ogiai Washington, D.C. 1991 Aboriret Copyright © National Academy of Sciences. All rights reserved. Environmental Epidemiology, Volume 1: Public Health and Hazardous Wastes http://www.nap.edu/catalog/1802.html ii ee er book, not from thg, however, cannot bersion for attribution. NNNotfhofaAOer St aiTTccopoIiInepCmOanrElmoNc :Rpe iAsTrteti,Lseh ateeteh eaA er prb eCcNrsaohAplaj aCoetDnicnooctEsnu eitManb.hlcla eYAitl ,fi c soPwa rtRd hhtehEeom esSse yurS e bmo p jf2eeo 1Ecmrt0tn b1owge fiCer nstrheo eaein srcres ihrnt eodigtpsru,aoe atwnrint o nfdwno ft rarAh osteh vma eIepn i.trp shW rtseiopt avuceseotcehdui ai onnblfc ygc iM olttsomh enoedp,f i G eDctthioe.neCvne ecN.. riT2eans0thiin 4eoag1 nnm 8adBle o wmAairbctdhae drorseef m gotafhyred pnv This report has been reviewed by a group other than the authors according to procedures approved al pamattiative bNya tai oRneapl oArtc aRdeevmieyw o Cf Eomngminiteteerei ncgo,n asnisdti tnhge oIfn smtietumteb eorfs Mofe tdhiec iNnea.tional Academy of Sciences, the e origincific forauthorit NroantmioEennnatvla iRlr oSenstuemadericenhsta aCl neodpu iTndcoeixml i(ciUooll.ooSgg.)yy. ./C Coommmmitittetee eo on nE Ennvviriornomnmenetnatla lE Epipdiedmemioiloolgoyg.y, Board on Envi- osed from XML files created from thding styles, and other typesetting-speprint version of this publication as the 7[D88N NLCICI1R3CDfSnoM2.6oAIoN crB73PEnm l:5LL5.Nu nt716emeiMdv2 .bn5p]0e ii'rEt..r8/ss-N asDo3 scp7:rbni m30yi—Lovidm29b Cn..oe 3-lde 1mfi0o cno .14Cn 2itgP94oa 0orL9ull9an o1bih6pgfgle-heiri0ac iceSc l s(thMacsvheli.. eae9 r12nelt1th).cfh- eoeE2 rdsa8pe,ns0 in.Ndd5 c2e 1aeh.mts aiH oziaoaannlzradodal g oriRnydud.oes seIu w.exs aT. aWrsicttlhaee s..Cteo—unacdivl.erse effects. 3. Refuse Disposal. WA been recompd breaks, heaease use the CCcteeoodspv,s ey,o Nrror i rpogo h ihtpnhota ett©rorhtwg eo1r iff9sao e9tprh 1hmci :osb pLobyifoE e taohdS ke pfM ohNmroOa anptyOiouo gbbRnrleEaia clrp/ eUAhopirNcrc opa IrddrPeiueHvcmcoaOetryeddT ioubOnfsyg eS ,,a c nnwioyeirn t mhcmoeeauscyth waitn rbiicteta esln,t o pprheeordmt oinigs rsaai oprenht irfcire,o vomar l e tshlyeecs tpteruombn,li ictsr hapenrros,m- it- ginal work has ne lengths, worally inserted. Pl ePFSxirericcsneottp nePtdd rf iiPonnrtr iittnnhhgteei, n UpAgun,u riMgpteuoadssr tecS s1ht 9a o1t9fe9 1so9 fo3ffic Aiaml uersiec aby the U.S. government. the original; liccident n of e orien a ohe w digital representatie breaks are true to thic errors may have b egp naa file: This ng files. Pme typogr PDF esettind so ut this nal typned, a ogiai Aboriret Copyright © National Academy of Sciences. All rights reserved. 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ADCANVTOHIMDO BMNAYIT TBET.S ME, UIELn iLOvEeNrRs i tE(yC NohfaV iBrImrRitaiOsnh),N UCMonliuvEmerNbsiiTtay, AoCfLa Tn aoEdrPoanItDo, EOMntaIrOio,L COanGadYa pnv al pamattiative THOoMf PAuSbl iCc HHAeaLltMh, EBRoSst,oDn,e pMaartsmsaecnhtu osf etVtseterans' Affairs and Harvard School e origincific forauthorit MJOOHLNL FYR JOOIENLE CS,O UYCEL,A C Salcihfooronli ao fD Peupbalritcm Heneat lothf ,H Leoaslt Ah nSgeervleicses osed from XML files created from thding styles, and other typesetting-speprint version of this publication as the JDSPSOtpAAaeEUfVcfTWCLiLIariD ainla sc SAnShHiCngdCinOnlHveHgaiE UsttPWoioL,aLn rrO,A, Tk NDhR,E iaN.oT,Ct ioZo.Nrn,t ahat liCU oIannnrasiottleli itdnuI natesS tiottafu ttEeesn vfoiErron nvOmircoecnnutmpaale tniHotaenlaa llt hPS rSaoefteervtcyitc ioeansn, d R AeHgseeeaanlrctchyh,, been recompd breaks, heaease use the DLPAIENUVDLRAEA TM LTIEELE LA DEDARAV PMIOSSO,, SPRcrEhooj,e lRcatre Asines aRsriceshtsai Adnetsnscoeciate s orPl ginal work hane lengths, wally inserted. the original; liccident n of e orien a ohe w digital representatie breaks are true to thic errors may have b egp naa file: This ng files. 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ROMD EONNN E(CNhaViTrImORaXOn)I,N CUMnOivELeNrOsiTGtyA YoLf W SaTshUinDgtIoEn,S S AeaNttlDe e original pacific formattiauthoritative FJORHEUCDNanE niCvRaed.Ir aCsBiKtAy ,I WLRA.a sRhA inNIIgDIto,E nMR, DScGO.CiNl.l , UWniavsehrsinitgyt oSnc hSocohl ooofl Mofe dLicaiwne,, AMmonetrriecaaln, osed from XML files created from thding styles, and other typesetting-speprint version of this publication as the YGJJLRAGPOOAAOOLEAAHUWFNRBRNRNRLNEEAYRieN Ed R MwLJEEDgDAT. .e.N .J C EL, LGeB LCTrBMIOIR.s.EOeK UeKHHnME yYERnNAEWWE,eNG UNRsURSE.sE D,Ne, MSR UReBSTEO,DnO,A hS YNieNvSRNN a,eN,J lN, Ler-e MFesRl TisiUwlootoolHyxy nnbnY OisoeC RvaorfLhUeetn r CraskatWSsoesb aiEBea tloAoy ir,oCrfco ,gaot hadaNtOrr no innLceJacriiuowyackaeblah,,r t loHnLuC RRGrsroaeaaoiusvdantlno t regtAgC derneMeireno, e,r ngm sCsePN,,e d ohpMlGaiUeniactlsrinniaanoelyeldlien bvc,eSna rtelSfilcoprc ithsohe.ui lolkiLtatdayo,bo ,,,lN o ,uPI rnieePPasdwniit,iss on aMccYrsnaayyiaott,slaa rvswwkoOaunaaayyrikai,, been recompd breaks, heaease use the DJNAOANTNNEHAe LALwUDN JBe MRrCsEeAHyETEDTN,I CHSOOobN, eO ,S Uroenguionvnde ,rS sFtilatoyter io dUfa nPiivttesrbsuitryg,h C, Porevnanlsliyslvania the original work has ginal; line lengths, worccidentally inserted. 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AAMLCBEOES,R MUTnSMiv (eICrShsiSatyiIr OmofaN Cn) aO,l iUfNonri nvLieaIr,sF BitEye r okSfe ClCeIayElifNorCniaE, SSan Francisco pnv al pamattiative FJ.R MAINCCHIASCEOL BJ.I SAHYOAPL,A U, nUivneivrseirtsyi toyf o Cf aCliafloifronrian,i aS,a Inr vFinraencisco e origincific forauthorit MGLICEHNNA EAL. CTR. COLSEBGYG, W, Uasnhivinegrstoitny Sotfa Ctea Ulifnoirvneiras,i tRyi,v Peursllimdean osed from XML files created from thding styles, and other typesetting-speprint version of this publication as the FLDMRSETJOTRMHEOIACESERONIRMMHEVLEOAMIPAE MaaAYALHsrANRyNs DA.ES al DEP aP Nc .En F h..DHE .dFJuRPI K..OT.s. 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PADILLA, Administrative Secretary ohe w digital representatie breaks are true to thic errors may have b egp naa file: This ng files. Pme typogr PDF esettind so ut this nal typned, a ogiai Aboriret Copyright © National Academy of Sciences. All rights reserved. Environmental Epidemiology, Volume 1: Public Health and Hazardous Wastes http://www.nap.edu/catalog/1802.html vi ee er book, not from thg, however, cannot bersion for attribution. pnv al pamattiative e origincific forauthorit perpeTtuhaet inNg atsioonciaelt y Aocfa ddemistyin goufi shSecdi ensccehso lairss ae npgraigveadte , inn osnc-ipernotfiifti,c saenlfd- osed from XML files created from thding styles, and other typesetting-speprint version of this publication as the eagiFtoorEthennruf rnse aadgttgp nsno iciiotntk ntatThenseo aneda Phse dedr irertrvttbmiieh oeinniinsNers leggs iigiemtt a or eyi rtbsfbnta ei u hyofpelgtssseoh rnerieto snreeaha , fs er elfaeNicse o dddphCrsAarevseho, ton .criian tsadnoatIhrs iltegnidoneo ndiraf egrgsge ilsmg toc s ahteAasvhuyeen wteencti eeNron aoidgnrtn fdfa aih1men oeltt 8d Eoiemmeo6ew etnnnro3yhtrtaeghaiu, e nl lielo s otfn g h Aafgnie fNerno uSceep vasarAr.cir tcettdioihisnceUiroeg eenangamnrpnrdmc daaaoteyewmminlenmfs cnoia, sic eyntsfA ta . h i aSsshacoeTei tcnasafm rahit dsdaa eaes eet punbaic dmtoat clNie hmierneyscaaoan shh alattr.cl einnineeootdmdidyl ncf a a aaeoiitnnonlleerS d gf t Atitm c1 ahnhit9tncegeaahe6ia ntt eczs td4c hneraee,eernctal miseqshtouo. icua lnyontoirDid tn rtogheooeearnyesrffrl. been recompd breaks, heaease use the naAcecheadidesTev, mehmeey n eoIcnnfot ssEu trnioatgfug ietneesen egorieinfdn eugeMc.raset.id oDincr i.n aeRn odwb earrste sMeesat.ra cWbhl,ih sihtaeend di s i npr erec1so9ig7dn0ein zteb syo f ttthhheee NNsuaapttiieoornnioaarll n of the original work has e original; line lengths, woren accidentally inserted. 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The Council is administered jointly by naa file: This ng files. Pme typogr bMRoe.ts heW aArhcchiat deC eomaurinee csi cla.hnadir mthaen I nasntidtu tve icoef Mcheadiircminaen., Drre.s Fperacntikv ePlyre, sso fa ntdh eD rN. aRtoiobneartl ut this PDF nal typesettined, and so DSeisrveaiTcsehes e.R epgroisjtercyt, Uw.aSs. Psuubplpico rHteeda ltbhy S ethrve icAe,g Denecpya rtfmore nTt ooxf iHc eSaluthb satanndc Hesu manadn ogiai www.national-academies.org Aboriret Copyright © National Academy of Sciences. All rights reserved. Environmental Epidemiology, Volume 1: Public Health and Hazardous Wastes http://www.nap.edu/catalog/1802.html PREFACE vii ee er book, not from thg, however, cannot bersion for attribution. Preface pnv al pamattiative e origincific forauthorit In response to a request from the Agency for Toxic Substances and osed from XML files created from thding styles, and other typesetting-speprint version of this publication as the DTCBeipaewrmesvfooooiifcsatlspexuaoehllecurirsunm acodtstacssoivm mtio eclelee onc hees (xag na nNRttpuyrtdhhosgosR eaee neesgaitC ddnuipitos ) s rupSt ntecbhtbrcu ushiyyeoleb pei nnasl Ceiehbtvtcr(CioxoeoefAf pumidonucThon met ms esdSdcmhmuab DiiastltreaaitthiezRnssehtje aeeoset,) rt iissr, Cofod .t i oi nodcoTnf th u amorhchlatseoilreait-mzuv nse wad i rgieefraiatBLiadvwnttrsepouaoigst efseltura ceu e rsuro ta ds-ehronStpw prian deecnoEta oncii ghrsesninntt tepfn vee ikoaoctc iehnlfresaEsdt oeoashlit n nlt hlw tye evmeooes lfi fe ffrce bftdeoasonheetcginnhmtcet taemdeste r lsms e oet ,cmEth Nfinooto aptet tnafatehids t ddlaecieui uoen eoe gehmcnddnuSgxtua vl iteadlmioui nsmro ldtbo aRod fiionen geneher msyvesoldhh ies.eweenee alTranaakao r llnntehcpttttaoodhdhdhesl been recompd breaks, heaease use the asmedecvtoahnnoWdcd eiort elhtohp geoa yrdft i deofiloftdi ro.t hneena lvc oirsmounpmmpiotetrnet eta fwlr oiemlpl i iddtehemne tiioEfylno vrgeiyrs oeananrmcdhe n wotapillpl oPsrertouletnecictt iteiaosn nda n Aedv giaselsnuucaeytse, inaa the original work has ginal; line lengths, worccidentally inserted. Pl sodtrheaefva mptiah eprhawltezame avdoeredfn obtn ueorseen-npw- posaerustesbtre j-sear.ecn vtd Ti tehorwei sleee xdvl tiaertneneptrs aiotvtreuetcrs he ro nenviicn iaetchlwl eue, d svbeuasubl utj esaauctritceo h on nfs o stofth rueoar vmceaep isiljd auebdamlsiec i ioasinltloa tgdtehie cec hisspetieuaoeldntryhs- n of e orien a ohe w digital representatie breaks are true to thic errors may have b egp naa file: This ng files. Pme typogr PDF esettind so ut this nal typned, a ogiai Aboriret Copyright © National Academy of Sciences. All rights reserved. Environmental Epidemiology, Volume 1: Public Health and Hazardous Wastes http://www.nap.edu/catalog/1802.html PREFACE viii ee er book, not from thg, however, cannot bersion for attribution. lasrietvtrveauirigealawgItunblee rldeedli. , rg wephTpiutoto hb or lttifishst sheft rh ecodeehm xasptr etEgaunueadt cs ietiefetasyerr an loys oEf if bo uplnireen.o, r fpWsotoehr enmea s nda dseetei vxoAcepnolso onisarpdee e tdahdr da eaittplht y moe hr ataap yvzoa aalblirisecldoa yorb euolwlesef-,i v wlllaot hanoasetkt.s eisCn egsosi smta etmsn ,pe iewtatenelryde- pnv also examining those studies involving environmental exposures similar to al pamattiative those that might be found at such sites. e origincific forauthorit numbTehr eo fc hcaopllteeargs ureesf lwecht ot hper ocvoindseedn dsurasf tosf atnhde ccroitmiqmueitst eoef. sWecet ioarnes gorfa ttheefu rle ptoo rat s been recomposed from XML files created from thord breaks, heading styles, and other typesetting-spePlease use the print version of this publication as the fENSCGSwNaArmrdoeelotcpaoiadalcleratch eint tolmmhndiuidvnttomoo dheommaiebLfcnnanemr nimeiiare,da ainttr wdsilnlCi neesEod tazs tr,nrhGolage n mIoaodso mnnDevtofugMPamoasn ivimpytntrurtgcviei iho e ,obrtyliifr aunrloapstnoln eSvttiiitmturser oconre ieo pe as r nftetnvaPi,gsshohn, ooinHi', oeereo id tnfdmtnAn oa ire eh,A ncl Ncr adsaeE geadlSylgsE t uau tnnui.coheOptd opivdvsiicdn Drieoniat ciinodacrrnPla ncAryoagvnuyet.taau niinm ica dulsopdDfrDdeb mmtolenaie, eCloor prntde eaits irlTNenr tan toT.ooee na ivatnsRgtt ossDabtishuhAateyexglClkrygei lnre iaada .gcB tHttF nSaoaCrf oieImreneooStauesrnaais gfrr,attuvsnn eWe cisl be opettcatteHmSehhsysnthrr a rtrc eet os,gaa aooa hapa.nSnnoe tnNfuln ae na ccftdagDErdh atgieeni hheE tnnsrreosdien H., SvPgodtt f ( chait n DAAaesBeratdetatdaeosthCi T uoallimbr ;na itsdcr eSaoshumsCtruyicl PiDfsy rnictmf,areeifAe o iissRenoanscatrte;Jpdetcrute )i snornaaor,emoc dCa thllirrdrpf t sa tilnaiI piuEr ,na;IvndEt so r(sniiipeof ewrisc vnsani aaepnti ditvsernnm ncdia,uaei tn tl WdreruteumaphguaoiA dt,zdpoatam een iieMsivonothi;omHn.hs nber;lenig Loetabe eesl K rrpgrmaeyntaaiv tafylrnnntnehotinuega)gndhnndeftltl,, ginal work hane lengths, wally inserted. meCsunoebouesrtnmtiacnnoigltu, i sawo lldrhygeo abt nont i oztttoha oetiD nodlnryr..a afDtMbienlyvog rs fatau nlDfidima llrvpeeidovs r,i ttshaSionec nthrl yooo,ll fea rtao hlfieln p crRhcooaejpmesctiedmt redsint itcrieneeec , tthoNaerca, ktrbienoupontow acrllto e.R ndWtegrsieibetshua ortiecutdhst the original; liccident hneerv esrk hilalvs ea bnede nin cpoumt, ptlheete dre ipno trht ew tiomueldly hmavaen nlearc ikte hda sm buecehn,. and our task could on of he orieen a commFiitnteaell yfo, ra tsh ecihr aeixrmpearnti,s eI, isnhpouutl da nldi kseu ptpoo rtth athnrko uaglhl oouft othuer dmeleimbebreartsio nosf .the w digital representatie breaks are true to thic errors may have b ACoNmTmHiOttNeeY o nB .E MnvIiLroLnEmRe, nCtahla Eirpmidaenmiology egp naa file: This ng files. Pme typogr PDF esettind so ut this nal typned, a ogiai Aboriret Copyright © National Academy of Sciences. All rights reserved. Environmental Epidemiology, Volume 1: Public Health and Hazardous Wastes http://www.nap.edu/catalog/1802.html CONTENTS ix ee er book, not from thg, however, cannot bersion for attribution. Contents pnv al pamattiative e origincific forauthorit Summary 1 osed from XML files created from thding styles, and other typesetting-speprint version of this publication as the SSEEFADIStCCnetoiiTTxtarmorHtt IIoeEdeOOad ;xnazu NNnpsBacidor toiTOdi osnFouolWNsnoeru edgoEsOsei f Wc rP t HahMulae asbC aztPleorairscknro tdeHberolxeesutam sfl to:W hrE Eaxanpsntodvesi srHu oirnanezm AAaerisnrds,teo aWsuls sEma pWteeindrate,s mSteoisoi:ll, oT aghnyed o Cfon- 11 05621705 been recompd breaks, heaease use the BDSoiooiWmll oaeagnssidttcie c F M SoWioatardekts eaersr sCP ioontn eSsnuttumidalpi eStsioo ounfr cHeasz oafr dEoxupso-sWuraes taet SHiatezsardous- 221107993 ginal work has ne lengths, worally inserted. Pl GInedneexral Conclusions 225761 the original; liccident n of e orien a ohe w digital representatie breaks are true to thic errors may have b egp naa file: This ng files. Pme typogr PDF esettind so ut this nal typned, a ogiai Aboriret Copyright © National Academy of Sciences. 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