Description:This book constitutes the refereed proceedings of the IFIP TC 5 International Conference on Enterprise Architecture, Integration, Interoperability and Networking, EAI2N 2010, held as part of the 21st World Computer Congress, WCC 2010, in Brisbane, Australia, in September 2010. The 15 revised full papers presented were carefully reviewed and selected from numerous submissions. The papers cover a broad range of topics relating to enterprise architecture and interoperability.