ENDOMETR!OZ!S Güncel Yönetim ve Gelecek Akımlar "! ! ENDOMETR!OZ!S Güncel Yönetim ve Gelecek Akımlar Juan A García-Velasco MD PhD Medikal Direktör IVI, Madrid, !spanya Doçent Rey Juan Carlos Üniversitesi Madrid, !spanya Botros RMB Rizk MD MA FACOG FACS HCLD FRCOG FRCS (C) Profesör ve Ba"kan Reprodüktif Endokrinoloji ve !nfertilite Bölümü Medikal ve Bilimsel Direktör ABD IVF Programı Güney Alabama Üniversitesi Tıp Fakültesi Alabama, ABD Çeviri Editörü Prof. Dr.Engin Oral !stanbul Üniversitesi, Cerrahpa"a Tıp Fakültesi Kadın Hastalıkları ve Do#um Anabilim Dalı, Reprodüktif Endokrinoloji Bilim Dalı ""! ! Jitendar P Vij Jaypee Brothers Medical Publishers (P) Ltd Tarafından yayınlanmı!tır. !irket Ofisi 4838/24 Ansari Road, Daryaganj, New Delhi 110 002, India, Phone: +91-11-43574357, Fax: +91-11-43574314 Lisanslı Ofis B-3 EMCA House, 23/23B Ansari Road, Daryaganj, New Delhi 110 002, India Phones: +91-11-23272143, +91-11-23272703, +91-11-23282021, +91-11-23245672, Rel: +91-11-32558559 Fax: +91-11-23276490, +91-11-23245683 e-mail: [email protected], Website: www.jaypeebrothers.com !ubeler q 2/B, Akruti Society, Jodhpur Gam Road Satellite Ahmedabad 380 015 Phones: +91-79-26926233, Rel: +91-79-32988717 Fax: +91-79-26927094 e-mail: [email protected] q 202 Batavia Chambers, 8 Kumara Krupa Road, Kumara Park East Bengaluru 560 001 Phones: +91-80-22285971, +91-80-22382956 +91-80-22372664, Rel: +91-80-32714073 Fax: +91-80-22281761 e-mail: [email protected] q 282 IIIrd Floor, Khaleel Shirazi Estate, Fountain Plaza, Pantheon Road Chennai 600 008 Phones: +91-44-28193265, +91-44-28194897 Rel: +91-44-32972089 Fax: +91-44-28193231 e-mail: [email protected] q 4-2-1067/1-3, 1st Floor, Balaji Building, Ramkote Cross Road Hyderabad 500 095 Phones: +91-40-66610020 +91-40-24758498, Rel:+91-40-32940929 Fax:+91-40-24758499, e-mail: [email protected] q No. 41/3098, B & B1, Kuruvi Building, St. Vincent Road Kochi 682 018, Kerala Phones: +91-484-4036109, +91-484-2395739 +91-484-2395740 e-mail: [email protected] q 1-A Indian Mirror Street, Wellington Square Kolkata 700 013 Phones: +91-33-22651926, +91-33-22276404 +91-33-22276415, Rel: +91-33-32901926 Fax: +91-33-22656075, e-mail: [email protected] q Lekhraj Market III, B-2, Sector-4, Faizabad Road, Indira Nagar Lucknow 226 016 Phones: +91-522-3040553, +91-522-3040554 e-mail: [email protected] q 106 Amit Industrial Estate, 61 Dr SS Rao Road, Near MGM Hospital, Parel Mumbai 400012 Phones: +91-22-24124863, +91-22-24104532, Rel: +91-22-32926896 Fax: +91-22-24160828, e-mail: [email protected] Kuzey Amerika Ofisi 1745, Pheasant Run Drive, Maryland Heights (Missouri), MO 63043, USA, Ph: 001-636-6279734 e-mail: [email protected], [email protected] Orta Amerika Ofisi Jaypee-Highlights Medical Publishers Inc. City of Knowledge, Bld. 237, Clayton, Panama City, Panama Ph: 507-317-0160 Endometriozis: Güncel Yönetim ve Gelecek Akımlar 2010, Jaypee Brothers Medical Publishers Her hakkı saklıdır. Bu yayının hiçbir bölümü, öncesinde editörlerden ve yayıncı kurulu!tan yazılı izin alınmaksızın ço"altılamaz, geri dönü!üm sisteminde depolanamaz veya herhangi bir !ekil veya yolla yayınlanamaz: elektronik, mekanik, fotokopi, kayıt veya di"er !ekiller. Bu kitap, yazarların sa!ladı!ı materyalin orijinal oldu!una yönelik iyi niyetle basılmı"tır. Materyalin do!rulu!undan emin olmak için gerekli her türlü çaba sarf edilmi"tir ama yayıncı, yazıcı, ve editörler kazara olan herhangi bir hata(lar)dan sorumlu tutulamaz. #htilaf halinde tüm yasal konular sadece Delhi yasalarıyla çözümlenecektir. #lk Baskı: 2010 ISBN 978-81-8448-808-1 Türkçe hakları için: IntroMed (www.intro-med.com) """! ! En güçlü destekçilerim ve en büyük motivasyonum Carmela, Maria ve Jaime’ye – Juan A García-Velasco Çok sevgili e!im ve hayat yolda!ım Mary’ye a!kı, deste"i ve fedakarlı"ı için – Botros RMB Rizk "#! ! Yazarlar A Schally Anna Sokalska Botros RMB Rizk Veterans Affairs Medical Department of Obstetrics Professor and Head Center and South Florida Gynecology and Division of Reproductive VA Foundation for Research Gynecological Oncology, Endocrinology and and Education, Miami, and Karol Marcinkoswski Infertility, Medical and Department of Pathology University of Medical Scientific Director, USA IVF and Division of Hematology Sciences Program and Oncology Department Poland University of South of Medicine, the Miller Alabama School of Medicne, Antoni J Duleba College of Medicine, University of Miami Miami, Department of Obstetrics Alabama, USA Florida, USA and Gynecology, University of California Davis, Bruno Borghese Alka Prakash Sacramento, California, USA Université Paris Descartes University Department of Service de Gynécologie Obstetrics and Gynaecology Antonio Pellicer Obstétrique II et Médecine University of Cambridge Fundación IVI de la Reproduction United Kingdom Instituto Universitario IVI Unité de Chirurgie Valencia University, Gynecologique CHU Anabel Salazar Valencia, Spain Cochin-Saint Vincent de IVI Madrid Paul Paris, France Rey Juan Carlos University Antoine Watrelot Madrid, Spain Centre de recherché et Carlos Simón d´Etude de la Stérilité, Lyon, Fundación IVI Andre van As France Instituto Universitario Repros Therapeutics Inc IVI Valencia University The Woodlands, Texas, USA Ashok Agarwal Valencia, Spain Professor of Surgery and Caroline E Gargett Andrea G Edlow Director Centr for Women's Health Department of Obstetrics Center for Reproductive Research Monash Institute and Reproductive Biology, Medicine of Medical Research and Brigham and Women's Infertility, and Sexual Monash University Hospital; Harvard Medical Function Department of Obstetrics School, Boston, Glickman Urological and and Gynaecology, Monash Massachusetts, USA Kidney Institute and Medical Center Department of Obstetrics Clayton, Victoria, Australia Andrew Prentice and Gynecology, The University Department of Cleveland Clinic Carolyn JP Jones Obstetrics and Gynaecology Foundation, Cleveland, USA Maternal and Fetal Research University of Cambridge Centre School of Clinical United Kingdom Attila Bokor and Laboratory Science, Leuven Unoversity Center Univeristy of Manchester Anjali Chandra Dept of Obstetrics and UK Center for Reproductive Gynecology Medicine, Glickman UZ Gastthuisberg, 3000 Chakib M Ayoub Urological and Kidney Leuven, Belgium MBA, Associate Professor Institute and Obstetrics- Department of Gynecology and Women’s Anesthesiology Health Institute; Cleveland American University of Clinic, Cleveland, USA Beirut Beirut, Lebanon Clinical Assistant Professor Department of Anesthesiology Yale University School of Medicine New Haven, CT USA "! ! Charles Chapron Edurne Novella-Maestre Ioannis Vasilopulos Service de Gynécologie Valencia University Université Paris Descartes Obstétrique Valencia, Spain Hôpital Cochin, Reprod II et Médicine de la Endocr and Infertility, Dept Reproduction Emile Daraï of Ob Gyn II, Paris, France Unité de Chirurgie Service de Gynécologie- Gynécologique Obstétrique, Hôpital Tenon, Irving M Spitz CHU Cochin-Saint Vincent Assistance Publique des Institute of Hormone de Paul Hôpitaux de Paris, Reseach and Ben Gurion Paris, France Université Pierre et Marie University of the Neveg Curie, Paris, France Jerusalem, Israel Charles Countant Service de Gynécologie- Engel, JB Isabelle Streuli Obstétrique Hôpital Tenon, Universitätsfrauenklinik Department of Obstetrics Assistance Publique des Würzburg, Würzburg, and Gynecology, Hôpital de Hôpitaux de Paris, Germany Morges Université Pierre et Marie Switzerland Curie, Paris, France Eric S Surrey Colorado Center for Jaques Donnez Christopher B Rizk Reproductive Medicine Lone Department of Gynecology Rice University Tree, CO, USA Université Catholique de Houston, Texas Louvain USA Felice Petraglia Cliniques Universitaires Obstetrics and Gynecology St Luc, Brussels, Belgium David Redwine Department of Pediatrics St. Charles Medical Center Obstetrics and Reproductive Jean-Christophe Lousse Bend, Oregon Medicine Department of Gynecology USA University of Siena, Siena, Université Catholique de Italy Louvain Brussels, Belgium David Smart Enovapharma Francisco Domínguez Jean Squifflet London, United Kingdom Fundación IVI Department of Gynecology Instituto Universitario Université Catholique de Deborah Eapen IVI Valencia University Louvain Brussels, Belgium Center for Reproductive Valencia, Spain Medicine Glickman José Schneider Urological and Kidney Friedrich Wieser Department of Obstetrics Institute and Obstetrics- Department of and Gynaecology, Rey Juan Gynecology and Women’s Gynecology and Obstetrics Carlos University, Madrid, Health Institute Cleveland Emory University School of Spain Clinic, Cleveland, USA Medicine Atlanta, Georgia, USA Juan A García-Velasco Dominique de Ziegler Medical Director, IVI Université Paris Descartes, Gareth C Weston Madrid, Spain Service de Gynécologie Center for Women’s Health Associate Professor, Rey Obstétrique II et Médecine Research Juan Carlos University, de la Reproduction, Unité de Department of Obstetrics Madrid, Spain Chirurgie Gynecologique, and Gynaecology and CHU Cochin-Saint Vincent Monash Institute of Medical Juan Balasch de Paul, Paris, France Research Professor and Chairman, Monash University Institute Clinic of Donald P Brawn Melbourne, Australia Gynecology, Obstetrics and Institute for the Study and Neonatology. Hospital Treatment of Endometriosis Gil Dubernard Clinic Chicago, IL, USA Service de Gynécologie- Institut d´Investigacions Obstétrique, Hôpital Tenon, Biomèdiques August Pi I Edgardo Somigliana Assistance Publique des Sunyer (IDIBAPS), Facultad Fondazione Hospédale Hôpitaux de Paris, of Medicine-University of Maggiore Policlinio, Université Pierre et Marie Barcelona Barcelona, Spain Mangiagalli e Regina Elena Curie, Paris, France Milan, Italy Karamouti M Department of Obstetrics and Gynecology, University of Crete Greece ""! ! Lone Hummelshoj Mary Lou Ballweg Rana Skaf Endometriosis.org President/Executive FACOG Active Staff London, England Director Greenwood OBGYN Endometriosis Association Associates Greenwood, MS Luciano G Nardo (International) USA Department of Reproductive USA Medicine Richard P Dickey St Mary’s Hospital, Michelle Nisolle Clinical Professor and Manchester, UK Gynecology-Obstetrics Division Head Maternal and Fetal Health Department CHR de la Louisiana State University Research Centre, School of Citadelle and Clinical and Laboratory University of Liège, Belgium Medical Director, Fertility Science, University of Institute of New Orleans, Manchester, UK Mohamed Aboulghar New Orleans Professor of Obstetrics and Louisiana, USA Makrigiannakis A Gynecology Faculty of Department of Obstetrics Medicine, Cairo University Roberto Matorras and Gynecology, University Egypt Human Reproduction Unit of Crete Department of Obstetrics Greece Mohamed FM Mitwally and Gynecology, Cruces Reproductive Endocrinology Hospital Marc Bazot and Infertility Specialist País Vasco University, Service de Radiologie, TCART (Toronto Center for Baracaldo Vizcaya, Spain, Hôpital Tenon, Assistance Advanced Reproductive and IVI-Bilbao, Spain Publique des Hôpitaux de Technology), University of Paris, Université Pierre et Toronto Robert F Casper Marie Curie Paris, France Toronto, Ontario, Canada Reproductive Endocrinology and Infertility Specialist Marc Princivalle P Cobos TCART (Toronto Center for Enovapharma Human Reproduction Unit Advanced Reproductive and London, United Kingdom Department of Obstetrics Technology), University of and Gynecology, Cruces Toronto Marc R Laufer Hospital Toronto, Ontario, Canada Chief of Gynecology, País Vasco University Department of Surgery, Baracaldo, Vizcaya, Spain Robert N Taylor Children’s Hospital; Department of Gynecology Division of Reproductive P Nervo and Obstetrics, Emory Endocrinology Department Gynecology-Obstetrics University School of of Obstetrics Department CHR de la Medicine, Atlanta, Georgia, Gynecology and Citadelle USA Reproductive Biology University of Liège, Belgium Brigham and Women’s Roman Rouzier Hospital Harvard Medical Paola Vigano Service de Gynécologie- School, Boston AO Sant’Anna, Como and Obstétrique, Hôpital Tenon, Massachusetts, USA Center for Research in Assistance Publique des Obstetrics and Gynecology Hôpitaux de Paris, Marcos Ballester (CROG), Milan, Italy Université Pierre et Marie Service de Gynécologie- Curie, Paris, France Obstétrique, Hôpital Tenon, Peter AW Rogers Assistance Publique des Center for Women’s Health Ronald D Wiehle Hôpitaux de Paris, Research Repros Therapeutics Inc Université Pierre et Marie Department of Obstetrics The Woodlands, Texas, USA Curie, Paris, France and Gynaecology and Monash Institute of Medical Sajal Gupta Marie-Madeleine Dolmans Research Center for Reproductive Department of Gynecology Monash University Medicine Université Catholique de Melbourne, Australia Glickman Urological and Louvain Brussels, Belgium Kidney Institute and Pascale Jadoul Obstetrics-Gynecology and Marina Bellavia Department of Gynecology Women’s Health Institute; Unité de medicine de la Université Catholique de Cleveland Clinic, Cleveland, Reproduction, CHUV, Louvain Brussels, Belgium USA Lausanne, Switzerland """! ! Stefano Luisi Sun-Wei Guo Tony G Zreik Obstetrics and Gynecology Renji Hospital and Institute MBA, Associate Professor Department of Pediatrics of Assistant Dean for Clinical Obstetrics and Reproductive Obstetric and Gynecologic Affairs Medicine University of Siena Research Dept OB/GYN, Lebanese Siena, Italy Shanghai Jiao Tong American University School University of Medicine School of Medicine Beirut, Lebanon Shubbangi Kesavan Shanghai 200001, China Clinical Assistant Professor Center for Reproductive Dept of Obstetrics, Medicine, Glickman Urological and Kidney Gynecology and Reproductive Sciences, Yale Institute and Obstetrics- Thomas M D´Hooghe University School of Gynecology and Women’s Leuven Unoversity Center Medicine Health Institute; Cleveland Dept Obstetrics and New Haven, CT USA Clinic Gynecology Cleveland, USA UZ Gastthuisberg, 3000 Leuven, Belgium W Paul Dmowski Institute for the Study and Treatment of Endometriosis Chicago IL, USA "#! ! Çevirenler Abdullah Karaer Bülent Berker Hakan Çakmak Y.Doç.Dr! Prof. Dr. Uzman Dr. !nönü Universitesi Tıp Ankara Üniversitesi Tıp Kaliforniya Üniversitesi San Fakültesi Kadın Hastalıkları ve Fakültesi Kadın Hastalıkları ve Francisco (UCSF) Do"um Anabilim Dalı Do"um Anabilim Dalı Kadın Hastalıkları ve Do"um Anabilim Dalı Adil Hakan !lhan Engin Oral Reprodüktif Endokrinoloji ve Uzman.Dr Prof. Dr. !nfertilite Bilim Dalı #i$li Etfal E"itim ve Ara$tırma Cerrahpa$a Tıp Fakültesi Hastanesi 1.Kadın Hastalıkları Kadın Hastalıkları ve Do"um Hulusi Bülent Zeynelo"lu ve Do"um Klini"i Ba$asistanı Anabilim Dalı, Prof. Dr. Reproduktif Endokrinoloji Bilim Ba$kent Üniversitesi Tıp Banu Kumbak Aygun dalı Fakültesi Kadın Hastalıkları ve Doç.Dr Do"um Anabilim Dalı Üremeye Fırat Üniversitesi Kadın Eray Çalı$kan Yardımcı Teknikler Merkezi Hastalıkları ve Do"um Doç. Dr. Anabilim Dalı Kocaeli Universitesi Kadın !brahim Yalçın IVF Üniversitesi Hastalıklarıve Do"um Anabilim Dr. Dalı Ankara Üniversitesi Tıp Barı$ Ata Fakültesi Kadın Hastalıkları ve Uzman.Dr. Ercan Yılmaz Do"um Anabilim Dalı Uluda" Üniversitesi Kadın Y. Doç. Dr. Hastalıkları ve Do"um !nönü Üniversitesi Tıp !lknur Çitil Anabilim Dalı, Üremeye Fakültesi Kadın Hastalıkları ve Uzman Dr. Yardımcı Tedaviler Merkezi Do"um Anabilim Dalı International Hospital Kadın Hastalıkları ve Do"um Begüm Aydo"an Erkan Alata$ Bölümü Dr. Prof. Dr. Üreme Sa"lık Merkezi Cerrahpa$a Tıp Fakultesi Pamukkale Üniversitesi Kadın Kadın Hastalıkları ve Do"um Hastalıkları ve Do"um Koray Elter Anabilim Dalı Anabilim Dalı Prof. Dr. Trakya Üniversitesi Tıp Berfu Demir Gonca !mir Yenicesu Fakültesi Uzman. Dr. Doç Dr. Kadın Hastalıkları ve Do"um Etlik Zübeyde Hanım Kadın Cumhuriyet Üniversitesi Tıp Anabilim Dalı Hastalıkları E"itim ve Fakültesi, Kadın Hastalıkları ve Ara$tırma Hastanesi Do"um Anabilim Dalı Berna Halilo"lu Doç. Dr. Maltepe Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Do"um Anabilim Dalı "! !
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