Endometriosis-An Enigma

199 Pages·2020·3.469 MB·\199

by  Seema Chopra (Editor)

Endometriosis

Endometriosis
An Enigma
Edited by
Seema Chopra
CRC Press
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Library of Congress Cataloging-in-Publication Data
Names: Chopra, Seema, editor.
Title: Endometriosis : an enigma / edited by Seema Chopra.
Other titles: Endometriosis (Chopra)
Description: Boca Raton : CRC Press, [2020] | Includes bibliographical references and index. |
Summary: “Endometriosis is a complex gynecological disorder with multifactorial etiology. It is an
estrogen-dependent disorder that occurs in 6-10% of women in the general population and in 35-50% of
women with pain and/or infertility. This book aims to discuss different aspects from basic to advanced
levels, in turn exploring this benign but chronic disease”-- Provided by publisher.
Identifiers: LCCN 2020002845 (print) | LCCN 2020002846 (ebook) | ISBN 9781138327962 (hardback) |
ISBN 9780429448980 (ebook)
Subjects: MESH: Endometriosis--therapy | Endometriosis--complications | Infertility, Female--etiology
Classification: LCC RG483.E53 (print) | LCC RG483.E53 (ebook) | NLM WP 390 | DDC 618.1--dc23
LC record available at https://lccn.loc.gov/2020002845
LC ebook record available at https://lccn.loc.gov/2020002846
Visit the Taylor & Francis Web site at
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Contents
Preface vii
Acknowledgments ix
Editor xi
Contributors xiii
1 Natural history: Basics of endometriosis 1
Arshi Syal and Seema Chopra
2 Epidemiology 7
Pooja Sikka and Rinnie Brar
3 Etiopathogenesis of endometriosis 9
Pooja Sikka and Rinnie Brar
4 Molecular basis and biomarkers of disease activity 13
Parikshaa Gupta and Nalini Gupta
5 Diagnostic evaluation 23
Neha Aggarwal, Seema Chopra, and Arshi Syal
6 Adolescents and endometriosis 31
Aashima Arora
7 Infertility attributed to endometriosis 37
Shalini Gainder and Neethi Mala Mekala
8 Medical management of endometriosis 47
Bharti Joshi and Neelam Aggarwal
9 Surgical exploration as the primary modality of treatment 57
Sujata Siwatch and Indu Saroha
10 Management of deep infiltrative endometriosis (DIE) causing gynecological morbidity:
A urologist’s perspective 67
Aditya Prakash Sharma and Girdhar Singh Bora
11 Management of deep infiltrative endometriosis (DIE) causing gynecological morbidity: A
colorectal surgeon’s perspective 81
Aditya Kulkarni and Rajesh Gupta
12 Adenomyosis and endometriosis 93
Minakshi Rohilla
13 Helping a woman afflicted with endometriosis to conceive 101
Seema Chopra and Shalini Gainder
14 Alternative medicine for endometriosis: Diet and nutrition 111
Nancy Sahni
15 Novel treatment modalities 119
Seema Chopra
v
vi Contents
16 Long-term complications associated with endometriosis 133
Bharti Joshi
17 Recurrence of endometriosis 139
Rakhi Rai and Seema Chopra
18 Quality of life affected by endometriosis: Lifestyle modification for symptom alleviation 149
Seema Chopra and Arshi Syal
19 Literature review: Guidelines for the management of endometriosis 155
Rashmi Bagga and Japleen Kaur
20 Hormone therapy after total surgery for endometriosis 163
Bharti Sharma
21 Ethical dilemmas in the management of endometriosis 167
Seema Chopra
22 Conclusion 173
Seema Chopra
Index 177
Preface
Knowledge and practice in the field of gynecology use of biomarkers, such as CA-125, is not sensitive
is constantly changing. With ongoing research, enough to detect the disease in the early stages.
changes in treatment modalities become neces- Peripheral biomarkers show promise as diag-
sary, as well as appropriate. nostic aids, but further research is necessary before
Endometriosis is a complex gynecological dis- these can be recommended in routine clinical care.
order that can affect women from menarche until Panels of markers may allow increased sensitivity
menopause. It is a benign, estrogen-dependent dis- and specificity of any diagnostic tests.
order with multifactorial etiology. Endometriosis is Management is both medical and surgical,
characterized by the presence of functional endo- depending upon age, fertility preservation, symp-
metrial glands and stroma outside the uterine cav- tomatic relief, and whether or not the disease is extra
ity, resulting in chronic pelvic pain, dysmenorrhea, pelvic/deep endometriosis. The disease is notorious
dyspareunia, and infertility, thus affecting the qual- for recurrence and requires long-term management.
ity of life. Availability of new drugs, alternative medi-
Several theories have been put forth to explain cines, and lifestyle modifications are helpful for
the etiopathogenesis of this disease. There is the women inflicted with the disease. Therefore,
increasing evidence to suggest that endometriosis this book aims to help the readers get a concise
is at least partially a genetic disease. knowledge in the field of endometriosis as a valued
At the time of diagnosis, most patients with resource, with evidence based from literature and
endometriosis have had the disease for an recent guidelines.
unknown period, making it difficult to initiate any The support of the publisher, CRC Press/Taylor
clinical experiments that would definitively deter- & Francis, for completion of this book is highly
mine the etiology or progression of the disease. As appreciated.
of now, the gold standard for diagnosis is laparo-
scopic visualization of endometriotic lesions. The Seema Chopra
vii

Acknowledgments
This book is dedicated to all the courageous I sincerely hope that the resource material
women living with endometriosis who have helped will be able to answer the queries in the minds of
us understand this entity. readers of this book.
I thank my family and friends for their constant
support and encouragement in successful comple-
tion of this responsibility.
ix