Emerging Conceptual, Ethical and Policy Issues in Bionanotechnology Philosophy and Medicine VOLUME 101 Founding Co-Editor Stuart F. Spicker Senior Editor H. Tristram Engelhardt, Jr., Department of Philosophy, Rice University, and Baylor College of Medicine, Houston, Texas Associate Editor Lisa M. Rasmussen, Department of Philosophy, University of North Carolina at Charlotte, Charlotte, North Carolina Editorial Board George J. Agich, Department of Philosophy, Bowling Green State University, Bowling Green, Ohio Nicholas Capaldi, College of Business Administration, Loyola University, New Orleans, New Orleans, Louisiana Edmund Erde, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey Christopher Tollefsen, Department of Philosophy, University of South Carolina, Columbia, South Carolina Kevin Wm. Wildes, S.J., President Loyola University, New Orleans, New Orleans, Louisiana For other titles published in this series , go to www.springer.com/series/6414 Fabrice Jotterand Editor Emerging Conceptual, Ethical and Policy Issues in Bionanotechnology Editor Fabrice Jotterand University of Texas Southwestern Medical Center Dallas, USA ISBN 978-1-4020-8648-9 e-ISBN 978-1-4020-8649-6 Library of Congress Control Number: 2008928519 © 2008 Springer Science + Business Media B.V. No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written p ermission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper 9 8 7 6 5 4 3 2 1 springer.com Contents Introduction Beyond Feasibility: Why Ethics Is Important for Bionanotechnology ..................................................................................... 3 Fabrice Jotterand Knowledge Production in Nanotechnoscience The World View of Nanotechnology – Philosophical Refl ections ................ 13 Andreas Woyke Nanomachine: Technological Concept or Metaphor? .................................. 27 Xavier Guchet and Bernadette Bensaude-Vincent No Future for Nanotechnology? Historical Development vs. Global Expansion .............................................. 43 Alfred Nordmann Ethics and (Bio)Nanotechnology Bionanotechnology: A New Challenge for Ethical Refl ection? ..................................................................................... 67 Christoph Baumgartner Nanoparticles: Risk Management and the Precautionary Principle ..................................................................... 85 Armin Grunwald Anticipating the Unknown: The Ethics of Nanotechnology ......................... 103 Joseph C. Pitt v vi Contents Applications of Nanotechnology in the Biomedical Sciences: Small Materials, Big Impacts, and Unknown Consequences ....................... 117 Audy G. Whitman, Phelps J. Lambert, Ossie F. Dyson, and Shaw M. Akula Public Policy and (Bio)Nanotechnology Nanobiotechnology and Ethics: Converging Civil Society Discourses .............................................................. 133 Alexandra Plows and Michael Reinsborough Allotropes of Fieldwork in Nanotechnology .................................................. 157 Christopher Kelty Law, Regulation and the Medical Use of Nanotechnology ........................... 181 Kenneth A. DeVille Human Enhancement and (Bio)Nanotechnology Stage Two Enhancements ................................................................................ 203 George Khushf Nanotechnology, the Body and the Mind ....................................................... 219 M. Ellen Mitchell Nanotechnology and Human Flourishing: Toward a Framework for Assessing Radical Human Enhancements..................................................................................... 239 Ronald Sandler Author Index..................................................................................................... 255 Subject Index .................................................................................................... 261 Introduction Beyond Feasibility: Why Ethics Is Important for Bionanotechnology Fabrice Jotterand Since Richard Feynman imagined arranging atoms one by one in 1959 to current research in nanoscience and (bio)nanotechnology, scientific progress continues to feed societal expectations. Increasingly, we read about new scientific develop- ments in (bio)nanotechnology that could bring solutions to vexing problems in human existence. Radical extension of life expectancy, human-machine interface, and nano-devices for targeted drug delivery represent only few examples of the potential applications of nanotechnology. These emerging technologies have t remendous applications and could enhance the quality of life of many people. However, they also raise important social, ethical and legal/regulatory questions. With the pressure to pursue scientific progress in order to find solutions to pressing human problems, the dangers of unreflectively developing (bio)nanotechnology lurks around the corner. Clearly we cannot stop scientific and technological progress. It is part of human nature to explore and conquer the infinitely big (space) and the infinitely small (nano- world). This quest for knowledge, however, is not limited to the understanding of novel properties of matter at the nanoscale. Ultimately the application of basic scientific knowledge to practical problems is always connected to human ends and goals. Hence, it is the exploitation of these novel phenomena at the nanoscale that requires a critical inquiry beyond the “imperative of feasibility”. Without clearly enunciating the hidden assumptions and the metaphysics of the (bio)nanotechnology project, we run the risk of killing the project itself and missing the opportunity to harvest its potential benefits (nanoscale biostructures [artificial bones, tissue engineering and cell therapy]; new types of drugs, either based on the human genome or structural genomics or biomimetics; tar- geted drug delivery; nanobots [sensors to monitor body parameters such as pulse, blood pressure, etc.]; nanomaterials; various types of nano-devices [neuro-digital interfaces]) George Santayana warns us that “those who ignore history are destined to repeat it”. Recent history from the GMO (Genetically Modified Organisms) experiment taught us that “feasibility” is not necessarily synonymous with commercial success and public acceptance of new technologies. Despite the potential benefits of GMOs (crops more resistant to diseases and climate; more productive farm animals; more productive lands, production of vaccines and medicines, etc.) the public is concerned University of Texas at Dallas, UT Southwestern Medical Center, Dallas, TX F. Jotterand (ed.) Emerging Conceptual, Ethical and Policy Issues in Bionanotechnology, 3 © Springer Science + Business Media B.V. 2008 4 F. Jotterand about GMOs, especially in the European context. The reasons are multiple. There is a concern about the safety and the possible unintended consequences (toxicity, Frankenfood, etc.) of genetically modified organisms once they are introduced in the food chain. Another concern is about the environment, in which genetic mutation could spread and would result in the tampering with nature (“Playing God” argument). Finally there is the question of labelling (label indicating whether the product was genetically modified), which is not required in some countries, including the United States. However, some activists argue that consumers have the right to know the proc- ess of fabrication and the ingredients of the products they buy. In addition, they con- tend that the public should be more involved in debates concerning the development of new products. This is not to say that the public has not been part of the discussion. As Alexandra Plows and Michael Reinsborough remarks in their contribution to this volume, “the necessity for better public engagement, are not new frames at all, but are increasingly louder, and perhaps better heard….” However, they also point out that the current emphasis is on the necessity for “upstream public engagement” which means an early dialogue between the scientific community and relevant parties. The lack of early public involvement has led to bad PR on the part of the scientific community and created fear in the mind of many citizens. Ultimately, this situation led to an economic and scientific failure (in the sense of the marketability of the products of scientific development). In short, the lack of transparency on the part of the scientific community and the failure to involve the public “upstream” produced fear and mistrust. What seems imperative in order to avoid the same situation in rela- tion to bionanotechnology is to put forward publicly a plan for a responsive develop- ment of nanotechnology. As Mihail C. Roco and William Sims Bainbridge from the National Science Foundation (NSF) point out, “proper attention to the ethical issues and societal needs” can result in the beneficial outcomes for the industry, society and human life. If well informed, the public and the politicians will be willing to finance and support new technologies. Therefore, it seems essential to have an open debate that includes scientists, politicians, the public, etc. early on with regards to the ethical, legal and social implications of bionanotechnology so as to avoid past mistakes. The Structure of the Volume This volume provides a critical overview of the nature of nanotechnology (and its applications in the biomedical sciences, i.e. bionanotechnology) and the philosophical and ethico-legal issues it raises. This collection of 13 articles represents an explora- tion by scholars from various disciplines (philosophy, anthropology, law, social sciences, psychology, and natural sciences) in North America and Europe. The book contains four major parts respectively entitled (1) Knowledge Production in Nanotechnoscience; (2) Ethics and (Bio)Nanotechnology; (3) Public Policy and (Bio)Nanotechnology; and (4) Human Enhancement and (Bio)Nanotechnology. In the first section, authors examine the nature of nanotechnology as a scientific project and critically reflect on its philosophical underpinnings. The next section