Elsevier's Integrated Review Biochemistry: With STUDENT CONSULT Online Access, 2e PDF
Preview Elsevier's Integrated Review Biochemistry: With STUDENT CONSULT Online Access, 2e
ELSEVIER’S INTEGRATED REVIEW BIOCHEMISTRY Intentionally left as blank ELSEVIER’S INTEGRATED REVIEW BIOCHEMISTRY SECOND EDITION John W. Pelley, PhD Professor TexasTechUniversity School ofMedicine Lubbock,Texas 1600JohnF.KennedyBlvd.Ste1800 Philadelphia,PA19103-2899 ELSEVIER’SINTEGRATEDREVIEWBIOCHEMISTRY, ISBN:978-0-323-07446-9 SECONDEDITION Copyright#2012bySaunders,animprintofElsevierInc. Copyright#2007byMosby,Inc.,anaffiliateofElsevierInc. Nopartofthispublicationmaybereproducedortransmittedinanyformorbyanymeans,electronicor mechanical,includingphotocopying,recording,oranyinformationstorageandretrievalsystem,without permissioninwritingfromthepublisher.Detailsonhowtoseekpermission,furtherinformationaboutthe Publisher’spermissionspoliciesandourarrangementswithorganizationssuchastheCopyrightClearance CenterandtheCopyrightLicensingAgency,canbefoundatourwebsite:www.elsevier.com/permissions. ThisbookandtheindividualcontributionscontainedinitareprotectedundercopyrightbythePublisher (otherthanasmaybenotedherein). Notices Knowledgeandbestpracticeinthisfieldareconstantlychanging.Asnewresearchandexperience broadenourunderstanding,changesinresearchmethods,professionalpractices,ormedical treatmentmaybecomenecessary. Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgein evaluatingandusinganyinformation,methods,compounds,orexperimentsdescribedherein.In usingsuchinformationormethodstheyshouldbemindfuloftheirownsafetyandthesafetyofothers, includingpartiesforwhomtheyhaveaprofessionalresponsibility. Withrespecttoanydrugorpharmaceuticalproductsidentified,readersareadvisedtocheckthe mostcurrentinformationprovided(i)onproceduresfeaturedor(ii)bythemanufacturerofeach producttobeadministered,toverifytherecommendeddoseorformula,themethodanddurationof administration,andcontraindications.Itistheresponsibilityofpractitioners,relyingontheirown experienceandknowledgeoftheirpatients,tomakediagnoses,todeterminedosagesandthebest treatmentforeachindividualpatient,andtotakeallappropriatesafetyprecautions. Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors, assumeanyliabilityforanyinjuryand/ordamagetopersonsorpropertyasamatterofproducts liability,negligenceorotherwise,orfromanyuseoroperationofanymethods,products,instructions, orideascontainedinthematerialherein. LibraryofCongressCataloging-in-PublicationData Pelley,JohnW. Elsevier’sintegratedreviewbiochemistry/JohnW.Pelley.–2nded. p.;cm. Integratedreviewbiochemistry Rev.ed.of:Elsevier’sintegratedbiochemistry/JohnW.Pelley.c2007. Includesindex. ISBN978-0-323-07446-9(pbk.:alk.paper) I.Pelley,JohnW.Elsevier’sintegratedbiochemistryII.Title.III.Title:Integratedreviewbiochemistry. [DNLM:1.BiochemicalPhenomena.2.MolecularBiology–methods.QU4] 612’.015–dc23 2011035525 AcquisitionsEditor:MadeleneHyde DevelopmentalEditor:AndrewHall PublishingServicesManager:PatriciaTannian TeamManager:HemamaliniRajendrababu ProjectManager:AntonyPrince Designer:StevenStave PrintedinChina Lastdigitistheprintnumber: 9 8 7 6 5 4 3 2 1 Preface Iwrotethisbooktomakebiochemistryeasiertolearnandeas- learningistheminimalinclusionofchemicalstructures,thus iertoremember.Learningandrememberingdonotalwaysgo shiftingthelearningemphasisinamorephysiologicdirection. together,sinceanynewmaterialcanbelearnedbutforgotten Informationinbiochemistryiseasiertorememberwhenitis quickly.Itisonlythroughintegrativelearningthatlong-term integrated with information from other basic science disci- memoryisbuilt.Evenifyouhaveneverhadabiochemistry plines.Thisapproachcanbeseenintheclinicalvignettecase courseorifyouhavetakenbiochemistrybutforgottenmuch studiesattheendofthetext,whichcontainquestionsabout ofit,youwillfindthisinnovativeapproachhelpful. other basic science disciplines in addition to biochemistry. To make learning easier, I have given careful attention to Suchintegrativethinkingwillbeneededintheclinic,where the sequence and organization of each chapter so that each patients present with symptoms that cross theboundaries of topic builds on previous topics. Also, within each chapter, traditionaldisciplines.Integrationacrossdisciplinesisfurther thematerialispresentedinawaythatsuggestshowitshould enhancedthroughouteachchapterbytheIntegrationBoxes. be learned. For example, each metabolic pathway has five Thisbookiswrittenasconcisely,clearly,andcompletelyas consistent organizing aspects: pathway components, regula- possible.Ihopethatitbringsyouthesamehelpfulassistance tionpoints,intersectionwithotherpathways,uniquefeatures, thatItrytobringtomystudentshereattheTexasTechSchool and clinical features. Hence all chapters on metabolism, for ofMedicine. example,havethesameheadings,allowingeasycomparison and quicker integrative learning. An additional aid to easier JohnW.Pelley,PhD Intentionally left as blank Editorial Review Board Chief Series Advisor Histology J. Hurley Myers,PhD Leslie P. Gartner, PhD ProfessorEmeritusofPhysiologyandMedicine ProfessorofAnatomy SouthernIllinoisUniversitySchoolofMedicine; DepartmentofBiomedicalSciences PresidentandCEO BaltimoreCollegeofDentalSurgery DxRDevelopmentGroup,Inc. DentalSchool Carbondale,Illinois UniversityofMarylandatBaltimore Baltimore,Maryland Anatomy and Embryology JamesL. Hiatt, PhD Thomas R.Gest, PhD ProfessorEmeritus UniversityofMichiganMedicalSchool DepartmentofBiomedicalSciences DivisionofAnatomicalSciences BaltimoreCollegeofDentalSurgery OfficeofMedicalEducation DentalSchool AnnArbor,Michigan UniversityofMarylandatBaltimore Baltimore,Maryland Biochemistry Immunology John W.Baynes,MS, PhD GraduateScienceResearchCenter DarrenG. Woodside, PhD UniversityofSouthCarolina PrincipalScientist Columbia,SouthCarolina DrugDiscovery EncysivePharmaceuticalsInc. Marek Dominiczak, MD,PhD, FRCPath, FRCP(Glas) Houston,Texas ClinicalBiochemistryService NHSGreaterGlasgowandClyde Microbiology GartnavelGeneralHospital Glasgow,UnitedKingdom Richard C. Hunt, MA,PhD ProfessorofPathology,Microbiology,andImmunology Clinical Medicine DirectoroftheBiomedicalSciencesGraduateProgram DepartmentofPathologyandMicrobiology Ted O’Connell, MD UniversityofSouthCarolinaSchoolofMedicine ClinicalInstructor Columbia,SouthCarolina DavidGeffenSchoolofMedicine UCLA; Neuroscience ProgramDirector WoodlandHillsFamilyMedicineResidencyProgram CristianStefan,MD WoodlandHills,California AssociateProfessor DepartmentofCellBiology Genetics UniversityofMassachusettsMedicalSchool Neil E.Lamb, PhD Worcester,Massachusetts DirectorofEducationalOutreach Pathology HudsonAlphaInstituteforBiotechnology Huntsville,Alabama; Peter G. Anderson,DVM, PhD AdjunctProfessor ProfessorandDirectorofPathologyUndergraduate DepartmentofHumanGenetics Education,DepartmentofPathology EmoryUniversity UniversityofAlabamaatBirmingham Atlanta,Georgia Birmingham,Alabama viii Editorial Review Board Pharmacology Physiology Joel Michael,PhD MichaelM. White,PhD DepartmentofMolecularBiophysicsandPhysiology ProfessorDepartmentofPharmacologyandPhysiology RushMedicalCollege DrexelUniversityCollegeofMedicine Chicago,Illinois Philadelphia,Pennsylvania Acknowledgments Mywife,MJ,hasalwaysseenmoreinmethanIhave.Herlove, togetherandcreatingtheearlyintegrationbetweenusthatwas encouragement,andpatiencewereessentialtotheorganization soessentialtothefirsteditionofaninnovativeseriessuchas andcompositionofthisbook.Itisalsoimportanttoacknowl- this.KateDimockhasbeenatremendoushelpincontinuingthis edgethemanyintelligentstudentswhomIhavetaughtatTexas integrativeauthorship,makingtherefinementsthathaveledto Tech.Theyprobablydonotrealizehowmuchtheirquestions asignificantupgradeforthissecondedition.And,finally,anote have taught me. Alex Stibbe deserves a substantial acknowl- of appreciation to Andy Hall, for his continuing support and edgmentforherskillinbringingsuchadiversegroupofauthors perfectbalanceofprofessionalismandagreatsenseofhumor.
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