Effects of Mineral Dusts on Cells

466 Pages·1989·13.697 MB·English

by  Andrew Churg, Joanne L. Wright (auth.), Brooke T. Mossman, Raymond O. Bégin (eds.)

Effects of Mineral Dusts on Cells
NATO ASI Series
Advanced Science Institutes Series
A series presenting the results of activities sponsored by the NA TO Science
Committee, which aims at the dissemination of advanced scientific and
technological knowledge, with a view to strengthening links between scientific
communities.
The Series is published by an international board of publishers in conjunction with
the NATO Scientific Affairs Division
A Life Sciences Plenum Publishing Corporation
B Physics London and New York
C Mathematical and Kluwer Academic Publishers
Physical Sciences Dordrecht, Boston and London
o
Behavioural and
Social Sciences
E Applied Sciences
F Computer and Springer -Verlag
Systems Sciences Berlin Heidelberg New York
G Ecological Sciences London Paris Tokyo Hong Kong
H Cell Biology
Series H: Cell Biology Vol. 30
Effects of Mineral Dusts on Cells
Edited by
Brooke T Mossman
University of Vermont
College of Medicine
Department of Pathology
Burlington, Vermont 05405, USA
Raymond O. Begin
Service de Pneumologie
CHUS
Sherbrooke, Quebec, Canada, JIH 5N4
Springer-Verlag Berlin Heidelberg New York
London Paris Tokyo Hong Kong
Published in cooperation with NATO Scientific Affairs Division
Proceedings of the NATO Advanced Research Workshop on In Vitro Effects of
Mineral Dusts on Cells held at Auberge Estrimont, Orford, Quebec, Canada,
September 20-23,1988
ISBN-13:978-3-642-74205-7 e-ISBN-13:978-3-642-74203-3
001: 10.1007/978-3-642-74203-3
Library of Congress Cataloging-in-Publication Data. NATO Advanced Research Workshop on In Vitro Effects
of Mineral Dusts on Cells (4th 1988 Orford, Quebec) Effects of mineral dusts on cells 1e dited by Brooke T.
Mossman, Raymond O. Begin. p. cm--(NATO ASI series. Series H, Cell biology. vol. 30) "Proceedings of the
NATO Advanced Research Workshop on In Vitro Effects of Mineral Dusts on Cells held at Auberge Estrimont,
Orford, Quebec, Canada, September 20-23.1988"-lp. verso. "Published in cooperation with NATO
Scientific Affairs Division."
ISBN-13978-3-642-74205-7 (U.S.)
1 Mineral dusts-·Toxicology-Congresses 2. Mineral dusts-Physiological effect-Congresses. 3. Toxicity
testing-In Vitro--Congresses.1. Mossman. Brooke T. 1947- 11. Begin. Raymond 0.111. North Atlantic
Treaty Organization Scientific Affairs Division. IV. Title. V Series. RA1231.M55N38 1988
615.9'25-dc20 89-11499
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© Springer-Verlag Berlin Heidelberg 1989
Softcover reprint of the hardcover 1s t edition 1989
2131/3140-543210 - Printed on acid-free paper
PREFACE
The Fourth International Workshop on "In Vitro Effects of Mineral Dusts on
Cells" was held on September 20 - 23, 1988 in Auberge Estrimont, Orford,
Quebec, Canada. The emphasis of the N.A.T.O. Advanced Research Workshop was
the use of cell and organ culture and lavage cell populations obtained from
man and laboratory animals to elucidate cellular and molecular events occur
ring after their interaction with fibrous and nonfibrous particulates,
including metal compounds. In seven sessions, an international representation
of scientists from 17 countries (Austria, Belgium, Canada, France, Federal
Republic of Germany, India, Japan, Netherlands, Norway, Poland, Portugal,
Union of South Africa, Sweden, Switzerland, United Kingdom, United States of
America, and Yugoslavia) presented recent research findings in the following
areas:
Epithelial cell injury and proliferation by minerals.
Physico-chemical properties of minerals in relation to their biologic
effects.
Mechanisms of dust-induced pneumoconioses. Clinical and experimental
studies.
Mechanisms of cytotoxicity, mutagenicity and carcinogenicity.
Oxidants, cytotoxicity and disease.
Mechanisms of mineral-induced inflammation.
Mechanisms of carcinogenesis.
A session on "Questions, risk and public policy" provided a lively discussion
on the relevance of in vitro experiments to carcinogenicity studies in man and
their implications in the formation of regulatory policies.
VI
The organizing committee for this workshop was:
Co-Chairs: B.T. Mossman (USA) and R. Begin (Canada)
E.G. Beck (FRG) A. Lange (Poland)
A. Brody (USA) P. Nettesheim (USA)
R.C. Brown (UK) Q. Rahman (India)
J. Bignon (France) K. Robock (FRG)
G. Fisher (FRG)
The workshop was sponsored by the Advance Study ARW Program of N.A.T.O. under
the directorship of Dr. Craig Sinclair. A conference grant from the National
Heart, Lung and Blood Institute with contributions from the National Institute
of Environmental Health Sciences and National Cancer Institute also played a
major role toward the success of this meeting. We thank Dr. Anthony Kalica,
National Institutes of Health for his support of this proposal. A number of
other organizations contributed financially to the workshop and deserve
special mention. These include:
Fonds de la Recherche en Sante du Quebec
Institut de Recherche en Sante et en Securite du Travail du Quebec
Thermal Insulation Manufacturers Association
The Asbestos Institute
Eurotalc
American Petroleum Institute
BP America, Inc.
Chevron U.S.A., Inc.
Mobil Oil Corporation
The Council for Tobacco Research
VII
The editors also wish to thank Ms. Claudette Laplume, the Conference Secre
tariat who also has assisted in preparation of these proceedings. Finally, we
thank Springer-Verlag for their interest in publishing this state-of-the-art
volume on cellular and molecular interactions between mineral dusts and cells.
The Fifth International Workshop on "In Vitro Effects of Mineral Dusts" will
be held in France in 1992 and co-chaired by J.M.G. Davis (UK) and M.C. Jaurand
(France).
TABLE OF CONTENTS
Preface
A. EPITHELIAL CELL INJURY AND PROLIFERATION BY MINERALS
1. A. Churg, J.L. Wright: Effects of Cigarette Smoke
on Uptake of Asbestos and Iron Oxide by Rat
Tracheal Explants ............................................ 1
2. V. Skaug, A. Haugen: Cytotoxicity of Asbestos and
Calcium-Silicates to Various Lung Epithelial
Cell Types In Vitro .......................................... 7
3. K. Donaldson, J. Slight, C.M. Brown: Injurious Effects
of Mineral Dust-Elicited Bronchoalveolar Leukocytes
on Epithelial Cells In Vitro: The Role of Extra
cellular Matrix
Components .................................................. 15
B. PHYSICO-CHEMICAL PROPERTIES OF MINERALS IN RELATION TO THEIR
BIOLOGIC EFFECTS
1. M. Martin, M. Page, F. Habashi, F.T. Awadalla: Toxicity
of Chrysotile Asbestos through Surface Modification
with Chelating Agents ....................................... 23
2. C.L. Fisher, K.L. McNeill, A.W. Singer, J.T. Smith: A
Comparison of the In Vitro and In Vivo Toxicity of
Fibrous and Non-Fibrous Silicon Nitride ..................... 27
3. R.P. Nolan, A.M. Langer, C.B. Herson: Membranolytic
Activity and Morphological Characterization of
Palygorskite and Sepiolite .................................. 37
4. W.E. Wallace, M.J. Keane, P.S. Mike, C.A. Hill, V.
Vallyathan: Mineral Surface-Specific Differences
in the Adsorption and Enzymatic Removal of Surfactant
and their Correlation with Cytotoxicity ..................... 49
C. MECHANISMS OF DUST-INDUCED PNEUMOCONIOSES.
CLINICAL AND EXPERIMENTAL STUDIES
1. A. Forni, C. Rivolta, C. Chiappino: Bronchoalveolar
Lavage Cells in Occupational Exposure to Mineral
Fibers ........ , ................ " ...... , .................... 57
2. P. Lassalle, P. Cosset, C. Aerts, M. Benhamou,
F. Fortin, B. Wallaert, A.B. Tonnel, C. Voisin:
Alveolar Macrophages Secretory Dysfunctions in
Coal Worker's Pneumoconiosis. Comparison Between
Simple Pneumoconiosis and Progressive Massive
Fibrosis .................................................... 65
3. A.J.A. Robalo-Cordeiro, M.F. Baganha, M. Melo, J.R.C.
Almeida, L. Chieira, I. Mesquita, A.C.P. Leite,
A. Pego, J.P. Sousa, A. Saraiva, M.A. Lima, E. Caspar:
Cellularity in Bronchoalveolar Lavage in Cement Dust
Aggression .................................................. 73
4. R. Begin, A. Dufresne, A. Cantin, S. Masse, P. Sebastien,
P. Durand, C. Perrault: Carborundum Pneumoconiosis ......... 81
IX
D. MECHANISMS OF CYTOTOXICITY, MUTAGENICITY AND CARCINOGENICITY
1. G.L. Finch, A.L. Brooks, J.M. Benson, M.D. Hoover,
J.A. Mewhinney, A.F. Edison, R.G. Cuddihy,
R.F. Henderson, C.H. Hobbs: Influence of
Physicochemical Properties of Beryllium
and Nickel Compounds on Cultured Cell Toxicity .............. 85
2. D. Godelaine, H. Beaufay: Comparative Study of
the Effect of Various Fibres on the Secretion
of Plasminogen Activator by Murine Peritoneal
Macrophages ................................................. 93
3. K.E. Driscoll, R.C. Lindenschmidt, J.K. Maurer, J.M.
Higgins: Release of Interleukin-l and Tumor
Necrosis Factor by Rat Alveolar Macrophages
after In Vivo or In Vitro Exposure to Mineral
Dusts ...................................................... 101
4. C.S. Wheeler, C.D. Garner: The Effect of Aramid and
Metaphosphate Fibers on Macrophage Viability and
Function ................................................... 109
5. D. Nadeau, D.A. Lane, D. Paradis, L. Fouquette: Effects
of Nicotinamide on the Cytotoxicity of Mineral
Dusts towards Pulmonary Alveolar Macrophages ............... 115
6. A. Lange, B. Pietrzyca, A. Moniewska, J. Rabczynski:
Long-Term Effect of 3Methylcholanthrene-Coated
Asbestos Fibres on the Immune Status of Fl
(NZB*C5 7Bl/6) Mice ......................................... 123
7. A. Van Der Meeren, G. Clement, J. Bignon, D.
Barritault, M.C. Jaurand: Production of
Growth Factors by Rat Pleural Mesothelial
Cells In Vivo or In Vitro Transformed by
Chrysotile Fibers .......................................... 133
8. E. Yano, M. Shimizu, N. Urano, P.H. Evans:
Mutagenicity of Asbestos and Erionite in
a Salmonella Tester Strain of TAl02 ........................ 141
9. A.B. Fischer: Induction of Sister Chromatid
Exchanges by Fibrous Dusts Alone and in
Combination with Other Xenobiotics in
Chinese Hamster Cells ...................................... 149
10. N.F. Johnson, J.C. Wagner: Pleural and Parenchymal
Responses in Rats to Short-Term Inhalation
Exposures to Erionite, Crocidolite, Chrysotile,
Silica and Titanium Dioxide ................................ 157
11. P.J. Haley, G.L. Finch, J.A. Mewhinney, F.F. Hahn,
M.D. Hoover, D.E. Bice: In Vitro Responses
of Canine Alveolar Lymphocytes to BeS04 After
Inhalation Exposure to BeO ................................. 165
E. OXIDANTS, CYTOTOXICITY AND DISEASE
1. P. Borm, N.Palmen, J. Engelen, W. Buurman:
Oxidants, Antioxidants and Monokines
in the Pathogenesis of Coal Workers'
Pneumoconiosis. Tumor Necrosis Factor
as a Mediator in Lung Fibrosis ............................. 173
x
2. V. Castranova, V. Vallyathan, K. Van Dyke,
N.S. Dalal: Use of Chemiluminescence
Assays to Monitor the Surface Charac
teristics and Biological Reactivity of
Freshly Fractured vs Aged Silica ........................... 181
3. D. Costa, J. Guignard, H. Pezerat: Pro
duction of Free Radicals by Non
Fibrous Materials in a Cell-Free
Buffer Medium .............................................. 189
4. M.. Gulumian, J .A. Van Wyk, B. Kolb: Detoxified
Crocidolite Exhibits Reduced Radical Generation
which Could Explain its Lower Toxicity: ESR
and Mossbauer Studies ...................................... 197
5. B. Fubini, V. Bolis, E. Giamello, L. Pugliese,
M. Volante: The Formation of Oxygen
Reactive Radicals at the Surface of
Crushed Quartz Dusts as a Possible
Cause of Silica Pathogenicity .............................. 205
6. S. Kouzan, T. Fournier, C. Voisin, M.C.
Jaurand, J. Bignon: Arachidonic
Acid Metabolite Production by Alveolar
Macrophages Cultured in Gazeous Phase.
Effects of N02 and Diesel Exhaust .......................... 215
7. A. Holian, P.L. Roney: Superoxide Anion
Production Induced by Chrysotile
Asbestos in the Guinea Pig Alveolar
Macrophage ................................................. 223
8. A.B. Kane, G.F. Gleva, L.A. Goodglick:
Altered Calcium Homeostasis and Mineral
Dust Toxicity .............................................. 231
9. P. Leanderson, P. Soderkvist, M. Gillner,
C. Tagesson: Formation of 8-Hydroxy-
deoxyguanosine in DNA by MMMF .............................. 239
10. Q.N. Myrvik, P. Wood, H. Hayakawa: Effect
of Chrysotile, Amosite and Crocidolite
on the Oxidative Burst of Rabbit Alveolar
Macrophages ................................................ 247
11. R. Zalma, J. Guignard, H. Pezerat, M.C. Jaurand:
Production of Radicals Arising from Surface
Activity of Fibrous Minerals ............................... 257
12. N.S. Dalal, X. Shi, V. Vallyathan: Potential Role of
Silicon-Oxygen Radicals in Acute Lung Injury ............... 265
13. N.S. Dalal, X. Shi, V. Vallyathan: Oxygenated
Radical Formation by Fresh Quartz Dust in
a Cell-Free Aqueous Medium and its Inhibition
by Scavengers .............................................. 273
F. MECHANISMS OF MINERAL-INDUCED INFLAMMATION
1. A. Seidel, E. Drosselmeyer, V. Hofheinz, W.G. Kreyling,
F. Krombach, S. Patzold, G. Pelzer, J. Schimmelpfeng,
G. Wurtemberger: Interaction of Quartz with Bovine
Alveolar Macrophages: Studies on Cytotoxicity,
Electrophoretic Mobility and Subcellular
Components ................................................. 281