Effects of chronic dietary inorganic arsenic in dogs PDF
Preview Effects of chronic dietary inorganic arsenic in dogs
Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 1987 Effects of chronic dietary inorganic arsenic in dogs Regg Darwyn Neiger Iowa State University Follow this and additional works at:https://lib.dr.iastate.edu/rtd Part of theAnimal Sciences Commons, and theVeterinary Medicine Commons Recommended Citation Neiger, Regg Darwyn, "Effects of chronic dietary inorganic arsenic in dogs " (1987).Retrospective Theses and Dissertations. 11713. https://lib.dr.iastate.edu/rtd/11713 This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please [email protected]. INFORMATION TO USERS While the most advanced technology has been used to photograph and reproduce this manuscript, the quality of the reproduction is heavily dependent upon the quality of the material submitted. For example: • Manuscript pages may have indistinct print. In such cases, the best available copy has been filmed. • Manuscripts may not always be complete. In such cases, a note will indicate that it is not possible to obtain missing pages. • Copyrighted material may have been removed from the manuscript. In such cases, a note will indicate the deletion. Oversize materials (e.g., maps, drawings, and charts) are photographed by sectioning the original, beginning at the upper left-hand corner and continuing from left to right in equal sections with small overlaps. Each oversize page is also filmed as one exposure and is available, for an additional charge, as a standard 35mm slide or as a 17"x 23" black and white photographic print. Most photographs reproduce acceptably on positive microfilm or microfiche but lack the clarity on xerographic copies made from the microfilm. For an additional charge, 35mm slides of 6"x 9" black and white photographic prints are available for any photographs or illustrations that cannot be reproduced satisfactorily by xerography. Order Number 8721915 Effects of chronic dietary inorganic arsenic in dogs Neiger, Regg Darwyn, Ph.D. Iowa State University, 1987 U M I 300 N. ZeebRd. Ann Aibor, MI 48106 PLEASE NOTE: In all cases this material has been filmed in the best possible way from the available copy. Problems encountered with this document have been identified here with a check mark V 1, Glossy photographs or pages. 2. Colored illustrations, paper or print 3. Photographs with dark background 4. Illustrations are poor copy 5. Pages with black marks, not original copy 6. Print shows through as there is text on both sides of page. 7. Indistinct, broken or small print on several pages — 8. Print exceeds margin requirements 9. Tightly bound copy with print lost in spine 10. Computer printout pages with indistinct print. 11. Page(s) lacking when material received, and not available from school or author. 12. Page(s) seem to be missing in numbering only as text follows. 13. Two pages numbered . Text follows. 14. Curling and wrinkled pages 15. Dissertation contains pages with print at a slant, filmed as received 16. Other University Microfilms International Effects of chronic dietary inorganic arsenic in dogs by Regg Darwyn Neiger A Dissertation Submitted to the Graduate Faculty in Partial Fulfillment of the Requirements for the Degree of DOCTOR OF PHILOSOPHY Major: Veterinary Pathology Approved: Signature was redacted for privacy. In Change of Major Work Signature was redacted for privacy. the Major Depgg^ment Signature was redacted for privacy. Iowa State University Ames, Iowa 1987 ii TABLE OF CONTENTS Page GENERAL INTRODUCTION 1 Explanation of Dissertation Format 4 LITERATURE REVIEW 5 Chemical Nature of Arsenic 5 Sources of Arsenic 8 Natural sources 8 Man-made sources 14 Inorganic Arsenic as a Toxicant 19 History 19 Metabolism 20 Factors effecting toxicity 29 Toxicosis 32 SECTION I. EFFECT OF LOW LEVEL DIETARY SODIUM ARSENITE ON FEED INTAKE AND BODY WEIGHT OF DOGS 45 ABSTRACT 47 INTRODUCTION 48 MATERIALS AND METHODS 51 RESULTS 55 DISCUSSION 60 REFERENCES 67 iii SECTION II. EFFECT OF LOW LEVEL DIETARY SODIUM ARSENITE ON BLOOD, SERUM, AND URINE OF DOGS 102 ABSTRACT 104 INTRODUCTION 105 MATERIALS AND METHODS 107 RESULTS 114 DISCUSSION 118 REFERENCES 124 SECTION III. EFFECT OF LOW LEVEL DIETARY SODIUM ARSENITE ON THE LIVER OF DOGS 129 ABSTRACT 131 INTRODUCTION 133 MATERIALS AND METHODS 135 RESULTS 142 DISCUSSION 144 REFERENCES 151 SUMMARY AND DISCUSSION 159 REFERENCES 161 ACKNOWLEDGMENTS 172 APPENDIX A. ANIMAL RESEARCH FORM 173 APPENDIX B. CLINICAL PATHOLOGY DATA 175 APPENDIX C. PHOTOMICROGRAPH OF HEPATOCYTIC MITOCHONDRIA 182
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