Evidence-Based Complementary and Alternative Medicine Acupuncture and Herbal Medicine for Cancer Patients 2014 Guest Editors: Thomas Efferth, Sookyung Lee, Yoshiharu Motoo, and Sven Schröder Acupuncture and Herbal Medicine for Cancer Patients 2014 Evidence-Based Complementary and Alternative Medicine Acupuncture and Herbal Medicine for Cancer Patients 2014 Guest Editors: Thomas Efferth, Sookyung Lee, Yoshiharu Motoo, and Sven Schro¨der Copyright©2014HindawiPublishingCorporation.Allrightsreserved. Thisisaspecialissuepublishedin“Evidence-BasedComplementaryandAlternativeMedicine.”Allarticlesareopenaccessarticles distributedundertheCreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninany medium,providedtheoriginalworkisproperlycited. Editorial Board TerjeAlraek,Norway AnwarulH.Gilani,Pakistan AndreasMichalsen,Germany ShrikantAnant,USA MichaelGoldstein,USA DavidMischoulon,USA SedighehAsgary,Iran SveinHaavik,Norway Hyung-InMoon,RepublicofKorea HyunsuBae,RepublicofKorea Seung-HeonHong,Korea AlbertMoraska,USA LijunBai,China MarkusHorneber,Germany MarkMoss,UK SarangBani,India Ching-LiangHsieh,Taiwan MinKyunNa,RepublicofKorea VassyaBankova,Bulgaria BennyT.K.Huat,Singapore RichardL.Nahin,USA WinfriedBanzer,Germany RomanHuber,Germany VitalyNapadow,USA VernonA.Barnes,USA AngeloAntonioIzzo,Italy F.R.F.Nascimento,Brazil JairoK.Bastos,Brazil K.Jarukamjorn,Thailand IsabellaNeri,Italy SujitBasu,USA StefanieJoos,Germany T.B.Nguelefack,Cameroon DavidBaxter,NewZealand Z.Kain,USA MartinOffenbacher,Germany Andre-MichaelBeer,Germany OsamuKanauchi,Japan Ki-WanOh,RepublicofKorea AlvinJ.Beitz,USA KrishnaKaphle,Nepal Y.Ohta,Japan YongC.Boo,RepublicofKorea KenjiKawakita,Japan OlumayokunA.Olajide,UK FrancescaBorrelli,Italy JongY.Kim,RepublicofKorea ThomasOstermann,Germany GloriaBrusotti,Italy YounC.Kim,RepublicofKorea StaceyA.Page,Canada ArndtBu¨ssing,Germany C.-H.Kim,RepublicofKorea Tai-LongPan,Taiwan RaffaeleCapasso,Italy YoshiyukiKimura,Japan BhushanPatwardhan,India OpherCaspi,Israel ToshiakiKogure,Japan BeritS.Paulsen,Norway Shun-WanChan,HongKong ChingLan,Taiwan AndreaPieroni,Italy Il-MooChang,RepublicofKorea AlfredLa¨ngler,Germany RichardPietras,USA RajnishChaturvedi,India LixingLao,USA XianqinQu,Australia Tzeng-JiChen,Taiwan Jang-HernLee,RepublicofKorea CassandraL.Quave,USA YunfeiChen,China MyeongS.Lee,UK RojaRahimi,Iran KevinChen,USA TatleangLee,Singapore KhalidRahman,UK Juei-TangCheng,Taiwan ChristianLehmann,Canada CheppailRamachandran,USA EvanP.Cherniack,USA MarcoLeonti,Italy KeRen,USA Jen-HweyChiu,Taiwan Ping-ChungLeung,HongKong Mee-RaRhyu,RepublicofKorea WilliamC.S.Cho,HongKong ChunGuangLi,Australia Jose´LuisR´ıos,Spain JaeYoulCho,Korea Xiu-MinLi,USA PaoloR.diSarsina,Italy Shuang-EnChuang,Taiwan ShaoLi,China B.Saad,PalestinianAuthority EdwinL.Cooper,USA SabinaLim,Korea A.Sandner-Kiesling,Austria VincenzoDeFeo,Italy WenChuanLin,China AdairSantos,Brazil R.DelaP.Va´zquez,Spain ChristopherG.Lis,USA G.Schmeda-Hirschmann,Chile AlexandraDeters,Germany GerhardLitscher,Austria RosaSchnyer,USA MohamedEddouks,Morocco I-MinLiu,Taiwan AndrewScholey,Australia TobiasEsch,Germany KeLiu,China VeroniqueSeidel,UK YibinFeng,HongKong YijunLiu,USA SenthamilR.Selvan,USA J.Fernandez-Carnero,Spain GaofengLiu,China TuhinadriSen,India JulianoFerreira,Brazil GailB.Mahady,USA RonaldSherman,USA PeterFisher,UK SubhashC.Mandal,India KarenJ.Sherman,USA RomainForestier,France JeanineMarnewick,SouthAfrica KanShimpo,Japan JoelJ.Gagnier,Canada VirginiaS.Martino,Argentina Byung-CheulShin,Korea MuhammadN.Ghayur,Pakistan JamesH.McAuley,Australia RachidSoulimani,France MohdR.Sulaiman,Malaysia ManiVasudevan,Malaysia HarukiYamada,Japan VenilN.Sumantran,India CarloVentura,Italy NobuoYamaguchi,Japan TokuTakahashi,USA WagnerVilegas,Brazil Yong-QingYang,China RabihTalhouk,Lebanon PradeepVisen,Canada KenYasukawa,Japan CheChunTao,USA AristoVojdani,USA M.Yoon,RepublicofKorea MeiTian,China Chong-ZhiWang,USA HongQ.Zhang,HongKong YaoTong,HongKong Shu-MingWang,USA BoliZhang,China K.V.Trinh,Canada Y.Wang,USA RuixinZhang,USA VolkanTugcu,Turkey ChenchenWang,USA HongZhang,Sweden Yew-MinTzeng,Taiwan KenjiWatanabe,Japan HaiboZhu,China DawnM.Upchurch,USA W.Weidenhammer,Germany AlfredoVannacci,Italy J.M.Wilkinson,Australia Contents AcupunctureandHerbalMedicineforCancerPatients2014,ThomasEfferth,SookyungLee, YoshiharuMotoo,andSvenSchro¨der Volume2014,ArticleID326179,2pages TheEffectsofHerbsandFruitsonLeukaemia,TayebehAzamSaedi,SabariahMdNoor,PatimahIsmail, andFauziahOthman Volume2014,ArticleID494136,8pages MedicinalPlantsandOtherLivingOrganismswithAntitumorPotentialagainstLungCancer, LuaradeSousaMonteiro,KatherineXavierBastos,Jose´MariaBarbosa-Filho, PetroˆnioFilgueirasdeAthayde-Filho,MargarethdeFa´timaFormigaMeloDiniz, andMariannaVieiraSobral Volume2014,ArticleID604152,15pages ApoptosisInductionbytheTotalFlavonoidsfromArachniodesexilisinHepG2CellsthroughReactive OxygenSpecies-MediatedMitochondrialDysfunctionInvolvingMAPKActivation,HuiminLi, JingChen,ChaomeiXiong,HanWei,ChangchangYin,andJinlanRuan Volume2014,ArticleID906941,11pages AntitumorActivityofChinesePropolisinHumanBreastCancerMCF-7andMDA-MB-231Cells, HongzhuanXuan,ZhenLi,HaiyueYan,QingSang,KaiWang,QingtaoHe,YuanjunWang,andFuliangHu Volume2014,ArticleID280120,11pages PharmacopunctureforCancerCare:ASystematicReview,SoyeonCheon,XiuyuZhang,In-SeonLee, Seung-HunCho,YounbyoungChae,andHyangsookLee Volume2014,ArticleID804746,14pages AcupunctureforPreventingComplicationsafterRadicalHysterectomy:ARandomizedControlled ClinicalTrial,Wei-minYi,QingChen,Chang-haoLiu,Jia-yunHou,Liu-danChen,andWei-kangWu Volume2014,ArticleID802134,6pages Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2014, Article ID 326179, 2 pages http://dx.doi.org/10.1155/2014/326179 Editorial Acupuncture and Herbal Medicine for Cancer Patients 2014 ThomasEfferth,1SookyungLee,2YoshiharuMotoo,3 andSvenSchröder4 1DepartmentofPharmaceuticalBiology,InstituteofPharmacyandBiochemistry,JohannesGutenbergUniversity, StaudingerWeg5,55128Mainz,Germany 2DepartmentofClinicalOncology,CollegeofKoreanMedicine,KyungHeeUniversity,149Sangil-dong,Gangdong-gu, Seoul134-727,RepublicofKorea 3DepartmentofMedicalOncology,KanazawaMedicalUniversity,Uchinada,Ishikawa920-0293,Japan 4HanseMerkurCenterforTraditionalChineseMedicine,UniversityMedicalCenterHamburg-Eppendorf,HouseO55, UniversityClinicCampus,Martinistraße52,22303Hamburg,Germany CorrespondenceshouldbeaddressedtoThomasEfferth;[email protected] Received6August2014;Accepted6August2014;Published28August2014 Copyright©2014ThomasEfferthetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Traditional medicine is a popular option for patients to get took a booming development. These facts and figures illus- medical information and care with various reasons world- tratethatthepresentspecialissuefocusesonahottopicin wide. Developing countries depend on it because of the cancerresearch. affordable prices, while a large portion of patients of devel- Forthisyear’sspecialissue,wewereabletogatherapanel oped or industrialized countries have a continuing interest ofscientistsfromdifferentfieldsworkingoninnovativetop- induced by the reluctance towards chemical drugs and ics.Thepapersofthisspecialissueincludethefollowing:“The mechanicalapproachestodisease.CAMoffersamultitudeof effects of herbs and fruits on leukemia” by T. A. Saedi et al., advantages for patients, especially in the chronic and life- “Medicinalplantsandotherlivingorganismswithantitumor threateningsevereailmentssuchascancer.Theglobaldem- potential against lung cancer” by L. S. Monteiro et al., andforCAMmakesitmandatorytoinvestigateitsscientific “Pharmacopuncture for cancer care: a systemic review” by S. evidencebasis. Cheonetal.,“Acupunctureforpreventingcomplicationsafter Among the different facets of CAM, acupuncture and radicalhysterectomy:arandomizedcontrolledclinicaltrial”by herbalmedicineraisedspecialinterestnotonlyfortreatment W.Yietal.,“AntitumoractivityofChinesepropolisinhuman ofpatientsbutalsoforresearchofmedicine.Ascanbeseen breast cancer MCF-7 and MDA-MB-231 cells” by H. Xuan inFigure1,acupunctureandherbalmedicineshavebecome et al., and “Apoptosis induction by the total flavonoids from thriving fields of research during the past half century. Arachnoides exilis in HepG2 cells through reactive oxygen A comprehensive survey of published papers from 1960 species-mediated mitochondrial dysfunction involving MAPK to 2013 shows the number of annually published papers activation”byH.Lietal. dealingwithacupunctureorherbalmedicinesforallmedical We, the editors, believe this issue may be of particular fields (Figure 1(a)) and in the context of cancer treatment interesttothereaders.Hopefully,thisissuewillgivehelpful (Figure1(b)).Sinceatremendousinterestinacupunctureand insightstoresearchers,physicians,andpatientsandwillalso herbalmedicinewasobservedin2000,theincreasingnum- beabletomakeaprogressinthefieldofcancerCAM. bersofpublishedpapersperyearareapparent.In2013,more ThomasEfferth than90papersonacupunctureandmorethan450paperson SookyungLee herbalmedicinesappearedintheareaofcancerprevention YoshiharuMotoo andtherapy.Theincreaserateofpublishedpapersconcerning SvenSchro¨der cancerovertheyearsindicatesthatthissmallresearchfield 2 Evidence-BasedComplementaryandAlternativeMedicine 4500 500 4000 450 400 3500 350 ns 3000 ns o o ati ati 300 blic 2500 blic pu pu 250 of 2000 of er er 200 b b m m u 1500 u N N 150 1000 100 500 50 0 0 1960 1980 2000 2020 1960 1980 2000 2020 Year Year Acupuncture Acupuncture and cancer Herbal Herbal and cancer (a) (b) Figure1:SurveyofliteraturedepositedinthePubMeddatabasefrom1960to2013withthekeywords(a)“acupuncture”or“herbal”and(b) “acupunctureandcancer”or“herbalandcancer.” Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2014, Article ID 494136, 8 pages http://dx.doi.org/10.1155/2014/494136 Review Article The Effects of Herbs and Fruits on Leukaemia TayebehAzamSaedi,1,2SabariahMdNoor,3PatimahIsmail,4andFauziahOthman2 1InstituteofBioscience,UniversitiPutraMalaysia,Malaysia 2DepartmentofHumanAnatomy,FacultyofMedicineandHealthSciences,UniversitiPutraMalaysia(UPM), 43400Serdang,SelangorDarulEhsan,Malaysia 3DepartmentofPathology,FacultyofMedicineandHealthSciences,UniversitiPutraMalaysia(UPM),43400Serdang, SelangorDarulEhsan,Malaysia 4DepartmentofBiomedicalSciences,FacultyofMedicineandHealthSciences,UniversitiPutraMalaysia(UPM), 43400Serdang,SelangorDarulEhsan,Malaysia CorrespondenceshouldbeaddressedtoFauziahOthman;[email protected] Received29April2014;Revised17June2014;Accepted17June2014;Published27August2014 AcademicEditor:ThomasEfferth Copyright©2014TayebehAzamSaedietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Indevelopingcountries,herbaltherapyisthefirstandbasisformoftreatmentformosttypesofdiseases.About75–80%ofthe world’spopulationprefersherbaltherapyasamajortreatmentduetoitsbetteradequacyandsatisfactoriness,whichenhancehuman body’ssymmetrywithminimalsideeffects.Fruitsandplantshavebeenpresentedfromthepastaspromisingtoolsinbecominga naturalanticanceragents.Manyoftheseplantextractsarecurrentlyusedincancertherapyandprevention.Thisreviewpaperwill particularlyexploreandemphasizeonherbsandfruitsusedinthetreatmentoftheleukaemia. 1.Introduction were 2.8 and 1.7 per 100.000 populations, respectively. On theotherhand,theincidenceratesofmyeloidleukaemiain Leukaemiahasbeenrecognizedsince1845,whenareportwas Malaysiaformalesandfemaleswere3.0and2.7per100.000 published on a patient who died of the disease which have populations,respectively[5]. shownanamplifiednumberofbloodcells.Twentyyearslater Leukaemia is diagnosed 10 times more often in adults it was found that diagnosis of leukaemia could be possible than in children and more common in males than females through bone marrow puncture [1]. Leukaemia is one of [6]. In the year 2000, nearly 2, 56,000 children and adults themostcommontypesofcancerworldwide.Decreasedin around the world developed some form of leukaemia, and incidence of infectious diseases and increased human life 2,09,000 died from it [7]. Many factors are related to the spancausedprevalenceofleukaemia.Theuseoftherapeutic development of leukaemia: prior chemotherapy, hereditary herbs in developing countries as cures against leukaemia is syndromes (Down syndrome), ionizing radiation, viruses prominent[2]. infection, and smoking. People with leukaemia are treated Currently, Denmark has the highest incidence of leu- with a combination of treatment including chemotherapy kaemia(29%incidenceper100,000individuals)intheworld (main treatment), antibiotic, blood transfusion, radiation [3].Itwasreportedthat21,464cancercases(9,400malesand therapy, and bone marrow transplantation. Although these 12,064females)werediagnosedamongMalaysiansofallages treatmentshaveprolongedthesurvivalrateofpatientswith in2003andtheincidencerateforcancerinMalaysiainthe leukaemia. Some of these treatments are difficult to handle year2003was134.3per100,1000malesand154.2per100,000 [8]. Thus, there is a need to seek for other remedies in females[4]. combatingthisdisease.Therefore,thisreviewpaperisaimed Among of 21, 464 cancer cases the incidence rates of at giving an overview of herbs and fruits which have been lymphoidleukaemiainMalaysiaforbothmalesandfemales demonstratedastherapeuticagentforleukaemia.
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