ECTOPIC PREGNANCY – MODERN DIAGNOSIS AND MANAGEMENT Edited by Michael Kamrava Ectopic Pregnancy – Modern Diagnosis and Management Edited by Michael Kamrava Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2011 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which permits to copy, distribute, transmit, and adapt the work in any medium, so long as the original work is properly cited. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Dragana Manestar Technical Editor Teodora Smiljanic Cover Designer Jan Hyrat Image Copyright Julie DeGuia, 2010. Used under license from Shutterstock.com First published October, 2011 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from [email protected] Ectopic Pregnancy – Modern Diagnosis and Management, Edited by Michael Kamrava p. cm. ISBN 978-953-307-648-5 free online editions of InTech Books and Journals can be found at www.intechopen.com Contents Preface IX Part 1 Epidemiology, Morbidity and Mortality 1 Chapter 1 Differential Diagnosis of Ectopic Pregnancy - Morbidity and Mortality 3 Panagiotis Tsikouras, Marina Dimitraki, Alexandros Ammari, Sofia Bouchlariotou, Stefanos Zervoudis, Panagiotis Oikonomidis, Constantinos Zakas, Theodoros Mylonas, Anastasios Liberis, Vasileios Liberis and Georgios Maroulis Part 2 Causes of Ectopic Pregnancy 11 Chapter 2 Tubal Damage, Infertility and Tubal Ectopic Pregnancy: Chlamydia trachomatis and Other Microbial Aetiologies 13 Louise M. Hafner and Elise S. Pelzer Chapter 3 Ectopic Pregnancy and Assisted Reproductive Technologies: A Systematic Review 45 Anastasia Velalopoulou, Dimitrios Peschos, Mynbaev Ospan, Eliseeva Marina, Ioannis Verginadis, Yannis Simos, Tsirkas Panagiotis, Spyridon Karkabounas, Vicky Kalfakakou, Angelos Evangelou and Ioannis P. Kosmas Chapter 4 Hysteroscopic Endometrial Embryo Delivery (HEED) 79 M.M. Kamrava, L. Tran and J.L. Hall Chapter 5 Ectopic Pregnancy Following Reconstructive, Organ-Preserving Microsurgery in Tubal Infertility 87 Cordula Schippert, Philipp Soergel and Guillermo-José Garcia-Rocha Chapter 6 Persistent Ectopic Pregnancy After Laparoscopic Linear Salpingostomy for Tubal Pregnancy: Prevention and Early Detection 97 Shigeo Akira, Takashi Abe and Toshiyuki Takeshita VI Contents Part 3 Diagnosis of Ectopic Pregnancy 107 Chapter 7 Management and Outcome of Ectopic Pregnancy in Developing Countries 109 Buowari Yvonne Dabota Chapter 8 Clinical Application of One-Step Diagnosis for Ectopic Pregnancy by HCG Ratio: Hemoperitoneum Versus Venous Serum 137 Yu-dong Wang, Wei-wei Cheng and Xiao-ping Wan Chapter 9 Inhibins and Activins as Possible Marker of Ectopic Pregnancy 151 Blazej Meczekalski and Agnieszka Podfigurna-Stopa Chapter 10 Term Extra-Uterine Pregnancy 163 Ismail A. Al-Badawi, Osama Al Omar and Togas Tulandi Part 4 Management of Ectopic Pregnancy 175 Chapter 11 Clinical Treatment of Unruptured Ectopic Pregnancy 177 Julio Elito Junior Chapter 12 MTX Could Be First-Line Therapy Even in Cases Where hCG Level is Greater than 5,000 IU/ml 209 Yoshiki Yamashita, Sousuke Katoh, Yoko Yoshida, Satoe Fujiwara, Sachiko Kawabe, Mika Hayashi, Atsushi Hayashi, Yoshito Terai and Masahide Ohmichi Chapter 13 The Treatment of Ectopic Pregnancy with Laparoscopy-Assisted Local Injection of Chemotherapeutic Agents 217 Ching-Hui Chen, Peng-Hui Wang, Li-Hsuan Chiu and Wei-Min Liu Chapter 14 Fertility-Preserving Surgery for Cervical Ectopic Pregnancy, from Past to Present 225 Seiryu Kamoi, Nao Iwasaki and Toshiyuki Takeshita Chapter 15 Modern Management of Cornual Ectopic Pregnancy 237 Maged Shendy and Rami Atalla Preface The objective in compiling this book has been to bring more worldwide awareness of this important cause of maternal morbidity and mortality. In addition to the sexually transmitted diseases, as advanced reproductive technologies have become available everywhere, occurrence of ectopic pregnancies has also increased more than before. With better understanding of the causes of this condition, earlier diagnosis and earlier treatment of sexually transmitted diseases, along with employing improved reproductive technologies, has led to more non-invasive treatment options and improved outcome in the management of these, potentially life-threatening, situations. This book is dedicated to all our patients from all over the world who have given us the impetus for giving them hope for having a family. Also, I would like to thank my wife, Soheila, and our children Mitchell and Michelle for their patience, understanding and encouragement in taking on this task. Michael Kamrava, MD West Coast IVF Clinic, Inc. LA Center for Embryo Implantation (SEED/ HEED) USA