ECOTOX Code Appendix

703 Pages·2017·5.65 MB·English

E C O T O X
ECOTOXicology Knowledgebase System
ECOTOX Code Appendix

Prepared for:
U.S. Environmental Protection Agency (EPA)
Office of Research and Development (ORD)
Center for Computational Toxicology and Exposure (CCTE)
Great Lakes Toxicology and Ecology Division (GLTED)
Duluth, Minnesota

By:
General Dynamics Information Technology (GDIT), Duluth, Minnesota
Contract CIO-SP3, HHSN316201200013W
Task Order: EP-G16H-01256, SMAVCS3
TDD 2-8 ECOTOX Application Development and Support

*CSRA is a General Dynamics Information Technology (GDIT) company

DECEMBER 2019
ECOTOX Code Appendix

NOTE: All code additions to the ECOTOX code appendices are forwarded quarterly to
EPA for approval.
Appendix A. Concentration Types .................................................................................. 4
Appendix B. Chemical Grade and Standards Codes ..................................................... 5
Appendix C. Chemical Formulation Codes** ................................................................ 12
Appendix D. Radiolabel Isotope Codes ........................................................................ 16
Appendix E. Organism Source Codes .......................................................................... 18
Appendix F. Lifestage Codes ....................................................................................... 19
Appendix G. Soil Type Codes ...................................................................................... 27
Appendix H. Test Location Codes ................................................................................ 28
Appendix I. Valid Duration Units ................................................................................... 29
Appendix J. Exposure Type Codes .............................................................................. 34
Appendix J.1 Diet (D) Exposure Codes ............................................................. 34
Appendix J.2 Injection (I) Codes ........................................................................ 35
Appendix J.3 Multiple (M) Application Codes .................................................... 35
Appendix J.4 AQUATIC ONLY Exposure Type Codes ...................................... 36
Aquatic Lab Exposure Types (EXP TYP)................................................... 36
Aquatic Field Exposure Types (EXP TYP) .................................................. 36
Appendix J.5 Topical (T) Application Codes ....................................................... 36
Appendix J.6 Environmental (V) Exposure Codes [Also used as Aquatic Field
Test Application Type] ............................................................................. 36
Appendix J.7 In Vitro Exposure Codes ............................................................... 38
Appendix K. Application Frequency Codes .................................................................. 39
Appendix L. Exposure Media Codes ............................................................................ 45
Aquatic Media Type ............................................................................................ 45
Terrestrial Media Type ........................................................................................ 45
Appendix M. Control Type and Dose ID Codes ............................................................ 47
Appendix N. Exposure Dose and Observation/Response Value Units ......................... 48
Appendix O. Ionic Fraction Codes ................................................................................ 88
Appendix P. Chemical Analysis Methods ..................................................................... 91
Appendix Q. Sample Unit Codes .................................................................................. 92
Appendix R. Effect Group Codes and Definitions ......................................................... 94
Appendix S. Group Effect, Effect and Measurement Codes and Definitions ................ 94
ACC Accumulation Group ................................................................................. 95
BEH Behavior Group ......................................................................................... 95
BCM Biochemical Group ................................................................................. 104
CEL Cellular Group ......................................................................................... 322
GRO Growth Group ......................................................................................... 656
MOR Mortality or Survivorship Group .............................................................. 668
PHY Physiological Group ................................................................................ 670
MED ECOTOXICOLOGY DATABASE SOPS DECEMBER 2019 i
ECOTOX Code Appendix

POP Population Group .................................................................................... 701
REP Reproduction Group ................................................................................ 706
SYS Ecosystem Group .................................................................................... 717
MLT Multiple Effect Group ............................................................................... 719
NER No Effect Group ...................................................................................... 719
Appendix T. Endpoint Codes and Definitions ............................................................. 721
Appendix U. Response Site Codes ............................................................................ 724
Appendix V. Common Keywords for Other Effects Text Field .................................... 759
Appendix W. Media Characteristic Units ................................................................... 760
Appendix X. Sub-Habitat Codes and Common Descriptors ....................................... 765
Appendix Y. Substrate Codes .................................................................................... 766
Appendix Z. Depth Units ............................................................................................ 767
Appendix AA. Field Location Abbreviations ................................................................ 768
Appendix AB. Geographic Codes ............................................................................... 769
Appendix AC. Aquatic Field Name Codes .................................................................. 799
Appendix AD. Terretox Field Name Codes ................................................................ 802
I. Quality Assurance Parameters ..................................................................... 802
II. Test Chemical Parameters .......................................................................... 802
III. Test Information .......................................................................................... 802
IV. Exposure Information .................................................................................. 803
V. Results Information ..................................................................................... 804
Appendix AE. Organic Carbon/Matter Type and Units ............................................... 805
Organic Matter Types ....................................................................................... 805
Organic Carbon/Matter Units ............................................................................ 805
Appendix AF. Cation Exchange Capacity Units ......................................................... 807
Appendix AG. ECOTOX Study Type Codes ............................................................... 808
Appendix AH. ECOTOX Test Method Codes ............................................................. 810
Appendix AI. ECOTOX Gender Codes ....................................................................... 813
Appendix AJ. ECOTOX Statistical Method Codes ..................................................... 814
Appendix AK. ECOTOX Trend Codes ........................................................................ 814
Appendix AL. ECOTOX Statistical Significance Codes .............................................. 814
Appendix AM. ECOTOX Endpoint Assignment Codes ............................................... 815
Appendix AN. ECOTOX Season Codes ..................................................................... 815
Appendix AO. ECOTOX Result Dry/Wet .................................................................... 816

MED ECOTOXICOLOGY DATABASE SOPS DECEMBER 2019 ii
ECOTOX Code Appendix

Appendix A. Concentration Types

Code Description Definition
Organic
A Active ingredient Chemical substance in a product that is responsible for
the pesticidal (toxic) effect (Ware, 1978). Reported as
"A" when the author refers to the concentration as
active ingredient, active principle, active substance
(A.S.), acid equivalent or various grades of reagents
(ie., Analytical, Reagent or Technical). When coding, a
value in the publication may be reported as “AI kg/ha”,
"AE kg/ha" or “kg AI/ha”; this type of value is reported
as ‘A =’ for CONC TYPE.
F Formulation Way in which basic pesticide (toxicant) is prepared for
practical use (Ware, 1978). Generally reserved for
commercial preparation prior to actual use and does not
include the final dilution (Insect-Pest Management and
Control, 1971) (e.g.; Baythroid, 2,4-D). Also included in
this category are organic compounds with no pesticidal
activity (e.g.; PCB, dioxin).
Metal/Organomentals
D Dissolved Those constituents of an unacidified sample that pass
through a 0.45 um membrane filter (e.g. soluble metal)
(APHA et.al. 1992).

L Labile The labile or free ion metal concentration determined by
various analytical methods. When coding, the specific
labile forms or complexes are not differentiated.

T Total The concentration of metals determined on an
unfiltered sample after vigorous digestion, or the sum of
the concentrations of metals in both dissolved and
suspended fractions (APHA et.al. 1992). Heavy metals
and single elements (e.g. Na, Cl, Br) are coded as T.
Inorganic non-metals
T Total The dissociated, charged form of nitrogen or hydrogen
related chemicals. This can take on numerous forms,
e.g.; ammonium (NH+4), nitrite (NO-2), etc. (Rand and
Petrocelli, 1985).T is the default for publications that do
not state whether Total or Unionized concentrations are
reported.
U Unionized The undissociated, uncharged form of ammonia or
hydrogen sulfide. The ammonia molecule, NH3, is the
unionized form. (In aqueous solution, ammonia
assumes an equilibrium between NH3 and NH+4.) The
NH3 is the toxic entity of the ammonia compound (Rand
and Petrocelli, 1985).
MED ECOTOXICOLOGY DATABASE SOPS DECEMBER 2019 4
ECOTOX Code Appendix

Appendix B. Chemical Grade and Standards Codes*
* Code all grades as “A” for concentration type for organic chemicals, refer to the ECOTOX Coding
Guidelines, Test Chemical Parameters, Grade and Test Information Parameters, Concentration Type for
details
Code Description Definition
A Analytical Grade
A or Analytical or
GU Guaranteed Grade
A or Analytical or
HPLC HPLC Grade
A or R Analytical or
Reagent Grade
A or S Analytical or
Spectrophotometri
c Grade
A or T Analytical or
Technical Grade
AAPS Atomic Absorption
Primary Standard
AASG Atomic
Absorption
Spectrometry
Grade
AB Absolute Grade Chemical created using the highest-purity starting materials and
suitable for ICP AES, DCP AES, ICP MS, High-Accuracy AA Flame or
Graphite Furnace work.
(https://www.absolutestandards.com/docs/catalog.pdf)
ACG Agrochemical
Grade
ACS American Meets or exceeds purity standards set by the American Chemical
Chemical Society Society (ACS). This grade is acceptable for food, drug, or medicinal use
Grade and can be used for ACS applications or for general procedures that
require stringent quality specifications and a purity of ≥95%.
(https://www.labmanager.com/business-management/2017/11/the-
seven-most-common-grades-for-chemicals-and-
reagents#.W6AR9eZlJXI)
AG Agricultural Grade
AL Analysis Grade
AN Analar Grade
AN or Analar or Reagent
R Grade
AR A.R. Grade The standard Mallinckrodt grade of analytical reagents; suitable for
(Analytical laboratory and general use. If the reagent also meets the requirements
Reagent Grade) of the American Chemical Society Committee on Analytical Reagent, it
will be denoted as an AR (ACS) reagent. (MBI trademark)
MED ECOTOXICOLOGY DATABASE SOPS DECEMBER 2019 5
ECOTOX Code Appendix

Code Description Definition
(https://camblab.info/wp/index.php/a-guide-to-chemical-grades/)
ARST Analytical An analytical material or substance one or more properties of which are
Reference sufficiently well established to be used for the calibration of apparatus
Standard the assessment of a measurement method or for assigning values to
materials. (https://www.reade.com/products/analytical-reference-
standards)
B Biological Grade Biological Grade, Biology Reagent and Biological Reagent
BC BioChemika
Grade
BP British Primary standards established using absolute methods. The declared
pharmacopeia content figures are determined without comparing to another substance.
grade (https://www.pharmacopoeia.com/reference-standards)
C Commercial
Grade
C or Commercial or
AN Analar Grade
C or T Commercial or
Technical Grade
CCG Cell Culture Grade Cell culture reagents include cell culture media, laboratory preparations,
biological extracts, selective and sterile reagents for several
applications. (http://www.advtechind.com/grade.htm)
CG Chemical Grade
CH Chromatographic
Grade
CL Clinical Grade
CT Certified Grade Reagent chemicals for which the purity standard is established by
Fisher Scientific. Purity is guaranteed to meet published maximum limits
of impurities.
(https://fscimage.fishersci.com/cmsassets/downloads/segm
ent
/Scientific/pdf/Chemicals/fisherchem_grades.pdf)
DS Dry Standard
Grade
EL Electrophoresis Material used specifi cally for electrophoresis applications. (https://beta-
Grade static.fishersci.com/content/dam/fishersci/en_US/
documents/programs/scientific/brochures-and-catalogs /fliers/fisher-
scientific-bioreagents-purity-grades-flyer.pdf
EM Eastman Grade “Eastman” grade, the highest in purity.
(https://pubs.acs.org/doi/pdf/10.1021/ac60049a725)
ER Excellent Analytical Reagents.
(http://www.thermofishersci.in/price_books
ExcelaR Grade /2016/Chemical%20&%20Glassware%202016%20-17.pdf)
MED ECOTOXICOLOGY DATABASE SOPS DECEMBER 2019 6
ECOTOX Code Appendix

Code Description Definition
EX Experimental
Grade
EXT Extra Grade
F Field Grade
FCAS Fisher Certified
S Atomic Absorption
Standard
FFL Free flowing
Grade
FG Feed grade Term to describe the quality of feedstuffssuitable for animal, but not
human consumption.
(http://www.omafra.gov.on.ca/english/livestock/dairy/facts/08-039.htm)
FOG Formulated Grade
FUG Fungicide grade
GC Gas
Chromatography
Grade
GCR Gas
Chromatograph
Standard
GR GR Grade General reagent (GR) – reagent that meets or exceed AR grade
specifications. (http://lab-training.com/2014/09/12/classification-
laboratory-reagents/)
GU Guaranteed Grade
GUR Guaranteed It is the ideal quality for laboratory purposes. Batch to batch
Reagant Grade reproducibility is specially controlled to guarantee consistent analytical
results. The grade is equivalent to Analytical grade (A.R.) Reagent
grade (R.G.), p.a. nomenclature of other manufacturers.
(http://www.advtechind.com/grade.htm)
HP High Purity Grade
HG Histological Grade
HPLC High Performance Product range is specially made for high performance liquid
Liquid chromatography. Within this range there are different qualities
Chromatography depending on whether they will be used for preparative chromatography
Grade or analytical in isocratic or gradient mode. The range includes high
purity solvents, tested to meet strict UV absorbance specifications as
well as ion pair reagents. (http://www.advtechind.com/grade.htm)
I Industrial Grade
L Laboratory Grade The most popular grade for use in educational applications, but its exact
levels of impurities are unknown. While excellent for teaching and
training, it is not pure enough to be offered for food, drug, or medicinal
use of any kind. (https://www.labmanager.com/business-
MED ECOTOXICOLOGY DATABASE SOPS DECEMBER 2019 7
ECOTOX Code Appendix

Code Description Definition
management/2017/11/the-seven-most-common-grades-for-chemicals-
and-reagents#.W6AR9eZlJXI)
LC LC-MS Grade Prepared according to LC-MS procedures and meets the requirements
set for by that standard. Also: LCMS Grade, LC/MS Grade.
(https://www.sigmaaldrich.com/analytical-
chromatography/hplc/lcms.html)
MBG Molecular Biology Equal to ultra-pure chemicals and are ideal for molecular biology
Grade applications. (https://www.goldbio.com/blog/379/demystifying-material-
grades-for-your-laboratory)
MD Medical Grade Designed, manufactured and purified to meet the strictest requirements
of the healthcare industry.
ME Monsanto
Electrical Grade
MK Merck Grade
MLT Military Grade
NAF National Meets or exceeds requirements of the National Formulary (NF). The
Formulary Grade USP and the NF (USP– NF) jointly publish a book of public
pharmacopeial standards for chemical and biological drug substances,
dosage forms, compounded preparations, excipients, medical devices,
and dietary supplements. The listings here should be reviewed to
determine which would be considered equivalent grades.
(https://www.labmanager.com/business-management/2017/11/the-
seven-most-common-grades-for-chemicals-and-
reagents#.W6AR9eZlJXI)
NP Normapur Grade
NR Not Reported
OP Optima Meets stringent purity requirements of LC/ MS and UHPLC by
addressing the need for minimal organic contamination with 0.1 micron
filtration to make particle free. Evaluated for 17 metal impurities at ppb
concentrations for minimal metal mass adduct formation. High ionization
efficiency to detect organic contaminants at 50 ppb max (positive) and
300 ppb max (negative) in full scan MS. Screened for UV-absorbing
contaminants at every wavelength in the 200 to 400 nm range to afford
smooth baselines and to reduce interferences.
(https://fscimage.fishersci.com/cmsassets/downloads
/segment/Scientific/pdf/Chemicals/fisherchem_grades.pdf)
PA Proanalysis
Grade, Pro Analsi
Quality,
analysenrein or
p.a.
PAN Pestanal Grade
PFG Purified Grade Also called pure or practical grade, meets no official standard; it is not
pure enough to be offered for food, drug, or medicinal use of any kind.
(https://www.labmanager.com/business-management/2017/11/the-
seven-most-common-grades-for-chemicals-and-
reagents#.W6AR9eZlJXI)
MED ECOTOXICOLOGY DATABASE SOPS DECEMBER 2019 8
ECOTOX Code Appendix

Code Description Definition
PG Pure Grade
PH Pharmaceutical A pharmaceutical-grade compound (PGC) is defined as any active or
Grade inactive drug, biologic or reagent, for which a chemical purity standard
has been established by a recognized national or regional
pharmacopeia (e.g., the U.S. Pharmacopeia (USP), British
Pharmacopeia (BP), National Formulary (NF), European
Pharmacopoeia (EP), Japanese Pharmacopeia (JP), etc.).
(https://oacu.oir.nih.gov/sites/default/files/uploads/arac-
guidelines/pharmaceutical_compounds.pdf)
PR Production Grade
PRA Practical Grade Defines chemicals of good quality where there are no official standards.
Suitable for use in general applications. Practical grade organic
chemicals may contain small amounts of isomers of intermediates.
(https://camblab.info/wp/index.php/a-guide-to-chemical-grades/)
PRG Pesticide Residue Solvents tested for suitability in Pesticide Residue Analysis.
Grade (http://www.emdmillipore.com/US/en/lab-technical-resources /grade-
definitions/c9Ob.qB.r7MAAAFEgSYWq.DI,nav)
PRM Premium Grade
PS Primary Standard Analytical reagent of exceptional purity that is specially manufactured
for standardizing volumetric solutions and preparing reference
standards. (https://camblab.info/wp/index.php/a-guide-to-chemical-
grades/)
PST Pesticide Grade Solvents for use in analysis of pesticide residue. Meet or exceed ACS
standards of purity for pesticide residue analysis.
(https://fscimage.fishersci.com/cmsassets/downloads/
segment/Scientific/pdf/Chemicals/fisherchem_grades.pdf)
PT Photographic
Grade
R Reagent Grade, Generally equal to ACS grade (≥95%) and is acceptable for food, drug,
Purissium, Purum, or medicinal use and is suitable for use in many laboratory and
Puriss or Puris analytical applications. (https://www.labmanager.com/business-
management/2017/11/the-seven-most-common-grades-for-chemicals-
and-reagents#.W6AR9eZlJXI)
R OR Reagent or
PRA Practical Grade
RE Research Grade
RE or Research or
A Analytical Grade
RE or Research or
CP chemically pure
grade
RFG Reference Grade
RS Residue Grade Suitabile for pesticide residue anaysis.
(http://www.info.dent.nu.ac.th/chemistry
/Files/chemical%20grade%20diagnosis.pdf)
MED ECOTOXICOLOGY DATABASE SOPS DECEMBER 2019 9
ECOTOX Code Appendix

Code Description Definition
RST Reference
Standard
S Spectrophotometri
c Grade
SC Scintillation Grade High purity, suitable for liquid scintillation counting.
(https://www.coleparmer.com/i/acros-organics-ac403731500-cab-o-sil-
m-5-scintillation-grade-150g/8834132)
SO Solvent Grade
SPC Spectrochemical Spectrophotometric grade solvents are high purity solvents made
Grade specifically for applications using spectrophotometers.
(https://www.alfa.com/en/spectrophotometric-grade/)
SPG Special Grade
SSG Super special Reagents with the highest quality standard guaranteed for which
grade (highest specification parameters andspecification values of JIS special grade or
quality standard higher are specified. (http://www.wako-
guaranteed for chem.co.jp/english/labchem/journals/analytical2012/index.ht
which specification
m)
parameters and
specification
values of JIS
special grade or
higher are
specified)
ST Standard
STD Standard Solution
for AA
SYG Synthesis Grade For organic synthesis and preparative tasks. Also: synthetic grade.
(http://lab-training.com/2014/09/12/classification-laboratory-reagents/)
T Technical Grade, Used for commercial and industrial purposes; however, like many
Technical product, others, it is not pure enough to be offered for food, drug, or medicinal
Technical use of any kind. (https://www.labmanager.com/business-
formulation management/2017/11/the-seven-most-common-grades-for-chemicals-
and-reagents#.W6AR9eZlJXI). Note that technical products can include
Technical Materials or Technical Concentrates abbreviated by TC and
TK respectively (https://apvma.gov.au/node/10901).
T or P Technical or
Purified Grade
T or Technical or Pure
PU Grade
TA Technical Acid
Grade
TAR Technical or
Analytical or
Reagent Grade
ULV ULV Grade
MED ECOTOXICOLOGY DATABASE SOPS DECEMBER 2019 10