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TV fjc %o g/oe: e 2-/77 ^ UMASS/AMHERST aieobb D2ba sivb i ASSESSMENT MANUAL U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE • Public Health Service Alcohol, Drug Abuse, and Mental Health Administration Digitized by the Internet Archive in 2010 with funding from Boston Library Consortium IVIember Libraries http://www.archive.org/details/ecdeuassessmentm1933guyw ECDEU ASSESSMENT MANUAL FOR PSYCHOPHARMACOLOGY Revised, 1976 William Guy, Ph.D. Biometric Laboratory The George Washington University Kensington, Maryland U.S. DEPARTMENTOF HEALTH, EDUCATION, ANDWELFARE Public Health Service Alcohol, DrugAbuse,and Mental Health Administration National InstituteofMental Health Psychopharmacology Research Branch DivisionofExtramural ResearchPrograms 5600FishersLane Rockville,Maryland 20852 Thispublication wassupported by NliVlH grant i\/lH-22019, fromthe Psychopharmacology Research Branch, Division of Extramural Research Programs. DHEW Publication No. (ADM) 76-338 Printed 1976 CONTENTS Acknowledgements 6 ntroduction 9 I Participation in ECDEU Program 11 Description of ECDEU Battery 12 Time Table for Using tine ECDEU Battery 1^ General Instructions 19 The Identification (ID) Block 23 Coding Duration of Study 25 Research Plan Report (021-RPR) 27 ECDEU Order Form (07^-EOF) ^9 General Scoring Sheet (050-GSS) 53 Encoding Non-Standard Data 59 DEMOGRAPHIC PACKET 65 Children's Personal Data Inventory (043-CPDl) 71 Children's Symptom History (044-CSH) 87 Adult Personal Data Inventory (041-APDl) 93 Prior Medication Record (046-PMR) 109 PSYCHIATRIST PACKETS 113 PEDIATRIC SCALES Children's Psychiatric Rating Scale (027-CPRS) 123 Children's Diagnostic Scale (030-CDS) 131 Diagnostic Cr teria-Pediatric Psychopharmacology Conference 135 i Children's Diagnostic Classification (031-CDC) 1^1 Instructions for CDC - Werry 1^3 Diagnosis for Psychopharmacologica1 Studies - Werry 1^7 ADULT SCALES Brief Psychiatric Rating Scale (047-BPRS) 157 Comments - Overall 166 Depression Status Inventory (072-DSl) 171 Comments - Zung 176 Hamilton Depression Scale (049-HAMD) 179 Comments - Hamilton 186 Hamilton Anxiety Scale (048-HAMA) 193 Anxiety Status Inventory (051-ASl) 199 Comments - Zung — 204 Wittenborn Psychiatric Rating Scale (052-WITT) 205 Comments - Wittenborn 210 UNIVERSAL SCALES Clinical Global Impressions (028-CGl) - - - -217 Dosage Record and Treatment Emergent Symptoms Scale (029-DOTES) 223 Patient Termination Record (032-PTR) 245 NURSE PACKET 253 NCuhrisledsr'en'OsbseBrevhaavtiioorn SIcnavleentofroyr (I0n3p4a-tCiBenIt) Evaluation (039-NOSIE) 226557 Comments - Honigfeld 271 Plutchik Geriatric Rating Scale (040-PLUT) 275 Nurses' Global Impressions (042-NGl) 283 INDEPENDENT PEDIATRIC SCALES Teacher Questionnaire (035-T(l) 287 parent Questionnaire (036-PQ.) 293 Parent-Teacher Questionnaire (037-PTQ) 299 Rating Scales for Use with Children - Conners 303 INDEPENDENT ADULT SCALES Self-Report Symptom Inventory (053-SCL-90) 313 Comments - Derogatis, Lipman, and Covi 320 Self-Rating Depression Scale (073-SDS) 333 Self-Rating Anxiety Scale (05^-SAS) 337 Comments - Zung 3^0 INDEPENDENT ADVERSE REACTION SCALES TESS Write-In Scale (033-TWIS) - - --- 3^1 Subject's Treatment Emergent Symptom Scale (O38-STESS) 3^7 Laboratory Data (055-LAB) -- 351 Clinical Laboratory Standards in Pediatric Psychopharmacology - Gershon 365 Clinical Laboratory Test Standards for Schizophrenics - McGlashan and Cleary 379 MEDICAL SCALES Physical and Neurological Examination for Soft Signs (O^l-PANESS) 383 Manual for Scored Examination for Soft Signs - Abbott Lab. and Close 39^ PSYCHOLOGIST PACKET kOJ PEDIATRIC SCALES 411 Wechsler Intel 1 igence Seale for Children (O6O-WISC) 4l5 Wide Range Achievement Test (062-WRAT) — k]7 Porteus Mazes (06I-MAZE) - - 4l8 Goodenough-Harris Figure Drawing Test (O63-GOOP) 422 Bender Gestalt Test - Koppitz Scoring (064-BENDK) 423 Psychological Examination Behavior Profile (O66-PEBP) 429 Performance Tests fo—r Children - Sprague 435 ADULT SCALES - - - 443 Wechsler Adult ntell igence Scale (O67-WAIS) 446 I Porteus Mazes (See Page 418) Bender Gestalt Test - Pascal-Suttel Scoring (O68-BENDP) 448 1 Wechsler Memory Scale (O69-WMEM) 449 Friedhoff Task Behavior Scale (O7O-FTBS) 450 Assembl ing Data for Shipment 451 Alternative Types of Data Submission 454 Data Shipment (07I-DS) 455 DOCUMENTATION (THE DATA PACKAGE) The Processing System (BLIPS II) 468 Contents of the Data Package 469 Editing and Error Correction 472 Raw and Computed Listings 474 Means and Standard Deviations 474 Frequency Tables 474 Cross-Tabulations 474 Graphic Displays 480 Data Inventory 483 The Analytic Cohort 483 Narrative Summary 483 Comments on Statistical Procedures - Cleary and Yang 486 Research Completion Report 497 APPENDICES 1. Occupation Categories 5)6 2. DSM-11 and WHO Diagnostic Codes 521 3. Formats for Non-Standard Instruments 528 Profile of Mood States (056-POMS) 529 Frostig Developmental Test of Visual Perception (O65-FROST) 532 Abnormal Involuntary Movement Scale (II7-AIMS) 534 Crichton Geriatric Rating Scale (201-CRICHT) 538 Beck Depression Inventory (203-BECK) Sk] Guild Memory Test (205-GUILD) Shk Physician Questionnaire (208-PHYS) 546 inpatient Multidimensional PersonaI ity Sea1e (210-IMPS) 5^9 Physician's Outpatient Psychopathology Scale (211-POPS) 559 Memory for Designs Test (212-MF-D) 562 Phillips Scale of Premorbid Adjustment in Schizophrenia (213-PHIL) 564 Sandoz Clinical Assessment-Geriatric (238-SCAG) 568 Clyde Mood Scale (239-CLYDE) 572 Hopkins Symptom Checklist (240-HSCL) 575 Self-Rating Symptom Scale (010-SRSS) 579 Global Assessment Scale (241-GAS) 583 Tartu Psychometric Battery (242-TARTU) 586 - ACKNOWLEDGEMENTS This revision of the 1970 ECDEU Assessment Manual represents the cooperative effort of many individuals whose comments and criticisms have served to sustain the ECDEU program as an evolving entity. The adult elements of the ECDEU Assess- ment Battery have been modified and expanded over the period of the last decade as a consequence of the interactions among those investigators employing the Battery in clinical drug trials, the pharmaceutical industry, the Psychopharmacol ogy Research Branch of the National Institute of Mental Health and the Biometric Laboratory of The George Washington University. The size of this group makes it difficult to acknowledge every individual by name as would wish, and, therefore, I appreciation for their contributions is extended collectively but no less warmly. The newer pediatric section of the ECDEU Assessment Battery is the culmina- tion of several years of effort on the part of the Pediatric Psychopharmacology Conference which was organized under the auspices of the Psychopharmacology Research Branch. The contributions of this Conference have been summarized in a 1973 Special Issue of the Psychopharmacology Bulletin, entitled "Pharmacotherapy of Children" and are happily acknowledged here. A number of individuals have been kind enough to provide special commentaries for sections of the Manual, A list of these contributing authors is given below. To them, and to the developers of all the assessment instruments cited in this Manual, deep appreciation is expressed. The emergence of the present Assessment Battery has been accompanied by the development of a data processing system called the Biometric Laboratory Information Processing System (BLIPS). To the entire staff of the Biometric Laboratory - and particularly to those cited below - want to extend special thanks for the ingenu- I ity and patience they have shown during the several years of almost continuous de- signing and redesigning of BLIPS. W.G. i . CONTRIBUTING AUTHORS Patricia A. Cleary, M.S. Biometric Laboratory, The George Washington University John H. Close, M.D. Abbott Laboratories C. Keith Conners, Ph.D. Western Psychiatric Institute & Clinic, Pittsburgh, Pa. Lino Covi M.D. Johns Hopkins University, Baltimore, Maryland , Leonard R. Derogatis, Ph.D. Johns Hopkins University, Baltimore, Maryland Barbara Fish, M.D. University of California at Los Angeles Samuel Gershon, M.D. New York University Medical Center Rachel G ttelman-Klein, Ph.D. Hillside Hospital, New York Max RamiIton, M.D. University of Leeds, Leeds, England Gilbert Honigfeld, Ph.D. Sandoz Pharmaceuticals Donald F. Klein, M.D. Hillside Hospital, New York Ronald S. Lipman, Ph.D. Psychopharmacology Research Branch Thomas McGlashan, M.D. Chestnut Lodge, Rockville, Maryland John E. Overal 1 , Ph.D. University of Texas Medical Branch, Galveston, Texas Robert L. Sprague, Ph.D. University of Illinois, Champaign, Illinois John Werry, M.B ,Dipl .Psychiat University of Auckland, New Zealand J. Richard Wittenborn, Ph.D. Rutgers University Kenneth Yang, B.A. Biometric Laboratory, The George Washington University Will iam W. K. Zung, M.D. Veterans Administration Hospital, Durham, North Carolina PSYCHOPHARMACOLOGY RESEARCH BRANCH Jerome Levine, M.D. Wil iam Petrie, M.D. 1 Nina Schooler, Ph.D. BIOMETRIC LABORATORY, THE GEORGE WASHINGTON UNIVERSITY Luis Agu lar Robert McCarter, M.S. i Roland R. Bonato, Ph.D. David Schaffer, M.S. Mary Cronin Richard Schoenberg Mary-Alice Goodridge Richard W. Switalski, M.A. Barbara Holmes Clarise Wi1 1 iams Nina Kit Robert L. Zimmermann, Ph.D.