Dynamics of the vascular system : interaction with the heart

296 Pages·2019·10.499 MB·English

by  John K. Li

Series on Bioengineering and Biomedical Engineering – Vol. 9
DYNAMICS of the
VASCULAR SYSTEM
Interaction with the Heart
Second Edition
9807_9789814723749_TP.indd 1 6/8/18 10:23 AM
SERIES ON BIOENGINEERING AND BIOMEDICAL
ENGINEERING
Series Editor: John K-J Li (Department of Biomedical Engineering,
Rutgers University, USA)
The aims of the book series are to present a publishing forum for established
researchers, educators and professionals in the field of bioengineering and
biomedical engineering to promote in-depth documentation of new scientific
findings, technological advances, and to provide effective teaching tools of the
fundamental aspects of the field. Single or multiple authored or edited books,
research monographs, textbooks, lab manuals and specialized conference pro-
ceedings are welcome. Topics of interest include biosensors, biomedical devices
and instrumentation, physiological modeling and signal processing, medical
imaging, drug delivery systems, clinical monitoring, tissue engineering, sys-
tems biology and bioinformatics, biomechanics and biomaterials, rehabilitation
and prostheses, nano and micro applications to biomedicine, biomedical optics,
biofluid mechanics, artificial organs and assist devices.
Published
Vol. 9: Dynamics of the Vascular System: Interaction with the Heart
(Second Edition)
by John K-J Li (Rutgers University, USA)
Vol. 8: Neuroprosthetics: Theory and Practice (Second Edition)
edited by Kenneth Horch (University of Utah, USA) and
Daryl Kipke (University of Utah, USA)
Vol. 7: Further Understanding of the Human Machine: The Road to
Bioengineering
edited by Max E Valentinuzzi (National Scientific and Technical
Research Council (CONICET), Argentina)
Vol. 6: Cardiac Fibrillation-Defibrillation: Clinical and Engineering Aspects
by Max E Valentinuzzi (University of Buenos Aires, Argentina &
University of Tucumán, Argentina)
Vol. 5: Biomedical Engineering Principles of the Bionic Man
by George K Hung (Department of Biomedical Engineering,
Rutgers University, USA)
For the complete list of volumes in this series, please visit
www.worldscientific.com/series/sbbe
Alex - 9807 - Dynamics of the Vascular System.indd 1 30-07-18 12:30:20 PM
Series on Bioengineering and Biomedical Engineering – Vol. 9
D Y N A M I C S of the
VASCULAR SYSTEM
Interaction with the Heart
Second Edition
John K-J Li
Rutgers University, USA
World Scientific
NEW JERSEY • LONDON • SINGAPORE • BEIJING • SHANGHAI • HONG KONG • TAIPEI • CHENNAI • TOKYO
9807_9789814723749_TP.indd 2 6/8/18 10:23 AM
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Library of Congress Cataloging-in-Publication Data
Names: Li, John K-J., 1950– author.
Title: Dynamics of the vascular system : interaction With the heart / by John K-J Li.
Other titles: Series on bioengineering and biomedical engineering ; v. 9.
Description: 2nd edition. | New Jersey : World Scientific, 2018. | Series: Series on bioengineering
and biomedical engineering ; volume 9 | Includes bibliographical references and index.
Identifiers: LCCN 2018010403 | ISBN 9789814723749 (hc : alk. paper)
Subjects: | MESH: Cardiovascular Physiological Phenomena | Models, Cardiovascular
Classification: LCC QP105 | NLM WG 102 | DDC 612.1--dc23
LC record available at https://lccn.loc.gov/2018010403
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.
Copyright © 2019 by World Scientific Publishing Co. Pte. Ltd.
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Preface to the First Edition

This book is the first volume of the Bioengineering and Biomedical
Engineering Book Series. As the Series Editor, and to set a good
example, I have taken the task of writing yet another book on the
cardiovascular system.
The contents of this book extends from Arterial System Dynamics,
my first book published some fifteen years ago, to distinctly different
regimes of the microcirculation and the venous system, as well as the
assisted circulation.
The vascular system is indeed so vast, that a binocular vision is often
needed to unravel the mystery of the many concurrent interactions
occurring at different sites of the vascular tree. This becomes more
challenging with the imposition of studying its dynamic phenomena. The
Dynamics of the Vascular System is written employing mathematical
techniques to formulate the physical principles involved in the structural
and functional correlates of the underlying physiology. The intriguing
control and geometric perspectives are also included wherever possible.
The book also serves as a companion text to The Arterial Circulation:
Physical Principles and Clinical Applications.
Selected topics and references are provided, so that I and the readers
are not overwhelmed by the otherwise exhaustive presentations of the
many observed phenomena and the subsequent diverse interpretations of
their origins and mechanisms.
I hope professionals and students in the field of bioengineering and
biomedical engineering, biomathematics, biophysics, cardiovascular
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vi Preface to the First Edition

physiology and medicine will find this book a relevant source of
reference. Much of the work is the culmination of my three decades of
learning, experimenting and investigation. I am aware that there are
other works of notable items and newer advances which I have not yet
included in this book. I will continue to learn more of them. Finally, I
like to thank those who have contributed to the completion of this book.

John Kong-Jiann Li
New Jersey, USA
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Preface to the Second Edition

This book was originally published in 2004 as the first volume of the
Bioengineering and Biomedical Engineering Book Series. A decade has
quickly passed, together with the many advances in the sciences,
medicine and technology. I decided to take up the task to update some of
the materials for this second edition, while preserving the fundamental
concepts of the original text.
The contents of this second edition include explicitly a chapter on the
Interaction of the Heart and the Arterial System. This topic was
supported by the National Science Foundation that I began working on
right after completing my doctorate at the University of Pennsylvania
four decades ago with the late Professor Abraham Noordergraaf. This
chapter includes basic cardiac muscle mechanics, the contractile function
of the heart and its dependence on the operating relations with the
vascular system under normal and heart failure conditions, with emphasis
on their dynamic interaction. Examples of mechanical cardiac assist
devices and drug treatment are also included.
This second edition continues to emphasize on quantitative treatment
of the vascular system by analyzing the structural and functional
correlates of the underlying physiology. This may purposefully overlook
some of the clinical aspects in terms of diagnosis and treatment efficacies
of certain cardiovascular diseases. Similar to the first edition, rather than
being exhaustive, only selected topics and references are provided. In
this regard, worthwhile publications from some investigators may not
have been included.
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viii Preface to the Second Edition

I hope many of the cardiovascular scientists, researchers and
clinicians, as well as students will continue to find this book a useful
reference. I like to thank those who have contributed to the completion
of this book.

John Kong-Jiann Li
New Jersey, USA
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About the Author
John K-J. Li obtained his Ph.D. in Bioengineering
from the University of Pennsylvania and has been a
Distinguished Professor of Biomedical Engineering
at Rutgers University since 1998. He has been an
elected Fellow of the American Institute for
Medical and Biological Engineering, the American
Colleges of Cardiology, the American College of
Angiology, and the Academy of Medicine of New
Jersey. He is also the Founding Editor-in-chief of
Springer’s Cardiovascular Engineering and Bioengineering and
Biomedical Engineering Book Series of World Scientific and Imperial
College Press, and is on the editorial boards of numerous journals. His
research has been founded by the NIH, NSF, AHA, and industry grants,
with interest in cardiac and vascular mechanics, modeling, medical
devices, controlled drug delivery, hypertension and heart failure,
neuroengineering, scaling in biology, and comparative physiology. He
has authored several books and published numerous articles and is a
frequently invited speaker at national and international conferences and
universities. He enjoys teaching and has been the adviser to more than 90
Ph.D. and M.S. students and 175 senior design students, and received
teaching excellence awards. He is also a holder of several US patents
and a recipient of the IEEE Millennium Medal.
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