Dupuytren’s Disease: Pathobiochemistry and Clinical Management

308 Pages·1994·19.38 MB·English

by  Alfred Berger

A. Berger A.Delbrück P.Brenner
R. Hinzmann (Eds.)
Dupuytren's
Disease
Pathobiochemistry and Clinical Management
With 143 Figures and 45 Tables
Springer-Verlag
Berlin Heidelberg New York London Paris
Tokyo Hong Kong Barcelona Budapest
Prof. Dr. med. Alfred Berger
Dr. med. Peter Brenner
Klinik für Plastische, Hand- und
Wiederherstellungschirurgie
Prof. Dr. med. Axel Delbrück
Dr. rer. nat. Rolf Hinzmann
Institut für Klinische Chemie 11
Krankenhaus Oststadt, Medizinische Hochschule Hannover
Podbielskistraße 380,30659 Hannover, Germany
ISBN-13: 978-3-540-57239-8 e-ISBN-13: 978-3-642-78517-7
DOI: 10.1007/978-3-642-78517-7
Library of Congress Cataloging-in-Publication Data
Dupuytren's disease: pathobiochemistry and c1inical management/
A. Berger ... [et aLl, (eds.). p. cm. Includes index.
1. Dupuytren's contracture. L Berger, Alfred.
[DNLM: 1. Dupuytren's Contracture-physiopathology. 2. Dupuytren's
Contracture-therapy. WE 830 D9453 1994)
RD778.5.D88 1994 617.5'75-dc20 DNLMIDLC 93-34322
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Preface
Dupuytren's disease has been known to physicians for cen
turies. Although much effort has been spent on clarifying its
origin and pathogenesis, our knowledge of it is stilllimited.
However, re cent growth in our knowledge of the pathobio
chemistry of connective tissue diseases in general has opened
up new research and clinical perspectives regarding Dupuy
tren's contracture.
To encourage work in this field, it is necessary for the
individual groups concerned with problems of the patho
genesis and therapy of the disease to discuss continuously
the state of the art in Dupuytren's research and to exchange
clinical experiences and results of biochemical research.
Following the meetings in Vienna (1983) and London,
Ontario (1985), the progress in this field over the last 6
years was presented at the Hannover Symposium on Patho
biochemistry and Clinical Management of Dupuytren's
Disease in 1991. In particular, the impact of biochemical
findings on the diagnosis and therapy of Dupuytren's disease
was diseussed. Therefore, this volume starts with the pre
sentation of new morphologieal aspects of the pathogenesis
of Dupuytren's disease (part I). In parts II to VI a com
prehensive delineation of general eonneetive tissue patho
biochemistry is followed by an extensive diseussion of
metabolie aberrations and abnormities of the maero
moleeular extracellular structure of the palmar fascia in
Dupuytren's contracture. Finally, parts VII and VIII deal
with the methods to detect these chrateristics and the pro
gress in diagnosis and surgical treatment procedures.
Let us add one comment to the term "Dupuytren's disease".
Although this disease has frequently been referred to as
"Dupuytren's contracture" in past, we agree with numerous
others that disease is the more appropriate word, reftecting
the fact that this condition involves more than a medical
shortening.
Preface V
This report of the Hannover conference should aid those
coBeagues and research groups who could not attend
the meeting and enourage and challenge them to actively
participate in further enlightenment of the problems we are
aB faced with in our work on this disease.
December 1993 The Editors
VI Preface
Contents
Morphology ................................... 1
W. Mohr and D. Wessinghage
Morphology of Dupuytren's Disease 3
G. Brandes, E. Reale, P. Brenner, and T. Körner
Interactions Between Proteoglycans
and Collagen Fibrils in the Palmar Fascia
in Dupuytren's Disease. . . . . . . . . . . . . . . . . . . . . . . . . . 16
G.A.C. MurrelI, M.J.O. Francis, and c.R. Howlett
Myofibroblasts Are Not Specific
to Dupuytren's Disease. . . . . . . . . . . . . . . . . . . . . . . . . . 24
A. Meinel
The Significance of Skin Anchoring Fibres
in Palmar Fibrosis: Brief Comment ............... 34
Pathobiochemistry of Fibrillar Component 35
A.J. Bailey
Collagen Changes in Dupuytren's Disease 37
E.J. Menzel, J. Neumüller, A. Rietseh,
and H. Millesi
Connective Tissue Autoantibodies in Dupuytren's
Disease: Associations with HLA DR3 ... . ... ...... 49
G.A.c. MurreIl and M.J.O. Francis
Collagen Production
by Cultured Dupuytren's Fibroblasts . . . . . . . . . . . . . . 62
Contents VII
Proteoglycans and Glycosaminoglycans ............ 71
E. Gurr, M. Borchert, W. Borchert, and
A. Delbrück
Proteoglycans in Biopsies
of Dupuytren's Contracture . . . . . . . . . . . . . . . . . . . . . . 73
N. Gässler
Glycosaminog1ycan Distribution Pattern
in Dupuytren's Contracture Biopsies. . . . . . . . . . . . . . 85
N. Gässler, P. Brenner, A. Berger, and A. Delbrück
Biochemical Parameters for the Diagnosis
of Dupuytren's Disease. . . . . . . . . . . . . . . . . . . . . . . . . . 94
Pathobiochemistry of Cells
in Dupuytren's Contracture . . . . . . . . . . . . . . . . . . . . . . 99
J. Neumüller
Investigations of Cell Cultures Derived from Patients
Suffering from Dupuytren's Contracture . . . . . . . . . . . 101
A. Delbrück and H. Schräder
Fibroblast Gel Culture: A Model for Biochemical
Investigations of Dupuytren's Contracture 111
C. Sachse and P. Brenner
Reactivity of Cells in Nodules of Dupuytren's
Contracture with Monoclonal Antibodies
Recognizing Leukocyte Antigens and
von Willebrand's Factor . . . . . . . . . . . . . . . . . . . . . . . . . 117
D.T. Shum, G. Pringle, B. Hasegawa, J.S. Botz,
and R.M. McFariane
Demonstration of Myofibroblasts Using a Novel
Murine Monoclonal Antibody, 3C2GI0.7 Raised
from Proliferating Cells in Dupuytren's Disease . . . . . 127
I.L. Naylor, D.J. Coleman, R.A. Coleman,
S.E. Cross, and I.T.H. Foo
Reactivity of Nodular Cells in Vitro:
A Guide to the Pharmacological Treatment
of Dupuytren's Contracture . . . . . . . . . . . . . . . . . . . . . . 139
VIII Contents
Extracellular Matrix Components and
Macromolecular Interactions . . . . . . . . . . . . . . . . . . . . . 151
A.M. Gressner
Stromal-Epithelial Cell Interactions
in the Mechanisms of Hepatocyte Injury,
Liver Cell Regeneration and Fibrogenesis . . . . . . . . . . 153
J.E. Scott
Proteoglycan - Collagen Fibril Interactions in
Tissues . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171
H. Millesi, R. Reihsner, J. Menzel, G. Hamilton,
and R. Mallinger
Changes in the Biomechanical Properties
of Diseased Tissue as Pathogenetic Factors
in Dupuytren's Contracture . . . . . . . . . . . . . . . . . . . . . . 178
Fibromatoses .................................. 191
W. Mohr and D. Wessinghage
Localization and Morphology
of Different Fibromatoses ....................... 193
H. Notbohm, S. Mosler, and J. Hoch
Thermal Stability and Fibrillogenesis of Collagen
trom Tissue of Patients with Dupuytren's Disease . . . 202
S. Shoshan, I. Babayof, I. Peleg, F. Grinnell,
N. Ron, S. Funk, and E.H. Sage
Macrophage Activity, Fibronectin, and SP ARC
Protein in Experimentally induced Granuloma 213
G. Gabbiani
Modulation of Fibroblastic Cytoskeletal Features
During Dupuytren's Disease . . . . . . . . . . . . . . . . . . . . . 222
G.A.C. MurreIl and M.J.O.Francis
Oxygen Free Radicals and Dupuytren's Disease 227
Clinical Findings and Epidemiology
of Dupuytren's Disease .... . . . . . . . . . . . . . . . . . . . . . . 235
P. Mailänder, P. Brenner, and A. Berger
Clinical Findings in Dupuytren's Disease. . . . . . . . . . . 237
Contents IX
P. Brenner, P. Mailänder, and A. Berger
Epidemiology of Dupuytren's Disease . . . . . . . . . . . . . 244
Clinical Management of Dupuytren's Disease 255
J. Geldmacher
Limited Fasciectomy . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257
P.Burge
Fasciotomy and the Open Palm Technique . . . . . . . . . 264
J. Varian
Skin Grafting in the Management
of Dupuytren's Disease. . . . . . . . . . . . . . . . . . . . . . . . . . 268
C. Leclercq and R. Tubiana
Recurrence in Dupuytren's Disease . . . . . . . . . . . . . . . 272
E. Euler, K. Wilhelm, and T. Kreusser
Refinements of Plastic Surgery in Relapsing
Dupuytren's Disease: Incisions, Flaps, Treatment of
Perfusion Disorders, Physiotherapy, and Splinting 275
J. T. Hueston
The Complications and Unsatisfactory Results
of Treatment for Dupuytren's Disease . . . . . . . . . . . . . 285
A. Messina
The Continuous Elongation Technique
in Dupuytren's Disease . . . . . . . . . . . . . . . . . . . . . . . . . . 291
Subject Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 297
X Contents
List of Contributors
Babyof, 1., M.D.
Connective Tissue Research Laboratory
Hebrew University of Jerusalem
P.O. Box 1172
Jerusalem, Israel
Bailey, A.J., M.D.
Muscle and Collagen Research Group
Department of Veterinary Medicine
Langford, Bristol BS18 7DY, Great Britain
Berger, A., Prof. Dr.
Klinik für Plastische, Hand-und Wiederherstellungschirurgie
Krankenhaus Oststadt, Medizinische Hochschule Hannover
Podielskistraße 380
30659 Hannover, Germany
Borchert, M., Dr.
Um Unter Dorf 30
38527 Meine, Germany
Borchert, W., Dr.
Medizinische Klinik I
Städtisches Klinikum Braunschweig
Salzdahlumer Straße 90
38126 Braunschweig, Germany
Botz, J.S., M.D.
Department of Pathology, Victoria Hospital
University of Western Ontario
375 South Street
London, Ontario N6A 4G5, Canada
List of Contributors XI