Dual Diagnosis and Psychiatric Treatment Medical Psychiatry Series Editor Emeritus William A.Frosch, M.D. Weill Medical College of Cornell University New York, New York, U.S.A. Advisory Board Jonathan E.Alpert, M.D., Ph.D. Massachusetts General Hospital and Harvard University School of Medicine Boston, Massachusetts, U.S.A. Bennett Leventhal, M.D. University of Chicago School of Medicine Chicago, Illinois, U.S.A. Siegfried Kasper, M.D. University Hospital for Psychiatry and University of Vienna Vienna, Austria Mark H.Rapaport, M.D. Cedars-Sinai Medical Center Los Angeles, California, U.S.A 1. Handbook of Depression and Anxiety: A Biological Approach, edited by Johan A.den Boer and J.M. Ad Sitsen 2. Anticonvulsants in Mood Disorders, edited by Russell T.Joffe and Joseph R.Calabrese 3. Serotonin in Antipsychotic Treatment: Mechanisms and Clinical Practice, edited by John M.Kane, H.-J.Möller, and Frans Awouters 4. Handbook of Functional Gastrointestinal Disorders, edited by Kevin W.Olden 5. Clinical Management of Anxiety, edited by Johan A. den Boer 6. Obsessive-Compulsive Disorders: Diagnosis • Etiology • Treatment, edited by Eric Hollander and Dan J.Stein 7. Bipolar Disorder: Biological Models and Their Clinical Application, edited by L.Trevor Young and Russell T.Joffe 8. Dual Diagnosis and Treatment: Substance Abuse and Comorbid Medical and Psychiatric Disorders, edited by Henry R.Kranzler and Bruce J.Rounsaville 9. Geriatric Psychopharmacology, edited by J.Craig Nelson 10. Panic Disorder and Its Treatment, edited by Jerrold F.Rosenbaum and Mark H.Pollack 11. Comorbidity in Affective Disorders, edited by Mauricio Tohen 12. Practical Management of the Side Effects of Psychotropic Drugs, edited by Richard Balon 13. Psychiatric Treatment of the Medically III, edited by Robert G. Robinson and William R.Yates 14. Medical Management of the Violent Patient: Clinical Assessment and Therapy, edited by Kenneth Tardiff 15. Bipolar Disorders: Basic Mechanisms and Therapeutic Implications, edited by Jair C.Soares and Samuel Gershon 16. Schizophrenia: A New Guide for Clinicians, edited by John G. Csernansky 17. Polypharmacy in Psychiatry, edited by S.Nassir Ghaemi 18. Pharmacotherapy for Child and Adolescent Psychiatric Disorders: Second Edition, Revised and Expanded, David R.Rosenberg, Pablo A.Davanzo, and Samuel Gershon 19. Brain Imaging in Affective Disorders, edited by Jair C.Soares 20. Handbook of Medical Psychiatry, edited by Jair C.Soares and Samuel Gershon 21. Handbook of Depression and Anxiety: Second Edition, Revised and Expanded, edited by Siegfried Kasper, Johan A.den Boer, and J.M.AdSitsen 22. Aggression: Psychiatric Assessment and Treatment, edited by Emil F.Coccaro 23. Depression in Later Life: A Multidisciplinary Psychiatric Approach, edited by James M.Ellison and Sumer Verma 24. Autism Spectrum Disorders, edited by Eric Hollander 25. Handbook of Chronic Depression: Diagnosis and Therapeutic Management, edited by Jonathan E.Alpert and Maurizio Fava 26. Clinical Handbook of Eating Disorders: An Integrated Approach, edited by Timothy D.Brewerton 27. Dual Diagnosis and Psychiatric Treatment: Substance Abuse and Comorbid Disorders, Second Edition, edited by Henry R.Kranzler and Joyce Tinsley 28. Atypical Antipsychotics: From Bench to Bedside, edited by John G. Csernansky and John Lauriello 29. Social Anxiety Disorder, edited by Borwin Bandelow and Dan J. Stein ADDITIONAL VOLUMES IN PREPARATION Dual Diagnosis and Psychiatric Treatment Substance Abuse and Comorbid Disorders Second Edition edited by Henry R.Kranzler Joyce A.Tinsley University of Connecticut School of Medicine Farmington, Connecticut, U.S.A. MARCEL DEKKER, INC. NEW YORK • BASEL This edition published in the Taylor & Francis e-Library, 2005. To purchase your own copy of this or any of Taylor & Francis or Routledge’s collection of thousands of eBooks please go to www.eBookstore.tandf.co.uk. The first edition was Dual Diagnosis and Treatment: Substance Abuse and Comorbid Medical and Psychiatric Disorders, edited by Henry R.Kranzler and Bruce J. Rounsaville (1998). Although great care has been taken to provide accurate and current information, neither the author(s) nor the publisher, nor anyone else associated with this publication, shall be liable for any loss, damage, or liability directly or indirectly caused or alleged to be caused by this book. The material contained herein is not intended to provide specific advice or recommendations for any specific situation. Trademark notice: Product or corporate names may be trademarks or registered trademarks and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging-in-Publication Data A catalog record for this book is available from the Library of Congress. ISBN 0-203-01761-7 Master e-book ISBN ISBN: 0-8247-5042-X (Print Edition) Headquarters Marcel Dekker, Inc., 270 Madison Avenue, New York, NY 10016, U.S.A. tel: 212–696–9000; fax: 212–685–4540 Distribution and Customer Service Marcel Dekker, Inc., Cimarron Road, Monticello, New York 12701, U.S.A. tel: 800–228–1160; fax: 845–796–1772 Eastern Hemisphere Distribution Marcel Dekker AG, Hutgasse 4, Postfach 812, CH-4001 Basel, Switzerland tel: 41–61–260–6300; fax: 41–61–260–6333 World Wide Web http://www.dekker.com The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the headquarters address above. Copyright © 2004 by Marcel Dekker, Inc. All Rights Reserved. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. Preface As with the first edition of this book, the second edition provides a scientific basis for the clinical care of dually diagnosed patients—specifically, those individuals who suffer from a substance use disorder in combination with either a psychiatric or medical disorder. The attention that was focused on the issue of dual diagnosis, which led to the publication of the first volume, has continued to grow unabated. This growth has been stimulated by a continued high rate of comorbidity and the difficulty inherent in providing appropriate care for dually diagnosed patients. Understanding the basis for such comorbidity is essential in the search for the etiology and pathogenesis of both substance use and comorbid disorders. Increased clarity of diagnostic criteria and improvements in diagnostic methods have enhanced the assessment process. Finally, new models for treatment of dually diagnosed patients continue to be developed and implemented, further underscoring the need for integrated care to ensure adequate attention to the complex treatment needs of this patient group. The book contains information that is relevant to both the clinician and the investigator interested in the empirical and theoretical dimensions of comorbidity. New chapters have been added and consolidation has occurred to allow greater comprehensiveness. The first part (Chapters 1–4) is devoted to basic issues of epidemiology, genetics, diagnosis, and treatment. It provides the scientific and methodological underpinnings for ongoing developments in the clinical care of patients with dual diagnosis. The second part (Chapters 5–16) focuses on specific comorbid disorders in the large, heterogeneous population of patients with comorbid substance use and psychiatric or medical disorders. Because differential diagnosis is particularly challenging in dually diagnosed patients, each of the chapters in this section of the book provides a detailed discussion of the diagnostic process relevant to the specific comorbid disorder(s) addressed in that chapter. The individual chapters also review in detail the options that exist for the treatment of dually diagnosed patients. New chapters have been added on the comorbidity of alcohol and drug use disorders. In addition, the growing recognition of the high degree of comorbidity of substance use disorders with compulsive gambling led to the inclusion of a chapter on that topic. These topics were added to chapters covering comorbidity with mood disorders, anxiety disorders, nicotine dependence, personality disorders, eating disorders, attention-deficit disorder, schizophrenia, and cognitive impairment. Finally, chapters are devoted to the diagnosis and treatment of HIV infection and of other major medical disorders that are directly related to substance abuse. We thank all the contributors for their diligence in providing up-to-date and definitive coverage of their topics in a form that can be useful to researcher and clinician alike. Henry R.Kranzler Joyce Tinsley Contents Preface vi Contributors ix BASIC ISSUES 1. Comorbidity of Alcohol, Drug, and Psychiatric Disorders: Epidemiology 1 Deborah Hasin, Edward Nunes, and Jacob Meydan 2. Genetic Basis of Dual Diagnosis 32 Jaakko Lappalainen 3. Overview of Diagnostic Methods: Diagnostic Criteria, Structured and Semi- 53 Structured Interviews, and Biological Markers Edward Nunes, Deborah Hasin, and Carlos Blanco 4. Overview of Treatment Modalities for Dual-Diagnosis Patients: 87 Pharmacotherapy, Psychotherapy, and 12-Step Programs Roger D.Weiss, Lisa M.Najavits, and Grace Hennessy SPECIFIC DISORDERS OR CONDITIONS 5. Multiple Substance Use and Multiple Dependencies 108 Michael Gossop 6. Substance Abuse and Mood Disorders: Prevalence, Diagnosis and Treatment 131 Vania Modesto-Lowe, Amira Pierucci-Lagha, and Henry R. Kranzler 7. Substance Dependence and Anxiety Disorders 159 Kathleen T.Brady 8. Comorbidity of Nicotine Dependence with Affective Psychotic and Substance 174 Use Disorders Judith L.Cooney, Ned L.Cooney, Christi A.Patten, and Tony P.George 9. Comorbidity of Personality Disorders and Substance Use Disorders 215 Roel Verheul and Wim van den Brink 10. Comorbidity of Eating Disorders and Substance-Related Disorders 261 Cynthia M.Bulik, Margarita C.T.Slof, and Patrick F.Sullivan 11. Attention-Deficit Hyperactivity Disorder and Substance Abuse 288 L.Randolph Waid, Steven D.LaRowe, Diane E.Johnson, and Raymond F.Anton 12. Co-Occurring Schizophrenia and Addiction 320 Douglas Ziedonis, Marc L.Steinberg, Karen D’Avanzo, and David Smelson 13. Comorbidity of Substance Use and Gambling Disorders 360 Nancy M.Petry and Robert H.Pietrzak 14. The Neuropsychology of Alcoholism: Effects of Premorbid and Comorbid 381 Disorders Richard F.Kaplan 15. HIV Infection: From Dual to Triple Diagnosis 402 Stephen J.Ferrando and Steven L.Batki 16. Medical Disorders in Substance Abuse Patients 425 Lynn E.Sullivan and Patrick G.O’Connor Index 458 Contributors Raymond F.Anton, M.D. Distinguished University Professor of Psychiatry and Director, Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina, U.S.A. Steven L.Batki, M.D. Professor and Director of Research, Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York, U.S.A. Carlos Blanco, M.D., Ph.D. New York State Psychiatric Institute, New York, New York, U.S.A. Kathleen T.Brady, M.D., Ph.D. Clinical Neuroscience Division, Institute of Psychiatry, Medical University of South Carolina, and Ralph A. Johnson VA Medical Center, Charleston, South Carolina, U.S.A. Cynthia M.Bulik, Ph.D. William R. and Jeanne H.Jordan Distinguished Professor of Eating Disorders, Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, U.S.A. Judith L.Cooney Psychology Service, VA Connecticut Healthcare System, Newington, and University of Connecticut School of Medicine, Farmington, Connecticut, U.S.A. Ned L.Cooney Psychology Service, VA Connecticut Healthcare System, Newington, and Yale University School of Medicine, New Haven, Connecticut, U.S.A. Karen D’Avanzo, Ph.D. Associate Research Scientist, Yale University—Connecticut Mental Health Center, New Haven, Connecticut, U.S.A. Stephen J.Ferrando, M.D. Associate Professor of Clinical Psychiatry, New York- Presbyterian Hospital and Weill Medical College of Cornell University, New York, New York, U.S.A. Tony P.George Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, U.S.A. Michael Gossop, Ph.D. National Addiction Centre, London, United Kingdom Deborah Hasin, Ph.D. Department of Epidemiology, Mailman School of Public Health and College of Physicians & Surgeons, Columbia University, and New York State Psychiatric Institute, U.S.A. Grace Hennessy, M.D. Instructor in Psychiatry, Harvard Medical School, and Medical Director, Partial Hospital Program, Alcohol and Drug Abuse Treatment Program, McLean Hospital, McLean Hospital, Belmont, Massachusetts, U.S.A. Diane E.Johnson, Ph.D. Aware House, LLC, Durham, North Carolina, U.S.A. Richard F.Kaplan, Ph.D. Professor, Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut, U.S.A. Henry R.Kranzler, M.D. Professor, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, U.S.A. Jaakko Lappalainen, M.D., Ph.D. Assistant Professor, Department of Psychiatry, Yale University School of Medicine, New Haven, and VA Connecticut Healthcare System, West Haven, Connecticut, U.S.A.
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