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DTIC ADA445069: DoD Policies on Force Health Protection: Medical Defense Against Biological Warfare Agents (DoD Directives, DoD Instructions) PDF

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ebd054 Chapter54 DoD POLICIESON FORCE HEALTH PROTECTION: MEDICAL DEFENSE ArticleContents AGAINST BIOLOGICAL WARFAREAGENTS (DoDDIRECTIVES, DoD • Introduction INSTRUCTIONS) • DoDIssuancesforFHPAgainst BWAgents FRANKJ.LEBEDA • MedicalCountermeasures AgainstBWAgents • Surveillance:RecordKeeping, Detection,andEpidemiology • Occupationaland EnvironmentalHealthRisk Assessments • MedicalTraining:Preparingfor aBWEvent • Conclusion • References Opinions, interpretations, conclusions, and recommenda- intoweaponsandintentionallyusedtocausehumandis- tions are those of the author and are not necessarily easeorfatalities(DoDDirective6205.3,1993).Drivenby endorsedbytheU.S.Army. thehealthconcernsafterOperationDesertStormin1991, newhealthcarepoliciesandplansarecontinuouslybeing developed and implemented to enhance the protection of INTRODUCTION U.S.militarypersonnelagainstdiseasesandenvironmen- talhazards,includingBWagents(Mazzuchietal.,2002). The concept of force health protection (FHP) defines In this effort, the DoD and other agencies were directed the medical defense approaches to maintain the health by(Presidential Review Directive, National Science and of the men and women who serve in the U.S. Armed Technology Council-5 (PRD/NSTC-5), 1998) to review Forces, to minimize or eliminate casualties, and to their existing policies and develop plans to help estab- provide superior casualty care. Medical defense against biological warfare (BW) agents, whether encountered lish new FHP programs. Recommendations were made on a battlefield or as a result of bioterrorism, forms to alter policies and doctrines concerning threat analy- an important part of this strategy. Summarized here ses, medical countermeasures (vaccines and therapeutic are directives, instructions, and other policy statements drugs), medical surveillance (record keeping, detection, published by the U.S. Department of Defense (DoD) andepidemiology),healthriskassessments(occupational that apply to the medical aspects of FHP against andenvironmental),andpreparednesstraining. BW threats (Tables1and2). These statements focus on DoD policies can be promulgated as DoD directives medical countermeasures, medical surveillance, health (DoDDs) that establish or guide activity of the Army, riskassessment,andpreparednesstraining. Navy, Air Force, Marines, National Guard, Reserve components, and other DoD organizational units. These broad policy statements reflect the requirements set DODISSUANCESFORFHPAGAINSTBWAGENTS forth by legislation, the President, or the Secretary of Defense (SECDEF). Senior military and civilian MedicalpoliciesintheU.S.militarytopreventdiseasecan DoD officials issue memoranda that can also become betracedbackto1777,whenGeneralGeorgeWashington policy statements. Within these directives, missions are ordered that his troops be variolated (the method of defined and responsibilities are assigned, while policies, conferring active immunity that was employed prior to programs,andorganizationsareestablishedordescribed. the advent of vaccination) against smallpox. More than Individuals affected by DoD’s health care policies, in 200years later, this disease is again a focal point of FHP efforts, as policies and instructions were given in addition to military personnel, can include essential 2002tobeginvaccinatingmilitarypersonnelagainstthis civiliansintheDoDandotherfederaldepartmentswhen potentialBWthreat.Thissectionwillreviewsomeofthe assigned as part of the U.S. Armed Forces, as well as more recent DoD medical policy statements and some of beneficiariesofthemilitaryhealthsystem(MHS). the federal laws mentioned within these issuances that General guidelines for implementing these policies, dealwiththesehealththreats. outliningprocedures,andassigningmoredetailedrespon- TheDoDdefinesBWagentsasmicroorganismsorbio- sibilitiesarefoundinDoDinstructions.Detailedtechnical logically derived poisons (i.e., toxins) that are developed instructions can come in the form of memos from the EncyclopediaofBioterrorismDefense, EditedbyRichardF.PilchandRaymondA.Zilinskas ISBN0-471-46717-0 Copyright2005Wiley-Liss 1 Report Documentation Page Form Approved OMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE 2. REPORT TYPE 3. DATES COVERED 1 JAN 2005 N/A - 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER DoD policies on force health protection: medical defense against 5b. GRANT NUMBER biological warfare agents (DoD directives, DoD instructions); in Pilch, RF Zalinskas, RA,Encyclopedia of Bioterrorism Defense, Wiley Liss 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Lebeda FJ 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION United States Army Medical Research Institute of Infectious Diseases, REPORT NUMBER RPP-03-046 Fort Detrick, MD 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release, distribution unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT The concept of force health protection (FHP) defines the medical defense approaches to maintain the health of the men and women who serve in the U.S. Armed Forces, to minimize or eliminate casualties, and to provide superior casualty care. Medical defense against biological warfare (BW) agents, whether encountered on a battlefield or as a result of bioterrorism, forms an important strategy. Summarized here are directives, instructions, and other policy statements published by the U.S. Department of Defense (DoD) that apply to the medical aspects of FHP against threats. These statements focus on medical countermeasures, medical surveillance, health risk assessment, preparedness training. 15. SUBJECT TERMS biowarfare, biodefense, bioterrorism, DoD policy 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF 18. NUMBER 19a. NAME OF ABSTRACT OF PAGES RESPONSIBLE PERSON a. REPORT b. ABSTRACT c. THIS PAGE SAR 6 unclassified unclassified unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 ebd054 2 DoDPOLICIESONFORCEHEALTHPROTECTION:MEDICALDEFENSEAGAINSTBIOLOGICALWARFAREAGENTS Table1. DoDDirectivesandInstructionsRelatedtoFHPAgainstBWAgentsa Publication DoDD/DoDI Numberb Title Date WebAddressc Directive 5136.1 AssistantSecretaryofDefense December2,1992 http://www.dtic.mil/whs/directives/corres/ forHealthAffairs html/51361.htm Directive 5160.5 ResponsibilitiesforResearch, May1985 http://www.dtic.mil/whs/directives/corres/ Development,andAcquisition html/51605.htm ofChemicalWeaponsand ChemicalandBiological Defense Directive 6025.3 ClinicalQualityManagement July20,1995 ProgramintheMilitary HealthServices Directive 6200.2 Useofinvestigationalnew August1,2000 http://www.dtic.mil/whs/directives/corres/ drugsforforcehealth html/62002.htm protection Directive 6205.2 Immunizationrequirements 1989 http://usmilitary.about.com/library/milinfo/ dodreg/bldodreg6205-2i.htm?terms=6205.2 Directive 6205.3 DoDimmunizationprogramfor 1993 http://www.dtic.mil/whs/directives/corres/ biologicalweaponsdefense html/62053.htm Directive 6490.2 JointMedicalSurveillance August30,1997 http://www.dtic.mil/whs/directives/corres/ html/64902.htm Instruction 1322.24 MilitaryMedicalReadiness December20,1995 http://www.dtic.mil/whs/directives/corres/ SkillTraining html/132224.htm Instruction 6490.3 Implementationand August7,1997 http://www.dtic.mil/whs/directives/corres/ ApplicationofJointMedical ins1.html SurveillanceforDeployments aTables1and2weremodifiedfrom(Mazzuchietal.,2002). bDoDDandDoDInumberedseriesofcategoriesrelevanttoBWdefense. 2000—InternationalandForeignAffairs. 3000—PlansandOperations,ResearchandDevelopment,Intelligence,andComputerLanguage. 5000—AcquisitionandAdministrativeManagement,OrganizationalCharters,Security,andPublicandLegislativeAffairs. 6000—Health. (fromhttp://www.fas.org/irp/doddir/dod/index.html) cAllwebsiteswereaccessibleinMarch2003. seniorleadership,suchasthe2002memofromtheAssis- multinational forces, and civilians who provide essential tant Secretary of Defense for Health Affairs (ASD(HA)) support(JointPublication3–11,2000). thatestablished policyforreinstating theadministration Policymakers are supplied with feedback regard- ofsmallpoxvaccine.Mostoftheseissuancesarecurrently ing FHP plans and their implementations from DoD- generatedreports,analysesbyothergovernmentagencies, available on the worldwide web (see Tables1and2 for and by nongovernment groups. Implementations of med- moreinformation). ical policy are summarized in congressionally mandated As described in DoDD 5136.1 (1992), the ASD(HA) reports.Forexample,annualDoDreportsontheChemical assists the SECDEF in DoD-related health policy issues and Biological Defense Program, in accordance with P.L. and oversees the MHS, including all aspects concerning 103–160Sec.1523, are presented to Congress describ- the delivery of health care services. The fundamental ing the overall organization of research and its progress missionsoftheMHSaretosupportmilitaryreadinessand towardprotectingthehealthofmilitaryservicemembers. • peacetimehealthcare,bothofwhichincludeFHP(•Baily, Q1 1999). FHP in turn involves three strategic programs: surveillance and casualty prevention programs designed MEDICALCOUNTERMEASURESAGAINSTBWAGENTS to protect against endemic diseases and environmental Themorerecent DoDbiodefensehealthpoliciesbeganin hazards(includingBWagents),andclinicalprogramsthat 1976withDoDD5160.5,whichassignedresponsibilityfor providecasualtycareandmanagement(JointPublication chemical and biological defense research, development, 4-02,2001). testing, and evaluation. Revised in 1985 to update pro- Public Law 105-85 established the requirements of ceduresforbudgeting,programming,andoperations,this maintaining records of all health care services, including directive also assigns responsibilities for DoD research, vaccinations, in a centralized location; conducting and development, and the acquisition of countermeasures recordingpre-andpostdeploymentmedicalexaminations; against chemical and biological agents. An example of and recording changes in a service member’s medical aresultingimplementationfromDoDD5160.5istheJoint condition during deployment. FHP policy by the Joint Medical Biological Defense Research Program. This pro- ChiefsofStaffalsotakesintoconsiderationhostcountries, gram integrates DoD-supported internal and extramural ebd054 DoDPOLICIESONFORCEHEALTHPROTECTION:MEDICALDEFENSEAGAINSTBIOLOGICALWARFAREAGENTS 3 Table2. DoD-issuedPolicyStatementsRelatedtoFHPAgainstBWAgents DoDIssuances Publication &Memoranda Number Title Date WebAddressa ASD(HA) HAPolicy01–017 Updatedpolicyforpre-and October25, http://chppm- Memorandum post-deploymenthealth 2001 www.apgea.army.mil/deployment/ assessmentsandblood #DODandArmyPolicies samples ASD(HA) Noneavailable ClinicalpolicyfortheDoD November26, http://www.smallpox.army.mil/resource/ Memorandum smallpoxvaccinationprogram 2002 policies.asp Joint 3-11 JointDoctrineforOperationsin July11,2000 http://www.dtic.mil/doctrine/jpoperations- Publication Nuclear,Biological,and seriespubs.htm ChemicalEnvironments Joint 4-02 DoctrineforHealthService July30,2001 http://www.dtic.mil/doctrine/jplogistics- Publication SupportinJointOperations seriespubs.htm Joint 5.00–2 JointTaskForcePlanning April13,1999 http://www.dtic.mil/doctrine/jpplanning- Publication GuidanceandProcedures seriespubs.htm CJCSMemo- MCM-251-98 DeploymentHealth December4, Notcurrentlyavailable randum SurveillanceandReadiness 1998 CJCSMemo- MCM-0006-02 UpdatedProceduresfor February1, http://www.dtic.mil/doctrine/ randum DeploymentHealth 2002 other directives.htm SurveillanceandReadiness Joint AFJI48-110; Immunizationsand November1, http://afpubs.hq.af.mil/pubfiles Instruction AR40-562; Chemoprophylaxis 1995 BUMEDINST 6230.15; CGCOMDTINST M6230.4E Army 525-13 AntiterrorismForceProtection: September10, Notcurrentlyavailable Regulation SecurityofPersonnel, 1998 Information,andCritical ResourcesfromAsymmetric Attacks ArmyMedical MEDCOM525-4 EmergencyPreparedness December11, http://chppm- Command 2000 www.apgea.army.mil/smallpox/ Regulation aAllwebsiteswereaccessibleinMarch2003. basic research efforts leading to the development of vac- DoDD 6200.2 also incorporates the mandates of Title cines, therapeutic drugs, and diagnostic tools to protect 10USC1107,ExecutiveOrder13139(1999),andtheFDA againstandtodetertheuseofBWagents(Lebeda,1997; interim final rule 21 CFR 50.23.The SECDEF, under DoD,2002). 10.1107,mustnotifyservicepersonnelinwritingthatthe Vaccinationpoliciesforallmembersofthearmedforces, specified drug they are to receive is an IND or a drug civilianemployeesoftheDoD,andeligiblebeneficiariesof whose use, under the circumstances, is not approved by theMHSarestatedinDoDD6205.2(1989).Programsare theFDA.Notificationmustalsobegivenfortherationale outlinedfordiseasesthatcanbepreventedbyvaccination. for administering the drug, possible adverse reactions Specified civilian personnel, for example at risk DoD laboratoryworkerswhomaybecomeexposedtopathogenic producedbythedrug,andanyotherinformationrequired organisms,mayalsoneedtousevaccinesotherthanthose bytheSecretaryoftheDepartmentofHealthandHuman thatareroutinelyadministered. Services. Title 10 USC 1107 also allows the president to ThemainDoDpoliciesthatarespecificforvaccinating waive the prior consent requirement for administering the armed forces against known or potential BW agents INDs to service personnel. The policy in E.O. 13139 are summarized in DoDD 6205.3 (1993). The policies outlines procedures for informed consent requirements involve ‘‘research, development, testing, acquisition, and and waiver provisions. The FDA’s interim rule 21 CFR stockpiling’’ of vaccines to be used for biological defense. 50.23 permits the waiver of prior consent if personnel Thesevaccinesare(orwillbe)eitherlicensedorclassified are already involved in a military operation in which as Investigational New Drugs (INDs) by the Food and exposurestoNBCthreatsorotherenvironmentalhazards DrugAdministration(FDA).DoDD6200.2(2000)provides are imminent and likely to be lethal or cause serious further policy and guidance forthe use of INDs for FHP. illness. Just before Operation Desert Shield, this rule This document identifies at-risk armed forces personnel and DoD-related civilians who need to be protected wasinvokedtoallowtheuseoftwoINDs,pyridostigmine fromnuclear, biological,andchemical(NBC)threatsand bromideandbotulinumtoxoidvaccine,tocounterchemical endemicdiseases. andbiologicalthreats,respectively. ebd054 4 DoDPOLICIESONFORCEHEALTHPROTECTION:MEDICALDEFENSEAGAINSTBIOLOGICALWARFAREAGENTS Thejointinstructionpublishedin1995forvaccinations standardsystemtohelpdeliverandtrackclinicalpreven- and chemoprophylaxis outlines implementation require- tiveservices. ments under the Armed Forces Immunizations Program for protecting individuals from endemic diseases and OCCUPATIONALANDENVIRONMENTALHEALTHRISK potentialBWthreats.Alsoprovidedarerequirementsfor ASSESSMENTS tracking vaccinations for an individual’s health record. These vaccinations are intended for service personnel Relevant to BW agents, guidance for joint medical andselectedcivilians(federalemployeesandMHS-eligible surveillance on nuclear, biological, or chemical battle or familymembers). operational environments contaminated by other factors, such as toxic industrial chemicals, was provided in 1997 by DoDD 6490.2 and DoDI 6490.3.Both documents SURVEILLANCE:RECORDKEEPING,DETECTION,AND emphasize the need for accurate communication about EPIDEMIOLOGY potential environmental and health risks to service members. ‘‘Environmental risk assessments’’ predict the Medical (health) surveillance programs are designed frequency of disease occurrence, based on environmental to warn of and to reduce the incidence of illness. A exposures,inapopulation,whilepredictionsfrom‘‘health memorandumbytheChairmanoftheJointChiefsofStaff hazardassessments’’arebasedonoccupationalexposures. (CJCS)(MCM-251-98,1998)initiallyoutlinedaFHPplan The CJCS memo (MCM-0006-002; 2002) outlines the thatfeaturedhealthsurveillanceasakeycomponent.For process of occupational and environmental health (OEH) joint operations, DoD Instruction (DoDI) 6490.3 (1997), risk assessment in such environments. A part of this bydefininghealthsurveillancerequirements,implements assessment is an Environmental Baseline Survey (EBS) policy, outlines procedures, and assigns responsibilities at the site of deployment, which identifies occupational set forth in DoDI 6490.2 (1997). Medical surveillance is and environmental health and safety hazards and mandated for all members of the military services and estimatestheirseverity.Technicalguidanceinconducting reserve components before, during, and after military this survey is in Field Manual FM 3–100.4 (2000). deployments. The main goals are to identify potential As part of the FHP program, the EBS documents threats to health, which may include exposure to BW these hazards. Commanders are instructed to use agents;tocollecthealthdatafrommultiplelocationsinthe these surveillance measures to determine appropriate deploymentarea;andtocommunicatequicklytherelevant responsesandcommunicatetheseriskswiththeirforces. dataforstorage,integration,andfurtherassessment.The Commanderscan thenmakeinformedchoices and weigh significant health risks are to be identified by the CJCS missionrequirementsduringoperationalplanningagainst in coordination with the ASD(HA). In this Instruction, occupationalandenvironmentalhealthhazards. theSecretaryoftheArmyisresponsiblefortheoperation and maintenance by the U.S. Army Center for Health MEDICALTRAINING:PREPARINGFORABWEVENT Promotion and Preventive Medicine of a DoD Serum Repository that stores specimens for exclusive use in the TheDoDhasdevelopedprogramsthatprovideandmonitor diagnosis, prevention, and treatment of health problems military medical skills training in accordance with DoDI associated with such deployments. Some of these FHP 1322.24 (1995). Knowledge of BW threats and medical procedures are also referred to in joint doctrine (Joint consequence responses to BW exposure are provided by Publication 5.00-2, 1999), while recent policies regarding the U.S. Army Medical Department. Courses have been health assessments before and after deployments are developed in the joint medical management of biological found in a memorandum by the ASD(HA) (HA Policy casualties. Three reference texts that accompany some 01–017,2001).TheDefenseMedicalSurveillanceSystem of these courses are cited in the Further Reading and is responsible for maintaining these assessment data, Web Resources section below. The U.S. Army Medical whichincludebothphysicalandpsychologicalevaluations. Command,inresponsetoMEDCOMRegulation525-4,is Instructions for assessing health readiness and con- preparing a pamphlet on emergency preparedness that ductinghealthsurveillanceinsupportofjointandunified provides guidance on responses to emergencies including commanddeploymentsweredeliveredinamemorandum those involving the use of NBC weapons. Health- care fromtheCJCS(MCM-251-98,1998).Amorerecentmemo- providers within the military must also be certified randum(MCM-0006-02,2002)instructsthatstandardized when assigned to military operations (DoDD 6025.3, health readiness assessments and health surveillances 1995). The certification process includes training in BW be conducted. This memo also places responsibility on defensemeasures. the combatant command to decide which specific med- ical countermeasures, such as vaccines, antibiotics, or other drugs, are needed(Embrey, 2002). Epidemiology CONCLUSION data are required to be analyzed and archived to report and track adversereactions andillnessesthatmayoccur Thesedirectives,instructions,andotherpolicystatements afterrequiredvaccinations(DoDI6205.2,1986).Although aredesignedtoenhanceFHPandthepreparednessofthe each military service currently has its own vaccination- U.S. Armed Forces. It is expected that some of these trackingprogram,thePreventiveHealthCareApplication health-related policies developed by the DoD after 1990 (PHCA) that is being developed will become the single for military personnel will have civilian applications in ebd054 DoDPOLICIESONFORCEHEALTHPROTECTION:MEDICALDEFENSEAGAINSTBIOLOGICALWARFAREAGENTS 5 thepost-September11era.Itisalsoreasonabletoexpect Public Law 104–201, National Defense Authorization Act for that some of the implementations resulting from these Fiscal Year 1997, Title XIV: Defense Against Weapons of DoD policies will help in the continuing struggle by the MassDestruction(WMD),SubtitleA:DomesticPreparedness, September23,1996. civilianpublichealthsectortoprotectagainstcurrentand emerginginfectiousdiseases. PublicLaw105-85,NationalDefenseAuthorizationActforFiscal Year1998. Report 106–945, Conference Report to Accompany H.R. 4205, REFERENCES Enactment of Provisions of H.R. 5408, The Floyd D. Spence NationalDefenseAuthorizationActForFiscalYear2001. Bailey,S.,MilitaryHealthSystemOverviewStatement,Submit- ted to the Personnel Subcommittee, Committee on Armed FURTHERREADINGANDWEBRESOURCES Services,USSenate,FirstSession,106thCongress,March11, Eitzen,E., Pavlin,J., Cieslak,T., Christopher,G., and Culpep- 1999. per,R., Eds., Medical Management of Biological Casualties Code of Federal Regulations (21 CFR 50.23), Title 21 Food Handbook, 4th ed., US Army Medical Research Institute and Drugs, Part50 Protection of Human Subjects, Subpart of Infectious Diseases, Fort Detrick, MD, February 2001, BInformedConsentofHumanSubjects,Sec.50.23Exception http://www.usamriid.army.mil/education/instruct.html. fromgeneralrequirements,Vol.1,RevisedasofApril1,2002, •Q2 pp.288–290•. Franz,D., Defense Against Toxin Weapons, US Army Medical Research and Materiel Command, Fort Detrick, MD, 1997, Code of Federal Regulations (21 CFR 312.21) Title 21 Food http://www.usamriid.army.mil/education/toxdefbook.doc. and Drugs, Part312 Investigational New Drug Application, HeadquartersDepartmentoftheArmy,EnvironmentalConsider- Sec.312.21 Phases of an investigation, Vol.5, pp. 61–62, ationsInMilitaryOperations,(FieldManual3–100.4,Marine RevisedasofApril1,2002. Corps Reference Publication, MCRP4-11B), Headquarters Department of Defense, Chemical and Biological Defense UnitedStatesMarineCorps,Washington,DC,June15,2000, Program,Vol.1,AnnualReporttoCongress,April2002. http://www.adtdl.army.mil/cgi-bin/atdl.dll/fm/3-100.4/toc.htm. Department of Defense, Chemical and Biological Defense Sidell,F.R., Takafuji,E.T., and Franz,D.R., ‘‘Medical Aspects Program, Annual Report to Congress and Performance Plan, of Chemical and Biological Warfare,’’ in R.Zajtchuk, Ed., July2001. Textbook of Military Medicine, Office of The Surgeon Gen- Embrey,E., Deputy Assistant Secretary of Defense for Force eral,TMMPublications;BordenInstitute,WalterReedArmy Health Protection and Readiness, Department of Defense, Medical Center, Washington, DC, •1997, http://www.nbc- •Q4 Statement to the House Committee on Veterans Affairs med.org/SiteContent/HomePage/WhatsNew/MedAspects/ SubcommitteeonHealth,February27,2002. contents.html. Lebeda,F.J.,Mil.Med.,162,156–161(1997). Treatment Of Biological Warfare Agent Casualties (Field Mazzuchi,J.F., Trump,D.H., Riddle,J., Hyanms,K.C., and Manual No. 8–284 NAVMED P-5042, Air Force Manual Balough,B.,Mil.Med.,167,179–185(2002). (Interservice) No. 44–156, Marine Corps MCRP 4–11.1C). PresidentialReviewDirective,NationalScienceandTechnology Headquarters Departments of The Army, The Navy, and Council-5, A National Obligation: Improving the Health of The Air Force and The Commandant, Marine Corps, Our Military, Veterans, and Their Families, Executive Office Washington, DC, July 17, 2000 (incorporates Change 1, of the President, Office of Science and Technology Policy, 8 July 2002), http://www.adtdl.army.mil/cgi-bin/atdl.dll/fm/8- August1998. 284/fm8-284.htm. Public Law 103–160, National Defense Authorization Act for FiscalYear1994,Title50USC,Sec.1522,Conductofchemical SeealsoDEPARTMENTOFDEFENSE;DETECTIONOFBIOTERRORIST and biological defense program, Sec.1523, Annual report on AGENTS;RISKASSESSMENTINBIOTERRORISM;andSYNDROMIC •Q3 chemicalandbiologicalwarfare•defense. SURVEILLANCE. Queriesinebd054 Q1. Pleaseclarifyifthisnameshouldbe‘Baily’or‘Bailey.’ Q2. ‘Code of Federal Regulations (21 CFR 50.23), 2002’, ‘CodeofFederalRegulations(21CFR312.21),2002’, ‘DoD,2001’,‘PublicLaw103–160,2002’,‘PublicLaw 104–201,1996’,‘PublicLaw105-85,1998(cid:1)and‘Report 106–945,2001(cid:1)havenotbeencitedinthetext.Please providetheplaceofcitation. Q3. Please provide the year of publication for this reference. Q4. Pleaseprovidethepagerangeforthisreference.

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